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RMN haut champ et bas champ pour l'analyse de produits de santé

Abstract : The purpose of this research was to demonstrate the interest of Nuclear Magnetic Resonance (NMR) to deal with analytical issues in the field of health products. The studies focused on two main axes. The first one targeted adulterated dietary supplements and the studies were conducted with high-field NMR. Various mono and bidimensional experiments revealed the illegal presence in dietary supplements claimed as natural, of erectile drugs and/or their structural analogues. These active substances can induce, without the consumer's knowledge, significant risks to his health. Moreover, analyses conducted with 1H and 13C NMR, highlighted cases of adulteration of dietary supplements for exercise and athletic performance with doping substances. The second axis explored the potential of low-field NMR for drug analysis. This technique, which is less expensive and more suitable for routine analyses than high-field NMR, has proved very effective in detecting cases of falsified medicines by simple one-dimensional 1H NMR experiments. Two-dimensional diffusion experiments (DOSY: Diffusion Ordered Spectroscopy), which provide virtual separation of the constituents of a complex mixture, were developed and applied for the first time to the de-formulation of a drug.
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Submitted on : Wednesday, October 30, 2019 - 10:25:30 AM
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Gaëtan Assemat. RMN haut champ et bas champ pour l'analyse de produits de santé. Chimie thérapeutique. Université Paul Sabatier - Toulouse III, 2018. Français. ⟨NNT : 2018TOU30268⟩. ⟨tel-02338817⟩

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