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, Animaux tenus en captivité (domestiques ou non domestiques) Oui
, Animaux fournis Mus musculus
, Votre propre établissement utilisateur fournit-il tout ou partie des animaux du projet ? Oui Un autre établissement utilisateur fournit-il tout ou partie des animaux du projet ? Non Les animaux sont-ils des animaux réutilisés d'un projet précédent? Non
types d'expérience avec 2 temps différents) composés chacun de 10 souris contrôles et 10 souris avec baisse de huntingtine pour atteindre la puissance statistique décrite au paragraphe 3.3.5. Au total, 120 souris sont nécessaires par modèle, Pour chacun des deux modèles, 6 lots sont nécessaires, 2013. ,
, Indiquez à quel(s) stade(s) de développement les animaux seront utilisés et le justifier Les animaux seront utilisés à l'âge adulte
, Indiquer pour chaque espèce les points limites adaptés, suffisamment prédictifs et précoces pour permettre de limiter la douleur à son minimum
Du paracétamol sera administré (200mg/kg) après l'injection. La nourriture hydratée sera proposée pour faciliter l'alimentation. Concernant la seconde procédure, il n'est pas attendu d'atrophie majeure, PNAS, 2016. ,