Rôle de la protéine Pleckstrin dans la génération de lymphocytes T CD8 mémoires et la mise en place d'une immunité tissulaire

Abstract : CD8 T cells are key players of adaptive immunity, and are involved in the elimination of intracellular pathogens and cancer cells. During a primary immune response, memory CD8 T cells are generated, and are able to maintain long-term and protect efficiently the organism against a secondary encounter with these threats. Indeed, memory CD8 T cells mediate durable protection through enhanced effector functions, increased proliferative capacity and distinct migratory behaviors, three processes that are tightly regulated by actin cytoskeleton.            Recently, the laboratory has shown that pleckstrin, a gene involved in actin cytoskeleton, is highly up-regulated in pathogen-induced memory CD8 T cells compared to naïve cells. Using pleckstrin deficient CD8 T cells, we show in an in vivo model of Vaccinia virus infection that pleckstrin deficiency does not affect global CD8 functions, in terms of cytokine production and cytotoxicity. However, pleckstrin is required for the optimal generation and localization of memory CD8 T cells within infected tissues.            As a whole, this work gives new insight into the molecular and cellular mechanisms that allow the establishment of a memory CD8 T cell compartment within non-lymphoid tissues.
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Mathilde Calvez. Rôle de la protéine Pleckstrin dans la génération de lymphocytes T CD8 mémoires et la mise en place d'une immunité tissulaire. Immunité adaptative. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSEN013⟩. ⟨tel-02275780⟩

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