Potential of omega-3 EPA/DHA 6/1 to ameliorate ageing-related endothelial dysfunction

Abstract : EPA:DHA 6:1 omega-3 formulation has been shown to induce a sustained endothelial NO synthase-derived formation of nitric oxide. This study examined if the intake of EPA:DHA 6:1 improves an established ageing-related endothelial dysfunction. Ageing-related endothelial dysfunction was characterized by a blunted NO-mediated component of relaxation, abolished EDH-mediated component and increased COX-derived endothelium-dependent contractile responses. Ageing increased vascular oxidative stress, expression of NADPH oxidase subunits, COX-2, eNOS, ACE, AT1R, and senescence markers, whereas COX-1 was down-regulated. Chronic intake of EPA:DHA 6:1 improved the NO-mediated relaxations, reduced EDCFs, vascular oxidative stress and normalized the expression of protein markers. In conclusion, chronic intake of EPA:DHA 6:1 prevented the ageing-related endothelial dysfunction in old rats, most likely by preventing activation of the local angiotensin system and the subsequent vascular oxidative stress.
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Muhammad Akmal Farooq. Potential of omega-3 EPA/DHA 6/1 to ameliorate ageing-related endothelial dysfunction. Cardiology and cardiovascular system. Université de Strasbourg, 2018. English. ⟨NNT : 2018STRAJ107⟩. ⟨tel-02310699⟩

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