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Etude des conséquences de stress hypoxiques répétés sur l’intégrité d’un modèle in vitro de barrière hémato-encéphalique

Abstract : The blood-brain barrier (BBB) is the essential structure of the central nervous system (CNS), located at the level of brain capillaries. The BBB is responsible for the maintenance of cerebral homeostasis and its protection. Indeed, diseases affecting the CNS are often related to a disorder at the BBB’s site. One of the several factors which can alter the homeostasis of the CNS, is hypoxia because the brain is one of the the first consumer of oxygen of the body. Several studies showed that acute hypoxia (mimic transient brain ischemia or stroke), could alter BBB permeability. However, some disorders are related to intermittent hypoxia, particularly sleep related breathing disorders, such as sleep apnea syndrome. This intermittent hypoxia does not seem to be innocent on the brain structure and function, since studies in humans have demonstrated that these patients suffer from cognitive disorders. The challenge in the study of such pathologies is represented by a better understanding of mechanisms leading to this alteration, in order to develop adequate therapeutic strategies. Nevertheless, few studies have focused, to date, on the impact of intermittent hypoxia on the BBB, due to the complexity of the brain structure in vivo. In this regard, in vitro BBB model appear to be suitable tools for the study of BBB in pathologies conditions. The aim of this thesis was to set up an in vitro BBB model suitable for the study of BBB’s integrity after repeated hypoxic stress exposure.
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Morgane Chatard. Etude des conséquences de stress hypoxiques répétés sur l’intégrité d’un modèle in vitro de barrière hémato-encéphalique. Médecine humaine et pathologie. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSES002⟩. ⟨tel-02369696⟩

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