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, Inhibiting Th17 cell generation is another strategy to target indirectly the IL-17 pathway. Inhibitors against the IL-6 pathway (anti-IL-6R or JAK in-hibitors) or IL-1 pathway (IL-1R antagonist or anti-IL-1?) may inhibit the initiation of Th17 cell generation and anti-IL-23 the stabilization of the Th17 cell phenotype. ROR?t inhibitors reduce the Th17 cell differentiation, IL-17 pathway is targeted directly with antibodies against IL-17 and IL-17 receptor or by inhibiting IL-17 signal transduction

J. Jak and . Kinase,

. Ror?t, retinoic acid receptor-related orphan nuclear receptor gamma t

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