Acute myeloid leukemia, N Engl J Med, vol.373, pp.1136-1152, 2015. ,
Genomic Classification and Prognosis in Acute Myeloid Leukemia, N Engl J Med, vol.374, pp.2209-2221, 2016. ,
Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome, Blood, vol.114, pp.2386-2392, 2009. ,
Midostaurin: an emerging treatment for acute myeloid leukemia patients, J Blood Med, vol.7, pp.73-83, 2016. ,
The role for autophagy in cancer, J Clin Invest, vol.125, pp.42-46, 2015. ,
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis, Genes Dev, vol.25, pp.460-470, 2011. ,
Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma, Cell Death Differ, vol.22, pp.946-958, 2015. ,
MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation, Autophagy, vol.11, pp.1790-802, 2015. ,
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells, J Clin Invest, vol.119, pp.1109-1123, 2009. ,
Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma, Oncotarget, vol.6, pp.30149-30164, 2015. ,
Emerging strategies to effectively target autophagy in cancer, Oncogene, vol.35, pp.1-11, 2016. ,
Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death ,
, PLoS One, vol.9, p.94374, 2014.
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia, Blood, vol.128, pp.1260-1269, 2016. ,
Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death, Proc Natl Acad Sci U S A, vol.109, pp.6561-6565, 2012. ,
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells, Blood, vol.122, pp.2467-2476, 2013. ,
Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes, Mol Cell, vol.36, pp.326-365, 2009. ,
The eIF2?/ATF4 pathway is essential for stress-induced autophagy gene expression, Nucleic Acids Res, vol.41, pp.7683-7699, 2013. ,
Activating transcription factor 4, Int J Biochem Cell Biol, vol.40, pp.14-21, 2008. ,
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers, Autophagy, vol.10, pp.2122-2142, 2014. ,
Pancreatic cancers require autophagy for tumor growth, Genes Dev, vol.25, pp.717-729, 2011. ,
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy, Nat Chem Biol, vol.10, pp.1013-1019, 2014. ,
Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells, Blood, vol.127, p.133, 2016. ,
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia, Cell Death Discov, vol.1, p.15008, 2015. ,
Complete mutational spectrum of the autophagy interactome: A novel class of tumor suppressor genes in myeloid neoplasms, Leukemia, vol.31, pp.505-510, 2016. ,
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein, Blood, vol.116, pp.2324-2331, 2010. ,
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia, Cell Rep, vol.11, pp.1446-1457, 2015. ,
ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies, Sci Signal, vol.9, p.17, 2016. ,
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia, Leukemia, 2016. ,
Targeting the ATF4 pathway in cancer therapy, Expert Opin Ther Targets, vol.16, pp.1189-1202, 2012. ,
The integrated stress response, EMBO Rep, vol.17, pp.1374-1395, 2016. ,
,
, AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest, Nat Cell Biol, vol.17, pp.1304-1316, 2015.
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress, Science, vol.336, pp.225-228, 2012. ,
Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1, Autophagy, vol.11, pp.2335-2345, 2015. ,
Autophagy proteins regulate ERK phosphorylation, Nat Commun, vol.4, pp.2799-134, 2013. ,
Flt3 inhibitors: recent advances and problems for clinical application, Nagoya J Med Sci, vol.77, pp.7-17, 2015. ,
Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations, Cancer, vol.120, pp.2142-2149, 2014. ,
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors, J Med Chem, vol.58, pp.376-400, 2015. ,
Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: Novel point of convergence between electrophilic and unfolded protein stress pathways, Arterioscler. Thromb. Vasc. Biol, vol.30, pp.1007-1013, 2010. ,
A molecular chaperone complex at the lysosomal membrane is required for protein translocation, J. Cell Sci, vol.114, pp.2491-2499, 2001. ,
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21, Genomics, vol.59, pp.59-65, 1999. ,
A mechanistic overview of translation initiation in eukaryotes, Nat. Struct. Mol. Biol, vol.19, pp.568-576, 2012. ,
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib, Blood, vol.103, pp.3222-3225, 2004. ,
Activating transcription factor 4, Int. J. Biochem. Cell Biol, vol.40, pp.14-21, 2008. ,
Role of platelet-derived growth factors in physiology and medicine, pp.1276-1312, 2008. ,
The Journal of The, Blood, vol.92, pp.1845-1851, 1998. ,
Emerging Mechanisms in Initiating and Terminating Autophagy, Trends Biochem. Sci, vol.42, pp.28-41, 2017. ,
SUP: Protein folding and quality control in the ER, Cold Spring Harb. Perspect. Biol, vol.4, 2012. ,
The 2016 revision to the World Health Organization classi fi cation of myeloid neoplasms and acute leukemia, Blood, vol.127, pp.2391-2406, 2016. ,
Studies on Cellular Autophagocytosis, Am. J. Pathol, vol.73, pp.641-670, 1973. ,
Autophagy, a key mechanism of oncogenesis and resistance in leukemia, Blood, vol.129, pp.547-552, 2017. ,
, , 2008.
, Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum, J. Cell Biol, vol.182, pp.685-701
The eIF2?/ATF4 pathway is essential for stress-induced autophagy gene expression, Nucleic Acids Res, vol.41, pp.7683-7699, 2013. ,
, , vol.10, pp.13-26, 2010.
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitor, Blood, vol.103, pp.2266-2275, 2004. ,
Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection, Immunity, vol.13, pp.129-141, 2000. ,
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells, J Clin Invest, vol.119, pp.1109-1123, 2009. ,
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group, Br J Haematol, vol.33, pp.451-458, 1976. ,
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia, Oncotarget, vol.6, pp.38061-38078, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01594827
Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages, Blood, vol.80, pp.2584-2593, 1992. ,
Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress, Mol. Cell. Biol. Cell. Biol, vol.24, pp.7469-7482, 2004. ,
The Phosphatidylinositol 3-Kinase Inhibitors Wortmannin and LY294002 Inhibit Autophagy in Isolated Rat Hepatocytes, Eur. J. Biochem, vol.243, pp.240-246, 1997. ,
Plasma FLT3-L levels predict bone marrow recovery from myelosuppressive therapy, Cancer, vol.88, pp.333-343, 2000. ,
Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases, vol.25, pp.3690-3703, 2005. ,
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly, Cell, vol.144, pp.253-267, 2011. ,
Ras Oncogenes in Human Cancer: A Review, Cancer Res, vol.49, pp.4682-4689, 1989. ,
Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death, PLoS One, vol.9, pp.1-12, 2014. ,
Inhibition of Macroautophagy Triggers Apoptosis Inhibition of Macroautophagy Triggers Apoptosis ?, Mol. Cell. Biol, vol.25, pp.1025-1040, 2005. ,
Atg1-independent induction of autophagy by the Drosophila Ulk3 homolog, ADUK. FEBS J, vol.283, pp.3889-3897, 2016. ,
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation, Cancer Res, vol.65, pp.9643-9650, 2005. ,
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription, Nat. Commun, vol.6, p.8261, 2015. ,
Molecular Responses to Hypoxia-Inducible Factor 1 and Beyond, Mol. Pharmacol, vol.85, pp.651-657, 2014. ,
Analysis of nelfinavir-induced endoplasmic reticulum stress, Methods Enzymol, vol.491, pp.127-142, 2011. ,
, , vol.10, pp.4173-4183, 2017.
Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: Causes and consequences, Target. Oncol, vol.6, pp.95-102, 2011. ,
PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs, J. Orthop. Res, vol.29, pp.1795-1803, 2011. ,
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias, Blood, vol.87, pp.1089-1096, 1996. ,
The PTEN-PI3K pathway: of feedbacks and cross-talks, Oncogene, vol.27, p.153, 2008. ,
Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling, Elife, vol.4, pp.1-16, 2015. ,
Keeping the eIF2 alpha kinase Gcn2 in check, Biochim. Biophys. Acta -Mol. Cell Res, vol.1843, pp.1948-1968, 2014. ,
Release of eIF6 (p27 BBP) from the 60S subunit allows 80S ribosome assembly, Nature, vol.426, pp.579-584, 2003. ,
Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response, Biochim. Biophys. Acta -Mol. Cell Res, vol.1833, pp.2165-2175, 2013. ,
Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism, Mol. Cell. Biol, vol.29, pp.157-171, 2009. ,
Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region Autoinhibition of the Kit Receptor Tyrosine Kinase by the Cytosolic Juxtamembrane Region, Society, vol.23, pp.3067-3078, 2003. ,
The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP, Nucleic Acids Res, vol.35, pp.5954-5965, 2007. ,
Pleiotropic Resistance to DNA-interactive Drugs Is Associated with Increased Expression of Genes Involved in DNA Replication, Repair, and Stress Response 1, DNA Repair (Amst, pp.5027-5030, 2000. ,
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations, Blood, vol.106, pp.265-273, 2005. ,
Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes, Mol. Cell, vol.36, pp.326-339, 2009. ,
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines, Leuk Lymphoma, vol.51, pp.671-679, 2010. ,
Developmental cell death: morphological diversity and multiple mechanisms, Anat. Embryol. (Berl), vol.181, pp.195-213, 1990. ,
Les gènes ATG, vol.20, pp.8-10, 2004. ,
MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation, Autophagy, vol.11, pp.1790-1802, 2015. ,
, , pp.2502-2511, 2016.
, Prediction of Resistance to Small Molecule FLT3 Inhibitors : Implications for Molecularly Targeted Therapy of Acute Leukemia Advances in Brief Prediction of Resistance to Small Molecule FLT3 Inhibitors : Implications for Molecularly Targeted Therapy of Ac, pp.6385-6389, 2004.
,
, Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma, Cell Death Differ, vol.22, pp.946-958
Alterations in Protein Kinase C in 1 , 2-Dimethylhydrazine, pp.2216-2221, 1992. ,
Autophagy: Many paths to the same end, Mol. Cell. Biochem, vol.263, pp.55-72, 2004. ,
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis, J. Exp. Med, vol.201, pp.1487-1502, 2005. ,
The role of lipids in the control of autophagy, Curr. Biol, vol.23, pp.33-45, 2013. ,
Specific Interaction of Eukaryotic Translation Initiation Factor 5 (eIF5) with the -Subunit of eIF2, J. Biol. Chem, vol.272, pp.31712-31718, 1997. ,
Non-invasive detection of fecal protein kinase C ??(I)I and ?? messenger RNA: Putative biomarkers for colon cancer, Carcinogenesis, vol.19, pp.253-257, 1998. ,
Regulation of B lymphocyte and macrophage development by graded expression of PU, Science, vol.1, pp.1439-1441, 2000. ,
Autophagy Creates a CTL Epitope That Mimics Tumor-Associated Antigens, PLoS One, vol.7, pp.1-13, 2012. ,
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway, Nat. Cell Biol, vol.8, pp.1053-1063, 2006. ,
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response, J. Biol. Chem, vol.285, pp.33165-33174, 2010. ,
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein ?? (C/EBP??) differentially regulates integrated stress response, J. Biol. Chem, vol.287, pp.21936-21949, 2012. ,
Hypoxia regulates TSC1 / 2 -mTOR signaling and tumor suppression through REDD1-mediated 14 -3 -3 shuttling, Genes, pp.239-251, 2008. ,
, Radiology, vol.34, pp.733-742, 2007.
Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability, Am. J. Pathol, vol.171, pp.513-524, 2007. ,
Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy, Mol. Cancer Ther, vol.8, pp.2036-2045, 2009. ,
The eIF2?? kinases: Their structures and functions, Cell. Mol. Life Sci, vol.70, pp.3493-3511, 2013. ,
Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells, Mol. Cell. Biol, vol.13, pp.6572-6585, 1993. ,
Autophagy and related mechanisms of lysosome-mediated protein degradation, Trends Cell Biol, vol.4, pp.139-143, 1994. ,
Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy, J. Biol. Chem, vol.290, pp.25497-25511, 2015. ,
Synergistic action of Flt3 and gp130 signalings in human hematopoiesis, Blood, vol.90, pp.4363-4368, 1997. ,
Leptin regulation of bone resorption by the sympathetic nervous system and CART, Nature, vol.434, pp.514-520, 2005. ,
Quality control in the endoplasmic reticulum, Nat. Rev. Mol. Cell Biol, vol.4, pp.181-191, 2003. ,
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy, Proc. Natl. Acad. Sci, vol.113, pp.182-187, 2016. ,
Studies on induced cellular autophagy: I. Electron microscopy of cells with in vivo labelled lysosomes, Exp. Cell Res, vol.55, p.155, 1969. ,
Maturation of autophagic vacuoles in Mammalian cells, Autophagy, vol.1, pp.1-10, 2005. ,
La formation de l ' autophagosome Un nouveau défi pour le biologiste, pp.217-220, 2017. ,
Signaling pathways and mechanisms of hypoxia-induced autophagy in the animal cells, Cell Biol. Int, vol.39, pp.891-898, 2015. ,
Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes, J. Biol. Chem, vol.281, pp.36303-36316, 2006. ,
, the Stress Response, vol.141, pp.135-141, 1999.
The Single Transmembrane Domains of Human Receptor Tyrosine Kinases Encode Self-Interactions, Sci. Signal, vol.2, pp.56-56, 2009. ,
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML study group Ulm, Blood, vol.100, pp.4372-4380, 2002. ,
Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: Ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II), Hum. Mol. Genet, vol.16, pp.618-629, 2007. ,
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1, Proc. Natl. Acad. Sci. U. S. A, vol.93, pp.12355-12358, 1996. ,
Ras is involved in the negative control of autophagy through the class I PI3-kinase, Oncogene, vol.23, pp.3898-3904, 2004. ,
Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors, Blood, vol.86, pp.1661-1670, 1995. ,
Autophagosome maturation and lysosomal fusion, Essays Biochem, vol.55, pp.65-78, 2013. ,
Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response, Science, vol.333, pp.1891-1894, 2011. ,
The roles of FLT3 in hematopoiesis and leukemia, Blood, vol.100, pp.1532-1542, 2002. ,
Cloning and expression of the human cDNA encoding the gamma subunit, Mol. Biochem. Parasitol, vol.269, pp.3415-3422, 1994. ,
The ageing haematopoietic stem cell compartment, Nat. Rev. Immunol, vol.13, pp.376-389, 2013. ,
, , vol.127, pp.2498-2502, 2016.
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis, Autophagy, vol.10, pp.603-617, 2014. ,
An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: Biology and treatment, Oncol. Rev, vol.6, pp.64-74, 2012. ,
,
, Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model, Blood, vol.119, pp.2883-2894
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia, Proc. Natl. Acad. Sci, vol.113, pp.6669-6678, 2016. ,
The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane Domain, Mol. Cell, vol.13, pp.169-178, 2004. ,
Protein kinase C and other diacylglycerol effectors in cancer, Nat. Rev. Cancer, vol.7, p.159, 2007. ,
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation, Nucleic Acids Res, vol.44, pp.8704-8713, 2016. ,
Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7-and calpain-mediated caspase-12 activation, Apoptosis, vol.19, pp.414-427, 2014. ,
Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens, Autophagy, vol.8, pp.1175-1184, 2012. ,
The autophagosome: origins unknown, biogenesis complex, Nat. Rev. Mol. Cell Biol, vol.14, pp.759-774, 2013. ,
The autophagosome: origins unknown, biogenesis complex, Nat. Rev. Mol. Cell Biol, vol.14, pp.759-774, 2013. ,
Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells, Blood, vol.127, pp.882-892, 2016. ,
, , 2001.
, ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF TrCP Ubiquitin Ligase, Mol. Cell. Biol, vol.21, pp.2192-2202
p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain, J. Biol. Chem, vol.280, pp.41537-41545, 2005. ,
Dimerization-induced allostery in protein kinase regulation, Trends Biochem. Sci, vol.39, pp.475-486, 2014. ,
, , vol.327, pp.1223-1228, 2011.
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2phosphorylation, J. Biol. Chem, vol.284, pp.6661-6673, 2009. ,
, SRC is a signaling mediator in FLT3-ITD -But not in FLT3-TKD-positive AML, vol.119, pp.4026-4033, 2012.
, Biochemistry, vol.141, pp.1117-1134, 2011.
FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia, Leukemia, vol.27, pp.260-268, 2013. ,
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations Brief report A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harbori, vol.98, pp.885-887, 2009. ,
Targeting Autophagy During Cancer Therapy to Improve Clinical Outcomes, Pharmacol Ther, vol.131, pp.130-141, 2011. ,
Receptor tyrosine kinase transmembrane domains: Function, dimer structure and dimerization energetics, Cell Adhes. Migr, vol.4, pp.249-254, 2010. ,
Protein Kinase C Enhances Growth and Expression of Cyclin D1 in Human Breast Cancer Cells, Cancer Res, vol.66, pp.11399-11408, 2006. ,
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells, Cell Death Differ, vol.15, pp.1460-1471, 2008. ,
Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation, Cell. Signal, vol.25, pp.50-65, 2013. ,
, , vol.6918, pp.165-176, 2017.
, , 2007.
, PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas, kinase C-beta, vol.2, p.8
Microautophagy: Lesser-known self-eating, Cell. Mol. Life Sci, vol.69, pp.1125-1136, 2012. ,
, , 2008.
, Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking, Nat. Cell Biol, vol.10, pp.776-787
, , vol.20, pp.436-443, 2013.
Structure and function of the ULK1 complex in autophagy, Curr. Opin. Cell Biol, vol.39, pp.61-68, 2016. ,
FIP200 is required for the cellautonomous maintenance of fetal hematopoietic stem cells, Blood, vol.116, pp.4806-4814, 2010. ,
Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases, EMBO J, vol.26, pp.891-901, 2007. ,
The initiation of mammalian protein synthesis and the mechanism of scanning, Nature, vol.500, pp.307-311, 2013. ,
Rheb binds and regulates the mTOR kinase, Curr. Biol, vol.15, pp.702-713, 2005. ,
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response, J. Cell Biol, vol.167, pp.27-33, 2004. ,
Growth factor regulation of autophagy and cell survival in the absence of apoptosis, Cell, vol.120, pp.237-248, 2005. ,
GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development, Mol. Cell. Biol, vol.26, pp.5688-5697, 2006. ,
Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells, Cell, vol.75, pp.1157-1167, 1993. ,
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R, Structure, vol.20, pp.676-687, 2012. ,
Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors, Immunity, vol.3, pp.147-161, 1995. ,
Mechanisms of chaperone-mediated autophagy, Int. J. Biochem. Cell Biol, vol.36, pp.2435-2444, 2004. ,
The PI3K-Akt Pathway Regulates Tuberin Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase / Akt Pathway An Approach to Determine Substrates of Protein Kinases a PI3K-Depen, Cell, vol.10, pp.151-162, 2002. ,
, Growth (Lakeland), vol.23, pp.1-7, 2008.
Eaten alive : a history of macroautophagy, vol.12, pp.814-822, 2013. ,
, , vol.494, pp.323-327, 2013.
, Nano, vol.6, pp.2166-2171, 2008.
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor, Leuk. Off. J. Leuk. Soc. Am. Leuk. Res. Fund, U.K, vol.13, pp.1374-1382, 1999. ,
FLT-3: A new focus in the understanding of acute leukemia, Int. J. Biochem. Cell Biol, vol.37, p.161, 2005. ,
TFEB and TFE3 are novel components of the integrated stress response, EMBO J, vol.35, pp.479-495, 2016. ,
Autophagy proteins regulate ERK phosphorylation, Nat. Commun, vol.4, pp.1-14, 2013. ,
Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation, Virchows Arch. B Cell Pathol. Incl. Mol. Pathol, vol.36, pp.219-234, 1981. ,
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice, Blood, vol.99, pp.736-745, 2002. ,
Role of autophagy in cancer, Nat. Rev. Cancer, vol.7, pp.961-967, 2007. ,
chromosomal instability Autophagy suppresses tumor progression by limiting chromosomal instability, Genes Dev, pp.1367-1381, 2007. ,
, , vol.137, pp.1062-1075, 2010.
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations, Cell, vol.65, pp.1143-1152, 1991. ,
Autophagy and cancer therapy, Cancer Biol. Ther, vol.11, pp.127-137, 2011. ,
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy, Autophagy, vol.8, pp.200-212, 2012. ,
Hypoxia-induced autophagy: Cell death or cell survival?, Curr. Opin. Cell Biol, vol.22, pp.177-180, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00457667
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells, Bloo, vol.95, pp.3489-3497, 2000. ,
Expression of FL T3 and FL T3 Ligand in Human Leukemia-Lymphoma Cell Lines, pp.185-192, 1997. ,
ASH 50th anniversary review Hematopoietic cytokines, Blood, vol.111, pp.485-491, 2009. ,
The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes: Figure 1, Biochem. Soc. Trans, vol.38, pp.1469-1473, 2010. ,
Inflammation-Associated Autophagy-Related Programmed Necrotic Death of Human Neutrophils Characterized by Organelle Fusion Events, J. Immunol, vol.186, pp.6532-6542, 2011. ,
Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum, Autophagy, vol.7, pp.673-682, 2011. ,
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib, Cancer Res, vol.69, pp.4415-4423, 2009. ,
Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation, EMBO Rep, vol.10, pp.459-465, 2009. ,
Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth, Cancer Cell, vol.19, pp.765-775, 2011. ,
Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo, Oncotarget, vol.6, pp.37471-37485, 2015. ,
Translational control by mTORindependent routes: how eIF6 organizes metabolism, Biochem. Soc. Trans, vol.44, pp.1667-1673, 2016. ,
, New England Journal. Library, pp.563-574, 2008.
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways, Blood, vol.96, pp.3907-3914, 2000. ,
Methods for monitoring autophagy, Int. J. Biochem. Cell Biol, vol.36, pp.2491-2502, 2004. ,
A protein conjugation system essential for autophagy, Nature, vol.395, pp.395-398, 1998. ,
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells, J. Cell Biol, vol.152, pp.657-667, 2001. ,
, Cell, vol.140, pp.313-326, 2010.
The Role of Atg Proteins in Autophagosome Formation, Annu. Rev. Cell Dev. Biol, vol.27, pp.107-132, 2011. ,
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases, EMBO J, vol.12, pp.2257-2264, 1993. ,
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance, J. Exp. Med, vol.208, pp.455-467, 2011. ,
Induction of autophagy by amino-acid deprivation in perfused rat liver, Nature, vol.270, pp.174-176, 1977. ,
A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice, Leukemia, vol.27, pp.1917-1920, 2013. ,
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody, Leuk. Lymphoma, vol.55, pp.2141-2150, 2014. ,
Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions, J. Biol. Chem, vol.279, pp.22820-22832, 2004. ,
Atg35, a micropexophagy-specific protein that regulates micropexophagic apparatus formation in Pichia pastoris, Autophagy, vol.7, pp.375-385, 2011. ,
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis, Genes Dev, vol.18, pp.2095-2107, 2004. ,
Atg1 family kinases in autophagy initiation, Cell. Mol. Life Sci, vol.72, pp.3083-3096, 2015. ,
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress, Mol. Cell. Biol, vol.26, pp.9220-9231, 2006. ,
The integrated stress response, EMBO Rep, vol.17, pp.1374-1395, 2016. ,
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation, J. Biol. Chem, vol.286, pp.10939-10949, 2011. ,
Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine-induced death of leukaemia cells, J. Cancer Res. Clin. Oncol, vol.140, pp.909-920, 2014. ,
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L, Cell Death Differ, vol.15, pp.1572-1581, 2008. ,
, FMS-Like Tyrosine Kinase, vol.3, p.163, 2006.
, Normal Hematopoiesis and Acute Myeloid Leukemia. Stem Cells, vol.24, pp.1174-1184
SAR405, a PIK3C3/VPS34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells, Autophagy, vol.11, pp.725-726, 2015. ,
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells, J. Biol. Chem, vol.278, pp.16667-16674, 2003. ,
Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies, Autophagy, vol.10, pp.562-571, 2014. ,
Distinct Classes of Phosphatidylinositol 3'-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in Distinct Classes of Phosphatidylinositol 3 -Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells, J. Biol. Chem, vol.275, pp.992-998, 2000. ,
Development of hematopoietic cells lacking transcription factor GATA-1, Development, vol.121, pp.163-172, 1995. ,
IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples, Cancer Res, vol.66, pp.4843-4851, 2006. ,
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways, Blood, vol.109, pp.1643-1652, 2007. ,
EIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins, BMC Cancer, vol.15, p.131, 2015. ,
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia, Blood, vol.128, pp.1260-1269, 2016. ,
Nutrient-regulated phosphorylation of ATG13 inhibits starvation-induced autophagy, J. Biol. Chem, vol.291, pp.6026-6035, 2016. ,
Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus, EMBO J, vol.7, pp.1003-1011, 1988. ,
Recent insights into the function of autophagy in cancer, Genes Dev, vol.30, pp.1913-1930, 2016. ,
Block of C/EBP? function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations, J. Exp. Med, vol.203, pp.371-381, 2006. ,
Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2? kinase activity of HRI, Biochemistry, vol.42, pp.6536-6544, 2003. ,
, and Flt3, pp.1947-1958, 1998.
Plasma membrane contributes to the formation of pre-autophagosomal structures, Nat. Cell Biol, vol.12, pp.747-757, 2010. ,
Early endosomes and endosomal coatomer are required for, Autophagy. J. Cell Biol, vol.185, pp.305-321, 2009. ,
Membrane Origin for Autophagy, Curr. Top. Dev. Biol, vol.74, pp.1-30, 2006. ,
The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication, Blood, vol.113, pp.5090-5093, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00452866
, the Mechanism of Eukaryotic Translation Initiation, vol.11, pp.113-127, 2015.
Purification of polysomes, Cold Spring Harb. Protoc, pp.303-305, 2015. ,
The protein tyrosine kinase family of the human genome, Oncogene, vol.19, pp.5548-5557, 2000. ,
A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy, Nat. Chem. Biol, vol.10, pp.1013-1019, 2014. ,
Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells, Blood, vol.82, pp.1110-1119, 1993. ,
Isolation and Chromosomal Localization of a Novel FMS-like Tyrosine Kinase Gene, Distribution, vol.385, pp.380-385, 1991. ,
Overexpression of p27BBP in head and neck carcinomas and their lymph node metastases, Head Neck, vol.26, pp.408-417, 2004. ,
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5, Cancer, vol.120, pp.127-141, 2010. ,
Autophagy modulation as a potential therapeutic target for diverse diseases, Nat. Rev. Drug Discov, vol.11, pp.709-730, 2012. ,
Mechanisms of autophagosome biogenesis, Curr. Biol, vol.22, pp.29-34, 2012. ,
, , vol.15, pp.741-750, 2014.
Autophagy regulation by nutrient signaling, Cell Res, vol.24, pp.42-57, 2014. ,
The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro, Blood, vol.87, pp.1317-1325, 1996. ,
Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia, Cell Cycle, vol.8, pp.3838-3847, 2009. ,
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.19090-19095, 2009. ,
Detailed Deletion Mapping of Chromosome 17q in Ovarian and Breast Cancers: 2-cM Region on 17q21.3 Often and Commonly Deleted in Tumors, Cancer Res, vol.53, pp.3382-3385, 1993. ,
Peroxisome Degradation by Microautophagy in, Cell, vol.141, pp.625-636, 1998. ,
A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia, Blood Cancer J, vol.5, p.297, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01219119
Autophagy is required for self-renewal and differentiation of adult human stem cells, Cell Res, vol.22, pp.432-435, 2012. ,
Expression of a Highly Conserved Protein , p27 BBP , during the Progression of Human Colorectal Cancer, Cancer Res, vol.60, pp.510-516, 2000. ,
FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo, vol.117, pp.3286-3293, 2012. ,
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy, EMBO J, vol.28, pp.1341-1350, 2009. ,
FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins, Oncogene, vol.23, pp.3338-3349, 2004. ,
Translational control is required for the unfolded protein response and in vivo glucose homeostasis, Mol. Cell, vol.7, pp.1165-1176, 2001. ,
Differential impact of allelic ratio and insertion site in FLT3 -ITD -positive AML with respect to allogeneic transplantation, vol.124, pp.3441-3450, 2015. ,
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FABsubtype, and prognosis in theAMLCGstudy and usefulness as a marker for the detection of minimal residual disease, Blood, vol.100, pp.59-67, 2002. ,
the Mammalian Unfolded Protein Response, Annu. Rev. Biochem, vol.74, pp.739-789, 2005. ,
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors, J. Biol. Chem, vol.282, pp.4094-4101, 2007. ,
The morphology of various types of cell death in prenatal tissues, Teratology, vol.7, pp.253-266, 1973. ,
, , 2014.
, Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2, PLoS Genet, vol.10
Requirement of transcription factor PU.1 in the development of multiple hematopietic lineages, Science, vol.265, pp.1573-1577, 1994. ,
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations, J. Clin. Invest, vol.123, pp.3664-3671, 2013. ,
, , vol.9, pp.563-575, 2010.
Phosphoinositide 3-kinase : the key switch mechanism in insulin signalling, Biochem. J, vol.333, pp.471-490, 1998. ,
Interleukin-3 and Flt3-Ligand Induce Adhesion of Baf3/Flt3 Precursor B-Lymphoid Cells to Fibronectin via Activation of VLA-4 and VLA-5, Cell. Immunol, vol.187, pp.27-33, 1998. ,
Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia : a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse, vol.100, pp.2387-2392, 2002. ,
Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress, Neurosci. Lett, vol.409, pp.192-195, 2006. ,
Targeting the ATF4 pathway in cancer therapy, Expert Opin. Ther. Targets, vol.16, pp.1189-1202, 2012. ,
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene, J. Biol. Chem, vol.277, pp.24120-24127, 2002. ,
, , vol.485, pp.260-263, 2012.
Protein kinase C-beta II (PKC-??II) expression in patients with colorectal cancer, Int. J. Colorectal Dis, vol.24, pp.641-645, 2009. ,
The role of FLT3 in haematopoietic malignancies, Nat. Rev. Cancer, vol.3, pp.650-665, 2003. ,
Brief report Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia, vol.107, pp.3724-3726, 2006. ,
, Protein Kinase B, vol.277, pp.567-570, 1997.
, , 2016.
, Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia, J. Clin. Endocrinol. Metab, vol.128, pp.931-943
Regulation of autophagy by Forkhead box (FOX) O transcription factors, Adv. Biol. Regul, vol.52, pp.122-136, 2012. ,
ATF4 regulates lipid metabolism and thermogenesis, Cell Res, vol.20, pp.174-184, 2010. ,
Effects of ATF4 on PGC1? expression in brown adipose tissue and metabolic responses to cold stress, Metabolism, vol.62, pp.282-289, 2013. ,
, , vol.154, pp.1269-1284, 2014.
Reversible resistance induced by FLT3 inhibition: A novel resistance mechanism in mutant FLT3-Expressing cells, PLoS One, vol.6, 2011. ,
Stem cells: units of development, units of regeneration, and units in evolution, Cell, vol.100, pp.157-168, 2000. ,
, STEM AND P ROGENITOR C ELLS : Origins , and Transdifferentiations, pp.387-403, 2001.
The origin and evolution of mutations in acute myeloid leukemia, Cell, vol.150, pp.264-278, 2012. ,
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia, vol.122, pp.3521-3532, 2013. ,
PKR; a sentinel kinase for cellular stress, Oncogene, vol.18, pp.6112-6120, 1999. ,
Flt3 ligand: role in control of hematopoietic and immune functions of the bone marrow, News Physiol. Sci, vol.18, pp.247-251, 2003. ,
Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia, Mol. Cell. Biol, vol.31, pp.1870-1884, 2011. ,
The ULK1 complex sensing nutrient signals for autophagy activation, Autophagy, vol.9, pp.124-137, 2013. ,
The role of mutations in epigenetic regulators in myeloid malignancies, Immunol. Rev, vol.263, pp.22-35, 2015. ,
,
, Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy, Aging (Albany. NY), vol.1, pp.425-437
Autophagy contributes to dasatinibinduced myeloid differentiation of human acute myeloid leukemia cells, Biochem. Pharmacol, vol.89, pp.74-85, 2014. ,
Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform, J. Biomol. Screen, vol.1087057116639202, 2016. ,
Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children, Br J Haematol, vol.105, pp.155-162, 1999. ,
, , 2014.
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: Implication for Coffin-Lowry syndrome, Cell, vol.117, pp.387-398, 2004. ,
The FLT3 internal tandem duplication mutation prevents apoptosis in interleukin-3-deprived BaF3 cells due to protein kinase A and ribosomal S6 kinase 1-mediated BAD phosphorylation at serine 112, Cancer Res, vol.65, pp.7338-7347, 2005. ,
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors, Nature, vol.323, pp.226-232, 1986. ,
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation, EMBO J, vol.29, pp.2082-2096, 2010. ,
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response, J. Cell Biol, vol.172, pp.565-575, 2006. ,
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD specific STAT5 activation, Blood, vol.114, pp.5034-5043, 2009. ,
Autophagy mediates the mitotic senescence transition, Genes Dev, vol.23, pp.798-803, 2009. ,
Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor, Cell, vol.130, pp.323-334, 2007. ,
, , 2008.
, Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia, J. Biol. Chem, vol.283, pp.10892-10903
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling, J. Exp. Med, vol.192, pp.719-728, 2000. ,
Further activation of FLT3 mutants by FLT3 ligand, Oncogene, vol.30, pp.4004-4014, 2011. ,
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML, Blood, vol.113, pp.4052-4062, 2009. ,
Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway, J. Biol. Chem, vol.289, pp.30567-30577, 2014. ,