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, RANK ?CD11c and RANK ?LysM mice were bred and kept in specific pathogen-free conditions. All experiments were carried out in conformity with the animal bioethics legislation and institutional guidelines. To generate mice with conditional RANKL deficiency in marginal reticular cells, Ly5.1 (CD45.1) and RANKL ?Ccl19
, RANKLf/f (B6.129-Tnfsf11tm1.1Caob/J) mice, vol.19
, CD11c Cre;RANK flox/flox (RANK ?CD11c ) mice and LysM Cre;RANK flox/flox (RANK ?LysM ) mice were kindly provided by Toby
To inhibit lymphotoxin, RANKL and TNF pathway, mice received 20 µg of LT?R-muIgG1 (LT?R-Fc , kindly provided by Biogen ,
, ?b-actin (CD45.2+) and from Ly5.1 (RANK +/+ ;CD45.1+) mice
Collagenase D (Roche,1mg/ml), DNase I (Roche, 0.1mg/ml) under agitation at 37°C for 1h. The cell suspension was then filtered at 100µm, RPMI + 2% FCS + Dispase II (Roche, 1mg/ml) ,
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