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Functionalized Silica Nanostructures : Degradation Pathways and Biomedical Application from 2D to 3D

Abstract : Silica nanoparticles, thanks to the great easy and adaptability of particle synthesis and limited biotoxicity, is very widely studied for biomedical applications. This thesis conducted a large diversity of investigations involving silica nanomaterials. Firstly, the physicochemical properties and biodegradation properties of three types of structured silica nanoparticles were studied in a buffer, a culture medium and in contact with human dermal fibroblasts that suggest that, under these conditions, the silica nanoparticles must be mainly considered as degraded by hydrolysis and not biodegraded. Then, multifunctional silica nanoparticles which are consist of hollow silica nanoparticles and MnO2 nanosheets were synthesized. And the control drug release and imaging performance of this nanoplatforms were studied from 2D to 3D models. This approach could be used for a rapid assessment of the biofunctionality of nanoparticles before setting up in vivo experiments. Furthermore, a new 3D collagen-based nanocomposites using silica rods were studied and the relationships between the composite composition, structure and mechanical properties, emphasizing the key role of collagen-silica interactions. The influence of these parameters on the adhesion and proliferation of fibroblast cells was also investigated. In addition, we prepared and used magnetic silica nanorods to control particle orientation within the collagen network thanks to an external magnetic field. All the results bring new insights on the preparation and properties of bionanocomposites and open the route to multifunctional hydrogels.
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Yupeng Shi. Functionalized Silica Nanostructures : Degradation Pathways and Biomedical Application from 2D to 3D. Material chemistry. Sorbonne Université, 2018. English. ⟨NNT : 2018SORUS122⟩. ⟨tel-02325780⟩

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