Caractéristiques génomiques du genre fongique Mucor et évolution adaptative liée à différents modes et conditions de vie au sein du genre

Abstract : The genus Mucor belongs to the phylum Mucoromycota; a group that derived from the lineages that diverged early in the evolution of fungal species (early diverging lineages). These groups have been less well studied and are less well understood in comparison to Ascomycetes and Basidiomycetes. The genus Mucor is composed of saprophytic species, but also encompasses species with diverse lifestyles.For example, it includes plant endophytes (such as M. endophyticus) or opportunistic animal pathogens (such as the thermophilic species M. circinelloides or M. indicus). The genus is ubiquitous but there are some associations with specific habitats which seem to indicate specialisation. The aim of this thesis is to better understand the genetic potential of the genus Mucor in particular, to decipher how it maintains this ubiquitous lifestyle, its capacity to adapt to diverses habitats and to better understand the existence within the genus of species that may have undergone specialization allowing them to preferentially or exclusively colonise certain habitats, such as cheese. In order to achieve this, we have performed comparative transcriptomic and genomic studies in order to determine the main structural and functional characteristics of the Mucor genomes, identify similarities among the species studied and also assess whether there exist specific genetic associations with lifestyle/habitat and determine whether the species frequently found in cheese (in particular those species considered as technological) harbour imprints of adaptation or even domestication.
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Annie Lebreton. Caractéristiques génomiques du genre fongique Mucor et évolution adaptative liée à différents modes et conditions de vie au sein du genre. Génomique, Transcriptomique et Protéomique [q-bio.GN]. Université de Bretagne occidentale - Brest, 2018. Français. ⟨NNT : 2018BRES0098⟩. ⟨tel-02275809⟩

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