Rôle des exosomes comme nouvelle voie de communication entre les neurones

Abstract : Exosomes are vesicles of endocytic origin released by cells into their environment following fusion of multivesicular endosomes with the plasma membrane. Exosomes represent a novel mechanism of cell communication allowing direct transfer of proteins, lipids and RNA. The goal of my PhD thesis was to study that exosomes represent a novel way of interneuronal communication. Our team has previously reported that neurons release exosomes in a way tightly regulated by synaptic activity. We observed that exosomes released by neurons are only endocytosed by neurons. We found that exosomes contain only small RNA and did a deep sequencing of all their microRNA. MicroRNA are selectively exported into exosomes. It seems that exosomal microRNA can modify the physiology of receiving neurons. Our results strengthen the hypothesis of the role of exosomes in the interneuronal communication by the way of microARN transfert.
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Charlotte Javalet. Rôle des exosomes comme nouvelle voie de communication entre les neurones. Neurosciences [q-bio.NC]. Université Grenoble Alpes, 2016. Français. ⟨NNT : 2016GREAV028⟩. ⟨tel-02301989⟩

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