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= 115) versus pemetrexed or docetaxel (n = 116) ? Second line after crizotinib 16.5 mo ? 39 ,
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3-year PFS: 62% ? NE; 3-year OS: 78%, vol.73, p.74 ,
,
= 72) versus docetaxel or pemetrexed (n = 35) ? Second line after crizotinib 6.5 mo ? 37 ,
, 001) ? 12.6 mo, NR) versus NR
, NCT01449461 ? Recommended phase II dose (phase I) or ORR (phase II) ? Brigatinib
, ? First line (10%, n = 8), second line after crizotinib (85%, n = 68) or third line after crizotinib and ceritinib (5%
, >31 mo b First-line brigatinib (n = 8): ? 100% ? 34.2 mo ? NR (2-year OS 100%) Brigatinib after crizotinib (n = 71): ? 73% ? 13.2 mo ? 30
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