Induction of atrial endothelial senescence by angiotensin II and thrombin : role of oxidative stress and characterization of pro-thrombotic, pro-adhesive, proteolytic and pro-fibrotic phenotype

Hira Hasan

Induction of atrial endothelial senescence by angiotensin II and thrombin : role of oxidative stress and characterization of pro-thrombotic, pro-adhesive, proteolytic and pro-fibrotic phenotype

Induction de la sénescence endothéliale auriculaire par l'angiotensine II et la thrombine : rôle du stress oxydant et caractérisation du phénotype pro-thrombotique, pro-adhésif, protéolytique et pro-fibrotique

Hira Hasan ¹

1 NanoRegMed - Nanomédecine Régénérative

Abstract : Many studies documented strong relationship between ageing and development of atrial fibrillation (AF). Moreover, it has been found that senescence and senescence-associated- secretory-phenotype play an important role in development of overall atrial inflammation which can ultimately ends up in atrial structural remodeling paving the way to AF perpetuation and maintenance. Moreover, it has been known for decades that AF has been associated with the activation of local and circulating coagulation factors. However, little is known about the impact of coagulation-derived factors, in particular thrombin, on the onset of AF. The aim of the present study was to determine the link between atrial endothelial cells (AECs) senescence and the induction of pro-inflammatory, pro-adhesive, pro-fibrotic and pro-remodelling AECs patterns and also to evaluate the contribution of coagulation derived-factors such as thrombin.

Keywords : Atrial endothelial cells Thrombin Coagulation Ageing Atrial fibrillation Senescence

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Theses

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Life Sciences [q-bio] / Human health and pathology / Cardiology and cardiovascular system

Life Sciences [q-bio] / Biochemistry, Molecular Biology

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