Altérations de composition des ribosomes dans les cancers du sein : analyses de cohortes humaines et modèles cellulaires

Abstract : Ribosomes are responsible of translating mRNAs to proteins. Alterations of ribosome composition modify its translation activity and favour tumourigenesis. Identification of ribosomes composition alterations in breast cancers might correspond to a new mechanism responsible of mammary tumourigenesis and might open up novel therapeutic approaches. Indeed breast cancers represent the first cause of women mortality due to cancers and their heterogeneity induces an important therapeutic problem.In this context, alterations of ribosomes composition were determined in human cohorts and in EMT (Epithelial to Mesenchymal Transition) cellular models, the EMT being a process involved in mammary tumourigenesis. This studies identify : (i) two factors involved in ribosome biogenesis, FBL (fibrillarin) and NCL (nucleolin) whose expression variations are associated with poor prognosis in patients and (ii) variations of ribosome composition and its translational activity in EMT. Altogether, this data support the presence of ribosomes composition alterations in breast cancers
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Submitted on : Tuesday, September 3, 2019 - 1:30:10 PM
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Flora Nguyen van Long. Altérations de composition des ribosomes dans les cancers du sein : analyses de cohortes humaines et modèles cellulaires. Cancer. Université de Lyon, 2019. Français. ⟨NNT : 2019LYSE1095⟩. ⟨tel-02277093⟩

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