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Rôle de XDSCR6 et de ses partenaires au cours du développement embryonnaire précoce de Xenopus laevis

Abstract : One of the most challenging questions in developmental biology is to understand how a totipotent zygote differentiates into an organism containing all cell lineages. The formation of the three germ layers and the establishment of embryonic axis are fundamental events during early development. In this context, we demonstrated that XDSCR6, a mesoderm and embryonic axis inducer that exhibits dorsalizing properties, physically and functionally interacts with the transcriptional factor XSTAT3. During early development, XSTAT3 is active throughout gastrulation step and its abnormal activation in dorsal region leads to embryonic tissues ventralization. Furthermore, we showed that XDSCR6 and XSTAT3 have antagonistic roles in vivo during axis formation. This antagonism can be explained by the fact that XDSCR6 negatively regulates the transcriptional activity of XSTAT3 by interfering with its methylation on lysine residues. Moreover, this post-translational modification plays a crucial role in the ventralization abilities of XSTAT3. In a previous study, it has been shown that XDSCR6 negatively regulates the XEZH2 repressive epigenetic activity on dorsal mesoderm genes. Thus, we propose that XDSCR6 is a transcriptional modulator acting between epigenetic regulators and transcriptional factors during embryonic axis formation.
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Submitted on : Tuesday, September 24, 2019 - 12:17:31 PM
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  • HAL Id : tel-02295574, version 1


Mafalda Loreti. Rôle de XDSCR6 et de ses partenaires au cours du développement embryonnaire précoce de Xenopus laevis. Biologie du développement. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066443⟩. ⟨tel-02295574⟩



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