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, Des études immunostructurales permettraient de rechercher des différences subtiles de structure tertiaire ou l'existence de cofacteurs/ligands moléculaires impliqués dans l'allergéni-cité de cette famille de protéines

, Cette étude nous a permis de mettre au point la méthode « test d'activation de baso

, évaluer le protocole expérimental de nos préparations d'extrait afin d'étudier ulté-rieurement l'effet des fullerènes sur les basophiles des patients allergiques, vol.1

, Letiam EA, vol.7375

B. Coulter, Life Science Research

I. Pasteur, C. , and P. , Des études ont montré que le [60]fullerène[1] et ses dérivés présentent une large gamme d'activités biologiques dans le domaine biomédical

, Ces activités seraient liées aux 30 doubleliaisons présentes à la surface de cette molécule sphérique

, Pour évaluer la capacité des fullerènes à interférer avec des mécanismes cellulaires impliquant un stress oxydatif leurs effets ont été testés sur l'activation des basophiles, vol.5

, Il a été démontré que la stimulation de ce type de cellules par le récepteur de haute affinité aux IgE induit la libération de médiateurs de l'inflammation et s'accompagne de la production de sous-produits du stress oxydatif, vol.6

, fullerène-sérinyl-malonate (FSM], dendro-[60]fullerène (DF) et poly-hydroxylé, le fullérol) ont été utilisés pour étudier leur impact sur l'activation IgE dépendante de basophiles humains. Le test d'activation des basophiles (TAB) est l'une des méthodes utilisées pour le diagnostic des allergies. Cette activation entraine la libération des médiateurs de l'inflammation et de la réponse immune contenus dans les granules intra cytoplasmiques. Ce test est évalué par l'expression des marqueurs de surface CD63 et CD203c, Le fullerène ayant une faible solubilité dans les solvants polaires et formant des agrégats, des dérivés hydrosolubles, ont été synthétisés. Le C60 et 4 dérivés hydrosolubles dont fullerène-cyclodextrine (FD)

, Nos résultats montrent que certains des dérivés testés, notamment le fullérol, le DF et le FSM, pré-incubés (1h) avec les cellules à des concentrations nano-molaires, sont capables de diminuer l'expression de CD203c traduisant une inhibition significative (jusqu'à 20 %) de l'activation des basophiles. Cette inhibition est plus importante avec les dérivés mono-adduit (ex :dendro-fullerène), ce qui suggère que cette inhibition serait liée à la molécule de C60 elle-même, plus accessible pour réagir avec les sites impliqués dans la réponse biologique. L'inhibition n'est observée que pour les concentrations les plus faibles. Au-delà d'un certain seuil de concentration, l'effet diminue de manière significative, L'étude a été réalisée ex vivo sur le sang de 5 enfants allergiques aux protéines de l'arachide en présence ou en absence de fullérènes à concentrations variables

. Le-c60, Pour confirmer cette hypothèse, des expériences complémentaires sont en cours pour déterminer la taille des agrégats, la bio-localisation des fullerènes et de plus des expériences sur des modèles in vivo

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