Contributions à la génétique et l’épidémiologie des maladies complexes pour une médecine personnalisée

Abstract : This thesis concerns the identification of the genetic and environmental causes of complex diseases. Our central application is Isis-Diab a study of type 1 diabetes. We propose a method to use phase information to improve genetic risk predictions. We replicate an estimate of genetic risk on Isis-Diab patients. We prove an asymptotic equivalence result between two paired data analysis methods. We then analyze the Isis-Diab case-control study based on environmental questionnaires. We try to confirm the results of this study by crossing the genetic risk and environmental factors in Isis-Diab patients. This leads us to propose a new methodology based on collider bias and a study of its influence in case-only studies for gene-environment interactions. Finally, we study the possibility of using randomized clinical trials to personalize treatments. We propose a new methodology to evaluate the benefit of personalization and we recommend a choice of personalization strategy.
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Félix Balazard. Contributions à la génétique et l’épidémiologie des maladies complexes pour une médecine personnalisée. Statistiques [math.ST]. Sorbonne université, 2018. Français. ⟨tel-02277736⟩

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