Polluants Organochlorés et Risque de Survenue du Cancer de la Prostate. Interactions Gène-Environnement

Abstract : Prostate cancer (PCa) is the most frequent type of cancer in Western countries. Advanced age, ethno-geographic origin and the presence of a family history of CaP are the main clearly established risk factors. The effects of exposure to synthetic chemicals with hormonal properties, also called endocrine disruptors (EDCs), on PCa are also are suspected. The main objective of this thesis is to evaluate the relationships between plasma concentration of persistent organochlorine pollutants with hormonal properties, such as DDE (the main metabolite of DDT) and PCBs as well polymorphisms of selected genes involved in xenobiotic (GSTM1, GSTT1) and estrogens (CYP17, CYP19, CYP1B1, COMT, UGT1A1) metabolism, and the occurrence of PCa or its recurrence after treatment with radical prostatectomy. This project is based on data obtained from the population-based case-control study (KARUPROSTATE) in Guadeloupe and from cases treated by radical prostatectomy.
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Elise Emeville. Polluants Organochlorés et Risque de Survenue du Cancer de la Prostate. Interactions Gène-Environnement. Médecine humaine et pathologie. Université Rennes 1, 2014. Français. ⟨NNT : 2014REN1B016⟩. ⟨tel-02301127⟩

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