Développement de polymères à empreintes moléculaires basé sur une manganoporphyrine utilisé comme catalyseur oxydatif de dérivés soufrés. Vers une nouvelle approche biomimétique de décontamination d'armes chimiques.

Abstract : Molecular imprinting polymer is a useful technique for creating artificial receptors able of selectively binding substrates. These recognition properties are particularly interesting for developing macromolecular catalysts. Our aim was to access to a reusable supramolecular catalyst able of oxidizing sulfur derivatives under heterogeneous conditions in the presence of a mild and eco-sustainable oxidant such as hydrogen peroxide. Given the expertise of the team, we decided to focus our work on the development of a catalytic system for the decontamination of surfaces or equipment, after an exposure to compounds that can be detoxified by a selective oxidation of sulfides. Thus, we prepared a porphyrin-based MIP that we tested in the oxidation of various sulfides. The mild conditions used for the catalysis allowed a control of the oxidation degree of a simulant of yperite, leading to a great selectivity the sulfoxide derivative, and avoiding the toxic sulfone formation. With other structures similar to VX, we showed that it is possible to regioselectively oxidize the sulfur atom, and highlighted the interest of this process to facilitate the cleavage of a C-S bond. This approach is then an interesting decontamination strategy that will be evaluated in the future to the case of true chemical warfare agents.
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Sophie Mohamed. Développement de polymères à empreintes moléculaires basé sur une manganoporphyrine utilisé comme catalyseur oxydatif de dérivés soufrés. Vers une nouvelle approche biomimétique de décontamination d'armes chimiques.. Autre. Normandie Université, 2019. Français. ⟨NNT : 2019NORMR027⟩. ⟨tel-02292782⟩

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