, Les figures (A) et (D) totalisent sept et six expériences indépendantes respectivement. Les figures (B) et (C) sont représentatives de quatre et trois expériences indépendantes respectivement, en phase G0/G1 (100K), S (150K) et G2/M (200K) du cycle cellulaire. Les nombres indiqués représentent les proportions de cellules G0/G1, S et G2/M. L'histogramme barre résume la proportion de cellules G2/M au sein de la population DN3b
, Les nombres indiqués représentent les proportions de cellules G0/G1, S et G2/M. L'histogramme barre résume la proportion de cellules G2/M au sein de la population LT CD4 + . (A, C, D) Les données totalisent deux expériences indépendantes. La figure (E) représente une expérience parmi deux et la figure (B) n'est représentative que d'une souris, CD4 + stimulés 48h en présence d'anti-CD28 et anti-CD3. Les droites sur les histogrammes FACS déterminent la population G0/G1 (40K)
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, stimulé des thymocytes issus de souris déficientes en USP9X ou en THEMIS1 avec des anticorps anti-CD3 et anti-CD4 pendant 1 ou 3 minutes. J'ai analysé par westernblot, la phosphorylation de SHP-1 et ZAP-70. Il s'agit de la figure 3F de l'article. D'autres expériences consistant à analyser la signalisation suite au traitement des thymocytes avec l'inhibiteur de déubiquitine enzyme PR619 ont aussi été réalisées mais n
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