Aziridine-2-carboxylates et leurs dérivées : Nouvelles perspectives en synthèse hétérocycliques et chimie des peptides.

Abstract : Our purpose in this thesis is to widen the range of compounds from aziridine-2-carboxylate, which obtained by its use as a feedstock for the synthesis of new hétérocycles through nucleophilic reactions openings and expansions cycle.The synthesis of fluorinated heterocycles will be approached from aziridine-2-carboxylate trifluorométhylées and amino alcohols and amino acids trifluoromethylated enantiopure.Fluorinated aziridines whose synthesis has already been described in the literature will lead to various fluorinated heterocycles according reactions and opening cycles of expansion methodologies involving setting the nonfluorinated series developed by the Tunisian partner.The new synthesized heterocycles find applications as chiral pseudo-peptide units useful in peptide chemistry.
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Oussema Ouerfelli. Aziridine-2-carboxylates et leurs dérivées : Nouvelles perspectives en synthèse hétérocycliques et chimie des peptides.. Chimie analytique. Université de Cergy Pontoise; Université de Tunis El Manar, 2018. Français. ⟨NNT : 2018CERG0973⟩. ⟨tel-02285887⟩

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