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Etude médico-économique de la prise en charge des Accidents Vasculaires Cérébraux au Liban : Coût de la maladie, Qualité de vie et Mortalité.

Abstract : Stroke is a disease with high morbidity and mortality rates, classified among the most common causes of death and acquired disability worldwide. Thus, assessing its epidemiology may play a crucial role in reducing its impact on the population and the society. Stroke late burden is attributable to developing countries mainly, as people in developed countries have a better access to optimal care and an increased awareness on stroke symptoms and risk factors. However, in less developed countries, where population confronts the huge impact of urbanization and globalization with a great increase in the prevalence of cardiovascular risk factors, the incidence of stroke remains high. Lebanon is lacking data on the epidemiology of stroke. Therefore, it was necessary to conduct this study and highlight some features of the disease epidemiology.We carried out a multicenter prospective incidence-based cohort study. We included 203 participants aged 18 years and more from 8 hospitals in Beirut between August 2015 and August 2016 with confirmed diagnosis of stroke. Patients were followed for a 1-year period (at hospital admission and discharge, and by home visits at 3, 6 and 12 months).Hypertension was the most powerful and prevalent risk factor for stroke. Only 2.5% of ischemic strokes received thrombolytic therapy. Cumulative mortality rates were 13.3% at 1-month and 21.2% at 1-year. Stroke severity and complications were predictors of death at 1-month and 1-year. Low socioeconomic status, dependency in daily living activities, and co-morbidities were additional 1-year mortality predictors. The quality of life was relatively low in stroke patients and more than 15% of them were depressed. The main determinants of quality of life were functional status, dependency in daily living activities, age, and depression. The main determinants of depression were functional status and quality of life. The direct in-hospital cost for all cases was 1,413,069 US dollars for 2626 days (538 US dollars per in-hospital day). The average in-hospital cost per stroke patient was 6961±15,663 US dollars. Hemorrhagic strokes were the most costly, transient ischemic attack being the least costly. Cost drivers were hospital and intensive care unit length of stay, type of stroke, stroke severity, modified Rankin Scale, third party payer, surgery and infectious complications.Primary prevention is of paramount importance in reducing the burden of stroke. Awareness campaigns on stroke symptoms especially among hypertensive population would help limit the incidence of the disease and therefore decrease the high financial and social burden of stroke (cost of illness and quality of life). The establishment of stroke units and increasing the percentage of thrombolysis may reduce short-term mortality and long term disabilities and therefore improve the quality of life of stroke patients.
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Submitted on : Tuesday, August 27, 2019 - 4:28:06 PM
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Rachel Abdo. Etude médico-économique de la prise en charge des Accidents Vasculaires Cérébraux au Liban : Coût de la maladie, Qualité de vie et Mortalité.. Médecine humaine et pathologie. Université Paris-Est; Université libanaise, 2018. Français. ⟨NNT : 2018PESC0072⟩. ⟨tel-02272334⟩



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