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Theses

Développement d'approches d'imagerie multimodale pour la recherche en oncologie

Abstract : In vivo preclinical imaging in oncology is a tool of choice to study the mechanisms thatgovern this pathology as well as for the evaluation of innovative diagnostic and therapeuticsolutions. Each imaging modality has its own strengths and limitations and that’s why thereis a real benefit to combine several modalities to collect complementary information. In thefirst part of this work, the combination of 3-D fluorescence imaging with microCT imaginghas been implemented and has been particularly relevant for the characterization ofdifferent animal models of lung cancer mimicking one or several stages from primary tumordevelopment to metastatic invasion. In a second part, we assessed the potential ofphotoacoustic imaging for non-invasive imaging of vascularization and tissue oxygenation indifferent pathophysiological contexts in mice as well as in humans, thus demonstrating itshigh translational potential. Fluorescent and photoacoustic contrast agents have been usedto increase tumor contrast and monitor changes in the level of expression of biomarkers ofinterest and the benefit provided by the use of a tumor specific marker has beendemonstrated. In parallel with biological studies, technological developments inphotoacoustic imaging have been initiated in order to improve the application potential ofthis imaging modality.
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Jonathan Lavaud. Développement d'approches d'imagerie multimodale pour la recherche en oncologie. Biochimie, Biologie Moléculaire. Université Grenoble Alpes, 2018. Français. ⟨NNT : 2018GREAV052⟩. ⟨tel-02343179⟩

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