Antibiorésistance en santé animale en France : caractérisation à des fins d’évaluation et de lutte et mises en perspective dans un contexte One Health

Abstract : Antimicrobial resistance is a major and global public health concern. In this context, the research problem was to provide decision support to the risk manager for the implementation and assessment of control measures in animal health. To limit and manage the phenomenon, we must know the dynamic of its evolution: the surveillance is therefore a key element in the fight against antimicrobial resistance. At first, using a population survey and a sociological approach, this research determined to what extent the data collected by the French surveillance network of antimicrobial resistance in diseased animals (RESAPATH) could be used to answer the research problem. Since the representativeness and the coverage of the RESAPATH were considered satisfactory, surveillance data were used to characterize the dynamics of the resistances and generalized additive models were developed. The comparison of resistance trends and control measures underscored the positive impact of changes in practices on the evolution of resistances. Finally, in the context of the ‘One Health’ concept that advocates an integrated and collaborative approach to health, the parallel was drawn between resistances in isolates from animals and humans. Data from the French surveillance network of antimicrobial resistance of bacteria isolated in community (MedQual) were analysed. Resistance dynamics were specific to each species. These results advocate that the efforts to fight antimicrobial resistance must be carried in all sectors and for all species, both in human and veterinary medicine
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Clémence Boireau. Antibiorésistance en santé animale en France : caractérisation à des fins d’évaluation et de lutte et mises en perspective dans un contexte One Health. Médecine vétérinaire et santé animal. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1114⟩. ⟨tel-02305431⟩

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