Utilisation d’unités γ-lactames pour le développement de vecteurs de pénétration intracellulaire et la conception de foldamères

Abstract : The use of α-amino-γ-lactam oligomers (Agl-αAA) as cell penetrating vectors are described in this work. These ribbon structured oligomers are able to cross the cell membrane to reach the cytosol and deliver a biologically active cargo. Unlike peptide sequences, these oligomers display a strong enzymatic resistance. A new family of α-amino-γ-lactam oligomers (Agl-βAA) obtained from conversion of /β peptide sequences are also described. Secondary structure of these molecules have been studied by NMR, FTIR, CD and XRD. These oligomers are able to adopt a stable 12-helix structure. Unexpectedly, these oligomers are soluble in aqueous mediums without any hydrophilic side chains
Document type :
Theses
Complete list of metadatas

Cited literature [250 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02297838
Contributor : Abes Star <>
Submitted on : Thursday, September 26, 2019 - 3:06:07 PM
Last modification on : Friday, September 27, 2019 - 1:18:59 AM

File

MESSERSCHMITT_2019_archivage.p...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02297838, version 1

Collections

Citation

Alexandre Messerschmitt. Utilisation d’unités γ-lactames pour le développement de vecteurs de pénétration intracellulaire et la conception de foldamères. Autre. Université Montpellier, 2019. Français. ⟨NNT : 2019MONTS018⟩. ⟨tel-02297838⟩

Share

Metrics

Record views

43

Files downloads

15