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. Méthodes, A l'appui des données clinico-biologiques de deux larges cohortes de patients avec CCIH réséqué (MSKCC, n=189 et AFC, n=522), trois objectifs ont été explorés

, Ensuite, définir la fiabilité de l'évaluation pronostique préopératoire à partir de, respectivement, l'imagerie, des microARN (miR) circulants diagnostiques et du profil génomique tumoral. Enfin, évaluer l'impact pronostique d'événements périopératoires tels que transfusion et morbidité

. Résultats and . Premièrement, Deuxièmement, la taille et la multifocalité tumorale sur l'imagerie préopératoire permettaient de différencier deux groupes de patients de pronostic clairement distincts (p<0,001). L'existence d'une mutation d'un gène de remodelage de la chromatine (BAP1, ARID1A, PBRM1) tendait à être associé à une survie sans récidive plus favorable qu'en l'absence de mutation (p=0,09), les nomogrammes apportaient une meilleure estimation pronostique en comparaison à la classification AJCC 7 ème édition

, Alors que les nomogrammes postopératoires apportent une meilleure estimation pronostique, le développement de modèles pronostiques préopératoires est faisable notamment à partir de l'imagerie et de marqueurs biologiques tumoraux complémentaires

, Mots-clés : cholangiocarcinome intrahépatique ; résection ; survie