Elaboration et caractérisation de biomatériaux antimicrobiens à base d'alginate pour des applications dans les domaines médicaux et marins

Abstract : Biofouling is a phenomenon that affects every surface that is immersed in an aquatic medium covering it by a biofilm either in the medical or marine field. In order to prevent this phenomenon, in this work, biosourced alginate materials were elaborated. For applications in the medical field, hydrogel films of smooth or porous surface and films coating stainless steel by electrophoresis were elaborated. The presence of copper and zinc in their ionic form Cu2+ and Zn2+ was demonstrated.All the copper and zinc based films showed antibacterial properties on pathogenic bacterial strains.Alginate hydrogels in bulk based on calcium, copper and zinc were also elaborated for applications in the marine field. Stability of the different materials was studied in different mediums and at different temperatures. The antimicrobial property of these hydrogels based on copper and zinc was demonstrated on two microalgae stains as well as on four marine bacteria strains with no sign of toxicity. Finally, the delay in the formation of biofilms on stainless steel surfaces was studied by the OCP method in the presence of zinc based materials.
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Léa Abi Nassif. Elaboration et caractérisation de biomatériaux antimicrobiens à base d'alginate pour des applications dans les domaines médicaux et marins. Science des matériaux [cond-mat.mtrl-sci]. Université de Bretagne occidentale - Brest; Université Saint-Joseph (Beyrouth), 2019. Français. ⟨NNT : 2019BRES0007⟩. ⟨tel-02281728⟩

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