Synthèse de nouveaux complexes aryl-palladium et aryl-or pour le marquage par du monoxyde de carbone de composés bioconjugués supportés et pour des réactions de couplages

Abstract : The growth of organometallic chemistry has allowed numerous developments in the field of medical diagnosis, especially for Positron Emission Tomography (PET). Developing new methodologies for the synthesis of biological tracers by a last-step 11C labeling, our team has been recently able to take advantage of the great functional tolerance of palladium-catalyzed carbonylation to achieve this goal. A new synthetic strategy involving preformed palladium complexes is described in this manuscript. Their anchoring on a polystyrene resin allowed subsequently to facilitate the carbonylation process by simplifying the purification. New palladium complexes have also been investigated for their potential photoredox applications. Finally, new coupling strategies implying gold (III) intermediates and photoredox catalysis being a very attractive subject, new gold complexes have been synthetized in order to investigate the reaction mechanisms that could operate. Possibilities of asymmetric induction in the synthesis of atropoisomeric biaryl compounds were also studied.
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Alexis Tabey. Synthèse de nouveaux complexes aryl-palladium et aryl-or pour le marquage par du monoxyde de carbone de composés bioconjugués supportés et pour des réactions de couplages. Chimie organique. Université de Bordeaux, 2019. Français. ⟨NNT : 2019BORD0025⟩. ⟨tel-02293793⟩

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