S. M. Thomas and J. S. Brugge, Cellular functions regulated by Src family kinases, Annu Rev Cell Dev Biol, vol.13, pp.513-609, 1997.

E. Ingley, Functions of the Lyn tyrosine kinase in health and disease, Cell Commun Signal, vol.10, p.21, 2012.

S. J. Parsons and J. T. Parsons, Src family kinases, key regulators of signal transduction, Oncogene, vol.23, pp.7906-7915, 2004.

L. C. Kim, L. Song, and E. B. Haura, Src kinases as therapeutic targets for cancer, Nat Rev Clin Oncol, vol.6, pp.587-95, 2009.

K. W. Harder, L. M. Parsons, J. Armes, N. Evans, N. Kountouri et al., Gain-and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage, Immunity, vol.15, pp.603-618, 2001.

M. L. Hibbs, D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson et al., Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease, Cell, vol.83, pp.301-312, 1995.

P. Scapini, S. Pereira, H. Zhang, and C. A. Lowell, Multiple roles of Lyn kinase in myeloid cell signaling and function, Immunol Rev, vol.228, pp.23-40, 2009.

A. Ptasznik, Y. Nakata, A. Kalota, S. G. Emerson, and A. M. Gewirtz, Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells, Nat Med, vol.10, pp.1187-1196, 2004.

A. Contri, A. M. Brunati, L. Trentin, A. Cabrelle, M. Miorin et al., Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis, J Clin Invest, vol.115, pp.369-78, 2005.

S. Tauzin, H. Ding, K. Khatib, I. Ahmad, D. Burdevet et al., Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts, Blood, vol.111, pp.2310-2330, 2008.

M. Goldenberg-furmanov, I. Stein, E. Pikarsky, H. Rubin, S. Kasem et al., Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts, Cancer Res, vol.64, pp.1058-66, 2004.

W. S. Chen, H. J. Kung, W. K. Yang, and W. Lin, Comparative tyrosinekinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa, Int J Cancer, vol.83, pp.579-84, 1999.

F. X. Mahon, S. Hayette, V. Lagarde, F. Belloc, B. Turcq et al., Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression, Cancer Res, vol.68, pp.9809-9825, 2008.

P. Gamas, S. Marchetti, A. Puissant, S. Grosso, A. Jacquel et al., Inhibition of imatinib-mediated apoptosis by the caspasecleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells, Leukemia, vol.23, pp.1500-1506, 2009.

F. Luciano, M. Herrant, A. Jacquel, J. E. Ricci, and P. Auberger, The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis, FASEB J, vol.17, pp.711-714, 2003.

F. Zonta, M. A. Pagano, L. Trentin, E. Tibaldi, F. Frezzato et al., Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia, Blood, vol.123, pp.875-83, 2014.

J. E. Chipuk, T. Moldoveanu, F. Llambi, M. J. Parsons, and D. R. Green, The BCL-2 family reunion, Mol Cell, vol.37, pp.299-310, 2010.

D. R. Green and F. Llambi, Cell death signaling, Cold Spring Harb Perspect Biol, vol.7, p.6080, 2015.

A. Hubner, T. Barrett, R. A. Flavell, and R. J. Davis, Multisite phosphorylation regulates Bim stability and apoptotic activity, Mol Cell, vol.30, pp.415-440, 2008.

J. D. Pinon, V. Labi, A. Egle, and A. Villunger, Bim and Bmf in tissue homeostasis and malignant disease, Oncogene, vol.27, issue.1, pp.41-52, 2008.

F. Luciano, A. Jacquel, P. Colosetti, M. Herrant, S. Cagnol et al., Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function, Oncogene, vol.22, pp.6785-93, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00323924

H. Puthalakath, D. C. Huang, L. A. O'reilly, S. M. King, and A. Strasser, The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex, Mol Cell, vol.3, pp.287-96, 1999.

P. Bouillet, D. Metcalf, D. C. Huang, D. M. Tarlinton, T. W. Kay et al., Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity, Science, vol.286, pp.1735-1743, 1999.

L. O'connor, A. Strasser, L. A. O'reilly, G. Hausmann, J. M. Adams et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis, EMBO J, vol.17, pp.384-95, 1998.

C. Clybouw, D. Merino, T. Nebl, F. Masson, M. Robati et al., Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo, Cell Death Differ, vol.19, pp.1060-1068, 2012.

A. Enders, P. Bouillet, H. Puthalakath, Y. Xu, D. M. Tarlinton et al., Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells, J Exp Med, vol.198, pp.1119-1145, 2003.

J. Kuroda, H. Puthalakath, M. S. Cragg, P. N. Kelly, P. Bouillet et al., Bim and Bad mediate imatinib-induced killing of Bcr/ Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic, Proc Natl Acad Sci USA, vol.103, pp.14907-14919, 2006.

J. E. Ricci, V. Lang, F. Luciano, N. Belhacene, V. Giordanengo et al., An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis, FASEB J, vol.15, pp.1777-1786, 2001.

T. Ban, G. R. Sato, A. Nishiyama, A. Akiyama, M. Takasuna et al., Lyn kinase suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity, Immunity, vol.45, pp.319-351, 2016.

F. Luciano, J. E. Ricci, and P. Auberger, Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation, Oncogene, vol.20, pp.4935-4976, 2001.

H. Puthalakath, L. A. Reilly, P. Gunn, L. Lee, P. N. Kelly et al., ER stress triggers apoptosis by activating BH3-only protein Bim, Cell, vol.129, pp.1337-1386, 2007.

P. Bouillet, J. F. Purton, D. I. Godfrey, L. C. Zhang, L. Coultas et al., BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes, Nature, vol.415, pp.922-928, 2002.

L. E. Aira,

S. Luo, M. Garcia-arencibia, R. Zhao, C. Puri, P. P. Toh et al., Bim inhibits autophagy by recruiting Beclin 1 to microtubules, Mol Cell, vol.47, pp.359-70, 2012.

R. Gogada, N. Yadav, J. Liu, S. Tang, D. Zhang et al., Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer, J Biol Chem, vol.288, pp.368-81, 2013.

J. Pecot, L. Maillet, L. Pen, J. Vuillier, C. Trecesson et al., Tight sequestration of BH3 proteins by BCL-xL at subcellular membranes contributes to apoptotic resistance, Cell Rep, vol.17, pp.3347-58, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01416194

S. W. Tait, M. J. Parsons, F. Llambi, L. Bouchier-hayes, S. Connell et al., Resistance to caspase-independent cell death requires persistence of intact mitochondria, Dev Cell, vol.18, pp.802-815, 2010.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-74, 2011.

A. Egle, A. W. Harris, P. Bouillet, and C. S. , Bim is a suppressor of Myc-induced mouse B cell leukemia, Proc Natl Acad Sci USA, vol.101, pp.6164-6173, 2004.

C. Mestre-escorihuela, F. Rubio-moscardo, J. A. Richter, R. Siebert, J. Climent et al., Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas, Blood, vol.109, pp.271-80, 2007.

F. Belloc, F. Moreau-gaudry, M. Uhalde, L. Cazalis, M. Jeanneteau et al., Imatinib and nilotinib induce apoptosis of chronic myeloid leukemia cells through a Bim-dependant pathway modulated by cytokines, Cancer Biol Ther, vol.6, pp.912-921, 2007.

R. V. Sionov, S. A. Vlahopoulos, and Z. Granot, Regulation of Bim in health and disease, Oncotarget, vol.6, pp.23058-134, 2015.

R. Ley, K. E. Ewings, K. Hadfield, E. Howes, K. Balmanno et al., Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover, J Biol Chem, vol.279, pp.8837-8884, 2004.

R. W. Rooswinkel, B. Van-de-kooij, E. De-vries, M. Paauwe, R. Braster et al., Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity, Blood, vol.123, pp.2806-2821, 2014.

E. Ingley, Src family kinases: regulation of their activities, levels and identification of new pathways, Biochim Biophys Acta, vol.1784, pp.56-65, 2008.

R. L. Carpenter, W. Han, I. Paw, and H. W. Lo, HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells, PLoS ONE, vol.8, p.78836, 2013.

J. L. Fox, F. Ismail, A. Azad, N. Ternette, S. Leverrier et al., Tyrosine dephosphorylation is required for Bak activation in apoptosis, EMBO J, vol.29, pp.3853-68, 2010.

H. Nishizumi, I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic et al., Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice, Immunity, vol.3, pp.549-60, 1995.

A. J. Gross, I. Proekt, and A. L. Defranco, Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells, Eur J Immunol, vol.41, pp.3645-55, 2011.

J. T. Leonard, J. S. Rowley, C. A. Eide, E. Traer, B. Hayes-lattin et al., Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia, Sci Transl Med, vol.8, pp.354-114, 2016.

J. Lopez, C. Hesling, J. Prudent, N. Popgeorgiev, R. Gadet et al., Src tyrosine kinase inhibits apoptosis through the Erk1/2-dependent degradation of the death accelerator Bik, Cell Death Differ, vol.19, pp.1459-69, 2012.

Y. Bian, L. Li, M. Dong, X. Liu, T. Kaneko et al., Ultradeep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder, Nat Chem Biol, vol.12, pp.959-66, 2016.

P. Mertins, D. R. Mani, K. V. Ruggles, M. A. Gillette, K. R. Clauser et al., Proteogenomics connects somatic mutations to signalling in breast cancer, Nature, vol.534, pp.55-62, 2016.

C. Ljungberg, R. Boye-kjellerup, L. Iversen, and C. Johansen, IL-17F regulates psoriasis-associated genes through IkappaBzeta, Bim tyrosine phosphorylation is anti-apoptotic References Bertelsen T, vol.26, pp.234-275, 2017.

K. A. Cho, J. W. Suh, K. H. Lee, J. L. Kang, and S. Y. Woo, IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway, Int Immunol, vol.24, issue.3, pp.147-58, 2012.

D. M. Clancy, C. M. Henry, G. P. Sullivan, and S. J. Martin, Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines, FEBS J, vol.284, issue.11, pp.1712-1737, 2017.

K. M. Coleman, J. E. Gudjonsson, and M. Stecher, Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1alpha, for the Treatment of Psoriasis, JAMA Dermatol, vol.151, issue.5, pp.555-561, 2015.

A. Companjen, L. Van-der-wel, L. Van-der-fits, J. Laman, and E. Prens, Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions, Eur Cytokine Netw, vol.15, issue.3, pp.210-216, 2004.

Y. Deng, C. Chang, and Q. Lu, The Inflammatory Response in Psoriasis: a Comprehensive Review, Clin Rev Allergy Immunol, vol.50, issue.3, pp.377-89, 2016.

Y. Dombrowski, M. Peric, S. Koglin, C. Kammerbauer, C. Goss et al., Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions, Sci Transl Med, vol.3, issue.82, pp.82-120, 2011.

T. Douglas, C. Champagne, A. Morizot, J. M. Lapointe, and M. Saleh, The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice, J Immunol, vol.195, issue.5, pp.2365-73, 2015.

L. Feldmeyer, S. Werner, L. E. French, and H. D. Beer, Interleukin-1, inflammasomes and the skin, Eur J Cell Biol, vol.89, issue.9, pp.638-682, 2010.

G. Fenini, E. Contassot, and L. E. French, Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases, Front Pharmacol, vol.8, p.278, 2017.

S. Fujishima, H. Watanabe, M. Kawaguchi, T. Suzuki, S. Matsukura et al., Involvement of IL-17F via the induction of IL-6 in psoriasis, Arch Dermatol Res, vol.302, issue.7, pp.499-505, 2010.

C. Gabay, C. Lamacchia, and G. Palmer, IL-1 pathways in inflammation and human diseases, Nat Rev Rheumatol, vol.6, issue.4, pp.232-273, 2010.

M. N. Hedrick, A. S. Lonsdorf, A. K. Shirakawa, R. Lee, C. C. Liao et al., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice, J Clin Invest, vol.119, issue.8, pp.2317-2346, 2009.

C. Johansen, T. Bertelsen, C. Ljungberg, M. Mose, and L. Iversen, Characterization of TNF-alphaand IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IkappaBzeta, J Invest Dermatol, vol.136, issue.8, pp.1608-1624, 2016.

C. Johansen, K. Moeller, K. Kragballe, and L. Iversen, The activity of caspase-1 is increased in lesional psoriatic epidermis, J Invest Dermatol, vol.127, issue.12, pp.2857-64, 2007.

K. Kuida, J. A. Lippke, G. Ku, M. W. Harding, D. J. Livingston et al., Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme, Science, vol.267, issue.5206, pp.2000-2003, 1995.

M. Lamkanfi and V. M. Dixit, Mechanisms and functions of inflammasomes, Cell, vol.157, issue.5, pp.1013-1035, 2014.

M. Lamkanfi, N. Festjens, W. Declercq, V. Berghe, T. Vandenabeele et al., Caspases in cell survival, proliferation and differentiation, Cell Death Differ, vol.14, issue.1, pp.44-55, 2007.

J. Li and J. Yuan, Caspases in apoptosis and beyond, Oncogene, vol.27, issue.48, pp.6194-206, 2008.

X. Liu, J. Lieberman, and . Mechanistic, Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection, Adv Immunol, vol.135, pp.81-117, 2017.

M. A. Lowes, M. Suarez-farinas, and J. G. Krueger, Immunology of psoriasis, Annu Rev Immunol, vol.32, pp.227-55, 2014.

S. M. Man and T. D. Kanneganti, Regulation of inflammasome activation, Immunol Rev, vol.265, issue.1, pp.6-21, 2015.

S. Marchetti, P. Gamas, N. Belhacene, S. Grosso, L. A. Pradelli et al., The caspasecleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice, EMBO J, vol.28, issue.16, pp.2449-60, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00419195

F. Martinon, K. Burns, and J. Tschopp, The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta, Mol Cell, vol.10, issue.2, pp.417-443, 2002.

D. R. Mcilwain, T. Berger, and T. W. Mak, Caspase functions in cell death and disease, Cold Spring Harb Perspect Biol, vol.5, issue.4, p.8656, 2013.

B. J. Nickoloff, H. Xin, F. O. Nestle, and J. Z. Qin, The cytokine and chemokine network in psoriasis, Clin Dermatol, vol.25, issue.6, pp.568-73, 2007.

R. Parisi, D. P. Symmons, C. E. Griffiths, D. M. Ashcroft, . Identification et al., Global epidemiology of psoriasis: a systematic review of incidence and prevalence, J Invest Dermatol, vol.133, issue.2, pp.377-85, 2013.

M. N. Patel, R. G. Carroll, S. Galvan-pena, E. L. Mills, R. Olden et al., Inflammasome Priming in Sterile Inflammatory Disease, Trends Mol Med, vol.23, issue.2, pp.165-80, 2017.

A. P. Perera, D. Kunde, and R. Eri, NLRP3 Inhibitors as Potential Therapeutic Agents for Treatment of Inflammatory Bowel Disease, Curr Pharm Des, vol.23, issue.16, pp.2321-2328, 2017.

R. Pierini, C. Juruj, M. Perret, C. L. Jones, P. Mangeot et al., AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages, Cell Death Differ, vol.19, issue.10, pp.1709-1730, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00965390

H. Rabeony, M. Pohin, P. Vasseur, I. Petit-paris, J. F. Jegou et al., IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome, Eur J Immunol, vol.45, issue.10, pp.2847-57, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01702889

J. A. Rickard, H. Anderton, N. Etemadi, U. Nachbur, M. Darding et al., TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice, Elife, vol.3, 2014.

L. Riol-blanco, J. Ordovas-montanes, M. Perro, E. Naval, A. Thiriot et al., Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation, Nature, vol.510, issue.7503, pp.157-61, 2014.

P. Ruscitti, P. Cipriani, D. Benedetto, P. Liakouli, V. Berardicurti et al., Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1beta via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients, Clin Exp Immunol, vol.182, issue.1, pp.35-44, 2015.

R. Sabat, W. Sterry, S. Philipp, and K. Wolk, Three decades of psoriasis research: where has it led us?, Clin Dermatol, vol.25, issue.6, pp.504-513, 2007.

M. L. Salskov-iversen, C. Johansen, K. Kragballe, and L. Iversen, Caspase-5 expression is upregulated in lesional psoriatic skin, J Invest Dermatol, vol.131, issue.3, pp.670-676, 2011.

N. Shimoura, H. Nagai, S. Fujiwara, H. Jimbo, T. Yoshimoto et al., Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia, Arch Dermatol Res, vol.309, issue.4, pp.315-336, 2017.

T. P. Singh, H. H. Zhang, I. Borek, P. Wolf, M. N. Hedrick et al., Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation, Nat Commun, vol.7, p.13581, 2016.

H. W. Stout-delgado, S. E. Vaughan, A. C. Shirali, R. J. Jaramillo, and K. S. Harrod, Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin, J Immunol, vol.188, issue.6, pp.2815-2839, 2012.

M. Uribe-herranz, L. H. Lian, K. M. Hooper, K. A. Milora, and L. E. Jensen, IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation, J Invest Dermatol, vol.133, issue.6, pp.1541-1550, 2013.

L. Van-der-fits, S. Mourits, J. S. Voerman, M. Kant, L. Boon et al., Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis, J Immunol, vol.182, issue.9, pp.5836-5881, 2009.

F. Ali, B. A. Khan, and S. Sultana, Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway, Eur J Pharmacol, vol.786, pp.253-264, 2016.

N. Ayala-fontanez, D. C. Soler, and T. S. Mccormick, Current knowledge on psoriasis and autoimmune diseases, Psoriasis (Auckl), vol.6, pp.7-32, 2016.

E. E. Ayli, W. Li, T. T. Brown, A. Witkiewicz, R. Elenitsas et al., Activation of Srcfamily tyrosine kinases in hyperproliferative epidermal disorders, J Cutan Pathol, vol.35, pp.273-277, 2008.

W. H. Boehncke and M. P. Schon, Psoriasis. Lancet, vol.386, pp.983-994, 2015.

S. Bundela, A. Sharma, P. Bisen, . Adm, . Tp53 et al., Potential therapeutic targets for oral cancer, PLoS One, vol.9, 2014.

A. Chiricozzi, P. Romanelli, E. Volpe, G. Borsellino, and M. Romanelli, Scanning the Immunopathogenesis of Psoriasis, Int J Mol Sci, vol.19, p.5796128, 2018.

K. Danielsen, A. O. Olsen, T. Wilsgaard, and A. S. Furberg, Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort, Br J Dermatol, vol.168, pp.1303-1310, 2013.

J. Espada and J. Martin-perez, An Update on Src Family of Nonreceptor Tyrosine Kinases Biology, Int Rev Cell Mol Biol, vol.331, pp.83-122, 2017.

S. E. Fenton and M. F. Denning, FYNagling divergent adhesive functions for Fyn in keratinocytes, Exp Dermatol, vol.24, pp.81-85, 2015.

S. E. Fenton, K. A. Hutchens, and M. F. Denning, Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion, Mol Carcinog, vol.54, pp.1181-1193, 2015.

R. Gao, Z. Ma, M. Ma, J. Yu, J. Chen et al., Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation, Am J Physiol Lung Cell Mol Physiol, vol.309, pp.1376-1381, 2015.

J. K. Gittler, A. Shemer, M. Suarez-farinas, J. Fuentes-duculan, K. J. Gulewicz et al., Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis, J Allergy Clin Immunol, vol.130, pp.1344-1354, 2012.

J. K. Gittler, J. G. Krueger, and E. Guttman-yassky, Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis, J Allergy Clin Immunol, vol.131, pp.300-313, 2013.

J. E. Greb, A. M. Goldminz, J. T. Elder, M. G. Lebwohl, D. D. Gladman et al., Psoriasis. Nat Rev Dis Primers, vol.2, p.16082, 2016.

T. Gutierrez, K. E. Halcomb, A. J. Coughran, Q. Z. Li, and A. B. Satterthwaite, Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice, Eur J Immunol, vol.40, pp.1897-1905, 2010.

M. N. Hedrick, A. S. Lonsdorf, A. K. Shirakawa, R. Lee, C. C. Liao et al., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice, J Clin Invest, vol.119, pp.2317-2329, 2009.

E. Ingley, Functions of the Lyn tyrosine kinase in health and disease, Cell Commun Signal, vol.10, 2012.

S. Liu, S. Chen, X. Li, S. Wu, Q. Zhang et al., Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses, Cell Host Microbe, vol.21, pp.754-768, 2017.

M. A. Lowes, M. Suarez-farinas, and J. G. Krueger, Immunology of psoriasis, Annu Rev Immunol, vol.32, pp.227-255, 2014.

M. C. Maa and T. H. Leu, Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages, Biomedicine (Taipei), vol.6, 2016.

S. Marchetti, P. Gamas, N. Belhacene, S. Grosso, L. A. Pradelli et al., The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice, EMBO J, vol.28, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00419195

A. A. Mello, M. F. Leal, J. A. Rey, G. R. Pinto, L. M. Lamarao et al., , 2015.

, Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis, PLoS One, vol.10

J. Mitchell, S. J. Kim, A. Seelmann, B. Veit, B. Shepard et al., Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses, Biochem Pharmacol, vol.147, pp.119-127, 2018.

E. Ogawa, Y. Sato, A. Minagawa, and R. Okuyama, Pathogenesis of psoriasis and development of treatment, J Dermatol, vol.45, pp.264-272, 2018.

S. J. Parsons and J. T. Parsons, Src family kinases, key regulators of signal transduction, Oncogene, vol.23, pp.7906-7909, 2004.

S. K. Raychaudhuri, E. Maverakis, and S. P. Raychaudhuri, Diagnosis and classification of psoriasis, Autoimmun Rev, vol.13, pp.490-495, 2014.

L. Riol-blanco, J. Ordovas-montanes, M. Perro, E. Naval, A. Thiriot et al., Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation, Nature, vol.510, p.4127885, 2014.

M. E. Roberts, J. L. Bishop, X. Fan, J. L. Beer, W. W. Kum et al., Lyn deficiency leads to increased microbiota-dependent intestinal inflammation and susceptibility to enteric pathogens, J Immunol, vol.193, pp.5249-5263, 2014.

A. K. Roseweir, T. Qayyum, Z. Lim, R. Hammond, A. I. Macdonald et al., Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients, BMC Cancer, vol.16, 2016.

R. Roskoski, Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors, Pharmacol Res, vol.94, pp.9-25, 2015.

P. Sophors, Y. M. Kim, G. Y. Seo, J. S. Huh, Y. Lim et al., A synthetic isoflavone, DCMF, promotes human keratinocyte migration by activating Src/FAK signaling pathway, Biochem Biophys Res Commun, vol.472, pp.332-338, 2016.

A. Szalmas, E. Gyongyosi, A. Ferenczi, B. Laszlo, T. Karosi et al., Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein, Virol J, vol.10, 2013.

D. Terhorst, R. Chelbi, C. Wohn, C. Malosse, S. Tamoutounour et al., Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis, J Immunol, vol.195, pp.5836-5845, 2009.

X. Wang, X. Yang, Y. Li, X. Wang, Y. Zhang et al., Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma, EBioMedicine, vol.15, pp.137-149, 2017.

P. Wu, G. Ma, X. Zhu, T. Gu, J. Zhang et al., Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-kappaB pathway, Clin Immunol, vol.174, pp.53-62, 2017.

Y. Xu, K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton, Lyn tyrosine kinase: accentuating the positive and the negative, Immunity, vol.22, pp.9-18, 2005.

J. R. Abrams, M. G. Lebwohl, C. A. Guzzo, B. V. Jegasothy, M. T. Goldfarb et al., CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris, J Clin Invest, vol.103, 1999.

T. Adachi, S. Stafford, S. Sur, and R. Alam, A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation, J Immunol, vol.163, pp.939-946, 1999.

G. Advani, Y. C. Lim, B. Catimel, D. Lio, N. Ng et al., Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine, Cell Commun Signal, vol.15, 2017.

L. E. Aira, A. Lopez-requena, D. Fuentes, L. Sanchez, T. Perez et al., Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab, MAbs, vol.6, pp.783-793, 2014.

L. E. Aira, P. Hernandez, D. Prada, A. Chico, J. A. Gomez et al., Immunological evaluation of rheumatoid arthritis patients treated with itolizumab, MAbs, vol.8, pp.187-195, 2016.

M. Akbar, M. M. Essa, G. Daradkeh, M. A. Abdelmegeed, Y. Choi et al., , 2016.

, Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress, Brain Res, vol.1637

T. Akiyama, C. R. Dass, and P. F. Choong, Bim-targeted cancer therapy: a link between drug action and underlying molecular changes, Mol Cancer Ther, vol.8, pp.3173-3180, 2009.

J. J. Alvarado, L. Betts, J. A. Moroco, T. E. Smithgall, and J. I. Yeh, Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism, J Biol Chem, vol.285, pp.35455-35461, 2010.

D. Alvarez-errico, Y. Yamashita, R. Suzuki, S. Odom, Y. Furumoto et al., Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation, J Immunol, vol.184, pp.5000-5008, 2010.

P. Alvarez and L. E. Jensen, Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner, Mediators Inflamm, 2016.

E. A. Alwawi, E. Krulig, and K. B. Gordon, Long-term efficacy of biologics in the treatment of psoriasis: what do we really know, Dermatol Ther, vol.22, pp.431-440, 2009.

L. Alland, S. M. Peseckis, R. E. Atherton, L. Berthiaume, and M. D. Resh, Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization, J Biol Chem, vol.269, pp.16701-16705, 1994.

H. Alluri, K. Wiggins-dohlvik, M. L. Davis, J. H. Huang, and B. Tharakan, Blood-brain barrier dysfunction following traumatic brain injury, Metab Brain Dis, vol.30, pp.1093-1104, 2015.

I. Amata, M. Maffei, and M. Pons, Phosphorylation of unique domains of Src family kinases, Front Genet, vol.5, pp.181-4075076, 2014.

N. Amatya, A. V. Garg, and S. L. Gaffen, IL-17 Signaling: The Yin and the Yang, Trends Immunol, vol.38, pp.310-322, 2017.

A. Arakelyan, L. Nersisyan, D. Poghosyan, L. Khondkaryan, A. Hakobyan et al., Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles, PLoS One, vol.12, 2017.
URL : https://hal.archives-ouvertes.fr/pasteur-01643667

M. Arbesu, M. Maffei, T. N. Cordeiro, J. M. Teixeira, Y. Perez et al., The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases, Structure, vol.25, pp.630-640, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01875247

O. Arican, M. Aral, S. Sasmaz, and P. Ciragil, Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity, Mediators Inflamm, pp.273-279, 2005.

M. Avila, A. Martinez-juarez, A. Ibarra-sanchez, and C. Gonzalez-espinosa, Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells, Innate Immun, vol.18, pp.648-660, 2012.

N. Ayala-fontanez, D. C. Soler, and T. S. Mccormick, Current knowledge on psoriasis and autoimmune diseases, Psoriasis (Auckl), vol.6, pp.7-32, 2016.

E. E. Ayli, W. Li, T. T. Brown, A. Witkiewicz, R. Elenitsas et al., Activation of Srcfamily tyrosine kinases in hyperproliferative epidermal disorders, J Cutan Pathol, vol.35, pp.273-277, 2008.

B. S. Baker, J. M. Ovigne, A. V. Powles, S. Corcoran, and L. Fry, Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis, Br J Dermatol, vol.148, pp.670-679, 2003.

B. S. Baker, J. D. Laman, A. Powles, L. Van-der-fits, J. S. Voerman et al., Peptidoglycan and peptidoglycan-specific Th1 cells in psoriatic skin lesions, J Pathol, vol.209, pp.174-181, 2006.

N. A. Balenga, M. Klichinsky, Z. Xie, E. C. Chan, M. Zhao et al., A fungal protease allergen provokes airway hyper-responsiveness in asthma, Nat Commun, vol.6, 2015.

T. Ban, G. R. Sato, A. Nishiyama, A. Akiyama, M. Takasuna et al., Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity, Immunity, vol.45, pp.319-332, 2016.

S. C. Barker, D. B. Kassel, D. Weigl, X. Huang, M. A. Luther et al., Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process, Biochemistry, vol.34, pp.14843-14851, 1995.

R. Barouch-bentov, C. J. Lee, C. C. Yang, Y. Herman, A. Jia et al., A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function, Mol Cell, vol.33, pp.43-52, 2009.

K. H. Basavaraj, N. M. Ashok, R. Rashmi, and T. K. Praveen, The role of drugs in the induction and/or exacerbation of psoriasis, Int J Dermatol, vol.49, pp.1351-1361, 2010.

R. C. Bates, N. S. Edwards, G. F. Burns, and D. E. Fisher, A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells, Cancer Res, vol.61, pp.5275-5283, 2001.

M. A. Battistone, V. G. Da-ros, A. M. Salicioni, F. A. Navarrete, D. Krapf et al., Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases, Mol Hum Reprod, vol.19, pp.570-580, 2013.

F. Bauer, K. Schweimer, H. Meiselbach, S. Hoffmann, P. Rosch et al., Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity, Protein Sci, vol.14, pp.2487-2498, 2005.

S. J. Beavitt, K. W. Harder, J. M. Kemp, J. Jones, C. Quilici et al., Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity, J Immunol, vol.175, pp.1867-1875, 2005.

C. Becker, A. J. Watson, and M. F. Neurath, Complex roles of caspases in the pathogenesis of inflammatory bowel disease, Gastroenterology, vol.144, pp.283-293, 2013.

P. Bernado, Y. Perez, D. I. Svergun, and M. Pons, Structural characterization of the active and inactive states of Src kinase in solution by small-angle X-ray scattering, J Mol Biol, vol.376, pp.492-505, 2008.

T. Berta, C. K. Park, Z. Z. Xu, R. G. Xie, T. Liu et al., Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion, J Clin Invest, vol.124, pp.1173-1186, 2014.

P. Besgen, P. Trommler, S. Vollmer, and J. C. Prinz, Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis, J Immunol, vol.184, pp.5392-5402, 2010.

K. R. Beutner and S. Tyring, Human papillomavirus and human disease, Am J Med, vol.102, pp.9-15, 1997.

P. K. Bhamidipati, H. Kantarjian, J. Cortes, A. M. Cornelison, and E. Jabbour, Management of imatinib-resistant patients with chronic myeloid leukemia, Ther Adv Hematol, vol.4, pp.103-117, 2013.

R. W. Birkinshaw and P. E. Czabotar, The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation, Semin Cell Dev Biol, vol.72, pp.152-162, 2017.

S. C. Bischoff, Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data, Nat Rev Immunol, vol.7, pp.93-104, 2007.

J. L. Bishop, M. E. Roberts, J. L. Beer, M. Huang, M. K. Chehal et al., Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells, Mucosal Immunol, vol.7, pp.405-416, 2014.

J. D. Bjorge, A. Pang, and D. J. Fujita, Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines, J Biol Chem, vol.275, pp.41439-41446, 2000.

A. Blazquez-castro, E. Carrasco, M. I. Calvo, P. Jaen, J. C. Stockert et al., Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation, Eur J Cell Biol, vol.91, pp.216-223, 2012.

W. H. Boehncke and M. P. Schon, Psoriasis. Lancet, vol.386, pp.983-994, 2015.

J. L. Boerner, M. L. Demory, C. Silva, and S. J. Parsons, Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II, Mol Cell Biol, vol.24, pp.7059-7071, 2004.

T. J. Boggon and M. J. Eck, Structure and regulation of Src family kinases, Oncogene, vol.23, pp.7918-7927, 2004.

B. Bonish, D. Jullien, Y. Dutronc, B. B. Huang, R. Modlin et al., Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells, J Immunol, vol.165, pp.4076-4085, 2000.

H. Bonnekoh, J. Scheffel, N. Kambe, and K. Krause, The role of mast cells in autoinflammation, Immunol Rev, vol.282, pp.265-275, 2018.

L. R. Bonser, L. Zlock, W. Finkbeiner, and D. J. Erle, Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma, J Clin Invest, vol.126, pp.2367-2371, 2016.

C. Bougeret, S. Jiang, I. Keydar, and H. Avraham, Functional analysis of Csk and CHK kinases in breast cancer cells, J Biol Chem, vol.276, pp.33711-33720, 2001.

P. Bouillet, D. Metcalf, D. C. Huang, D. M. Tarlinton, T. W. Kay et al., Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity, Science, vol.286, pp.1735-1738, 1999.

M. A. Boutet, A. Nerviani, G. Gallo-afflitto, and C. Pitzalis, Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints, Int J Mol Sci, vol.19, 2018.

A. M. Bowcock, The genetics of psoriasis and autoimmunity, Annu Rev Genomics Hum Genet, vol.6, pp.93-122, 2005.

A. M. Bowcock and J. G. Krueger, Getting under the skin: the immunogenetics of psoriasis, Nat Rev Immunol, vol.5, pp.699-711, 2005.

D. N. Bronner, B. H. Abuaita, X. Chen, K. A. Fitzgerald, G. Nunez et al., Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3-and Caspase-2-Driven Mitochondrial Damage, Immunity, vol.43, pp.451-462, 2015.

J. K. Brooks, Psoriasis: A review of systemic comorbidities and dental management considerations, Quintessence Int, vol.49, pp.209-217, 2018.

M. T. Brown and J. A. Cooper, Regulation, substrates and functions of src, Biochim Biophys Acta, vol.1287, pp.121-149, 1996.

P. Broz and V. M. Dixit, Inflammasomes: mechanism of assembly, regulation and signalling, Nat Rev Immunol, vol.16, pp.407-420, 2016.

F. Brozzi, C. Arcuri, I. Giambanco, and R. Donato, S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH, J Biol Chem, vol.284, pp.8797-8811, 2009.

A. M. Brunati, R. Deana, A. Folda, M. L. Massimino, O. Marin et al., Thrombininduced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein, J Biol Chem, vol.280, pp.21029-21035, 2005.

J. K. Brunelle and A. Letai, Control of mitochondrial apoptosis by the Bcl-2 family, J Cell Sci, vol.122, pp.437-441, 2009.

S. Bundela, A. Sharma, P. Bisen, . Adm, . Tp53 et al., Potential therapeutic targets for oral cancer, PLoS One, vol.9, 2014.

C. ,

Y. Cai, X. Shen, C. Ding, C. Qi, K. Li et al., Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation, Immunity, vol.35, pp.596-610, 2011.

E. Calautti, C. Missero, P. L. Stein, R. M. Ezzell, and G. P. Dotto, fyn tyrosine kinase is involved in keratinocyte differentiation control, Genes Dev, vol.9, pp.2279-2291, 1995.

G. A. Calin and C. M. Croce, MicroRNA signatures in human cancers, Nat Rev Cancer, vol.6, pp.857-866, 2006.

A. Campanati, G. Ganzetti, M. E. Giannoni, M. Gesuita, R. Bendia et al., , 2015.

, Helicobacter pylori infection in psoriasis: results of a clinical study and review of the literature, Int J Dermatol, vol.54, pp.109-114

I. Canobbio, L. Cipolla, G. F. Guidetti, D. Manganaro, C. Visconte et al., The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets, Biochem J, vol.469, pp.199-210, 2015.

F. Capon, M. Munro, J. Barker, and R. Trembath, Searching for the major histocompatibility complex psoriasis susceptibility gene, J Invest Dermatol, vol.118, pp.745-751, 2002.

F. Capon, The Genetic Basis of Psoriasis, Int J Mol Sci, vol.18, p.5751129, 2017.

R. L. Carpenter, W. Han, I. Paw, and H. W. Lo, HER2 phosphorylates and destabilizes proapoptotic PUMA, leading to antagonized apoptosis in cancer cells, PLoS One, vol.8, 2013.

P. H. Carter and Q. Zhao, Clinically validated approaches to the treatment of autoimmune diseases, Expert Opin Investig Drugs, vol.19, pp.195-213, 2010.

D. M. Clancy, C. M. Henry, G. P. Sullivan, and S. J. Martin, Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines, FEBS J, vol.284, pp.1712-1725, 2017.

J. F. Cloutier and A. Veillette, Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells, EMBO J, vol.15, 1996.

C. Clybouw, D. Merino, T. Nebl, F. Masson, M. Robati et al., Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo, Cell Death Differ, vol.19, pp.1060-1068, 2012.

K. M. Coleman, J. E. Gudjonsson, and M. Stecher, Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1alpha, for the Treatment of Psoriasis, JAMA Dermatol, vol.151, pp.555-556, 2015.

G. Collin, M. Franco, V. Simon, C. Benistant, and S. Roche, The Tom1L1-clathrin heavy chain complex regulates membrane partitioning of the tyrosine kinase Src required for mitogenic and transforming activities, Mol Cell Biol, vol.27, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00189124

S. A. Conos, K. E. Lawlor, D. L. Vaux, J. E. Vince, and L. M. Lindqvist, Cell death is not essential for caspase-1-mediated interleukin-1beta activation and secretion, Cell Death Differ, vol.23, 2016.

C. Conrad and M. Gilliet, Psoriasis: from Pathogenesis to Targeted Therapies, Clin Rev Allergy Immunol, vol.54, pp.102-113, 2018.

A. Contri, A. M. Brunati, L. Trentin, A. Cabrelle, M. Miorin et al., Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis, J Clin Invest, vol.115, pp.369-378, 2005.

P. W. Cook, M. Piepkorn, C. H. Clegg, G. D. Plowman, J. M. Demay et al., Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype, J Clin Invest, vol.100, pp.2286-2294, 1997.

A. Corcoran and T. G. Cotter, Redox regulation of protein kinases, FEBS J, vol.280, pp.1944-1965, 2013.

S. Cory, A. W. Roberts, P. M. Colman, and J. M. Adams, Targeting BCL-2-like Proteins to Kill Cancer Cells, Trends Cancer, vol.2, pp.443-460, 2016.

S. P. Cullen and S. J. Martin, Caspase activation pathways: some recent progress, Cell Death Differ, vol.16, pp.935-938, 2009.

J. R. Chan, W. Blumenschein, E. Murphy, C. Diveu, M. Wiekowski et al., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis, J Exp Med, vol.203, pp.2577-2587, 2006.

V. W. Chan, F. Meng, P. Soriano, A. L. Defranco, and C. A. Lowell, Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation, Immunity, vol.7, pp.69-81, 1997.

A. Chandra, A. Ray, S. Senapati, and R. Chatterjee, Genetic and epigenetic basis of psoriasis pathogenesis, Mol Immunol, vol.64, pp.313-323, 2015.

N. Charles, W. T. Watford, H. L. Ramos, L. Hellman, H. C. Oettgen et al., Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation, Immunity, vol.30, pp.533-543, 2009.

N. Charles, D. Hardwick, E. Daugas, G. G. Illei, and J. Rivera, Basophils and the T helper 2 environment can promote the development of lupus nephritis, Nat Med, vol.16, pp.701-707, 2010.

K. Chen, Y. Tu, Y. Zhang, H. C. Blair, L. Zhang et al., PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells, J Biol Chem, vol.283, pp.2508-2517, 2008.

L. Chen and T. F. Tsai, HLA-Cw6 and psoriasis, Br J Dermatol, 2017.

M. Chen, Y. Xing, A. Lu, W. Fang, B. Sun et al., Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8, 2015.

. Inflammasomes, J Immunol, vol.195, pp.4962-4972

R. Chen, S. Latour, X. Shi, and A. Veillette, Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor, Mol Cell Biol, vol.26, pp.5559-5568, 2006.

R. Chen and B. Chen, The role of dasatinib in the management of chronic myeloid leukemia, Drug Des Devel Ther, vol.9, pp.773-779, 2015.

S. Chen, R. Bing, N. Rosenblum, and D. E. Hillman, Immunohistochemical localization of Lyn (p56) protein in the adult rat brain, Neuroscience, vol.71, pp.89-100, 1996.

S. Chen, Y. Zhang, L. Zhou, Y. Leng, H. Lin et al., A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis, Blood, vol.124, pp.2687-2697, 2014.

W. S. Chen, H. J. Kung, W. K. Yang, and W. Lin, Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa, Int J Cancer, vol.83, pp.579-584, 1999.

Z. Chen, D. Oh, A. K. Dubey, M. Yao, B. Yang et al., EGFR family and Src family kinase interactions: mechanics matters?, Curr Opin Cell Biol, vol.51, pp.97-102, 2017.

S. Cheuk, M. Wiken, L. Blomqvist, S. Nylen, T. Talme et al., Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis, J Immunol, vol.192, 2014.

H. Chin, A. Arai, H. Wakao, R. Kamiyama, N. Miyasaka et al., Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway, Blood, vol.91, pp.3734-3745, 1998.

A. Chiricozzi, E. Guttman-yassky, M. Suarez-farinas, K. E. Nograles, S. Tian et al., Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis, J Invest Dermatol, vol.131, pp.677-687, 2011.

A. Chiricozzi, K. E. Nograles, L. M. Johnson-huang, J. Fuentes-duculan, I. Cardinale et al., IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model, PLoS One, vol.9, 2014.

A. Chiricozzi, M. V. Cannizzaro, G. A. Salandri, B. Marinari, R. Pitocco et al., Increased levels of IL-17 in tear fluid of moderate-to-severe psoriatic patients is reduced by adalimumab therapy, J Eur Acad Dermatol Venereol, vol.30, pp.128-129, 2016.

A. Chiricozzi, M. Suarez-farinas, J. Fuentes-duculan, I. Cueto, K. Li et al., Increased expression of interleukin-17 pathway genes in nonlesional skin of moderate-to-severe psoriasis vulgaris, Br J Dermatol, vol.174, pp.136-145, 2016.

A. Chiricozzi, P. Romanelli, E. Volpe, G. Borsellino, and M. Romanelli, Scanning the Immunopathogenesis of Psoriasis, Int J Mol Sci, vol.19, p.5796128, 2018.

K. A. Cho, J. W. Suh, K. H. Lee, J. L. Kang, and S. Y. Woo, IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway, Int Immunol, vol.24, pp.147-158, 2012.

Y. L. Choi, M. Bocanegra, M. J. Kwon, Y. K. Shin, S. J. Nam et al., LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer, Cancer Res, vol.70, pp.2296-2306, 2010.

Y. P. Chong, T. D. Mulhern, H. J. Zhu, D. J. Fujita, J. D. Bjorge et al., A novel noncatalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity, J Biol Chem, vol.279, pp.20752-20766, 2004.

C. C. Chu, D. Meglio, P. Nestle, and F. O. , Harnessing dendritic cells in inflammatory skin diseases, Semin Immunol, vol.23, 2011.

D. A. Chudakova, Y. H. Zeidan, B. W. Wheeler, J. Yu, S. A. Novgorodov et al., Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity, J Biol Chem, vol.283, pp.28806-28816, 2008.

Y. Chung, S. H. Chang, G. J. Martinez, X. O. Yang, R. Nurieva et al., Critical regulation of early Th17 cell differentiation by interleukin-1 signaling, Immunity, vol.30, pp.576-587, 2009.

Y. Dai, M. Rahmani, S. J. Corey, P. Dent, and S. Grant, A Bcr/Abl-independent, Lyndependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2, J Biol Chem, vol.279, pp.34227-34239, 2004.

R. Daneman and A. Prat, The blood-brain barrier, Cold Spring Harb Perspect Biol, vol.7, 2015.

K. Danielsen, A. O. Olsen, T. Wilsgaard, and A. S. Furberg, Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort, Br J Dermatol, vol.168, pp.1303-1310, 2013.

E. De-bruyne, T. J. Bos, F. Schuit, E. Van-valckenborgh, E. Menu et al., IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms, Blood, vol.115, pp.2430-2440, 2010.

L. De-franceschi, L. Fumagalli, O. Olivieri, R. Corrocher, C. A. Lowell et al., Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport, J Clin Invest, vol.99, pp.220-227, 1997.

A. M. Deaton and A. Bird, CpG islands and the regulation of transcription, Genes Dev, vol.25, pp.1010-1022, 2011.

R. Denadai, F. V. Teixeira, F. Steinwurz, R. Romiti, and R. Saad-hossne, Induction or exacerbation of psoriatic lesions during anti-TNF-alpha therapy for inflammatory bowel disease: a systematic literature review based on 222 cases, J Crohns Colitis, vol.7, pp.517-524, 2013.

G. Denecker, E. Hoste, B. Gilbert, T. Hochepied, P. Ovaere et al., Caspase-14 protects against epidermal UVB photodamage and water loss, Nat Cell Biol, vol.9, pp.666-674, 2007.

G. Denecker, P. Ovaere, P. Vandenabeele, and W. Declercq, Caspase-14 reveals its secrets, J Cell Biol, vol.180, pp.451-458, 2008.

R. M. Derita, B. Zerlanko, A. Singh, H. Lu, R. V. Iozzo et al., c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes, J Cell Biochem, vol.118, pp.66-73, 2017.

D. Meglio, P. Villanova, F. Navarini, A. A. Mylonas, A. Tosi et al., Targeting CD8(+) T cells prevents psoriasis development, J Allergy Clin Immunol, vol.138, pp.274-276, 2016.

L. S. Dickens, R. S. Boyd, J. , R. Hughes, M. A. Robinson et al., A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death, Mol Cell, vol.47, pp.291-305, 2012.

Q. Ding, J. Stewart, J. Olman, M. A. Klobe, M. R. Gladson et al., The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged, J Biol Chem, vol.278, pp.39882-39891, 2003.

M. Doerflinger, J. A. Glab, and H. Puthalakath, BH3-only proteins: a 20-year stock-take, FEBS J, vol.282, pp.1006-1016, 2015.

Y. Dombrowski, M. Peric, S. Koglin, C. Kammerbauer, C. Goss et al., Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions, Sci Transl Med, vol.3, 2011.

N. J. Donato, J. Y. Wu, J. Stapley, G. Gallick, H. Lin et al., BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571, Blood, vol.101, pp.690-698, 2003.

M. J. Dorfel and O. Huber, Modulation of tight junction structure and function by kinases and phosphatases targeting occludin, J Biomed Biotechnol, 2012.

A. Doria, J. M. Dayer, and L. Punzi, Autoinflammatory diseases: how to put the fire inside the body out, Autoimmun Rev, vol.12, pp.1-4, 2012.

A. Doria, M. Zen, S. Bettio, M. Gatto, N. Bassi et al., Autoinflammation and autoimmunity: bridging the divide, Autoimmun Rev, vol.12, pp.22-30, 2012.

D. Santos, C. Demur, C. Bardet, V. Prade-houdellier, N. Payrastre et al., A critical role for Lyn in acute myeloid leukemia, Blood, vol.111, pp.2269-2279, 2008.

D. Santos, C. Mcdonald, T. Ho, Y. W. Liu, H. Lin et al., The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents, Blood, vol.122, pp.1900-1913, 2013.

T. Douglas, C. Champagne, A. Morizot, J. M. Lapointe, and M. Saleh, The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice, J Immunol, vol.195, pp.2365-2373, 2015.

S. K. Drexler, L. Bonsignore, M. Masin, A. Tardivel, R. Jackstadt et al., Tissuespecific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis, Proc Natl Acad Sci U S A, vol.109, pp.18384-18389, 2012.

J. Du, P. Bernasconi, K. R. Clauser, D. R. Mani, S. P. Finn et al., Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy, Nat Biotechnol, vol.27, pp.77-83, 2009.

F. Dubois, C. Leroy, V. Simon, C. Benistant, and S. Roche, YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells, Am J Cancer Res, vol.5, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01883466

K. C. Duffin and G. G. Krueger, Genetic variations in cytokines and cytokine receptors associated with psoriasis found by genome-wide association, J Invest Dermatol, vol.129, pp.827-833, 2009.

S. Dunphy and C. M. Gardiner, NK cells and psoriasis, J Biomed Biotechnol, 2011.

J. Dupaul-chicoine, G. Yeretssian, K. Doiron, K. S. Bergstrom, C. R. Mcintire et al., Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases, Immunity, vol.32, pp.367-378, 2010.

A. R. Dwyer, K. A. Mouchemore, J. H. Steer, A. J. Sunderland, N. G. Sampaio et al., Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration, J Leukoc Biol, vol.100, pp.163-175, 2016.

L. Eckhart, C. Ballaun, M. Hermann, J. L. Vandeberg, W. Sipos et al., Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire, Mol Biol Evol, vol.25, pp.831-841, 2008.

F. Edlich, BCL-2 proteins and apoptosis: Recent insights and unknowns, Biochem Biophys Res Commun, 2017.

A. M. Eghlileb, E. E. Davies, and A. Y. Finlay, Psoriasis has a major secondary impact on the lives of family members and partners, Br J Dermatol, vol.156, pp.1245-1250, 2007.

M. Emaduddin, M. J. Edelmann, B. M. Kessler, and S. M. Feller, Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells, Cell Commun Signal, vol.6, 2008.

M. Endele, D. Loeffler, K. D. Kokkaliaris, O. Hilsenbeck, S. Skylaki et al., CSF-1-induced Src signaling can instruct monocytic lineage choice, Blood, vol.129, pp.1691-1701, 2017.

J. Espada and J. Martin-perez, An Update on Src Family of Nonreceptor Tyrosine Kinases Biology, Int Rev Cell Mol Biol, vol.331, pp.83-122, 2017.

J. Estaquier, F. Vallette, J. L. Vayssiere, and B. Mignotte, The mitochondrial pathways of apoptosis, Adv Exp Med Biol, vol.942, pp.157-183, 2012.

A. C. Evans, J. L. Ireland, M. E. Winn, P. Lonergan, G. W. Smith et al., Identification of genes involved in apoptosis and dominant follicle development during follicular waves in cattle, Biol Reprod, vol.70, pp.1475-1484, 2004.

K. E. Ewings, C. M. Wiggins, and S. J. Cook, Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels, Cell Cycle, vol.6, pp.2236-2240, 2007.

J. V. Fahy, Type 2 inflammation in asthma--present in most, absent in many, Nat Rev Immunol, vol.15, pp.57-65, 2015.

M. Fajer, Y. Meng, and B. Roux, The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape, J Phys Chem B, vol.121, pp.3352-3363, 2017.

P. A. Fanti, E. Dika, S. Vaccari, C. Miscial, and C. Varotti, Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod, Int J Dermatol, vol.45, pp.1464-1465, 2006.

L. L. Fava, F. J. Bock, S. Geley, and A. Villunger, Caspase-2 at a glance, J Cell Sci, vol.125, pp.5911-5915, 2012.

S. R. Feldman and G. G. Krueger, Psoriasis assessment tools in clinical trials, Ann Rheum Dis, vol.64, issue.2, pp.65-68, 2005.

L. Feldmeyer, M. Keller, G. Niklaus, D. Hohl, S. Werner et al., The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes, Curr Biol, vol.17, pp.1140-1145, 2007.

G. Fenini, E. Contassot, and L. E. French, Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases, Front Pharmacol, vol.8, 2017.

S. E. Fenton and M. F. Denning, FYNagling divergent adhesive functions for Fyn in keratinocytes, Exp Dermatol, vol.24, pp.81-85, 2015.

R. Ferracini and J. Brugge, Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416, Oncogene Res, vol.5, pp.205-219, 1990.

S. L. Fink and B. T. Cookson, Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells, Infect Immun, vol.73, pp.1907-1916, 2005.

A. Y. Finlay, B. Flood, K. Oficjalska, D. Laukens, J. Fay et al., Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential, Clin Exp Immunol, vol.152, pp.39-50, 2005.

C. Fotiadou, E. Lazaridou, E. Sotiriou, and D. Ioannides, Targeting IL-23 in psoriasis: current perspectives, Psoriasis (Auckl), vol.8, pp.1-5, 2018.

J. L. Fox, F. Ismail, A. Azad, N. Ternette, S. Leverrier et al., Tyrosine dephosphorylation is required for Bak activation in apoptosis, EMBO J, vol.29, pp.3853-3868, 2010.

M. Franco, O. Furstoss, V. Simon, C. Benistant, W. J. Hong et al., The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors, Mol Cell Biol, vol.26, pp.1932-1947, 2006.

T. S. Freedman, Y. X. Tan, K. M. Skrzypczynska, B. N. Manz, F. V. Sjaastad et al., LynA regulates an inflammation-sensitive signaling checkpoint in macrophages, p.4626889, 2015.

L. Fry, B. S. Baker, A. V. Powles, A. Fahlen, and L. Engstrand, Is chronic plaque psoriasis triggered by microbiota in the skin?, Br J Dermatol, vol.169, pp.47-52, 2013.

L. Fry, B. S. Baker, A. V. Powles, and L. Engstrand, Psoriasis is not an autoimmune disease?, Exp Dermatol, vol.24, pp.241-244, 2015.

J. Fuentes-duculan, M. Suarez-farinas, L. C. Zaba, K. E. Nograles, K. C. Pierson et al., A subpopulation of CD163-positive macrophages is classically activated in psoriasis, J Invest Dermatol, vol.130, pp.2412-2422, 2010.

P. Fuentes-prior and G. S. Salvesen, The protein structures that shape caspase activity, specificity, activation and inhibition, Biochem J, vol.384, pp.201-232, 2004.

M. Fujimoto, Y. Fujimoto, J. C. Poe, P. J. Jansen, C. A. Lowell et al., CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification, Immunity, vol.13, pp.47-57, 2000.

K. Furue, T. Ito, G. Tsuji, T. Kadono, T. Nakahara et al., Autoimmunity and autoimmune co-morbidities in psoriasis, Immunology, 2018.

S. L. Gaffen, R. Jain, A. V. Garg, and D. J. Cua, The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing, Nat Rev Immunol, vol.14, 2014.

B. J. Galgut, D. A. Lemberg, A. S. Day, and S. T. Leach, The Value of Fecal Markers in Predicting Relapse in, Inflammatory Bowel Diseases. Front Pediatr, vol.5, 2017.

L. Galluzzi, J. M. Bravo-san-pedro, O. Kepp, and G. Kroemer, Regulated cell death and adaptive stress responses, Cell Mol Life Sci, vol.73, pp.2405-2410, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01301985

L. Galluzzi, A. Lopez-soto, S. Kumar, and G. Kroemer, Caspases Connect Cell-Death Signaling to Organismal Homeostasis, Immunity, vol.44, pp.221-231, 2016.

P. Gamas, S. Marchetti, A. Puissant, S. Grosso, A. Jacquel et al., Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells, Leukemia, vol.23, pp.1500-1506, 2009.

T. Gambichler, S. Kobus, A. Kobus, C. Tigges, N. Scola et al., Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients, Regul Pept, vol.167, pp.163-166, 2011.

S. Ganesan, V. Rathinam, L. Bossaller, K. Army, W. J. Kaiser et al., Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans, J Immunol, vol.193, 2014.

A. K. Ganguly, S. Laghimsetty, and N. Bhagyalakshmi, Koebner Phenomenon Triggered by External Dacryocystorhinostomy Scar in a Patient With Psoriasis: A Case Report and Literature Review, Ophthal Plast Reconstr Surg, vol.34, pp.52-53, 2018.

D. Ganguly, G. Chamilos, R. Lande, J. Gregorio, S. Meller et al., Self-RNAantimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8, J Exp Med, vol.206, 1983.

R. Gao, Z. Ma, M. Ma, J. Yu, J. Chen et al., Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation, Am J Physiol Lung Cell Mol Physiol, vol.309, pp.1376-1381, 2015.

J. M. Garcia-martinez, A. Calcabrini, L. Gonzalez, E. Martin-forero, M. T. Agullo-ortuno et al., A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling, Cell Signal, vol.22, pp.415-426, 2010.

I. Garcia-valladares, R. Cuchacovich, and L. R. Espinoza, Comparative assessment of biologics in treatment of psoriasis: drug design and clinical effectiveness of ustekinumab, Drug Des Devel Ther, vol.5, pp.41-49, 2011.

S. Gardai, B. B. Whitlock, C. Helgason, D. Ambruso, V. Fadok et al., Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils, J Biol Chem, vol.277, pp.5236-5246, 2002.

S. B. Gauld and J. C. Cambier, Src-family kinases in B-cell development and signaling, Oncogene, vol.23, pp.8001-8006, 2004.

T. Gavrilova, Immune Dysregulation in the Pathogenesis of Atopic Dermatitis, Dermatitis, vol.29, pp.57-62, 2018.

J. K. Geisse, P. Rich, A. Pandya, K. Gross, K. Andres et al., Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study, J Am Acad Dermatol, vol.47, pp.390-398, 2002.

A. Geissler, F. Haun, D. O. Frank, K. Wieland, M. M. Simon et al., Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK, Cell Death Differ, vol.20, pp.1317-1329, 2013.

J. M. Gelfand, R. Weinstein, S. B. Porter, A. L. Neimann, J. A. Berlin et al., Prevalence and treatment of psoriasis in the United Kingdom: a population-based study, Arch Dermatol, vol.141, pp.1537-1541, 2005.

M. Ghasemi, Y. Mayasi, A. Hannoun, S. M. Eslami, and R. Carandang, Nitric Oxide and Mitochondrial Function in Neurological Diseases, Neuroscience, vol.376, pp.48-71, 2018.

E. Giannoni, F. Buricchi, G. Raugei, G. Ramponi, and P. Chiarugi, Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchoragedependent cell growth, Mol Cell Biol, vol.25, pp.6391-6403, 2005.

A. M. Gilfillan and J. Rivera, The tyrosine kinase network regulating mast cell activation, Immunol Rev, vol.228, pp.149-169, 2009.

M. Gilliet, C. Conrad, M. Geiges, A. Cozzio, W. Thurlimann et al., Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors, Arch Dermatol, vol.140, pp.1490-1495, 2004.

A. Goblos, J. Danis, K. Vas, Z. Bata-csorgo, L. Kemeny et al., Keratinocytes express functional CARD18, a negative regulator of inflammasome activation, and its altered expression in psoriasis may contribute to disease pathogenesis, Mol Immunol, vol.73, pp.10-18, 2016.

R. K. Goel and K. E. Lukong, Tracing the footprints of the breast cancer oncogene BRKPast till present, Biochim Biophys Acta, vol.1856, pp.39-54, 2015.

R. K. Goel, K. E. Lukong, R. Goldbach-mansky, and D. L. Kastner, Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses, J Allergy Clin Immunol, vol.35, pp.1141-1149, 2009.

M. Goldenberg-furmanov, I. Stein, E. Pikarsky, H. Rubin, S. Kasem et al., Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts, Cancer Res, vol.64, pp.1058-1066, 2004.

A. M. Goldminz, S. C. Au, N. Kim, A. B. Gottlieb, and P. F. Lizzul, NF-kappaB: an essential transcription factor in psoriasis, J Dermatol Sci, vol.69, pp.89-94, 2013.

P. Gomez-bougie, S. Wuilleme-toumi, E. Menoret, V. Trichet, N. Robillard et al., Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma, Cancer Res, vol.67, pp.5418-5424, 2007.

M. L. Gonzalez-ramirez, M. Poreba, S. J. Snipas, K. Groborz, M. Drag et al., Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1, J Biol Chem, Gottlieb AB, vol.4, pp.19-34, 2005.

S. L. Gottlieb, P. Gilleaudeau, R. Johnson, L. Estes, T. G. Woodworth et al., Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis, Nat Med, vol.1, pp.442-447, 1995.

S. G. Grant, T. J. O'dell, K. A. Karl, P. L. Stein, P. Soriano et al., Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice, Science, vol.258, pp.1903-1910, 1992.

A. Grasland, E. Mahe, E. Raynaud, and I. Mahe, Psoriasis onset with tocilizumab, Joint Bone Spine, vol.80, pp.541-542, 2013.

S. Grazide, N. Maestre, R. J. Veldman, C. Bezombes, S. Maddens et al., Ara-Cand daunorubicin-induced recruitment of Lyn in sphingomyelinase-enriched membrane rafts, FASEB J, vol.16, pp.1685-1687, 2002.

J. E. Greb, A. M. Goldminz, J. T. Elder, M. G. Lebwohl, D. D. Gladman et al., Psoriasis. Nat Rev Dis Primers, vol.2, p.16082, 2016.

D. R. Green and F. Llambi, Cell Death Signaling, Cold Spring Harb Perspect Biol, vol.7, p.4665079, 2015.

F. R. Greten, M. C. Arkan, J. Bollrath, L. C. Hsu, J. Goode et al., NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta, Cell, vol.130, pp.918-931, 2007.

C. E. Griffiths and J. N. Barker, Pathogenesis and clinical features of psoriasis, Lancet, vol.370, pp.263-271, 2007.

L. Grine, L. Dejager, C. Libert, and R. E. Vandenbroucke, An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17, Cytokine Growth Factor Rev, vol.26, pp.25-33, 2015.

E. Gringeri, A. Carraro, E. Tibaldi, D. 'amico, F. E. Mancon et al., Lynmediated mitochondrial tyrosine phosphorylation is required to preserve mitochondrial integrity in early liver regeneration, Biochem J, vol.425, pp.401-412, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00479212

S. I. Gringhuis, T. M. Kaptein, B. A. Wevers, B. Theelen, M. Van-der-vlist et al., , 2012.

, Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome, Nat Immunol, vol.13, pp.246-254

A. J. Gross, I. Proekt, and A. L. Defranco, Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells, Eur J Immunol, vol.41, pp.3645-3655, 2011.

T. Groves, P. Smiley, M. P. Cooke, K. Forbush, R. M. Perlmutter et al., Fyn can partially substitute for Lck in T lymphocyte development, Immunity, vol.5, pp.417-428, 1996.

I. Grozdev, N. Korman, and N. Tsankov, Psoriasis as a systemic disease, Clin Dermatol, vol.32, pp.343-350, 2014.

H. Guan, Z. Zhou, G. E. Gallick, S. F. Jia, J. Morales et al., Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma, Mol Cancer Ther, vol.7, pp.1807-1816, 2008.

G. Guarda, M. Braun, F. Staehli, A. Tardivel, C. Mattmann et al., Type I interferon inhibits interleukin-1 production and inflammasome activation, Immunity, vol.34, pp.213-223, 2011.

M. Guarino, Src signaling in cancer invasion, J Cell Physiol, vol.223, pp.14-26, 2010.

J. E. Gudjonsson, A. Johnston, M. Dyson, H. Valdimarsson, and J. T. Elder, Mouse models of psoriasis, J Invest Dermatol, vol.127, pp.1292-1308, 2007.

A. Guo, P. Lu, J. Lee, C. Zhen, G. Chiosis et al., HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment, Oncogene, vol.36, pp.3441-3449, 2017.

R. Gupta, M. G. Debbaneh, and W. Liao, Genetic Epidemiology of Psoriasis, Curr Dermatol Rep, vol.3, pp.61-78, 2014.

P. Gurung and T. D. Kanneganti, Novel roles for caspase-8 in IL-1beta and inflammasome regulation, Am J Pathol, vol.185, pp.17-25, 2015.

T. Gutierrez, K. E. Halcomb, A. J. Coughran, Q. Z. Li, and A. B. Satterthwaite, Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice, Eur J Immunol, vol.40, pp.1897-1905, 2010.

J. A. Hagar, D. A. Powell, Y. Aachoui, R. K. Ernst, and E. A. Miao, Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock, Science, vol.341, pp.1250-1253, 2013.

K. Hamamura, M. Tsuji, H. Hotta, Y. Ohkawa, M. Takahashi et al., Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3, J Biol Chem, vol.286, pp.18526-18537, 2011.

J. Han, G. Zhang, E. J. Welch, Y. Liang, J. Fu et al., A critical role for Lyn kinase in strengthening endothelial integrity and barrier function, Blood, vol.122, pp.4140-4149, 2013.

D. Hanahan and R. A. Weinberg, Hallmarks of cancer: the next generation, Cell, vol.144, pp.646-674, 2011.

J. L. Harden, J. G. Krueger, and A. M. Bowcock, The immunogenetics of Psoriasis: A comprehensive review, J Autoimmun, vol.64, 2015.

K. W. Harder, L. M. Parsons, J. Armes, N. Evans, N. Kountouri et al., Gain-and lossof-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage, Immunity, vol.15, pp.603-615, 2001.

K. W. Harder, C. Quilici, E. Naik, M. Inglese, N. Kountouri et al., Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1, Blood, vol.104, pp.3901-3910, 2004.

S. Harrach, B. Edemir, C. Schmidt-lauber, T. Pap, J. Bertrand et al., Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts, Sci Rep, vol.7, 2017.

K. F. Harris, I. Shoji, E. M. Cooper, S. Kumar, H. Oda et al., Ubiquitin-mediated degradation of active Src tyrosine kinase, Proc Natl Acad Sci, vol.96, pp.13738-13743, 1999.

S. C. Harrison, Variation on an Src-like theme, Cell, vol.112, pp.737-740, 2003.

J. E. Hawkes, J. A. Adalsteinsson, J. E. Gudjonsson, and N. L. Ward, Research Techniques Made Simple: Murine Models of Human Psoriasis, J Invest Dermatol, vol.138, pp.1-8, 2018.

L. He, L. Dang, J. Zhou, J. Bai, and Y. Z. Li, Association of angiopoietin-1, angiopoietin-2 and caspase-5 polymorphisms with psoriasis vulgaris, Clin Exp Dermatol, vol.40, pp.556-563, 2015.

E. Hebert-chatelain, C. Jose, G. Cortes, N. Dupuy, J. W. Rocher et al., Preservation of NADH ubiquinone-oxidoreductase activity by Src kinasemediated phosphorylation of NDUFB10, Biochim Biophys Acta, vol.1817, pp.718-725, 2012.

E. Hebert-chatelain, Src kinases are important regulators of mitochondrial functions, Int J Biochem Cell Biol, vol.45, pp.90-98, 2013.

H. L. Hebert, F. R. Ali, J. Bowes, C. E. Griffiths, A. Barton et al., Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy, Br J Dermatol, vol.166, pp.474-482, 2012.

M. N. Hedrick, A. S. Lonsdorf, A. K. Shirakawa, R. Lee, C. C. Liao et al., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice, J Clin Invest, vol.119, pp.2317-2329, 2009.

V. Hernandez-hansen, A. J. Smith, Z. Surviladze, A. Chigaev, T. Mazel et al., , 2004.

, Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyndeficient mast cells, J Immunol, vol.173, pp.100-112

J. Hernandez-rapp, S. Martin-lanneree, T. Z. Hirsch, E. Pradines, A. Alleaume-butaux et al., A PrP(C)-caveolin-Lyn complex negatively controls neuronal GSK3beta and serotonin 1B receptor, Sci Rep, vol.4, 2014.

P. Hernandez, E. Moreno, L. E. Aira, and P. C. Rodriguez, Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab, Curr Drug Targets, vol.17, pp.666-677, 2016.

V. M. Heydendael, P. I. Spuls, B. C. Opmeer, C. A. De-borgie, J. B. Reitsma et al., Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis, N Engl J Med, vol.349, pp.658-665, 2003.

M. L. Hibbs, D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson et al., Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease, Cell, vol.83, pp.301-311, 1995.

M. L. Hibbs, K. W. Harder, J. Armes, N. Kountouri, C. Quilici et al., Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity, J Exp Med, vol.196, pp.1593-1604, 2002.

M. L. Hibbs and K. W. Harder, The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling, Growth Factors, vol.24, pp.137-149, 2006.

D. Hijnen, E. F. Knol, Y. Y. Gent, B. Giovannone, S. J. Beijn et al., CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-gamma, IL-13, IL-17, and IL-22, J Invest Dermatol, vol.133, pp.973-979, 2013.

M. G. Hinds, C. Smits, R. Fredericks-short, J. M. Risk, M. Bailey et al., Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets, Cell Death Differ, vol.14, pp.128-136, 2007.

F. Hochgrafe, L. Zhang, S. A. O'toole, B. C. Browne, M. Pinese et al., Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells, Cancer Res, vol.70, pp.9391-9401, 2010.

S. M. Hoffman, J. E. Tully, J. D. Nolin, K. G. Lahue, D. H. Goldman et al., Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis, Respir Res, vol.14, 2013.

W. C. Horne, A. Sanjay, A. Bruzzaniti, and R. Baron, The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function, Immunol Rev, vol.208, pp.106-125, 2005.

M. I. Hossain, C. L. Roulston, M. A. Kamaruddin, P. W. Chu, D. C. Ng et al., A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity, J Biol Chem, vol.288, p.3617272, 2013.

Y. Hu, Y. Liu, S. Pelletier, E. Buchdunger, M. Warmuth et al., Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia, Nat Genet, vol.36, pp.453-461, 2004.

J. Huang, L. Yao, R. Xu, H. Wu, M. Wang et al., Activation of Src and transformation by an RPTPalpha splice mutant found in human tumours, EMBO J, vol.30, pp.3200-3211, 2011.

S. Huang, Z. Li, Y. Liu, D. Gao, X. Zhang et al., Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone, J Cell Physiol, 2018.

S. R. Hubbard and J. H. Till, Protein tyrosine kinase structure and function, Annu Rev Biochem, vol.69, pp.373-398, 2000.

E. Ichihara, D. Westover, C. B. Meador, Y. Yan, J. A. Bauer et al., SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer, Cancer Res, vol.77, 2017.

M. Iida, T. M. Brand, D. A. Campbell, C. Li, and D. L. Wheeler, Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor, Oncogene, vol.32, p.3381861, 2013.

K. Ikeda, Y. Nakayama, Y. Togashi, Y. Obata, T. Kuga et al., Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity, Exp Cell Res, vol.314, pp.3392-3404, 2008.

N. S. Imjeti, K. Menck, A. L. Egea-jimenez, C. Lecointre, F. Lembo et al., Syntenin mediates SRC function in exosomal cell-to-cell communication, Proc Natl Acad Sci U S A, vol.114, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01765373

R. Incrocci, S. Hussain, A. Stone, K. Bieging, L. A. Alt et al., Epstein-Barr virus Latent Membrane Protein 2A (LMP2A)-mediated changes in Fas expression and Fas-dependent apoptosis: Role of Lyn/Syk activation, Cell Immunol, vol.297, pp.108-119, 2015.

S. Infantino, S. A. Jones, J. A. Walker, M. J. Maxwell, A. Light et al., The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice, Sci Signal, vol.7, p.77, 2014.

E. Ingley, M. K. Sarna, J. G. Beaumont, P. A. Tilbrook, S. Tsai et al., HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells, J Biol Chem, vol.275, pp.7887-7893, 2000.

E. Ingley, D. J. Mccarthy, J. R. Pore, M. K. Sarna, A. S. Adenan et al., Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis, Oncogene, vol.24, pp.336-343, 2005.

E. Ingley, J. R. Schneider, C. J. Payne, D. J. Mccarthy, K. W. Harder et al., Cskbinding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells, J Biol Chem, vol.281, pp.31920-31929, 2006.

E. Ingley, Src family kinases: regulation of their activities, levels and identification of new pathways, Biochim Biophys Acta, vol.1784, pp.56-65, 2008.

E. Ingley, Csk-binding protein can regulate Lyn signals controlling cell morphology, Int J Biochem Cell Biol, vol.41, pp.1332-1343, 2009.

E. Ingley, Functions of the Lyn tyrosine kinase in health and disease, Cell Commun Signal, vol.10, 2012.

R. B. Irby, W. Mao, D. Coppola, J. Kang, J. M. Loubeau et al., Activating SRC mutation in a subset of advanced human colon cancers, Nat Genet, vol.21, pp.187-190, 1999.

J. M. Irish, D. K. Czerwinski, G. P. Nolan, and R. Levy, Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry, J Immunol, vol.177, pp.1581-1589, 2006.

N. Irrera, M. Vaccaro, A. Bitto, G. Pallio, G. Pizzino et al., BAY 11-7082 inhibits the NF-kappaB and NLRP3 inflammasome pathways and protects against IMQinduced psoriasis, Clin Sci, vol.131, pp.487-498, 2017.

M. Jiang, W. Ma, Y. Gao, K. Jia, Y. Zhang et al., IL-22-induced miR-122-5p promotes keratinocyte proliferation by targeting Sprouty2, Exp Dermatol, vol.26, pp.368-374, 2017.

Y. Jin, S. Yang, F. Zhang, Y. Kong, F. Xiao et al., Combined effects of HLA-Cw6 and cigarette smoking in psoriasis vulgaris: a hospital-based case-control study in China, J Eur Acad Dermatol Venereol, vol.23, pp.132-137, 2009.

C. Johansen, K. Moeller, K. Kragballe, and L. Iversen, The activity of caspase-1 is increased in lesional psoriatic epidermis, J Invest Dermatol, vol.127, pp.2857-2864, 2007.

C. Johansen, M. Mose, P. Ommen, T. Bertelsen, H. Vinter et al., IkappaBzeta is a key driver in the development of psoriasis, Proc Natl Acad Sci U S A, vol.112, 2015.

C. Johansen, T. Bertelsen, C. Ljungberg, M. Mose, and L. Iversen, Characterization of TNFalpha-and IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IkappaBzeta, J Invest Dermatol, vol.136, pp.1608-1616, 2016.

L. M. Johnson-huang, M. Suarez-farinas, M. Sullivan-whalen, P. Gilleaudeau, J. G. Krueger et al., Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques, J Invest Dermatol, vol.130, pp.2654-2663, 2010.

T. M. Johnson, N. A. Williamson, G. Scholz, A. Jaworowski, R. E. Wettenhall et al., Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain, J Biol Chem, vol.275, pp.33353-33364, 2000.

C. T. Jordan, L. Cao, E. D. Roberson, S. Duan, C. A. Helms et al., Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis, Am J Hum Genet, vol.90, pp.796-808, 2012.

C. T. Jordan, L. Cao, E. D. Roberson, K. C. Pierson, C. F. Yang et al., PSORS2 is due to mutations in CARD14, Am J Hum Genet, vol.90, pp.784-795, 2012.

S. Kagami, H. L. Rizzo, J. J. Lee, Y. Koguchi, and A. Blauvelt, Circulating Th17, Th22, and Th1 cells are increased in psoriasis, J Invest Dermatol, vol.130, pp.1373-1383, 2010.

A. Kalayciyan, E. H. Aydemir, and A. Kotogyan, Experimental Koebner phenomenon in patients with psoriasis, Dermatology, vol.215, pp.114-117, 2007.

T. Kaneko, L. Li, and S. S. Li, The SH3 domain--a family of versatile peptide-and proteinrecognition module, Front Biosci, vol.13, pp.4938-4952, 2008.

H. Kang, C. Freund, J. S. Duke-cohan, A. Musacchio, G. Wagner et al., SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55, EMBO J, vol.19, pp.2889-2899, 2000.

T. B. Kang, T. Ben-moshe, E. E. Varfolomeev, Y. Pewzner-jung, N. Yogev et al., Caspase-8 serves both apoptotic and nonapoptotic roles, J Immunol, vol.173, pp.2976-2984, 2004.

S. Kannan, A. Audet, J. Knittel, S. Mullegama, G. F. Gao et al., Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells, Eur J Immunol, vol.36, pp.1739-1752, 2006.

S. Kanoh, T. Tanabe, and B. K. Rubin, IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells, Clin Exp Allergy, vol.41, pp.1747-1756, 2011.

T. Kanou, C. Oneyama, K. Kawahara, A. Okimura, M. Ohta et al., The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation, Mol Cancer Res, vol.9, pp.103-114, 2011.

R. Kapoor, F. Rizvi, and P. Kakkar, Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases, Apoptosis, vol.18, pp.9-27, 2013.

K. Kasahara, Y. Nakayama, K. Ikeda, Y. Fukushima, D. Matsuda et al., Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain, J Cell Biol, vol.165, pp.641-652, 2004.

K. Kasahara, Y. Nakayama, A. Kihara, D. Matsuda, K. Ikeda et al., Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes, Exp Cell Res, vol.313, pp.2651-2666, 2007.

D. L. Kastner, I. Aksentijevich, and R. Goldbach-mansky, Autoinflammatory disease reloaded: a clinical perspective, Cell, vol.140, 2010.

A. C. Kaufman, S. V. Salazar, L. T. Haas, J. Yang, M. A. Kostylev et al., Fyn inhibition rescues established memory and synapse loss in Alzheimer mice, Ann Neurol, vol.77, pp.953-971, 2015.

M. Kawabuchi, Y. Satomi, T. Takao, Y. Shimonishi, S. Nada et al., Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases, Nature, vol.404, pp.999-1003, 2000.

N. Kayagaki, S. Warming, M. Lamkanfi, L. Vande-walle, S. Louie et al., Noncanonical inflammasome activation targets caspase-11, Nature, vol.479, pp.117-121, 2011.

S. Keck, M. Freudenberg, and M. Huber, Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1, J Immunol, vol.184, pp.5809-5818, 2010.

D. K. Kim, H. S. Kim, A. R. Kim, J. H. Kim, B. Kim et al., DJ-1 regulates mast cell activation and IgE-mediated allergic responses, J Allergy Clin Immunol, vol.131, pp.1653-1662, 2013.

D. K. Kim, M. A. Beaven, J. M. Kulinski, A. Desai, G. Bandara et al., Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis, PLoS One, vol.11, 2016.

D. K. Kim, M. A. Beaven, D. D. Metcalfe, and A. Olivera, Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells, J Allergy Clin Immunol, 2017.

H. J. Kim, K. Zhang, L. Zhang, F. P. Ross, S. L. Teitelbaum et al., The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo, Proc Natl Acad Sci U S A, vol.106, 2009.

H. J. Kim, J. T. Warren, S. Y. Kim, J. C. Chappel, C. J. Deselm et al., Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells, J Cell Biochem, vol.111, pp.1107-1113, 2010.

I. H. Kim, C. E. West, S. G. Kwatra, S. R. Feldman, O. Neill et al., Comparative efficacy of biologics in psoriasis: a review, Am J Clin Dermatol, vol.13, pp.365-374, 2012.

J. E. Kim, J. H. Kim, Y. Lee, H. Yang, Y. S. Heo et al., Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase, Oncotarget, vol.7, pp.14616-14627, 2016.

J. H. Kim, D. K. Lee, J. Kim, S. Choi, W. Park et al., A miRNA-101-3p/Bim axis as a determinant of serum deprivation-induced endothelial cell apoptosis, Cell Death Dis, vol.8, 2017.

P. W. Kim, Z. Y. Sun, S. C. Blacklow, G. Wagner, and M. J. Eck, A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8, Science, vol.301, pp.1725-1728, 2003.

S. O. Kim, S. Avraham, S. Jiang, R. Zagozdzon, Y. Fu et al., Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors, Cancer, vol.101, pp.1018-1027, 2004.

T. G. Kim, H. Jee, J. Fuentes-duculan, W. H. Wu, D. Byamba et al., Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis, J Invest Dermatol, vol.134, pp.1462-1465, 2014.

S. Kimura, H. Naito, H. Segawa, J. Kuroda, T. Yuasa et al., NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinibresistant leukemia, Blood, vol.106, pp.3948-3954, 2005.

H. M. Ko, S. H. Lee, M. Bang, K. C. Kim, S. J. Jeon et al., Tyrosine kinase Fyn regulates iNOS expression in LPS-stimulated astrocytes via modulation of ERK phosphorylation, Biochem Biophys Res Commun, vol.495, pp.1214-1220, 2018.

E. C. Koc, J. L. Miller-lee, and H. Koc, Fyn kinase regulates translation in mammalian mitochondria, Biochim Biophys Acta, vol.1861, pp.533-540, 2017.

M. Koegl, P. Zlatkine, S. C. Ley, S. A. Courtneidge, and A. I. Magee, Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif, Biochem J, vol.303, 1994.

T. Koga, M. Inui, K. Inoue, S. Kim, A. Suematsu et al., Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis, Nature, vol.428, pp.758-763, 2004.

F. Kolbinger, C. Loesche, M. A. Valentin, X. Jiang, Y. Cheng et al., beta-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis, J Allergy Clin Immunol, vol.139, pp.923-932, 2017.

T. Kopp, P. Lenz, C. Bello-fernandez, R. A. Kastelein, T. S. Kupper et al., IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity, J Immunol, vol.170, pp.5438-5444, 2003.

S. B. Koralov, S. A. Muljo, G. R. Galler, A. Krek, T. Chakraborty et al., Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage, Cell, vol.132, pp.860-874, 2008.

M. Kovacs, T. Nemeth, Z. Jakus, C. Sitaru, E. Simon et al., The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment, J Exp Med, vol.211, 1993.

D. Krapf, E. Arcelay, E. V. Wertheimer, A. Sanjay, S. H. Pilder et al., Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors, J Biol Chem, vol.285, pp.7977-7985, 2010.

J. Kuroda, H. Puthalakath, M. S. Cragg, P. N. Kelly, P. Bouillet et al., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic, Proc Natl Acad Sci U S A, vol.103, pp.14907-14912, 2006.

M. Kurzeja, L. Rudnicka, and M. Olszewska, New interleukin-23 pathway inhibitors in dermatology: ustekinumab, briakinumab, and secukinumab, Am J Clin Dermatol, vol.12, pp.113-125, 2011.

O. Kutuk and A. Letai, Regulation of Bcl-2 family proteins by posttranslational modifications, Curr Mol Med, vol.8, pp.102-118, 2008.

S. Kyo, K. Sada, X. Qu, K. Maeno, S. M. Miah et al., Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation, Genes Cells, vol.8, pp.825-836, 2003.

B. Ladizinski, K. C. Lee, W. E. Alavi, A. Mistry, N. Sibbald et al., A review of the clinical variants and the management of psoriasis, Adv Skin Wound Care, vol.26, pp.285-276, 2013.

C. Lamagna, P. Scapini, J. A. Van-ziffle, A. L. Defranco, and C. A. Lowell, Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation, Proc Natl Acad Sci U S A, vol.110, 2013.

C. Lamagna, Y. Hu, A. L. Defranco, and C. A. Lowell, B cell-specific loss of Lyn kinase leads to autoimmunity, J Immunol, vol.192, pp.919-928, 2014.

M. Lamkanfi and V. M. Dixit, Mechanisms and functions of inflammasomes, Cell, vol.157, pp.1013-1022, 2014.

R. Lande and M. Gilliet, Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses, Ann N Y Acad Sci, vol.1183, pp.89-103, 2010.

R. Lande, E. Botti, C. Jandus, D. Dojcinovic, G. Fanelli et al., The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis, Nat Commun, vol.5, p.5621, 2014.

R. G. Langley and C. N. Ellis, Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment, and Lattice System Physician's Global Assessment, J Am Acad Dermatol, vol.51, pp.563-569, 2004.

S. Latour, R. Roncagalli, R. Chen, M. Bakinowski, X. Shi et al., Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation, Nat Cell Biol, vol.5, pp.149-154, 2003.

M. C. Lebre, A. M. Van-der-aar, L. Van-baarsen, T. M. Van-capel, J. H. Schuitemaker et al., Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9, J Invest Dermatol, vol.127, pp.331-341, 2007.

M. Lebwohl, Psoriasis. Lancet, vol.361, pp.1197-1204, 2003.

M. G. Lebwohl, D. L. Breneman, B. S. Goffe, J. R. Grossman, M. R. Ling et al., Tazarotene 0.1% gel plus corticosteroid cream in the treatment of plaque psoriasis, J Am Acad Dermatol, vol.39, pp.590-596, 1998.

B. C. Lee, A. S. Imamoto, A. Avraham, and H. K. , Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice, Blood, vol.108, pp.904-907, 2006.

M. A. Lemmon and J. Schlessinger, Cell signaling by receptor tyrosine kinases, Cell, vol.141, pp.1117-1134, 2010.

E. C. Lerner and T. E. Smithgall, SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo, Nat Struct Biol, vol.9, pp.365-369, 2002.

E. C. Lerner, R. P. Trible, A. P. Schiavone, J. M. Hochrein, J. R. Engen et al., Activation of the Src family kinase Hck without SH3-linker release, J Biol Chem, vol.280, pp.40832-40837, 2005.

D. Levine and A. Gottlieb, Evaluation and management of psoriasis: an internist's guide, Med Clin North Am, vol.93, pp.1291-1303, 2009.

A. G. Li, D. Wang, X. H. Feng, and X. J. Wang, Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder, EMBO J, vol.23, pp.1770-1781, 2004.

G. Li, K. Yuan, C. Yan, J. Fox, M. Gaid et al., 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice, Free Radic Biol Med, vol.52, pp.392-401, 2012.

G. Li, J. Fox, Z. Liu, J. Liu, G. F. Gao et al., Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models, J Immunol, vol.191, pp.5359-5370, 2013.

H. Li, H. Li, R. Huo, P. Wu, Z. Shen et al., Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis, J Dermatol Sci, vol.88, pp.46-56, 2017.

S. Li, F. Li, R. Niu, H. Zhang, A. Cui et al., Mir-192 suppresses apoptosis and promotes proliferation in esophageal aquamous cell caicinoma by targeting Bim, Int J Clin Exp Pathol, vol.8, pp.8048-8056, 2015.

X. Li, S. He, X. Zhou, Y. Ye, S. Tan et al., Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis, PLoS Pathog, vol.12, 2016.

X. L. Li and C. X. Zhang, New emerging therapies in the management of chronic lymphocytic leukemia, Oncol Lett, vol.12, pp.3051-3054, 2016.

Z. Liao, X. Wang, H. Liang, A. Yu, U. Ur-rehman et al., miR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src, Cancer Med, vol.6, pp.2957-2965, 2017.

E. Lien, T. J. Sellati, A. Yoshimura, T. H. Flo, G. Rawadi et al., Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products, J Biol Chem, vol.274, pp.33419-33425, 1999.

W. A. Lim, F. M. Richards, and R. O. Fox, Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains, Nature, vol.372, pp.375-379, 1994.

A. M. Lin, C. J. Rubin, R. Khandpur, J. Y. Wang, M. Riblett et al., Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis, J Immunol, vol.187, 2011.

P. Y. Lin, S. L. Yu, and P. C. Yang, MicroRNA in lung cancer, Br J Cancer, vol.103, 2010.

M. Lindauer and A. Hochhaus, Dasatinib. Recent Results Cancer Res, vol.201, pp.27-65, 2014.

D. Linnekin, C. S. Deberry, and S. Mou, Lyn associates with the juxtamembrane region of cKit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells, J Biol Chem, vol.272, pp.27450-27455, 1997.

H. Liu, J. Yin, C. Wang, Y. Gu, M. Deng et al., FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells, Anticancer Drugs, vol.25, pp.898-907, 2014.

S. Liu, X. Hao, X. Ouyang, X. Dong, Y. Yang et al., Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study, Oncotarget, vol.7, pp.75468-75481, 2016.

S. Liu, S. Chen, X. Li, S. Wu, Q. Zhang et al., Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses, Cell Host Microbe, vol.21, pp.754-768, 2017.

X. Liu, S. Dai, Y. Zhu, P. Marrack, and J. W. Kappler, The structure of a Bcl-xL/Bim fragment complex: implications for Bim function, Immunity, vol.19, pp.341-352, 2003.

X. Liu, Z. Zhang, J. Ruan, Y. Pan, V. G. Magupalli et al., Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores, Nature, vol.535, pp.153-158, 2016.

X. J. Liu, J. R. Gingrich, M. Vargas-caballero, Y. N. Dong, A. Sengar et al., Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex, Nat Med, vol.14, 2008.

Y. Liu, J. Dong, R. Mu, Y. Gao, X. Tan et al., MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn, Arthritis Rheum, vol.65, pp.1603-1611, 2013.

P. Lock, S. Ralph, E. Stanley, I. Boulet, R. Ramsay et al., Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization, Mol Cell Biol, vol.11, 1991.

J. Lopez, C. Hesling, J. Prudent, N. Popgeorgiev, R. Gadet et al., Src tyrosine kinase inhibits apoptosis through the Erk1/2-dependent degradation of the death accelerator Bik, Cell Death Differ, vol.19, pp.1459-1469, 2012.

C. Lowe, T. Yoneda, B. F. Boyce, H. Chen, G. R. Mundy et al., Osteopetrosis in Srcdeficient mice is due to an autonomous defect of osteoclasts, Proc Natl Acad Sci U S A, vol.90, pp.4485-4489, 1993.

C. A. Lowell, P. Soriano, and H. E. Varmus, Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity, Genes Dev, vol.8, pp.387-398, 1994.

C. A. Lowell, L. Fumagalli, and G. Berton, Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions, J Cell Biol, vol.133, 1996.

C. A. Lowell and P. Soriano, Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories, Genes Dev, vol.10, pp.1845-1857, 1996.

M. A. Lowes, A. M. Bowcock, and J. G. Krueger, Pathogenesis and therapy of psoriasis, Nature, vol.445, pp.866-873, 2007.

M. A. Lowes, C. B. Russell, D. A. Martin, J. E. Towne, and J. G. Krueger, The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses, Trends Immunol, vol.34, 2013.

M. A. Lowes, M. Suarez-farinas, and J. G. Krueger, Immunology of psoriasis, Annu Rev Immunol, vol.32, pp.227-255, 2014.

Q. Lu, The critical importance of epigenetics in autoimmunity, J Autoimmun, vol.41, pp.1-5, 2013.

F. Luciano, J. E. Ricci, and P. Auberger, Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation, Oncogene, vol.20, pp.4935-4941, 2001.

F. Luciano, M. Herrant, A. Jacquel, J. E. Ricci, and P. Auberger, The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis, FASEB J, vol.17, pp.711-713, 2003.

C. V. Lund, M. T. Nguyen, G. C. Owens, A. J. Pakchoian, A. Shaterian et al., Reduced glioma infiltration in Src-deficient mice, J Neurooncol, vol.78, pp.19-29, 2006.

A. Lleo, P. Invernizzi, B. Gao, M. Podda, and M. E. Gershwin, Definition of human autoimmunity--autoantibodies versus autoimmune disease, Autoimmun Rev, vol.9, pp.259-266, 2010.

E. Ma, T. Wan, C. H. Au, D. N. Ho, S. Y. Ma et al., Next-generation sequencing and molecular cytogenetic characterization of ETV6-LYN fusion due to chromosomes 1, 8 and 12 rearrangement in acute myeloid leukemia, Cancer Genet, vol.218, pp.15-19, 2017.

Y. C. Ma, J. Huang, S. Ali, W. Lowry, and X. Y. Huang, Src tyrosine kinase is a novel direct effector of G proteins, Cell, vol.102, pp.635-646, 2000.

M. C. Maa and T. H. Leu, Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages, Biomedicine (Taipei), vol.6, 2016.

T. Mabuchi, T. Takekoshi, and S. T. Hwang, Epidermal CCR6+ gammadelta T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis, J Immunol, vol.187, pp.5026-5031, 2011.

T. Mabuchi, T. W. Chang, S. Quinter, and S. T. Hwang, Chemokine receptors in the pathogenesis and therapy of psoriasis, J Dermatol Sci, vol.65, pp.4-11, 2012.

A. Maccaglia, C. Mallozzi, and M. Minetti, Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells, Biochem Biophys Res Commun, vol.305, pp.541-547, 2003.

J. Maelfait, E. Vercammen, S. Janssens, P. Schotte, M. Haegman et al., Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8, J Exp Med, vol.205, pp.1967-1973, 2008.

S. K. Mahil, F. Capon, and J. N. Barker, Update on psoriasis immunopathogenesis and targeted immunotherapy, Semin Immunopathol, vol.38, pp.11-27, 2016.

V. I. Maltez, A. L. Tubbs, K. D. Cook, Y. Aachoui, E. L. Falcone et al., Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium, Immunity, vol.43, pp.987-997, 2015.

E. Mallon, R. Newson, and C. B. Bunker, HLA-Cw6 and the genetic predisposition to psoriasis: a meta-analysis of published serologic studies, J Invest Dermatol, vol.113, pp.693-695, 1999.

G. Manning, D. B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam, The protein kinase complement of the human genome, Science, vol.298, pp.1912-1934, 2002.

S. Marchetti, P. Gamas, N. Belhacene, S. Grosso, L. A. Pradelli et al., The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice, EMBO J, vol.28, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00419195

G. S. Martin, The hunting of the Src, Nat Rev Mol Cell Biol, vol.2, pp.467-475, 2001.

J. Martinez-perez, I. Lopez-calderero, C. Saez, M. Benavent, M. L. Limon et al., Prognostic relevance of Src activation in stage II-III colon cancer, Hum Pathol, vol.67, pp.119-125, 2017.

V. Martini, C. Gattazzo, F. Frezzato, V. Trimarco, M. Pizzi et al., Cortactin, a Lyn substrate, is a checkpoint molecule at the intersection of BCR and CXCR4 signalling pathway in chronic lymphocytic leukaemia cells, Br J Haematol, vol.178, pp.81-93, 2017.

F. Martinon, K. Burns, and J. Tschopp, The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta, Mol Cell, vol.10, pp.417-426, 2002.

M. Masalha, Y. Sidi, and D. Avni, The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis, Exp Dermatol, 2018.

S. Mashiko, S. Bouguermouh, M. Rubio, N. Baba, R. Bissonnette et al., Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis, J Allergy Clin Immunol, vol.136, pp.351-359, 2015.

H. Matsui, I. Harada, and Y. Sawada, Src, p130Cas, and Mechanotransduction in Cancer Cells, Genes Cancer, vol.3, 2012.

S. Matsushima, J. Kuroda, P. Zhai, T. Liu, S. Ikeda et al., Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling, J Clin Invest, vol.126, pp.3403-3416, 2016.

A. Mavropoulos, T. Simopoulou, A. Varna, C. Liaskos, C. G. Katsiari et al., , 2016.

, Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis, Arthritis Rheumatol, vol.68, pp.494-504

J. B. Mccabe and L. G. Berthiaume, Functional roles for fatty acylated amino-terminal domains in subcellular localization, Mol Biol Cell, vol.10, pp.3771-3786, 1999.

M. J. Mcgeachy, K. S. Bak-jensen, Y. Chen, C. M. Tato, W. Blumenschein et al., TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology, Nat Immunol, vol.8, pp.1390-1397, 2007.

N. Mcgivern, A. El-helali, P. Mullan, I. A. Mcneish, P. Harkin et al., Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer, Oncotarget, vol.9, pp.4722-4736, 2018.

D. Mcgonagle and M. F. Mcdermott, A proposed classification of the immunological diseases, PLoS Med, vol.3, 2006.

I. B. Mcinnes, G. G. Illei, C. L. Danning, C. H. Yarboro, M. Crane et al., IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis, J Immunol, vol.167, pp.4075-4082, 2001.

A. A. Mello, M. F. Leal, J. A. Rey, G. R. Pinto, L. M. Lamarao et al., Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis, PLoS One, vol.10, 2015.

A. Menter, A. Gottlieb, S. R. Feldman, A. S. Van-voorhees, C. L. Leonardi et al., Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics, J Am Acad Dermatol, vol.58, pp.826-850, 2008.

D. Merino, S. A. Best, M. L. Asselin-labat, F. Vaillant, B. Pal et al., Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2, Oncogene, vol.34, pp.3926-3934, 2015.

C. Mestre-escorihuela, F. Rubio-moscardo, J. A. Richter, R. Siebert, J. Climent et al., Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas, Blood, vol.109, pp.271-280, 2007.

U. Meyer-hoffert, J. Wingertszahn, and O. Wiedow, Human leukocyte elastase induces keratinocyte proliferation by epidermal growth factor receptor activation, J Invest Dermatol, vol.123, pp.338-345, 2004.

J. Mitchell, S. J. Kim, A. Seelmann, B. Veit, B. Shepard et al., Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses, Biochem Pharmacol, vol.147, pp.119-127, 2018.

S. Miyata, T. Matsuyama, T. Kodama, Y. Nishioka, K. Kuribayashi et al., STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells, Clin Exp Allergy, vol.29, pp.114-123, 1999.

T. Miyazaki, S. Tanaka, A. Sanjay, and R. Baron, The role of c-Src kinase in the regulation of osteoclast function, Mod Rheumatol, vol.16, pp.68-74, 2006.

S. B. Mkaddem, A. Murua, H. Flament, D. Titeca-beauport, C. Bounaix et al., Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation, Nat Commun, vol.8, pp.246-5557797, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01592681

A. Mocsai, J. Ruland, and V. L. Tybulewicz, The SYK tyrosine kinase: a crucial player in diverse biological functions, Nat Rev Immunol, vol.10, 2010.

T. J. Molina, K. Kishihara, D. P. Siderovski, W. Van-ewijk, A. Narendran et al., Profound block in thymocyte development in mice lacking p56lck, Nature, vol.357, pp.161-164, 1992.

T. Morinaga, S. Yanase, A. Okamoto, N. Yamaguchi, and N. Yamaguchi, Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cellcell interactions upon polarization of inducible Lyn-expressing MDCK cells, Sci Rep, vol.7, p.5428707, 2017.

A. Morita, Current developments in phototherapy for psoriasis, J Dermatol, vol.45, pp.287-292, 2018.

S. Morizane and R. L. Gallo, Antimicrobial peptides in the pathogenesis of psoriasis, J Dermatol, vol.39, 2012.

S. Morizane, H. Nomura, K. Tachibana, Y. Nakagawa, and K. Iwatsuki, The synergistic activities of the combination of TNF-alpha, IL-17A, and IFN-gamma in epidermal keratinocytes, Br J Dermatol, 2018.

D. Moujalled, R. Weston, H. Anderton, R. Ninnis, P. Goel et al., Cyclic-AMPdependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim, EMBO Rep, vol.12, pp.77-83, 2011.

M. Moustafa-kamal, I. Gamache, Y. Lu, S. Li, and J. G. Teodoro, BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by betaTrCP1, Cell Death Differ, vol.20, pp.1393-1403, 2013.

A. S. Murthy and K. Leslie, Autoinflammatory Skin Disease: A Review of Concepts and Applications to General Dermatology, Dermatology, vol.232, pp.534-540, 2016.

S. Nagata and M. Tanaka, Programmed cell death and the immune system, Nat Rev Immunol, vol.17, pp.333-340, 2017.

K. Nakajima and S. Sano, Mouse models of psoriasis and their relevance, J Dermatol, vol.45, pp.252-263, 2018.

Y. Nakata, B. Tomkowicz, A. M. Gewirtz, and A. Ptasznik, Integrin inhibition through Lyndependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells, Blood, vol.107, pp.4234-4239, 2006.

L. Naldi, L. Peli, F. Parazzini, and C. F. Carrel, Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case-control study, J Am Acad Dermatol, vol.44, pp.433-438, 2001.

L. Naldi, L. Chatenoud, D. Linder, B. Fortina, A. Peserico et al., Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case-control study, J Invest Dermatol, vol.125, pp.61-67, 2005.

S. T. Nam, Y. H. Park, H. W. Kim, H. S. Kim, D. Lee et al., Suppression of IgEmediated mast cell activation and mouse anaphylaxis via inhibition of Syk activation by 8-formyl-7-hydroxy-4-methylcoumarin, 4mu8C, Toxicol Appl Pharmacol, vol.332, pp.25-31, 2017.

R. Negro, S. Gobessi, P. G. Longo, Y. He, Z. Y. Zhang et al., Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigenstimulated CLL cells by selectively activating AKT, Blood, vol.119, pp.6278-6287, 2012.

F. O. Nestle, C. Conrad, A. Tun-kyi, B. Homey, M. Gombert et al., Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production, J Exp Med, vol.202, pp.135-143, 2005.

F. O. Nestle, D. H. Kaplan, J. Barker, O. Ngalamika, Y. Zhang et al., Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review, N Engl J Med, vol.361, pp.451-465, 2009.

P. H. Nguyen, O. Fedorchenko, N. Rosen, M. Koch, R. Barthel et al., LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia, Cancer Cell, vol.30, pp.610-622, 2016.

U. Nguyen, Y. Zhang, N. Lu, Q. Louie-gao, J. Niu et al., Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study, Ann Rheum Dis, vol.77, pp.119-123, 2018.

H. Nishizumi, I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic et al., Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyndeficient mice, Immunity, vol.3, pp.549-560, 1995.

K. E. Nograles, L. C. Zaba, E. Guttman-yassky, J. Fuentes-duculan, M. Suarez-farinas et al., Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways, Br J Dermatol, vol.159, pp.1092-1102, 2008.

B. Nuche-berenguer, P. Moreno, and R. T. Jensen, Elucidation of the roles of the Src kinases in pancreatic acinar cell signaling, J Cell Biochem, vol.116, pp.22-36, 2015.

C. E. Nunes-xavier, J. Martin-perez, A. Elson, and R. Pulido, Protein tyrosine phosphatases as novel targets in breast cancer therapy, Biochim Biophys Acta, vol.1836, pp.211-226, 2013.

H. B. Nygaard, Targeting Fyn Kinase in Alzheimer's Disease, Biol Psychiatry, vol.83, pp.369-376, 2018.

M. O-o'brien and K. J. , The mechanism of lithium and beta-blocking agents in inducing and exacerbating psoriasis, J Drugs Dermatol, vol.5, pp.426-432, 2006.

R. L. O'brien and W. K. Born, Dermal gammadelta T cells--What have we learned?, Cell Immunol, vol.296, pp.62-69, 2015.

H. Ochi and T. Watanabe, Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity, Int Immunol, vol.12, pp.1417-1423, 2000.

S. Odom, G. Gomez, M. Kovarova, Y. Furumoto, J. J. Ryan et al., Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase, J Exp Med, vol.199, pp.1491-1502, 2004.

P. Oettgen, Y. Akbarali, J. Boltax, J. Best, C. Kunsch et al., Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1, Mol Cell Biol, vol.16, pp.5091-5106, 1996.

E. Ogawa, Y. Sato, A. Minagawa, and R. Okuyama, Pathogenesis of psoriasis and development of treatment, J Dermatol, vol.45, pp.264-272, 2018.

P. S. Ohashi and A. L. Defranco, Making and breaking tolerance, Curr Opin Immunol, vol.14, pp.744-759, 2002.

H. Ohnishi, Y. Murata, H. Okazawa, and T. Matozaki, Src family kinases: modulators of neurotransmitter receptor function and behavior, Trends Neurosci, vol.34, pp.629-637, 2011.

M. Okada, S. Nada, Y. Yamanashi, T. Yamamoto, and H. Nakagawa, CSK: a protein-tyrosine kinase involved in regulation of src family kinases, J Biol Chem, vol.266, pp.24249-24252, 1991.

M. Okada, Regulation of the SRC family kinases by Csk, Int J Biol Sci, vol.8, pp.1385-1397, 2012.

A. Okamoto, T. Morinaga, N. Yamaguchi, and N. Yamaguchi, Golgi Distribution of Lyn to Caveolin-and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network, Biol Pharm Bull, vol.41, pp.142-146, 2018.

C. Oneyama, T. Hikita, K. Enya, M. W. Dobenecker, K. Saito et al., The lipid raftanchored adaptor protein Cbp controls the oncogenic potential of c-Src, Mol Cell, vol.30, pp.426-436, 2008.

C. Oneyama, T. Iino, K. Saito, K. Suzuki, A. Ogawa et al., Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain, Mol Cell Biol, vol.29, pp.6462-6472, 2009.

N. Onsun, A. Ulusal, H. Su, O. Beycan, I. et al., Aldose Reductase Mediates NLRP3 Inflammasome-Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice, Eur J Dermatol, vol.22, pp.3661-3675, 2012.

A. Palmer, M. Zimmer, K. S. Erdmann, V. Eulenburg, A. Porthin et al., EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase, Mol Cell, vol.9, pp.725-737, 2002.

V. Parravicini, M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-espinosa et al., Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation, Nat Immunol, vol.3, pp.741-748, 2002.

S. J. Parsons and J. T. Parsons, Src family kinases, key regulators of signal transduction, Oncogene, vol.23, pp.7906-7909, 2004.

A. Parthasaradhi, V. Singh, S. G. Parasramani, N. Yadav, D. S. Krupashankar et al., A Real-World Study to Assess the Effectiveness of Itolizumab in Patients with Chronic Plaque Psoriasis, Indian Dermatol Online J, vol.8, pp.246-249, 2017.

A. B. Patel, I. Tsilioni, Z. Weng, and T. C. Theoharides, TNF stimulates IL-6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin, Exp Dermatol, vol.27, pp.135-143, 2018.

A. J. Patel, C. P. Liao, Z. Chen, C. Liu, Y. Wang et al., BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction, Cell Rep, vol.6, pp.81-92, 2014.

T. Pelaseyed, J. H. Bergstrom, J. K. Gustafsson, A. Ermund, G. M. Birchenough et al., The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system, Immunol Rev, vol.260, 2014.

E. Peleva, L. S. Exton, K. Kelley, C. E. Kleyn, K. J. Mason et al., Risk of cancer in patients with psoriasis on biological therapies: a systematic review, Br J Dermatol, vol.178, pp.103-113, 2018.

Y. Perez, M. Maffei, A. Igea, A. I. Gairi, M. Nebreda et al., Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism, Sci Rep, vol.3, 2013.

S. Pickles, P. Vigie, and R. J. Youle, Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance, Curr Biol, vol.28, pp.170-185, 2018.

J. H. Plani-lam, N. S. Slavova-azmanova, N. Kucera, A. Louw, J. Satiaputra et al., Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity, Exp Hematol, vol.46, p.10, 2017.

C. M. Pleiman, C. Abrams, L. T. Gauen, W. Bedzyk, J. Jongstra et al., Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha, Proc Natl Acad Sci U S A, vol.91, pp.4268-4272, 1994.

A. R. Poh, R. J. O'donoghue, and M. Ernst, Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells, Oncotarget, vol.6, pp.15752-15771, 2015.

P. Pontrelli, M. Ursi, E. Ranieri, C. Capobianco, F. P. Schena et al., CD40L proinflammatory and profibrotic effects on proximal tubular epithelial cells: role of NF-kappaB and lyn, J Am Soc Nephrol, vol.17, pp.627-636, 2006.

F. Poot, Depression and suicidality in psoriasis patients: emotional needs to discover, J Eur Acad Dermatol Venereol, vol.31, pp.1947-1948, 2017.

C. Pop, J. Timmer, S. Sperandio, and G. S. Salvesen, The apoptosome activates caspase-9 by dimerization, Mol Cell, vol.22, pp.269-275, 2006.

C. Pouplard, E. Brenaut, C. Horreau, T. Barnetche, L. Misery et al., Risk of cancer in psoriasis: a systematic review and meta-analysis of epidemiological studies, J Eur Acad Dermatol Venereol, vol.27, pp.36-46, 2013.

D. Prabhakar, E. L. Peterson, Y. Hu, R. C. Rossom, F. L. Lynch et al., Dermatologic Conditions and Risk of Suicide: A Case-Control Study, Psychosomatics, vol.59, pp.58-61, 2018.

J. C. Prinz, E. Pucheta-martinez, G. Saladino, M. A. Morando, J. Martinez-torrecuadrada et al., An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of, J Eur Acad Dermatol Venereol, vol.17, pp.257-270, 2003.

M. Qiao, R. Li, X. Zhao, J. Yan, and Q. Sun, Up-regulated lncRNA-MSX2P1 promotes the growth of IL-22-stimulated keratinocytes by inhibiting miR-6731-5p and activating S100A7, Exp Cell Res, 2018.

T. Quan, A. Johnston, J. E. Gudjonsson, and G. J. Fisher, CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?, J Invest Dermatol, vol.135, 2015.

H. R-rabeony, M. Pohin, P. Vasseur, I. Petit-paris, J. F. Jegou et al., IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome, Eur J Immunol, vol.45, pp.2847-2857, 2015.

Y. Radhakrishnan, X. Shen, L. A. Maile, G. Xi, and D. R. Clemmons, IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells, Mol Endocrinol, vol.25, p.3165910, 2011.

M. Ramirez, G. S. Salvesen, S. K. Raychaudhuri, E. Maverakis, and S. P. Raychaudhuri, Diagnosis and classification of psoriasis, Semin Cell Dev Biol, vol.13, pp.490-495, 2014.

S. P. Raychaudhuri and J. Gross, A comparative study of pediatric onset psoriasis with adult onset psoriasis, Pediatr Dermatol, vol.17, pp.174-178, 2000.

S. P. Raychaudhuri and E. M. Farber, The prevalence of psoriasis in the world, J Eur Acad Dermatol Venereol, vol.15, pp.16-17, 2001.

S. M. Reddy, S. Kopetz, J. Morris, N. Parikh, W. Qiao et al., Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer, Invest New Drugs, vol.33, pp.977-984, 2015.

T. A. Rege, M. A. Pallero, C. Gomez, H. E. Grenett, J. E. Murphy-ullrich et al., Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I, Exp Cell Res, vol.312, pp.3752-3767, 2006.

K. Reich, K. A. Papp, R. T. Matheson, J. H. Tu, R. Bissonnette et al., Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis, Exp Dermatol, vol.24, pp.529-535, 2015.

R. Ren, Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia, Nat Rev Cancer, vol.5, pp.172-183, 2005.

X. Ren, C. Cao, L. Zhu, K. Yoshida, S. Kharbanda et al., Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor, Cancer Biol Ther, vol.1, pp.703-708, 2002.

M. D. Resh, Trafficking and signaling by fatty-acylated and prenylated proteins, Nat Chem Biol, vol.2, pp.584-590, 2006.

M. D. Resh, Palmitoylation of ligands, receptors, and intracellular signaling molecules, Sci STKE, p.14, 2006.

J. E. Ricci, L. Maulon, F. Luciano, S. Guerin, A. Livolsi et al., Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes, Oncogene, vol.18, pp.3963-3969, 1999.

J. E. Ricci, V. Lang, F. Luciano, N. Belhacene, V. Giordanengo et al., An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis, FASEB J, vol.15, pp.1777-1779, 2001.

J. A. Rickard, H. Anderton, N. Etemadi, U. Nachbur, M. Darding et al., TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice, vol.3, p.4270099, 2014.

M. Ridinger-saison, E. Evanno, I. Gallais, P. Rimmele, D. Selimoglu-buet et al., Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia, Cell Death Differ, vol.20, 2013.

M. E. Roberts, J. L. Bishop, X. Fan, J. L. Beer, W. W. Kum et al., Lyn deficiency leads to increased microbiota-dependent intestinal inflammation and susceptibility to enteric pathogens, J Immunol, vol.193, pp.5249-5263, 2014.

A. K. Roseweir, T. Qayyum, Z. Lim, R. Hammond, A. I. Macdonald et al., Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients, BMC Cancer, vol.16, 2016.

R. Roskoski, Src protein-tyrosine kinase structure and regulation, Biochem Biophys Res Commun, vol.324, pp.1155-1164, 2004.

R. Roskoski, Src kinase regulation by phosphorylation and dephosphorylation, Biochem Biophys Res Commun, vol.331, pp.1-14, 2005.

R. Roskoski, Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors, Pharmacol Res, vol.94, pp.9-25, 2015.

V. Rotzer, E. Hartlieb, F. Vielmuth, M. Gliem, V. Spindler et al., E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion, Cell Mol Life Sci, vol.72, pp.4885-4897, 2015.

S. Roy, J. R. Sharom, C. Houde, T. P. Loisel, J. P. Vaillancourt et al., Confinement of caspase-12 proteolytic activity to autoprocessing, Proc Natl Acad Sci U S A, vol.105, pp.4133-4138, 2008.

L. Rubbi, B. Titz, L. Brown, E. Galvan, E. Komisopoulou et al., Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling, Sci Signal, vol.4, 2011.

S. V. Russello and S. K. Shore, Src in human carcinogenesis, Front Biosci, vol.8, pp.1068-1073, 2003.

S. M. Sa, P. A. Valdez, J. Wu, K. Jung, F. Zhong et al., The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis, J Immunol, vol.178, pp.2229-2240, 2007.

R. Sabat, S. Philipp, C. Hoflich, S. Kreutzer, E. Wallace et al., Immunopathogenesis of psoriasis, Exp Dermatol, vol.16, pp.779-798, 2007.

L. Sagi and H. Trau, The Koebner phenomenon, Clin Dermatol, vol.29, pp.231-236, 2011.

M. L. Salskov-iversen, C. Johansen, K. Kragballe, and L. Iversen, Caspase-5 expression is upregulated in lesional psoriatic skin, J Invest Dermatol, vol.131, pp.670-676, 2011.

M. Salvi, A. M. Brunati, and A. Toninello, Tyrosine phosphorylation in mitochondria: a new frontier in mitochondrial signaling, Free Radic Biol Med, vol.38, pp.1267-1277, 2005.

I. Samokhvalov, J. Hendrikx, J. Visser, A. Belyavsky, D. Sotiropolous et al., Mice lacking a functional chk gene have no apparent defects in the hematopoietic system, Biochem Mol Biol Int, vol.43, pp.115-122, 1997.

M. Sampson, Q. S. Zhu, and S. J. Corey, Src kinases in G-CSF receptor signaling, Front Biosci, vol.12, pp.1463-1474, 2007.

J. Sand, E. Haertel, T. Biedermann, E. Contassot, E. Reichmann et al., Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes, Cell Death Dis, vol.9, 2018.

S. Sano, K. S. Chan, S. Carbajal, J. Clifford, M. Peavey et al., Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model, Nat Med, vol.11, pp.43-49, 2005.

V. Santini, B. Scappini, A. Grossi, A. Gozzini, L. Bonsi et al., Lyn kinase is activated following thrombopoietin stimulation of the megakaryocytic cell line B1647, Haematologica, vol.87, pp.1242-1247, 2002.

I. Sato, Y. Obata, K. Kasahara, Y. Nakayama, Y. Fukumoto et al., Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain, J Cell Sci, vol.122, pp.965-975, 2009.

P. Scapini, S. Pereira, H. Zhang, and C. A. Lowell, Multiple roles of Lyn kinase in myeloid cell signaling and function, Immunol Rev, vol.228, 2009.

P. Scapini, Y. Hu, C. L. Chu, T. S. Migone, A. L. Defranco et al., Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice, J Exp Med, vol.207, pp.1757-1773, 2010.

T. Schindler, F. Sicheri, A. Pico, A. Gazit, A. Levitzki et al., Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor, Mol Cell, vol.3, pp.639-648, 1999.

M. Schon and M. P. Schon, The antitumoral mode of action of imiquimod and other imidazoquinolines, Curr Med Chem, vol.14, pp.681-687, 2007.

M. P. Schon and W. H. Boehncke, Psoriasis. N Engl J Med, vol.352, pp.1899-1912, 2005.

M. P. Schon and M. Schon, Imiquimod: mode of action, Br J Dermatol, vol.157, pp.8-13, 2007.

C. Selmi, P. S. Leung, D. H. Sherr, M. Diaz, J. F. Nyland et al., Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop, J Autoimmun, vol.39, pp.272-284, 2012.

C. Selmi, Q. Lu, and M. C. Humble, Heritability versus the role of the environment in autoimmunity, J Autoimmun, vol.39, pp.249-252, 2012.

Y. A. Senis, A. Mazharian, and J. Mori, Src family kinases: at the forefront of platelet activation, Blood, vol.124, pp.2013-2024, 2014.

M. S. Serfas and A. L. Tyner, Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases, Oncol Res, vol.13, pp.409-419, 2003.

S. Severin, C. A. Nash, J. Mori, Y. Zhao, A. C. Lowell et al., Distinct and overlapping functional roles of Src family kinases in mouse platelets, J Thromb Haemost, vol.10, 2012.

K. Shams, M. Kurowska-stolarska, F. Schutte, A. D. Burden, C. S. Mckimmie et al., MicroRNA-146 and cell trauma down-regulate expression of the psoriasisassociated atypical chemokine receptor ACKR2, J Biol Chem, vol.293, pp.3003-3012, 2018.

S. Shenoy, I. Chackalaparampil, S. Bagrodia, P. H. Lin, and D. Shalloway, Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis, Proc Natl Acad Sci, vol.89, 1992.

E. Shinya, M. Shimizu, A. Owaki, S. Paoletti, L. Mori et al., Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the downregulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells, Virology, vol.487, pp.285-295, 2016.

N. Shirsath, K. Wagner, S. Roos, M. Schlederer, C. Ringel et al., 8-Methoxypsoralen Plus Ultraviolet A Reduces the Susceptibility of Murine Skin to Mount a Psoriatic Response to Imiquimod Linked with Senescence and Downregulation of Interleukin-9, 17 and Interferon-gamma, Acta Derm Venereol, 2018.

S. Shukla, S. Saxena, B. K. Singh, and P. Kakkar, BH3-only protein BIM: An emerging target in chemotherapy, Eur J Cell Biol, vol.96, pp.728-738, 2017.

S. L. Sigurdardottir, R. H. Thorleifsdottir, H. Valdimarsson, and A. Johnston, The role of the palatine tonsils in the pathogenesis and treatment of psoriasis, Br J Dermatol, vol.168, pp.237-242, 2013.

F. E. Simons and K. J. Simons, Histamine and H1-antihistamines: celebrating a century of progress, J Allergy Clin Immunol, vol.128, pp.1139-1150, 2011.

D. K. Singh, R. K. Deshmukh, P. K. Narayanan, S. Shivaji, and A. B. Siva, SRC family kinases in hamster spermatozoa: evidence for the presence of LCK, Reproduction, vol.153, pp.655-669, 2017.

S. Singh, C. Taylor, H. Kornmehl, and A. W. Armstrong, Psoriasis and suicidality: A systematic review and meta-analysis, J Am Acad Dermatol, vol.77, pp.425-440, 2017.

K. M. Skrzypczynska, J. W. Zhu, and A. Weiss, Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells, Immunity, vol.45, pp.1232-1244, 2016.

M. J. Smolinska, N. J. Horwood, T. H. Page, T. Smallie, and B. M. Foxwell, Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages, Mol Immunol, vol.45, pp.990-1000, 2008.

I. Snast, O. Reiter, L. Atzmony, Y. A. Leshem, E. Hodak et al., Psychological stress and psoriasis: a systematic review and meta-analysis, Br J Dermatol, 2017.

H. Sofen, S. Smith, R. T. Matheson, C. L. Leonardi, C. Calderon et al., , 2014.

, Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis, J Allergy Clin Immunol, vol.133, pp.1032-1040

S. Solier, M. Fontenay, W. Vainchenker, N. Droin, and E. Solary, Non-apoptotic functions of caspases in myeloid cell differentiation, Cell Death Differ, vol.24, 2017.

A. K. Somani, J. S. Bignon, G. B. Mills, K. A. Siminovitch, and D. R. Branch, Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase, J Biol Chem, vol.272, pp.21113-21119, 1997.

E. D. Son, H. J. Kim, K. H. Kim, B. H. Bin, I. H. Bae et al., S100A7 (psoriasin) inhibits human epidermal differentiation by enhanced IL-6 secretion through IkappaB/NFkappaB signalling, Exp Dermatol, vol.25, pp.636-641, 2016.

M. Songane, M. Khair, and M. Saleh, An updated view on the functions of caspases in inflammation and immunity, Semin Cell Dev Biol, 2018.

E. Sonkoly, T. Wei, P. C. Janson, A. Saaf, L. Lundeberg et al., MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?, PLoS One, vol.2, 2007.

S. M. Srinivasula, J. L. Poyet, M. Razmara, P. Datta, Z. Zhang et al., The PYRIN-CARD protein ASC is an activating adaptor for caspase-1, J Biol Chem, vol.277, pp.21119-21122, 2002.

E. Stanley, S. Ralph, S. Mcewen, I. Boulet, D. A. Holtzman et al., Alternatively spliced murine lyn mRNAs encode distinct proteins, Mol Cell Biol, vol.11, pp.3399-3406, 1991.

D. Stehelin, H. E. Varmus, J. M. Bishop, and P. K. Vogt, DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA, Nature, vol.260, pp.170-173, 1976.

M. R. Stettner, W. Wang, L. B. Nabors, S. Bharara, D. C. Flynn et al., Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells, Cancer Res, vol.65, pp.5535-5543, 2005.

F. K. Stevenson, S. Krysov, A. J. Davies, A. J. Steele, and G. Packham, B-cell receptor signaling in chronic lymphocytic leukemia, Blood, vol.118, pp.4313-4320, 2011.

D. R. Stover, P. Furet, and N. B. Lydon, Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain, J Biol Chem, vol.271, pp.12481-12487, 1996.

P. Stuart, F. Malick, R. P. Nair, T. Henseler, H. W. Lim et al., Analysis of phenotypic variation in psoriasis as a function of age at onset and family history, Arch Dermatol Res, vol.294, pp.207-213, 2002.

N. Su, L. Peng, B. Xia, Y. Zhao, A. Xu et al., Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancer, Mol Cancer, vol.11, 2012.

V. Sulimenko, E. Draberova, T. Sulimenko, L. Macurek, V. Richterova et al., Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases, J Immunol, vol.176, pp.7243-7253, 2006.

M. Sumitomo, R. Shen, M. Walburg, J. Dai, Y. Geng et al., Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling, J Clin Invest, vol.106, pp.1399-1407, 2000.

G. Sun, A. K. Sharma, and R. J. Budde, Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation, Oncogene, vol.17, pp.1587-1595, 1998.

G. Sun, L. Ramdas, W. Wang, J. Vinci, J. Mcmurray et al., Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src, Arch Biochem Biophys, vol.397, pp.11-17, 2002.

Y. Sun, J. Zhang, T. Zhai, H. Li, H. Li et al., CCN1 promotes IL-1beta production in keratinocytes by activating p38 MAPK signaling in psoriasis, Sci Rep, vol.7, pp.43310-5339692, 2017.

S. Suzu, H. Harada, T. Matsumoto, and S. Okada, HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities, vol.105, pp.3230-3237, 2005.

H. Suzuki, B. Wang, G. M. Shivji, P. Toto, P. Amerio et al., Imiquimod, a topical immune response modifier, induces migration of Langerhans cells, J Invest Dermatol, vol.114, pp.135-141, 2000.

W. R. Swindell, A. Johnston, S. Carbajal, G. Han, C. Wohn et al., Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis, PLoS One, vol.6, 2011.

A. Szalmas, E. Gyongyosi, A. Ferenczi, B. Laszlo, T. Karosi et al., Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein, Virol J, vol.10, 2013.

K. H. Szymczyk, T. A. Freeman, C. S. Adams, V. Srinivas, and M. J. Steinbeck, Active caspase-3 is required for osteoclast differentiation, J Cell Physiol, vol.209, pp.836-844, 2006.

S. Tabaries, M. G. Annis, B. E. Hsu, C. E. Tam, P. Savage et al., Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis, Oncotarget, vol.6, pp.9476-9487, 2015.

H. Takeda, Y. Kawamura, A. Miura, M. Mori, A. Wakamatsu et al., Comparative analysis of human SRC-family kinase substrate specificity in vitro, J Proteome Res, vol.9, pp.5982-5993, 2010.

Y. Takeda, C. Nakaseko, H. Tanaka, M. Takeuchi, M. Yui et al., Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis, Br J Haematol, vol.153, pp.589-598, 2011.

H. Tanaka, M. Takeuchi, Y. Takeda, S. Sakai, D. Abe et al., Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis, Leukemia, vol.24, pp.197-200, 2010.

M. Tanaka, K. Kobiyama, T. Honda, K. Uchio-yamada, Y. Natsume-kitatani et al., Essential Role of CARD14 in Murine Experimental Psoriasis, J Immunol, vol.200, pp.71-81, 2018.

D. Tartar, T. Bhutani, M. Huynh, T. Berger, and J. Koo, Update on the immunological mechanism of action behind phototherapy, J Drugs Dermatol, vol.13, pp.564-568, 2014.

S. Tauzin, H. Ding, K. Khatib, I. Ahmad, D. Burdevet et al., Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts, Blood, vol.111, pp.2310-2320, 2008.

J. Terzic, S. Grivennikov, K. E. Karin, and M. , Inflammation and colon cancer, Gastroenterology, vol.138, pp.2101-2114, 2010.

D. Thaper, S. Vahid, K. M. Nip, I. Moskalev, X. Shan et al., Targeting Lyn regulates Snail family shuttling and inhibits metastasis, Oncogene, vol.36, pp.3964-3975, 2017.

A. Thirupathi, T. Elango, S. Subramanian, and P. Gnanaraj, Methotrexate regulates Th-1 response by suppressing caspase-1 and cytokines in psoriasis patients, Clin Chim Acta, vol.453, pp.164-169, 2016.

R. M. Thomas, C. Schmedt, M. Novelli, B. K. Choi, J. Skok et al., C-terminal SRC kinase controls acute inflammation and granulocyte adhesion, Immunity, vol.20, pp.181-191, 2004.

S. M. Thomas and J. S. Brugge, Cellular functions regulated by Src family kinases, Annu Rev Cell Dev Biol, vol.13, pp.513-609, 1997.

E. Tibaldi, A. M. Brunati, M. L. Massimino, A. Stringaro, M. Colone et al., SrcTyrosine kinases are major agents in mitochondrial tyrosine phosphorylation, J Cell Biochem, vol.104, pp.840-849, 2008.

E. Tibaldi, M. A. Pagano, F. Frezzato, V. Trimarco, M. Facco et al., Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells, Haematologica, vol.102, pp.1401-1412, 2017.

M. Tohyama, Y. Hanakawa, Y. Shirakata, X. Dai, L. Yang et al., IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression, Eur J Immunol, vol.39, pp.2779-2788, 2009.

M. Tong, J. G. Pelton, M. L. Gill, W. Zhang, F. Picart et al., Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites, Nat Commun, vol.8, 2017.

J. Toubiana, A. L. Rossi, N. Belaidouni, D. Grimaldi, F. Pene et al., Src-familytyrosine kinase Lyn is critical for TLR2-mediated NF-kappaB activation through the PI 3-kinase signaling pathway, Innate Immun, vol.21, pp.685-697, 2015.

M. Traub and K. Marshall, Psoriasis--pathophysiology, conventional, and alternative approaches to treatment, Altern Med Rev, vol.12, pp.319-330, 2007.

R. P. Trible, L. Emert-sedlak, and T. E. Smithgall, HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction, J Biol Chem, vol.281, pp.27029-27038, 2006.

R. M. Trowbridge and M. R. Pittelkow, Epigenetics in the pathogenesis and pathophysiology of psoriasis vulgaris, J Drugs Dermatol, vol.13, pp.111-118, 2014.

L. C. Tsoi, S. L. Spain, J. Knight, E. Ellinghaus, P. E. Stuart et al., Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity, Nat Genet, vol.44, 2012.

S. Tsukita, K. Oishi, T. Akiyama, Y. Yamanashi, T. Yamamoto et al., Specific protooncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated, J Cell Biol, vol.113, pp.867-879, 1991.

A. Y. Tsygankov, Non-receptor protein tyrosine kinases, Front Biosci, vol.8, pp.595-635, 2003.

C. L. Tu, W. Chang, and D. D. Bikle, The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A, J Invest Dermatol, vol.131, pp.1119-1128, 2011.

F. M. U-uckun, L. Tuel-ahlgren, K. G. Waddick, X. Jun, J. J. Myers et al., Physical and functional interactions between Lyn and p34cdc2 kinases in irradiated human Bcell precursors, J Biol Chem, vol.271, pp.6389-6397, 1996.

M. Uribe-herranz, L. H. Lian, K. M. Hooper, K. A. Milora, and L. E. Jensen, IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation, J Invest Dermatol, vol.133, pp.1541-1549, 2013.

H. V-valdimarsson, R. H. Thorleifsdottir, S. L. Sigurdardottir, J. E. Gudjonsson, and A. Johnston, Psoriasis--as an autoimmune disease caused by molecular mimicry, Trends Immunol, vol.30, pp.494-501, 2009.

A. B. Van-belle, M. De-heusch, M. M. Lemaire, E. Hendrickx, G. Warnier et al., Psoriasis in the perspective of predictive, preventive participatory and personalized medicine, J Dermatolog Treat, vol.188, pp.5836-5845, 1995.

E. Van-nuffel, A. Schmitt, I. S. Afonina, K. Schulze-osthoff, R. Beyaert et al., CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis, J Invest Dermatol, vol.137, pp.569-575, 2017.

T. Vang, W. H. Liu, L. Delacroix, S. Wu, S. Vasile et al., LYP inhibits T-cell activation when dissociated from CSK, Nat Chem Biol, vol.8, pp.437-446, 2012.

G. A. Vena, M. Vestita, and N. Cassano, Psoriasis and cardiovascular disease, Dermatol Ther, vol.23, pp.144-151, 2010.

G. A. Vena, M. Vestita, and N. Cassano, Can early treatment with biologicals modify the natural history of comorbidities?, Dermatol Ther, vol.23, pp.181-193, 2010.

A. M. Verhagen, M. E. Wallace, A. Goradia, S. A. Jones, H. A. Croom et al., A kinasedead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency, J Immunol, vol.182, pp.2020-2029, 2009.

C. Verollet, A. Gallois, R. Dacquin, C. Lastrucci, S. N. Pandruvada et al., Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors, FASEB J, vol.27, pp.3608-3618, 2013.

T. Vogl, K. Tenbrock, S. Ludwig, N. Leukert, C. Ehrhardt et al., Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock, Nat Med, vol.13, pp.1042-1049, 2007.

E. F. Wagner, H. B. Schonthaler, J. Guinea-viniegra, and E. Tschachler, Psoriasis: what we have learned from mouse models, Nat Rev Rheumatol, vol.6, pp.704-714, 2010.

G. Waksman and J. Kuriyan, Structure and specificity of the SH2 domain, Cell, vol.116, p.48, 2004.

B. Wang, S. Lemay, S. Tsai, and A. Veillette, SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF, Mol Cell Biol, vol.21, pp.1077-1088, 2001.

J. Wang, T. Koizumi, and T. Watanabe, Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice, J Exp Med, vol.184, pp.831-838, 1996.

J. Wang, R. Chen, X. Liu, J. Shen, Y. Yan et al., Hck Promotes Neuronal Apoptosis Following Intracerebral Hemorrhage, Cell Mol Neurobiol, vol.37, pp.251-261, 2017.

N. Wang, H. Liang, Y. Zhou, C. Wang, S. Zhang et al., miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC, PLoS One, vol.9, 2014.

S. Wang, M. Miura, Y. K. Jung, H. Zhu, E. Li et al., Murine caspase-11, an ICEinteracting protease, is essential for the activation of ICE, Cell, vol.92, pp.501-509, 1998.

X. Wang, X. Yang, Y. Li, X. Wang, Y. Zhang et al., Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma, EBioMedicine, vol.15, pp.137-149, 2017.

Y. Wang, X. Ning, P. Gao, S. Wu, M. Sha et al., Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection, Immunity, vol.46, pp.393-404, 2017.

W. Wannamaker, R. Davies, M. Namchuk, J. Pollard, P. Ford et al., (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoy l)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18, J Pharmacol Exp Ther, vol.321, pp.509-516, 2007.

B. A. Weigl, The significance of stress hormones (glucocorticoids, catecholamines) for eruptions and spontaneous remission phases in psoriasis, Int J Dermatol, vol.39, pp.678-688, 2000.

S. Weisman, C. R. Pollack, and R. W. Gottschalk, Psoriasis disease severity measures: comparing efficacy of treatments for severe psoriasis, J Dermatolog Treat, vol.14, pp.158-165, 2003.

R. A. Weiss and P. K. Vogt, 100 years of Rous sarcoma virus, J Exp Med, vol.208, pp.2351-2355, 2011.

H. Wen, J. P. Ting, O. Neill, and L. A. , A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?, Nat Immunol, vol.13, pp.352-357, 2012.

K. A. Whelan, L. P. Schwab, S. V. Karakashev, L. Franchetti, G. J. Johannes et al., The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance, J Biol Chem, vol.288, pp.15865-15877, 2013.

C. M. Wiggins, P. Tsvetkov, M. Johnson, C. L. Joyce, C. A. Lamb et al., BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation, J Cell Sci, vol.124, pp.969-977, 2011.

D. Wilsmann-theis, J. Wagenpfeil, D. Holzinger, J. Roth, S. Koch et al., Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity, J Eur Acad Dermatol Venereol, vol.30, pp.1165-1170, 2016.

E. Witte, G. Kokolakis, K. Witte, S. Philipp, W. D. Doecke et al., IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis, J Invest Dermatol, vol.134, pp.2757-2767, 2014.

R. Wolf, O. M. Howard, H. F. Dong, C. Voscopoulos, K. Boeshans et al., Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15, J Immunol, vol.181, pp.1499-1506, 2008.

J. A. Wolfram, D. Diaconu, D. A. Hatala, J. Rastegar, D. A. Knutsen et al., , 2009.

, Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis, Am J Pathol, vol.174, pp.1443-1458, 2671375.

K. M. Woods and M. F. Verderame, Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of vsrc, J Virol, vol.68, 1994.

A. Wortmann, Y. He, M. E. Christensen, M. Linn, J. W. Lumley et al., Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734, J Biol Chem, vol.286, pp.42303-42315, 2011.

P. Wu, G. Ma, X. Zhu, T. Gu, J. Zhang et al., Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-kappaB pathway, Clin Immunol, vol.174, pp.53-62, 2017.

K. Wuertz, L. Quero, M. Sekiguchi, M. Klawitter, A. Nerlich et al., The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo, Spine, vol.36, pp.1373-1384, 1976.

S. Xi, Q. Zhang, K. F. Dyer, E. C. Lerner, T. E. Smithgall et al., Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck, J Biol Chem, vol.278, pp.31574-31583, 2003.

Z. Xiao, C. Wang, D. Mo, J. Li, Y. Chen et al., Promoter CpG methylation status in porcine Lyn is associated with its expression levels, Gene, vol.511, pp.73-78, 2012.

N. Xu, P. Brodin, T. Wei, F. Meisgen, L. Eidsmo et al., MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2, J Invest Dermatol, vol.131, pp.1521-1529, 2011.

W. Xu, S. C. Harrison, and M. J. Eck, Three-dimensional structure of the tyrosine kinase cSrc, Nature, vol.385, pp.595-602, 1997.

W. Xu, A. Doshi, M. Lei, M. J. Eck, and S. C. Harrison, Crystal structures of c-Src reveal features of its autoinhibitory mechanism, Mol Cell, vol.3, pp.629-638, 1999.

Y. Xu, K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton, Lyn tyrosine kinase: accentuating the positive and the negative, Immunity, vol.22, pp.9-18, 2005.

Y. Xue, A. Daly, B. Yngvadottir, M. Liu, G. Coop et al., Spread of an inactive form of caspase-12 in humans is due to recent positive selection, Am J Hum Genet, vol.78, 2006.

Y. Yagi, R. Waguri, S. Sumikawa, Y. Nada, S. Oneyama et al., C-terminal Src kinase controls development and maintenance of mouse squamous epithelia, EMBO J, vol.26, 2007.

Y. Yamanashi, S. Fukushige, K. Semba, J. Sukegawa, N. Miyajima et al., The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck, Mol Cell Biol, vol.7, pp.237-243, 1987.

Y. Yamanashi, M. Miyasaka, M. Takeuchi, D. Ilic, J. Mizuguchi et al., Differential responses of p56lyn and p53lyn, products of alternatively spliced lyn mRNA, on stimulation of B-cell antigen receptor, Cell Regul, vol.2, pp.979-987, 1991.

Y. Yamashita, N. Charles, Y. Furumoto, S. Odom, T. Yamashita et al., Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses, J Immunol, vol.179, pp.740-743, 2007.

K. Yanaba, M. Kamata, N. Ishiura, S. Shibata, Y. Asano et al., Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation, J Leukoc Biol, vol.94, pp.563-573, 2013.

C. C. Yang, L. Fazli, S. Loguercio, I. Zharkikh, P. Aza-blanc et al., Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass, Oncotarget, vol.6, pp.22060-22071, 2015.

T. L. Yi, J. B. Bolen, and J. N. Ihle, Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus, Mol Cell Biol, vol.11, pp.2391-2398, 1991.

Y. S. Yi, Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses, Immunology, vol.152, pp.207-217, 2017.

K. W. Yip and J. C. Reed, Bcl-2 family proteins and cancer, Oncogene, vol.27, pp.6398-6406, 2008.

M. Yokouchi, T. Kondo, A. Sanjay, A. Houghton, A. Yoshimura et al., Srccatalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins, J Biol Chem, vol.276, pp.35185-35193, 2001.

S. K. Yoo, T. W. Starnes, Q. Deng, and A. Huttenlocher, Lyn is a redox sensor that mediates leukocyte wound attraction in vivo, Nature, vol.480, pp.109-112, 2011.

S. H. Yoon, Y. Lee, H. J. Kim, Z. H. Lee, S. W. Hyung et al., Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling, FEBS Lett, vol.583, pp.1164-1170, 2009.

K. Yoshida, R. Weichselbaum, S. Kharbanda, and D. Kufe, Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage, Mol Cell Biol, vol.20, pp.5370-5380, 2000.

R. M. Young, D. Holowka, and B. Baird, A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation, J Biol Chem, vol.278, pp.20746-20752, 2003.

L. C. Zaba, J. G. Krueger, and M. A. Lowes, Resident and "inflammatory" dendritic cells in human skin, J Invest Dermatol, vol.129, pp.302-308, 2009.

L. C. Zaba, M. Suarez-farinas, J. Fuentes-duculan, K. E. Nograles, E. Guttman-yassky et al., Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes, J Allergy Clin Immunol, vol.124, 2009.

B. Zbytek, A. Mysliwski, A. Slominski, J. Wortsman, E. T. Wei et al., Corticotropinreleasing hormone affects cytokine production in human HaCaT keratinocytes, Life Sci, vol.70, pp.1013-1021, 2002.

Y. Zermati, C. Garrido, S. Amsellem, S. Fishelson, D. Bouscary et al., Caspase activation is required for terminal erythroid differentiation, J Exp Med, vol.193, pp.247-254, 2001.

F. Zhang, L. Wang, J. J. Wang, P. F. Luo, X. T. Wang et al., The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities, Sci Rep, vol.6, 2016.

L. Zhang, Z. Ren, Q. Yang, and G. Ding, Csk regulates angiotensin II-induced podocyte apoptosis, Apoptosis, vol.21, pp.846-855, 2016.

P. Zhang, Y. Su, H. Chen, M. Zhao, and Q. Lu, Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris, J Dermatol Sci, vol.60, pp.40-42, 2010.

X. Zhang, C. Simerly, C. Hartnett, G. Schatten, and T. E. Smithgall, Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells, Stem Cell Res, vol.13, 2014.

Y. K. Zhang, G. N. Zhang, Y. J. Wang, B. A. Patel, T. T. Talele et al., Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters, Sci Rep, vol.6, 2016.

X. Zhao, R. Li, M. Qiao, J. Yan, and Q. Sun, MiR-548a-3p Promotes Keratinocyte Proliferation Targeting PPP3R1 after Being Induced by IL-22, 2017.

Y. Zhao, D. He, B. Saatian, T. Watkins, E. W. Spannhake et al., Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases, J Biol Chem, vol.281, 2006.

H. Zhi, J. Dai, J. Liu, J. Zhu, D. K. Newman et al., Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin alphaIIbbeta3 and Lyn Kinase, PLoS One, vol.10, 2015.

S. Zhu, J. D. Bjorge, H. C. Cheng, and D. J. Fujita, Decreased CHK protein levels are associated with Src activation in colon cancer cells, Oncogene, vol.27, pp.2027-2034, 2008.

T. Zieciak, T. Rzepa, J. Krol, and R. Zaba, Stigmatization feelings and depression symptoms in psoriasis patients, Psychiatr Pol, vol.51, pp.1153-1163, 2017.

F. Zonta, M. A. Pagano, L. Trentin, E. Tibaldi, F. Frezzato et al., Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia, Blood, vol.123, pp.875-883, 2014.

S. Zwicker, E. Hattinger, D. Bureik, A. Batycka-baran, A. Schmidt et al., Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation, Inserm U1242 «Chemistry, vol.12, 2017.

, Inserm U1065, équipe 3, 151 route de St Antoine de Ginestière, BP 23194, 06204 Nice Cedex 03

, Fax +33 4 89 06 42 21, email: ricci@unice.fr ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines

A. Le, D. Gonçalves, P. Colosetti, J. E. Ricci, J. P. Ortonne et al.,

-. Latinpharma, , 2013.

L. Havane,

A. Itolizumab, . Le, I. Pineda, M. Frometa, A. Urquiza et al., Preliminary results of immunological biomarkers in patients with Rheumatoid Arthritis treated with

L. Havane,

A. Itolizumab, . Le, I. Pineda, M. Frometa, A. Urquiza et al., « Therapeutic manipulation of the inflammatory microenvironment » Preliminary results of immunological biomarkers in patients with Psoriasis treated with

. Liste, . Publications, and . Publies,

, Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production

M. Viaud, S. Ivanov, N. Vujic, M. Duta-mare, L. E. Aira et al.,

, Circ Res, 2009.

, The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim

L. E. Aira, E. Villa, P. Colosetti, P. Gamas, L. Signetti et al., , 2018.

, The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial

P. C. Rodríguez, D. M. Prada, E. Moreno, L. E. Aira, C. Molinero et al.,

, Safety and Immunogenicity of a Human Epidermal Growth Factor Receptor 1 (HER1)-Based Vaccine in Prostate Castration-Resistant Carcinoma Patients: A Dose-Escalation Phase I Study Trial, Clin Exp Immunol, vol.191, issue.2, pp.229-239, 2018.

I. Caballero, L. Aira, A. Lavastida, X. Popa, J. Rivero et al., Front Pharmacol, vol.8, p.263, 2017.

, Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab

P. Hernández, E. Moreno, L. E. Aira, and P. C. Rodríguez, Curr Drug Targets, vol.17, issue.6, pp.666-77, 2016.

, Immunological evaluation of rheumatoid arthritis patients treated with itolizumab

L. E. Aira, P. Hernández, D. Prada, A. Chico, J. A. Gómez et al.,

, Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab, MAbs, vol.8, issue.1, pp.187-95, 2016.

L. E. Aira, A. López-requena, D. Fuentes, L. Sánchez, T. Pérez et al.,

, MAbs, vol.6, issue.3, pp.783-93, 2014.

, Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections

L. Sarmiento, J. A. Galvan, E. Cabrera-rode, L. E. Aira, C. Correa et al.,

, J Med Virol, vol.84, issue.7, pp.1049-53, 2012.

, Evaluación inmunológica de la proteína recombinante dominio III cápsida del virus dengue 2 en ratones Balb/c

L. Aira and . Ricci, , p.1, 2010.

L. E. Aira, D. Gonçalves, C. Rubio-patino, J. Chiche, L. Mondragon et al., Journal of Investigative Dermatology MANUSCRITS EN

, Lyn tyrosine kinase: a pivotal factor in psoriasis pathogenesis

L. E. Aira, D. Gonçalves, C. Rubio-patino, J. Chiche, P. Lecuq-ottavi et al.,