Skip to Main content Skip to Navigation

Préparation et caractérisation de surfaces poreuses ordonnées en polymères en vue d'applications médicales.

Abstract : Ureteral stents and nephrostomy catheters are made of silicone or thermoplastic polyurethane (TPU). A topographical modification creating an ordered porous surface could limit the infectious risks during their implantation, by reducing bacterial adhesion and creating a loading platform from which anti-infectious compounds could be released.In this work, a two-steps replication method was used to create ordered porous polymer surfaces (silicone or TPU) using porous anodic aluminium oxide (PAAO) as master template. The PAAO surfaces were prepared by double mild or double hard/mild anodization. Three intermediate mould materials were tested (acrylonitrile butadiene styrene, polystyrene, polyacrylate resin). The polymer material (silicone or TPU) was then moulded onto the intermediate mould surfaces that possessed freestanding pillar arrays, to imprint pores. The obtained surfaces were characterized by microscopic and spectroscopic methods. The initial PAAO surfaces prepared by double mild anodization possessed pores of about 50 nm diameter and 100 nm depth, whereas those prepared after development of the double hard/mild anodization method were bigger, of about 125 nm diameter and several hundred nanometers deep. The intermediate mould structure possessed freestanding arrays, but instabilities (lateral adhesion) were noted for certain conditions. The best pattern replication was observed for TPU. In conclusion, these novel porous polymeric surfaces could be optimized and tested for an anti-biofilm effect.
Document type :
Complete list of metadatas

Cited literature [302 references]  Display  Hide  Download
Contributor : Abes Star :  Contact
Submitted on : Wednesday, September 25, 2019 - 11:04:09 AM
Last modification on : Saturday, November 30, 2019 - 1:24:33 AM
Long-term archiving on: : Sunday, February 9, 2020 - 8:54:02 PM


Version validated by the jury (STAR)


  • HAL Id : tel-02296411, version 1


Philip Chennell. Préparation et caractérisation de surfaces poreuses ordonnées en polymères en vue d'applications médicales.. Médecine humaine et pathologie. Université Clermont Auvergne, 2018. Français. ⟨NNT : 2018CLFAS005⟩. ⟨tel-02296411⟩



Record views


Files downloads