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Equilibrium patterns of genetic diversity shuffled by migration and recombination

Abstract : This thesis presents two different models to study how recombination and migration shuffle genetic diversity. In the first model, recombination is the only evolutionary force. At time 0, each individual has her unique chromosome painted in a distinct color. By the blending effect of recombination, the genomes of the descending individuals look like mosaics of colors, each color representing the genetic material inherited from a different ancestral individual. Each segment of the same color is called an identical-by-descent (IBD) segment. We have been able to characterize the sizes and positions of the segments that are IBD to a given locus in the chromosome of a randomly sampled individual in the population. The second model is devoted to the study of the effects of geographic structure, migration, mutation and recombination in the genetic composition of a metapopulation. The metapopulation is modelled as a graph where vertices correspond to subpopulations and edges are associated to migration rates. The idea behind this project is to study speciation: when two subpopulations accumulate enough genetic differences they may become separate species. We have been able to characterize the distribution of the genetic distances between subpopulations in a low mutation - low migration regime, depending on the geographic structure, and to show that some geographic configurations can promote speciation.
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Submitted on : Monday, June 15, 2020 - 2:23:24 PM
Last modification on : Friday, August 5, 2022 - 3:00:08 PM


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  • HAL Id : tel-02277731, version 2


Verónica Miró Pina. Equilibrium patterns of genetic diversity shuffled by migration and recombination. Statistics [math.ST]. Sorbonne Université, 2018. English. ⟨NNT : 2018SORUS253⟩. ⟨tel-02277731v2⟩



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