Skip to Main content Skip to Navigation
Theses

Noyaux réuniens et rhomboïde du thalamus et persistance d'un souvenir chez le rat

Abstract : Neuroanatomical and electrophysiological data place the thalamic Reuniens and Rhomboid nuclei as a key relay between the hippocampus (HP) and the medial prefrontal cortex (mPFC), two brain structures essential for memory. As such, the ReRh nuclei are thought to be involved in HP-mPFC interactions, supporting consolidation processes, and thus memory persistence. Using excitotoxic lesion, chemogenetic inactivation and cellular imaging approaches in various behavioral paradigms, we assessed the implication of the ReRh nuclei in memory processes, particularly consolidation. Our results show that the ReRh nuclei are necessary for offline consolidation of contextual fear memory in rats. A similar conclusion has been drawn from a previous study taxing spatial memory, another HP-dependent type of memory. Thus, the present data show that the necessity of the ventral midline thalamus to systems-level consolidation is not limited to a particular type of memory but could be more general.
Document type :
Theses
Complete list of metadatas

Cited literature [180 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02328215
Contributor : Abes Star :  Contact
Submitted on : Wednesday, October 23, 2019 - 10:33:12 AM
Last modification on : Thursday, October 24, 2019 - 1:30:50 AM

File

QUET_Etienne_2019_ED414.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02328215, version 1

Collections

Citation

Étienne Quet. Noyaux réuniens et rhomboïde du thalamus et persistance d'un souvenir chez le rat. Neurosciences [q-bio.NC]. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ008⟩. ⟨tel-02328215⟩

Share

Metrics

Record views

120

Files downloads

116