Récepteurs auto-assemblés pour des molécules d’intérêt biologique

Abstract : Since the end of the 20th century, dynamic combinatorial chemistry under thermodynamic control has enabled the synthesis of macrocyclic receptors towards targeted guest. So, many supramolecular hosts have been reported to be efficent in the molecular recognition of biologically relevant molecules in water. We describe a new family of hydrosoluble macrocycles called polycarboxylated dyn[n]renes. Their molecular recognition properties with polyamines, amino acids and metals allow biological studies. From the fundamental view, the role of each parameters, including the solvent, has been deeply studied to identify the strength of the association. In cellulo experiments have shown an antiproliferative and cytostatic effect of the dyn[4]arene on HeLa cancer cells for several hours. In order to modulate their molecular recognition properties, sulfur extrusion process has been carried out to synthesize more robust derivatives of dynarenes. Finally, a new family of similar macrocycles has been studied, based on imino-1,5-dithiocines. Syntheses and physico-chemical studies for the design of futurs cavitands pave the way for similar biological applications as described for Tröger’s bases
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Submitted on : Friday, October 4, 2019 - 10:24:07 AM
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Alexandre Héloin. Récepteurs auto-assemblés pour des molécules d’intérêt biologique. Autre. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1096⟩. ⟨tel-02305400⟩

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