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, VT64246/amn-RNAi1 and VT64246/amn-RNAi2 flies exhibit normal shock reactivity (amn-RNAi1: F (2,29) = 0.9378, p = 0.4059, n = 10; amnRNAi2: F (2,29) = 0.7252, p = 0.4934, n = 10) and normal olfactory acuity for octanol, Supplementary Table 1. Shock reactivity and olfactory acuity of flies expressing amnRNAi in DPM neurons Data are shown as means ± SEM

, Supplementary Table 2. Shock reactivity and olfactory acuity of flies expressing amnRNAi in adult MB neurons Data are shown as means ± SEM

, amn-RNAi2: F (2,29) = 0.9917, p = 0.3840, n = 10) and normal olfactory acuity for octanol

, 29) = 1.628, p = 0.2150, n = 10)

, 23) = 0.1736, p = 0.8418, n = 8) and normal olfactory acuity for octanol (F (2,23) = 1.156, p = 0.3340, n = 8) and methylcyclohexanol, VT30559/amn-RNAi1 induced flies exhibit normal shock reactivity

, 238Y/amn-RNAi1 and Gal80 ts ;238Y/amn-RNAi2

, p = 0.9517, n = 10) and normal olfactory acuity for octanol

, En conclusion, nous proposons que les défauts de mémoire observés chez les mouches amn X8 /Y proviennent à la fois d'un défaut de développement, a minima des neurones DPM, possiblement dus au peptide homologue à la GH, et d'un défaut de détection de coïncidence

. Keene, Concernant les neurones DPM, il a déjà été montré que les projections sur les MB sont des neurites qui peuvent recevoir et transmettre des informations, pouvaient recevoir des informations d'autres neurones, ce qui indique que des synapses postsynaptiques y sont aussi présentes, 2006.

. Iwata, ou enfin les deux, Il serait donc intéressant de déterminer si le rôle des néprilysines est présynaptique ou postsynaptique. En effet, chez les mammifères, la littérature rapporte des informations contradictoires sur la localisation des néprilysines : pour certains, elles sont présynaptiques, 1990.

. Mittal, Ces neuropeptides pourraient provenir des MB eux--mêmes ou des nombreuses afférences à ces neurones, et agir sur les MB ou des neurones adjacents. Les DPM pourraient jouer un rôle en arrêtant l'activation des voies de signalisation nécessaires à la formation de la MTM et de la LTM, et en dégradant les neuropeptides présents près des lobes des MB. En effet, il a été montré que la suractivité d'une voie de signalisation produisait un effet négatif et/ou inverse (Arundine and Tymianski, Importance de la dégradation de neuropeptides pour la formation de la mémoire Les résultats obtenus indiquent la nécessité de la dégradation de neuropeptides impliqués dans la mémoire dans le milieu extracellulaire, 2003.

. Gourlet, De nombreux peptides pourraient être clivés par les néprilysines : amnesiac, PDF, sNPF, dNPF, peptides amyloïdes? Ces cibles pourraient soit être dégradées, pour stopper de l'activation d'une voie de signalisation, soit clivées pour produire une forme active ou une forme ayant une affinité spécifique pour un type de récepteur, 1997.

. Enfin, nous avons quantifié les RNA--amn dans des têtes de drosophile exprimant l'un ou l'autre des RNAi spécifiques d'amn sous le contrôle de deux drivers des MB. Nos résultats montrent que l'expression des

, et que cette expression est requise pour la mémoire. Nos expériences de sauvetage montrent que les défauts de MTM et de LTM d'un mutant nul amn sont sauvés par l'expression constitutive d'amnesiac aussi bien dans les MB que dans les neurones DPM (Figure 49A et B). Par conséquent, on peut supposer que la surexpression d'amnesiac dans les neurones DPM permet non seulement de restaurer un développement normal de ces neurones, Ainsi, l'ensemble de nos résultats démontre qu'amn est exprimé dans les MB, vol.238, p.240

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