Conditions for the emergence of corticostriatal synaptic plasticity

Abstract : According to Hebbian theory, neural networks refine their connectivity by patterned firing of action potentials in pre- and postsynaptic neurons. Spike-timing-dependent plasticity (STDP) is a synaptic Hebbian learning rule relying on the precise order and the millisecond timing of the paired activities on either side of the synapse. Temporal coding via STDP may be essential for the role of the striatum in learning of motor sequences in which sensory and motor events are associated in a precise time sequence. Corticostriatal long-term plasticity provides a fundamental mechanism for the function of the basal ganglia in procedural learning. Striatal output neurons act as detectors of distributed patterns of cortical and thalamic activity. Thus, corticostriatal STDP should play a major role in information processing in the basal ganglia, which is based on a precise time-coding process. Here, we explored the conditions required for the emergence of corticostriatal STDP.
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Silvana Valtcheva. Conditions for the emergence of corticostriatal synaptic plasticity. Neurons and Cognition [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2016. English. ⟨NNT : 2016PA066627⟩. ⟨tel-02295569⟩

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