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Synthèse et fonctionnalisation de nano-ferrites pour le traitement par hyperthermie

Abstract : The superparamagnetic iron oxide nanoparticles (NPs) are a class of nanomaterials with a high interest in the nanomedicine field. Their magnetic properties and biocompatibility recommend them as potential candidates for diagnostics purposes (MRI, optical or nuclear Imaging ...) and therapy (hyperthermia, nanovectorization...). The aim of this thesis was to study the influence of the synthesis parameters on the final properties of magnetic zinc doped iron oxide nanoparticles. Two synthesis methods were considered, the co-precipitation and the thermal decomposition. The characterization of the obtained nanoparticles by complementary techniques allowed us to propose a consistent relationship between the size, shape and chemical composition on the one hand, and the magnetic properties of the nanoparticles on the other hand. The functionalization of NPs, that is a crucial step for ensuring their biocompatibility and use in magnetic hyperthermia, was also realised and the hyperthermia properties were measured on some typical nanoparticles.
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Submitted on : Friday, November 15, 2019 - 11:28:24 AM
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Mohamed Alae Ait Kerroum. Synthèse et fonctionnalisation de nano-ferrites pour le traitement par hyperthermie. Chimie théorique et/ou physique. Université de Strasbourg; Université Mohammed V (Rabat), 2019. Français. ⟨NNT : 2019STRAE016⟩. ⟨tel-02364986⟩

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