B. C. Abbott, A. Siger, and M. Spigelstein, Toxins from the blooms of Gymnodinium breve, Proceedings of the First International Conference on Toxic Dinoflagellate Blooms. Massachusetts Science and Technology Foundation, p.355, 1975.

R. I. Newell, Ecosystem influences of natural and cultivated populations of suspensionfeeding bivalve molluscs: a review, J. Shellfish Res, vol.23, issue.1, pp.51-62, 2004.

R. I. Newell and S. J. Jordan, Preferential ingestion of organic material by the American oyster Crassostrea virginica, Mar. Ecol. Prog. Ser, vol.13, issue.1, pp.47-53, 1983.

J. Nicolas, P. J. Hendriksen, A. Gerssen, T. F. Bovee, and I. M. Rietjens, Marine neurotoxins: State of the art, bottlenecks, and perspectives for mode of action based methods of detection in seafood, Mol. Nutr. Food Res, vol.58, issue.1, pp.87-100, 2014.

A. Nozawa, K. Tsuji, and H. Ishida, Implication of brevetoxin B1 and PbTx-3 in neurotoxic shellfish poisoning in New Zealand by isolation and quantitative determination with liquid chromatographytandem mass spectrometry, Toxicon, vol.42, issue.1, pp.91-103, 2003.

P. Otero, S. P?rez, A. Alfonso, C. Vale, P. Rodr?guez et al., First toxin profile of ciguateric fish in Madeira Arquipelago (Europe), Anal. Chem, vol.82, issue.14, pp.6032-6039, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00506113

K. V. Palmer, The Veneridae of eastern, America. Cenozoic and Recent. Palaeontogr. Americana, vol.1, issue.5, pp.209-522, 1927.

J. A. Pechenik, Environmental influences on larval survival and develop-ment, pp.551-608, 1987.

A. Pérez-gómez, A. Ferrero-gutierrez, A. Novelli, J. M. Franco, B. Paz et al., Potent neurotoxic action of the shellfish biotoxin yessotoxin on cultured cerebellar neurons, Toxicol. Sci, vol.90, issue.1, pp.168-177, 2006.

A. Persson, B. C. Smith, S. Morton, A. Shuler, and G. H. Wikfors, Sexual life stages and temperature dependent morphological changes allow cryptic occurrence of the Florida red tide dinoflagellate Karenia brevis, Harmful Algae, vol.30, pp.1-9, 2013.

S. P. Pshenichkin and B. C. Wise, Okadaic acid increases nerve growth factor secretion, mRNA stability, and gene transcription in primary cultures of cortical astrocytes, J. Biol. Chem, vol.270, issue.11, pp.5994-5999, 1995.

R. H. Pierce and M. Henry, Harmful algal toxins of the Florida red tide (Karenia brevis): natural chemical stressors in South Florida coastal ecosystems, Ecotoxicol, vol.17, issue.7, pp.623-631, 2008.

R. Pierce, M. Henry, and P. Blum, Brevetoxin abundance and composition during ECOHABFlorida field monitoring cruises in the Gulf of Mexico, Continental Shelf Res, vol.28, issue.1, pp.45-58, 2008.

R. H. Pierce, R. S. Henry, R. Dickey, and S. Plakas, NSP Toxins and metabolites in oysters, clams and whelks, pp.294-296, 2002.

R. H. Pierce, M. Henry, P. Blum, and S. Payne, Gymnodinium breve toxins without cells: intracellular and extra-cellular toxins, Harmful Algal Blooms, pp.421-424, 2001.

R. H. Pierce, M. S. Henry, L. S. Proffitt, and P. A. Hasbrouck, Red tide toxin (brevetoxin) enrichment in marine aerosol, Toxic Marine Phytoplankton. Elsivere, 1990.

. Amsterdam, , pp.397-402

G. A. Rounsefell and W. R. Nelson, Red-tide research summarized to 1964 including an annotated bibliography. In: United States Department of the interior Fish and Wildlife Service, Contribution number 20. Bureau of CommercialFisheries Special Scientific Report. Fisheries number 535, pp.1-85, 1966.

J. Royer, C. Seguineau, K. I. Park, S. Pouvreau, K. S. Choi et al., Gametogenetic cycle and reproductive effort assessed by two methods in 3 age classes of Pacific oysters, Crassostrea gigas, reared in Normandy, Aquaculture, vol.277, issue.3, pp.313-320, 2008.

J. L. Ruesink, H. S. Lenihan, A. C. Trimble, K. W. Heiman, F. Micheli et al., Introduction of non-native oysters: ecosystem effects and restoration implications, Annu. Rev. Ecol. Evol. Syst, vol.36, pp.643-89, 2005.

T. Seki, M. Satake, L. Mackenzie, H. F. Kaspar, and T. Yasumoto, Gymnodimine, a new marine toxin of unprecedented structure isolated from New Zealand oysters and the dinoflagellate, Gymnodinium sp, Tetrahedron Lett, vol.36, issue.39, pp.7093-7096, 1995.

M. Shen, J. Xu, T. Y. Tsang, and D. W. Au, Toxicity comparison between Chattonella marina and Karenia brevis using marine medaka ( Oryzias melastigma): Evidence against the suspected ichthyotoxins of Chattonella marina, Chemosphere, vol.80, issue.5, pp.585-591, 2010.

P. F. Sheridan, Comparative habitat utilization by estuarine macrofauna within the mangrove ecosystem of Rookery Bay, Florida. Bull. Mar. Sci, vol.50, issue.1, pp.21-39, 1992.

F. Shi, P. Mcnabb, L. Rhodes, P. Holland, S. Webb et al., The toxic effects of three dinoflagellate species from the genus Karenia on invertebrate larvae and finfish, New Zealand J. Mar. and Freshwater Res, vol.46, issue.2, pp.149-165, 2012.

Y. Shimizu, H. N. Chou, H. Bando, G. Van-duyne, and J. Clardy, Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis), J. Am. Chem. Soc, vol.108, issue.3, pp.514-515, 1986.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aquaculture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

S. E. Shumway, T. L. Cucci, L. Gainey, and C. M. Yentsch, A preliminary study of the behavioral and physiological effects of Gonyaulax tamarensis on bivalve molluscs.Toxic Dinoflagellates, pp.389-394, 1985.

A. M. Sievers, Comparative toxicity of Gonyaulax monilata and Gymnodinium breve to annelids, crustaceans, molluscs and a fish, J. Protozool, vol.16, issue.3, pp.401-404, 1969.

J. L. Simon and D. M. Dauer, A quantitative evaluation of red-tide induced mass mortalities of benthic invertebrates in Tampa Bay, Florida. Environ. Lett, vol.3, issue.4, pp.229-234, 1972.

R. E. Sipler, L. R. Mcguinness, G. J. Kirkpatrick, L. J. Kerkhof, and O. M. Schofield, Bacteriocidal effects of brevetoxin on natural microbial communities, Harmful Algae, vol.38, pp.101-109, 2014.

T. J. Smayda, Harmful algal blooms: their ecophysiology and general relevance to phytoplankton blooms in the sea, Limnol. Oceanogr, vol.42, issue.5, pp.1137-1153, 1997.

M. J. Snyder, Cytochrome P450 enzymes in aquatic invertebrates: Recent advances and future directions, Aquat. Toxicol, vol.48, pp.529-547, 2000.

P. Soletchnik, D. Razet, P. Geairon, N. Faury, and P. Goulletquer, Ecophysiology of maturation and spawning in oyster Crassostrea gigas: metabolic (respiration) and feeding (clearance and absorption rates) responses at different maturation stages, Aquatic Living Res, vol.10, pp.177-185, 1997.

T. J. Starr, Notes on a toxin from Gymnodinium breve, Tex. Rep. Biol. Med, vol.16, pp.500-507, 1958.

K. A. Steidinger, Historical perspective on Karenia brevis red tide research in the Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.549-561, 2009.

K. A. Steidinger, J. H. Landsberg, L. J. Flewelling, B. A. Kirkpatrick, P. J. Walsh et al., Oceans and Human Health; Risks and Remedies From the Seas, pp.239-56, 2008.

K. A. Steidinger, J. L. Wolny, and A. J. Haywood, Identification of Kareniaceae (Dinophyceae) in the Gulf of Mexico (With 9 figures and 1 table), Nova Hedwigia Beihefte, vol.133, pp.269-84, 2008.

K. A. Steidinger, P. Carlson, D. Baden, C. Rodriguez, and J. Seagle, Neurotoxic shellfish poisoning due to toxin retention in the clam Chionecancellata, Xunta de Galicia, IOC, pp.457-458, 1998.

K. A. Steidinger, Some taxonomic and biological aspects of toxic dinoflagellates, Algal Toxins in Seafood and Drinking Water, pp.1-28, 1993.

K. A. Steidinger, Implications of dinoflagellate life cycles on initiation of Gymnodinium breve red tides, Environ. Lett, vol.9, issue.2, pp.129-139, 1975.

K. A. Steidinger, M. Burklew, and R. M. Ingle, The effects of Gymnodinium breve toxin on estuarine animals, Marine Pharmacognosy: Action of Marine Toxins at the Cellular Level, pp.179-202, 1973.

K. A. Steidinger and R. M. Ingle, Observations on the 1971 summer red tide in Tampa Bay, Florida. Environ. Lett, vol.3, issue.4, pp.271-278, 1972.

D. Stoecker, J. Adolf, A. Place, P. Glibert, and D. Meritt, Effects of the toxic dinoflagellate Karlodinium veneficum and Prorocentrum minimum on early life history stages of the eastern oyster (Crassostrea virginica), Mar. Biol, vol.154, pp.81-90, 2008.

R. P. Stumpf, R. W. Litaker, L. Lanerolle, and P. Tester, Hydrodynamic accumulation of Karenia off the west coast of Florida, Continental Shelf Res, vol.28, issue.1, pp.189-213, 2008.

R. P. Stumpf, V. Ransibrahmanakal, K. A. Steidinger, and P. A. Tester, Observations of sea surface temperature and winds in association with Florida USA red tides (Gymnodinium breve blooms). Harmful Algae, Proc. VIII International Conference on Harmful Algae, pp.145-148, 1997.

S. Sudaranam, G. Duke-virca, D. J. March, and S. Srinivasan, An approach to computer aided inhibitor design: application to cathepsin l, J Comput Aided Mol Des, vol.6, pp.223-233, 1992.

G. A. Vargo, A brief summary of the physiology and ecology of Karenia brevis Davis (G. Hansen and Moestrup comb. nov.) red tides on the West Florida Shelf and of hypotheses posed for their initiation, growth, maintenance, and termination, Harmful Algae, vol.8, issue.4, pp.573-584, 2009.

M. Van-deventer, K. Atwood, G. A. Vargo, L. J. Flewelling, J. H. Landsberg et al.,

, Karenia brevis red tides and brevetoxin-contaminated fish: a high risk factor for Florida's scavenging shorebirds?, Botanica Marina, vol.55, issue.1, pp.31-37

F. M. Van-dolah, K. B. Lidie, E. A. Monroe, D. Bhattacharya, L. Campbell et al., The Florida red tide dinoflagellate Karenia brevis: New insights into cellular and molecular processes underlying bloom dynamics, Harmful Algae, vol.8, issue.4, pp.562-572, 2009.

T. M. Vinagre, J. C. Alciati, F. Regoli, R. Bocchetti, J. S. Yunes et al., Effect of microcystin on ion regulation and antioxidant system in gills of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae), Comp. Biochem. Physiol. C. Toxicol. Pharmacol, vol.135, issue.1, pp.67-75, 2003.

A. K. Volety, M. Savarese, S. G. Tolley, W. S. Arnold, P. Sime et al., Eastern oysters (Crassostrea virginica) as an indicator for restoration of everglades ecosystems, Ecol. Indic, vol.9, issue.6, pp.120-136, 2009.

A. K. Volety, Effects of salinity, heavy metals and pesticides on health and physiology of oysters in the Caloosahatchee Estuary, Florida. Ecotoxicol, vol.17, pp.579-590, 2008.

L. M. Walker, Evidence for a sexual cycle in the Florida red tide dinoflagellate, Ptychodiscus brevis (= Gymnodinium breve), Trans. Am. Microbiol. Soc, vol.101, pp.287-293, 1982.

L. Wang, T. Yan, and M. Zhou, Impacts of HAB species Heterosigma akashiwo on early development of the scallop Argopecten irradians Lamarck, Aquaculture, vol.255, pp.374-383, 2006.

J. E. Ward and S. E. Shumway, Separating the grain from the chaff: particle selection in suspension-and deposit-feeding bivalves, J. Exp. Mar. Biol. Ecol, vol.300, issue.1, pp.83-130, 2004.

J. E. Ward, J. S. Levinton, S. E. Shumway, and T. Cucci, Site of particle selection in a bivalve mollusc, Nature, vol.390, issue.6656, pp.131-132, 1997.

J. E. Ward, R. I. Newell, R. J. Thompson, and B. A. Macdonald, In vivo studies of suspensionfeeding processes in the eastern oyster, Crassostrea virginica (Gmelin), Biol. Bull, vol.186, issue.2, pp.221-240, 1994.

B. S. Washburn, D. G. Baden, N. J. Gassman, and P. J. Walsh, Brevetoxin: Tissue distribution and effect on cytochrome P450 enzymes in fish, Toxicon, vol.32, pp.799-805, 1994.

S. M. Watkins, A. Reich, L. E. Fleming, and R. Hammond, Neurotoxic shellfish poisoning, Mar. Drugs, vol.6, issue.3, pp.431-455, 2008.

C. Wazniak and P. Glibert, Potential impacts of brown tide, Aureococcus anophagefferens, on juvenile hard clams, Mercenaria mercenaria, in the Coastal Bays of Maryland, USA. Harmful Algae, vol.3, pp.321-329, 2004.

R. H. Weisberg, A. Barth, A. Alvera-azcárate, and L. Zheng, A coordinated coastal ocean observing and modeling system for the West Florida Continental Shelf, Harmful Algae, vol.8, issue.4, pp.585-597, 2009.

H. W. Wells, The fauna of oyster beds, with special reference to the salinity factor, Ecol. Monogr, vol.31, pp.239-266, 1961.

W. B. Wilson, Forms of the dinoflagellate Gymnodinium breve Davis in cultures, Contr. Mar. Sci. Univ. Texas, vol.13, pp.120-134, 1967.

T. Yan, M. Zhou, M. Fu, Y. Wang, R. Yu et al., Inhibition of egg hatching success and larvae survival of the scallop, Chlamys farreri, associated with exposure to cells and cell fragments of the dinoflagellate Alexandrium tamarense, Toxicon, vol.39, pp.1239-1244, 2001.

T. Yan, M. Zhou, M. Fu, R. Yu, Y. Wang et al., Effects of the dinoflagellate Alexandrium tamarense on early development of the scallop Argopecten irradians concentricus, Aquaculture, vol.217, pp.167-178, 2003.

C. M. Yonge, Oysters, Collins London, 1960.

T. Zhang, H. S. Yang, B. Z. Liu, Y. Liu, H. X. Wen et al., Primary study on modes of seed hard clam Mercenaria mercenaria (Linnaeus, 1758) culture in field, Oceanologia Et Limnologia Sinica, vol.34, issue.6, pp.648-655, 2003.

M. C. Alliegro and D. A. Wright, Polyspermy inhibition in the oyster, Crassostrea virginica, J. Exper. Zool, vol.227, issue.1, pp.127-137, 1983.

C. Arias-de-león, F. Lango-reynoso, J. Chávez-villalba, M. R. Castañeda-chávez, and S. C. Ramírez-gutiérrez, Oocyte cohort analysis: reproductive patterns of Crassostrea virginica (Bivalvia) in tropical lagoons of the Gulf of Mexico, Invertebr. Reprod. Dev, vol.57, issue.2, pp.85-94, 2013.

E. Bachère, Y. Gueguen, M. Gonzalez, J. De-lorgeril, J. Garnier et al., Insights into the anti-microbial defence of marine invertebrates: the penaeid shrimps and the oyster Crassostrea gigas, Immunol. Rev, vol.198, issue.1, pp.149-168, 2004.

D. G. Baden, A. J. Bourdelais, H. Jacocks, S. Michelliza, and J. Naar, Natural and derivative brevetoxins: historical background, multiplicity, and effects, Environ. Health Persp, vol.113, issue.5, pp.621-625, 2005.

D. G. Baden, Marine food-borne dinoflagellate toxins, Int. Rev. Cytol, vol.82, pp.99-150, 1983.

B. J. Barber, Neoplastic diseases of commercially important marine bivalves, Aquat. Living Resour, vol.17, issue.4, pp.449-466, 2004.

L. Basti, M. Endo, and S. Segawa, Physiological, Pathological, and Defense Alterations in Manila Clams (Short-Neck Clams), Ruditapes philippinarum, Induced by Heterocapsa circularisquama, J. Shellfish Res, vol.30, issue.3, pp.829-844, 2011.

L. E. Brand and A. Compton, Long-term increase in Karenia brevis abundance along the Southwest Florida Coast, Harmful Algae, vol.6, issue.2, pp.232-252, 2007.

V. M. Bricelj, .. G. Haubois, M. R. Sengco, R. H. Pierce, J. K. Culter et al., Trophic transfer of brevetoxins to the benthic macrofaunal community during a bloom of the harmful dinoflagellate Karenia brevis in Sarasota Bay, Florida. Harmful Algae, vol.16, pp.27-34, 2012.

V. M. Bricelj, L. Connell, K. Konoki, S. P. Macquarrie, T. Scheuer et al., Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP, Nature, vol.434, issue.7034, pp.763-767, 2005.

V. M. Bricelj and S. E. Shumway, Paralytic Shellfish Toxins in Bivalve Molluscs: Occurrence, Transfer Kinetics, and Biotransformation, vol.6, pp.315-383, 1998.

N. T. Brun, N. W. Ross, and A. D. Boghen, Changes in the electrophoretic profiles of gill mucus proteases of the eastern Oyster Crassostrea virginica in response to infection by the turbellarian Urastoma cyprinae, J. Invertebr. Pathol, vol.75, issue.2, pp.163-170, 2000.

M. D. Burkenroad, Sex in the Louisiana oyster, Ostrea virginica, Science, vol.74, pp.71-72, 1907.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Biology of the hard clam, vol.31, pp.77-115, 2001.

P. M. Da-silva, H. Hégaret, C. Lambert, G. H. Wikfors, N. Le-goïc et al., Immunological responses of the Manila clam (Ruditapes philippinarum) with varying parasite (Perkinsus olseni) burden, during a long-term exposure to the harmful alga, Karenia selliformis, and possible interactions, Toxicon, vol.51, issue.4, pp.563-73, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00470652

M. Delaporte, P. Soudant, J. Moal, E. Kraffe, Y. Marty et al., Incorporation and modification of dietary fatty acids in gill polar lipids by two bivalve species Crassostrea gigas and Ruditapes philippinarum, Comp. Biochem. Phys. A, vol.140, issue.4, pp.460-70, 2005.
URL : https://hal.archives-ouvertes.fr/hal-01763743

, Exposure of adult Crassostrea virginica to Karenia brevis

A. W. Griffith, S. E. Shumway, and A. K. Volety, Bioaccumulation and depuration of brevetoxins in the eastern oyster (Crassostrea virginica) and the northern quahog (= hard clam, Mercenaria mercenaria), Toxicon, vol.66, pp.75-81, 2013.

R. R. Guillard, Culture of phytoplankton for feeding marine invertebrates, pp.29-60, 1975.

G. Gunter, R. H. Williams, C. C. Davis, and F. W. Smith, Catastrophic mass mortality of marine animals and coincident phytoplankton bloom on the west coast of Florida, Ecol. Monogr, vol.18, pp.310-324, 1946.

H. Haberkorn, D. Tran, J. C. Massabuau, P. Ciret, V. Savar et al., Relationship between valve activity, microalgae concentration in the water and toxin accumulation in the digestive gland of the Pacific oyster Crassostrea gigas exposed to Alexandrium minutum, Mar. Pollut. Bull, vol.62, issue.6, pp.1191-1197, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00596808

H. Haberkorn, C. Lambert, N. Le-goïc, M. Guéguen, J. Moal et al., Effects of Alexandrium minutum exposure upon physiological and hematological variables of diploid and triploid oysters, Crassostrea gigas, Aquat. Toxicol, vol.97, issue.2, pp.96-108, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00589357

H. Haberkorn, C. Lambert, N. Le-goïc, J. Moal, M. Suquet et al., Effects of Alexandrium minutum exposure on nutrition-related processes and reproductive output in oysters Crassostrea gigas, Harmful Algae, vol.9, issue.5, pp.427-439, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00589386

L. E. Haley, Sex determination in the American oyster, J. Hered, vol.68, issue.2, pp.114-116, 1977.

J. M. Harding, E. N. Powell, R. Mann, and M. J. Southworth, Variations in eastern oyster (Crassostrea virginica) sex-ratios from three Virginia estuaries: protandry, growth and demographics, J. Mar. Biol. Assoc. U.K, vol.93, issue.2, pp.519-531, 2013.

P. F. Hayes and R. W. Menzel, The reproductive cycle of early setting Crassostrea virginica (Gmelin) in the northern Gulf of Mexico, and its implications for population recruitment, Biol. Bull, vol.160, issue.1, pp.80-88, 1981.

H. Hégaret, P. M. Da-silva, I. Sunila, S. E. Shumway, M. S. Dixon et al., Perkinsosis in the Manila clam Ruditapes philippinarum affects responses to the harmful-alga, Prorocentrum minimum, J. Exp. Mar. Biol. Ecol, vol.371, issue.2, pp.112-120, 2009.

J. Marshall, T. Ross, S. Pyecroft, and G. Hallegraeff, Superoxide production by marine microalgae 2: Towards understanding ecological consequences and possible functions, Mar. Biol, vol.147, pp.541-549, 2005.

R. Martoja and M. Martoja-pierson, Initiation aux techniques de l'histologie animale, 1967.

S. P. May, J. M. Burkholder, S. E. Shumway, H. Hégaret, G. H. Wikfors et al., Effects of the toxic dinoflagellate Alexandrium monilatum on survival, grazing and behavioral response of three ecologically important bivalve molluscs, Harmful Algae, vol.9, issue.3, pp.281-293, 2010.

E. F. Mcfarren, H. Tanabe, F. J. Silva, W. B. Wilson, J. E. Campbell et al., The occurrence of a ciguatera-like poison in oysters, clams and Gymnodinium breve cultures, Toxicon, vol.3, pp.111-123, 1965.

W. Medhioub, P. Lassus, P. Truquet, M. Bardouil, Z. Amzil et al.,

, Spirolide uptake and detoxification by Crassostrea gigas exposed to the toxic dinoflagellate Alexandrium ostenfeldii, Aquaculture, vol.358, pp.108-115

D. F. Mello, E. S. De-oliveira, R. C. Vieira, E. Simoes, R. Trevisan et al., Cellular and Transcriptional Responses of Crassostrea gigas Hemocytes Exposed in Vitro to Brevetoxin (PbTx-2), Mar. Drugs, vol.10, pp.583-597, 2012.

B. Morton, Feeding and digestion in Bivalvia, The Mollusca, vol.2, pp.65-340, 1983.

J. Naar, A. Bourdelais, C. Tomas, J. Kubanek, P. L. Whitney et al., A competitive ELISA to detect brevetoxins from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid, Environ. Health Perspect, vol.110, issue.2, pp.179-185, 2002.

A. B. Needler, Sex reversal in Ostrea virginica, Contrib. Can. Biol. Fish, vol.7, issue.1, pp.283-294, 1932.

T. Neely and L. Campbell, A modified assay to determine hemolytic toxin variability among Karenia clones isolated from the Gulf of Mexico, Harmful Algae, vol.5, pp.592-598, 2006.

. Nssp, National Shellfish Sanitation Program (NSSP) Guide for the Control of Molluscan Shellfish. 2011 Revision U. S. Department of Health and Human Services Public Health Service Food and Drug Administration Interstate Shellfish Sanitation Conference, 2011.

C. C. Parrish, G. Bodennec, and P. Gentien, Haemolytic glycoglycerolipids from Gymnodinium species, Phytochemistry, vol.47, issue.5, pp.783-787, 1998.

R. Pierce, M. Henry, and P. Blum, Brevetoxin abundance and composition during ECOHABFlorida field monitoring cruises in the Gulf of Mexico, Continental Shelf Res, vol.28, pp.45-58, 2008.

R. Pierce, M. Henry, P. Blum, and S. Payne, Gymnodinium breve toxins withoutcells: intra-cellular and extra-cellular toxins, Harmful Algal Blooms. Intergovernmental Oceano-graphic Commission of UNESCO, pp.421-424, 2001.

S. M. Plakas, E. L. Jester, K. R. El-said, H. R. Granade, A. Abraham et al., Monitoring of brevetoxins in the Karenia brevis bloom-exposed Eastern oyster (Crassostrea virginica), Toxicon, vol.52, issue.1, pp.32-38, 2008.

, Exposure of adult Crassostrea virginica to Karenia brevis

S. M. Plakas, Z. H. Wang, K. R. El-said, E. L. Jester, H. R. Granade et al., Brevetoxin metabolism and elimination in the Eastern oyster (Crassostrea virginica) after controlled exposures to Karenia brevis, Toxicon, vol.44, pp.677-685, 2004.

S. M. Plakas, K. R. El-said, E. L. Jester, H. R. Granade, S. M. Musser et al., Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures, Toxicon, vol.40, pp.721-729, 2002.

M. A. Poli, S. M. Musser, R. W. Dickey, P. P. Eilers, and S. Hall, Neurotoxic shellfish poisoning and brevetoxin metabolites: A case study from Florida, Toxicon, vol.38, issue.7, pp.981-993, 2000.

E. K. Prince, K. L. Poulson, T. L. Myers, R. D. Sieg, and J. Kubanek, Characterization of allelopathic compounds from the red tide dinoflagellate Karenia brevis, Harmful Algae, vol.10, pp.39-48, 2010.

S. M. Ray and D. V. Aldrich, Ecological interactions of toxic dinoflagellates and molluscs in the Gulf of Mexico, Animal Toxins, pp.75-83, 1967.

A. Rolton, P. Soudant, J. Vignier, R. Pierce, M. Henry et al., Susceptibility of gametes and embryos of the eastern oyster, Crassostrea virginica, to Karenia brevis and its toxins, Toxicon, vol.99, pp.6-15, 2015.

A. Rolton, J. Vignier, P. Soudant, S. E. Shumway, V. M. Bricelj et al., Effects of the red tide dinoflagellate, Karenia brevis, on early development of the eastern oyster Crassostrea virginica and northern quahog Mercenaria mercenaria, Aquat. Toxicol, vol.155, pp.199-206, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01056612

M. R. Sengco, Review Prevention and control of Karenia brevis blooms, Harmful Algae, vol.8, pp.623-628, 2009.

B. .. Shaw and H. I. Battle, The gross and microscopic anatomy of the digestive tract of the oyster Crassostrea virginica (Gmelin), Can. J. Zool, vol.35, pp.325-347, 1957.

S. E. Shumway, Phycotoxin-related shellfish poisoning: Bivalve molluscs are not the only vectors, Rev. Fish. Sci, vol.3, issue.1, pp.1-31, 1995.

S. E. Shumway and L. F. Gainey, A review of physiological effects of toxic dinoflagellates on bivalve molluscs, Proceedings of Ninth International Malac. Congress, pp.357-362, 1992.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aquaculture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

S. E. Shumway, T. L. Cucci, L. Gainey, and C. M. Yentsch, A preliminary study of the behavioral and physiological effects of Gonyaulax tamarensis on bivalve mollusks, Toxic dinoflagellates, pp.389-394, 1985.

A. M. Sievers, Comparative toxicity of Gonyaulax monilata and Gymnodinium breve to annelids, crustaceans, molluscs and a fish, J. Protozool, vol.16, issue.3, pp.401-404, 1969.

J. L. Simon and D. M. Dauer, A quantitative evaluation of red-tide induced mass mortalities of benthic invertebrates in Tampa Bay, Florida. Environ. Lett, vol.3, issue.4, pp.229-234, 1972.

P. A. Anderson, J. Roberts-misterly, and R. M. Greenberg, The evolution of voltage-gated sodium channels: were algal toxins involved, Harmful Algae, vol.4, pp.95-107, 2005.

J. Andrews, Sea shells of the Texas coast, p.285, 1971.

L. Basti, M. Endo, and S. Segawa, Physiological, pathological, and defense alterations in Manila clams (short-neck clams), Ruditapes philippinarum, induced by Heterocapsa circularisquama, J. Shellfish Res, vol.30, issue.3, pp.829-844, 2011.

L. E. Brand and A. Compton, Long-term increase in Karenia brevis abundance along the Southwest Florida Coast, Harmful Algae, vol.6, issue.2, pp.232-252, 2007.

V. M. Bricelj, A. G. Haubois, M. R. Sengco, R. H. Pierce, J. K. Culter et al., Trophic transfer of brevetoxins to the benthic macrofaunal community during a bloom of the harmful dinoflagellate Karenia brevis in Sarasota Bay, Florida. Harmful Algae, vol.16, pp.27-34, 2012.

V. M. Bricelj and S. E. Shumway, Paralytic shellfish toxins in bivalve molluscs: occurrence, transfer kinetics, and biotransformation, Rev. Fish. Sci, vol.6, issue.4, pp.315-383, 1998.

V. M. Bricelj, J. H. Lee, A. Cembella, and D. M. Anderson, Uptake of Alexandrium fundyense by Mytilus edulis and Mercenaria mercenaria under controlled conditions, Toxic Marine Phytoplankton, pp.269-274, 1990.

V. M. Bricelj, Fecundity and related aspects of the hard clam (Mercenaria mercenaria) reproduction in Great South Bay, 1979.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Dev. Aquac. Fish. Sci, vol.31, pp.77-115, 2001.

H. A. Chebib, A. D. Cembella, and P. Anderson, Differential paralytic shellfish toxin accumulation and detoxification kinetics in transplanted populations of Mytilus edulis exposed to natural blooms of Alexandrium excavatum, Toxic Phytoplankton Blooms in the Sea, pp.383-388, 1993.

J. M. Cummins, A. C. Jones, and A. A. Stevens, Occurrence of toxic bivalve molluscs during a Gymnodinium breve "red tide, T. Am. Fish. Soc, vol.100, issue.1, pp.112-116, 1971.

A. Rolton, J. Vignier, P. Soudant, L. Donaghy, S. Shumway et al., prep a. Short and long-term effects of Karenia brevis exposure on Crassostrea virginica: Toxin accumulation and histopathological responses in adults

A. Rolton, J. Vignier, P. Soudant, A. Barbe, S. E. Shumway et al., in prep b. Transfer of brevetoxin to the gametes of eastern oysters (Crassostrea virginica) and northern quahogs (= hard clam, Mercenaria mercenaria)

M. R. Sengco, Prevention and control of Karenia brevis blooms, Harmful Algae, vol.8, issue.4, pp.623-628, 2009.

A. M. Sievers, Comparative toxicity of Gonyaulax monilata and Gymnodinium breve to annelids, crustaceans, molluscs and a fish, J. Protozool, vol.16, issue.3, pp.401-404, 1969.

J. L. Simon and D. M. Dauer, A quantitative evaluation of red-tide induced mass mortalities of benthic invertebrates in Tampa Bay, Florida. Environ. Lett, vol.3, issue.4, pp.229-234, 1972.

B. .. Shaw and H. I. Battle, The gross and microscopic anatomy of the digestive tract of the oyster Crassostrea virginica (Gmelin), Can. J. Zoolog, pp.325-347, 1957.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

R. Smolowitz and S. E. Shumway, Possible cytotoxic effects of the dinoflagellate, Gyrodinium aureolum, on juvenile bivalve molluscs, Aquacult. Int, vol.5, issue.4, pp.291-300, 1997.

P. Soudant, C. Paillard, G. Choquet, C. Lambert, H. I. Reid et al., Impact of season and rearing site on the physiological and immunological parameters of the Manila clam Venerupis (=Tapes, =Ruditapes) philippinarum, Aquaculture, vol.229, issue.1-4, pp.401-418, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00590963

K. A. Steidinger, Historical perspective on Karenia brevis red tide research in the Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.549-561, 2009.

, Census of Aquaculture 2005: United States Summary and State Data, Geographic Area Series. Part, vol.51, pp.59-65, 2002.

S. D. Utting and B. E. Spencer, The hatchery culture of bivalve mollusc larvae and juveniles. Laboratory leaflet no. 68. Ministry of Agriculture, fisheries and food. Directorate of fisheries research, p.31, 1991.

J. M. Whetstone, L. N. Sturmer, and M. J. Oesterling, Biology and culture of the Hard Clam, Southern Regional Aquaculture Center, issue.433, pp.1-6, 2005.

G. H. Wikfors and R. M. Smolowitz, Detrimental effects of a Prorocentrum isolate upon hard clams and bay scallops in laboratory feeding studies, Dev. Mar. Biol, 1993.

Y. Zou, Y. Yamasaki, Y. Matsuyama, K. Yamaguchi, T. Honjo et al., Possible involvement of hemolytic activity in the contact-dependent lethal effects of the dinoflagellate Karenia mikimotoi on the rotifer Brachionus plicatilis, Harmful Algae, vol.9, pp.367-373, 2010.

D. A. Apeti, Y. Kim, G. Lauenstein, J. Tull, and R. Warner, Occurrence of Parasites and Diseases in Oysters and Mussels of the U.S. Coastal Waters. National Status and Trends, the Mussel Watch monitoring program. NOAA Technical Memorandum NOSS/NCCOS 182, 2014.

D. G. Baden, L. E. Fleming, and J. A. Bean, Marine toxins. Handbook of clinical neurology, Intoxications of the Nervous System, Part II. Elservier Science B.V, vol.21, pp.141-175, 1995.

D. G. Baden and C. R. Tomas, Variations in major toxin composition for six clones of Ptychodiscus brevis, Toxicon, vol.26, issue.10, pp.961-963, 1988.

D. G. Baden, T. J. Mende, G. Bikhazi, and I. Leung, Bronchoconstriction caused by Florida red tide toxins, Toxicon, vol.20, pp.929-932, 1982.

B. J. Barber and N. J. Blake, Intra-organ biochemical transformations associated with oogenesis in the bay scallop, Argopecten irradians concentricus (Say), as indicated by 14C incorporation, Biol. Bull, vol.168, issue.1, pp.39-49, 1985.

J. M. Benson, A. P. Gomez, G. L. Statom, B. M. Tibbetts, L. E. Fleming et al., Placental transport of brevetoxin-3 in CD-1 mice, Toxicon, vol.48, issue.8, pp.1018-1026, 2006.

V. M. Bricelj, Fecundity and related aspects of the hard clam (Mercenaria mercenaria) reproduction in Great South Bay, 1979.

N. T. Brun, N. W. Ross, and A. D. Boghen, Changes in the electrophoretic profiles of gill mucus proteases of the eastern oyster Crassostrea virginica in response to infection by the Turbellarian, Urastoma cyprinae, J. Invert. Pathol, vol.75, issue.2, pp.163-170, 2000.

E. W. Cake and R. W. Menzel, Infections of Tylocephalum metacestodes in commercial oysters and three predaceous gastropods of the eastern Gulf of Mexico, P. Nat. Shellfisheries Assoc, vol.70, issue.1, pp.94-104, 1980.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Biology of the hard clam, vol.31, pp.77-115, 2001.

M. R. Carriker, The Eastern Oyster Crassostrea virginica. Maryland Sea Grant College, pp.75-168, 1996.

F. L. Chu, P. Soudant, L. A. Cruz-rodr??uez, and R. C. Hale, PCB uptake and accumulation by oysters (Crassostrea virginica) exposed via a contaminated algal diet, Mar. Environ. Res, vol.50, issue.1, pp.217-221, 2000.

M. Delaporte, P. Soudant, J. Moal, C. Lambert, C. Quéré et al., Effect of a mono-specific algal diet on immune functions in two bivalve species Crassostrea gigas and Ruditapes philippinarum, J. Exp. Biol, vol.206, issue.17, pp.3053-3064, 2003.
URL : https://hal.archives-ouvertes.fr/hal-01154278

S. S. Desser, S. M. Bower, and H. Hong, Pseudoklossia semiluna N. sp.(Apicomplexa: Aggregatidae): A coccidian parasite of the kidney of blue missels, species of Mytilus, from British Columbia, Canada. Parasite, vol.5, issue.1, pp.17-22, 1998.

R. W. Dickey, S. M. Plakas, E. L. Jester, K. R. Said, . El et al., Multi-Laboratory Study of Five Methods for the Determination of Brevetoxins in Shellfish Tissue Extracts, Proceedings of the Xth International Conference on Harmful Algae. Florida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and the Intergovernmental Oceanographic Commission of UNESCO, pp.300-302, 2002.

Q. Dong, B. Eudeline, C. Huang, and T. R. Tiersch, Standardization of photometric measurement of sperm concentration from diploid and tetraploid Pacific oysters, 2005.

, Aquac. Res, vol.36, issue.1, pp.86-93

J. S. Edmunds, R. Mccarthy, and J. S. Ramsdell, Ciguatoxin reduces larval survivability in finfish, Toxicon, vol.37, issue.12, pp.1827-1832, 1999.

N. Estrada, M. De-jesús-romero, A. Campa-córdova, A. Luna, and F. Ascencio, Effects of the toxic dinoflagellate, Gymnodinium catenatum on hydrolytic and antioxidant enzymes, in tissues of the giant lions-paw scallop Nodipecten subnodosus, Comp. Biochem. Phys. C, vol.146, issue.4, pp.502-510, 2007.

A. G. Eversole, Gametogenesis of Mercenaria mercenaria, M. campechiensis and their hybrids, Nautilus, vol.110, issue.4, pp.107-110, 1997.

W. S. Fisher, J. T. Winstead, L. M. Oliver, H. L. Edmiston, and G. O. Bailey, Physiologic variability of eastern oysters from Apalachicola Bay, Florida.J. Shellfish Res, vol.15, issue.3, pp.543-553, 1996.

W. S. Fisher, Occurrence of agglutinins in the pallial cavity mucus of oysters, J. Exp. Mar. Biol. Ecol, vol.162, issue.1, pp.1-13, 1992.

L. J. Flewelling, D. H. Adams, J. P. Naar, K. E. Atwood, A. A. Granholm et al., Brevetoxins in sharks and rays (Chondrichthyes, Elasmobranchii) from Florida coastal waters, Mar. Biol, vol.157, issue.9, pp.1937-1953, 2010.

C. S. Friedman, G. R. Gardner, R. P. Hedrick, M. Stephenson, R. J. Cawthorn et al., Pseudoklossia haliotis sp. n.(Apicomplexa) from the Kidney of California Abalone, Haliotis spp.(Mollusca), J. Invert. Path, vol.66, issue.1, pp.33-38, 1995.

E. Galimany, A. R. Place, M. Ramón, M. Jutson, and R. K. Pipe, The effects of feeding Karlodinium veneficum (PLY # 103; Gymnodinium veneficum Ballantine) to the blue mussel Mytilus edulis, Harmful Algae, vol.7, issue.1, pp.91-98, 2008.

E. Galimany, I. Sunila, H. Hégaret, M. Ramón, and G. H. Wikfors, Experimental exposure of the blue mussel (Mytilus edulis, L.) to the toxic dinoflagellate Alexandrium fundyense: Histopathology, immune responses, and recovery, Harmful Algae, vol.7, issue.5, pp.702-711, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00654371

E. Galimany, I. Sunila, H. Hégaret, M. Ramón, and G. H. Wikfors, Pathology and immune response of the blue mussel (Mytilus edulis L.) after an exposure to the harmful dinoflagellate Prorocentrum minimum, Harmful Algae, vol.7, issue.5, pp.630-638, 2008.

S. M. Gallager and R. Mann, Growth and survival of larvae of Mercenaria mercenaria (L.) and Crassostrea virginica (Gmelin) relative to broodstock conditioning and lipid content of eggs, Aquaculture, vol.56, issue.2, pp.105-121, 1986.

S. M. Gallager, R. Mann, and G. C. Sasaki, Lipid as an index of growth and viability in three species of bivalve larvae, Aquaculture, vol.56, issue.2, pp.81-103, 1986.

R. E. Gawley, K. S. Rein, G. Jeglitsch, D. J. Adams, E. A. Theodorakis et al., The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels, Chem. Biol, vol.2, issue.8, pp.533-541, 1995.

B. Halliwell, Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life, Plant Physiol, vol.141, issue.2, pp.312-322, 2006.

C. A. Heil and K. A. Steidinger, Monitoring, management, and mitigation of Karenia blooms in the eastern Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.611-617, 2009.

D. M. Hesselman, B. J. Barber, and N. J. Blake, The reproductive cycle of adult hard clams, Mercenaria spp. in the Indian River Lagoon, Florida. J. Shellfish Res, vol.8, pp.43-49, 1989.

D. W. Howard, E. J. Lewis, B. J. Keller, and C. S. Smith, Histological Techniques for Marine Bivalve Mollusks and Crustaceans, NOAA Technical Memorandum. NOSNCCOS, p.218, 2004.

C. Hu, F. E. Muller-karger, and P. W. Swarzenski, Hurricanes, submarine groundwater discharge, and Florida's red tides, Geophys. Res. Lett, vol.33, p.11601, 2006.

G. L. Humason, Animal Tissue Techniques, 1979.

J. D. Humphrey, J. H. Norton, J. B. Jones, M. A. Barton, M. T. Connell et al., Pearl oyster (Pinctada maxima) aquaculture: health survey of Northern Territory, Western Australia and Queensland pearl oyster beds and farms. FRDC Final Report 94. Fisheries Research Development Corporation, Canberra. International Mussel Watch Program (IMW), p.248, 1980.

J. B. Jones, M. Crockford, J. Creeper, and F. Stephens, Histopathology of oedema in pearl oysters Pinctada maxima, Dis. Aquat. Organ, vol.91, issue.1, pp.67-73, 2010.

D. Kang, I. Ahn, and K. Choi, Quantitative assessment of reproductive condition of the Antarctic clam, Laternula elliptica (King and Broderip), using image analysis, Invertebr. Reprod. Dev, vol.44, issue.1, pp.71-78, 2003.

K. L. Kimm-brinson and J. S. Ramsdell, The red tide toxin, brevetoxin, induces embryo toxicity and developmental abnormalities, Environ. Health Perspect, vol.109, issue.4, pp.377-81, 2001.

J. H. Landsberg, The effects of harmful algal blooms on aquatic organisms, Rev.Fish. Sci, vol.10, issue.2, pp.113-390, 2002.

G. Lauckner, Diseases of mollusca: bivalvia, Diseases of marine animals, 1983.

, Introduction: bivalvia to scaphopoda, vol.2, pp.477-879

M. Lassudrie, P. Soudant, G. Richard, N. Henry, W. Medhioub et al., Physiological responses of Manila clams Venerupis (=Ruditapes) philippinarum with varying parasite Perkinsus olseni burden to toxic algal Alexandrium ostenfeldii exposure, Aquat. Toxicol, vol.154, pp.27-38, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01023217

R. F. Lee and P. B. Heffernan, Lipids and proteins in eggs of eastern oysters (Crassostrea virginica (Gmelin 1791)) and northern quahogs (Mercenaria mercenaria (Linnaeus, 1758), J. Shellfish Res, vol.10, issue.1, pp.203-206, 1991.

L. Goïc, N. Hégaret, H. Fabioux, C. Miner, P. Suquet et al., Impact of the toxic dinoflagellate Alexandrium catenella on Pacific oyster reproductive output : application of flow cytometry assays on spermatozoa, Aquat. Living Resour, vol.26, pp.221-228, 2013.

L. Goïc, N. Hégaret, H. Lambert, L. Fabioux, C. Soudant et al., Cellular changes of Crassostrea gigas spermatozoa upon exposure to the toxic dinoflagellate Alexandrium catenella, Aquaculture, 2013.

R. Martoja and M. Martoja-pierson, Initiation aux techniques de l'histologie animale, 1967.

M. A. Miller, Maternal transfer of organochlorine compounds in salmonines to their eggs, Can. J. Fish. Aquatic Sci, vol.50, issue.7, pp.1405-1413, 1993.

J. F. Morado, A. K. Sparks, and S. K. Reed, A coccidian infection of the kidney of the native littleneck clam, Protothaca staminea, J. Invert. Path, vol.43, issue.2, pp.207-217, 1984.

R. Morales-alamo and R. Mann, Anatomical features in histological sections of Crassostrea virginica (Gmelin, 1791) as an aid in measurements of gonad area for reproductive assessment, J. Shellfish Res, vol.8, issue.1, pp.71-82, 1989.

J. P. Naar, L. J. Flewelling, A. Lenzi, J. P. Abbott, A. Granholm et al., Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish, Toxicon, vol.50, issue.5, pp.707-723, 2007.

J. Naar, J. Kubanek, A. Weidner, L. Flewelling, A. Bourdelais et al., Brevetoxin Depuration in Shellfish via Production of Non-toxic Metabolites : Consequences for Seafood Safety and the Environmental Fate of Biotoxins, Proceedings of the Xth International Conference on Harmful Algae. Florida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and the Intergovernmental Oceanographic Commission of UNESCO, pp.488-490, 2002.

J. Normand, B. Ernande, J. Haure, H. Mccombie, and P. Boudry, Reproductive effort and growth in Crassostrea gigas: comparison of young diploid and triploid oysters issued from natural crosses or chemical induction, Aquat. Biol, vol.7, issue.3, pp.229-241, 2009.

, National Shellfish Sanitation Program (NSSP) Guide for the Control of Molluscan Shellfish 2011 Revision U. S. Department of Health and Human Services Public Health Service Food and Drug Administration Interstate Shellfish Sanitation Conference, NSSP, 2011.

R. S. Overstreet, Marine maladies? Worms, germs and other symbionts from the northern Gulf of Mexico, 1978.

R. H. Pierce, M. Henry, and P. Blum, Brevetoxin abundance and composition during ECOHABFlorida field monitoring cruises in the Gulf of Mexico, Continental Shelf Res, vol.28, issue.1, pp.45-58, 2008.

R. H. Pierce, M. S. Henry, P. C. Blum, S. M. Plakas, H. R. Granade et al., Comparison of methods for determination of brevetoxins and their metabolites in NSP-toxic bivalve molluscs, Proceedings of the Fifth International Conference on Molluscan Shellfish Safety, Galway Ireland, Current and Emerging Analytical Methods, pp.37-42, 2004.

R. H. Pierce, M. S. Henry, P. C. Blum, J. Lyons, Y. S. Cheng et al., Brevetoxin concentrations in marine aerosol: human exposure levels during a Karenia brevis harmful algal bloom, B. Environ. Contam. Tox, vol.70, issue.1, pp.161-165, 2003.

S. M. Plakas and R. W. Dickey, Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish, Toxicon, vol.56, issue.2, pp.137-149, 2010.

M. A. Poli, C. B. Templeton, W. L. Thompson, and J. F. Hewetson, Distribution and elimination of brevetoxin PbTx-3 in rats, Toxicon, vol.28, issue.8, pp.903-910, 1990.

M. A. Poli, C. B. Templeton, J. G. Pace, and H. B. Hines, Detection, metabolism, and pathophysiology of brevetoxins, ACS symposium series, vol.418, pp.176-191, 1990.

M. A. Poli, T. J. Mende, and D. G. Baden, Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes, Mol. Pharmacol, vol.30, issue.2, pp.129-135, 1986.

C. M. Riley, S. A. Holt, G. J. Holt, J. Edward, and C. R. Arnold, Mortality of larval Red Drum (Sciaenops ocellatus) associated with Ptychodiscus brevis red tide, Cont. Mar. Sci, vol.31, pp.137-146, 1989.

B. S. Roberts, G. E. Henderson, and R. A. Medlyn, The effect of Gymnodinium breve toxin(s) on selected mollusks and crustaceans, Toxic Dinoflagellate Blooms, pp.419-424, 1979.

A. Rolton, P. Soudant, J. Vignier, L. Donaghy, S. E. Shumay et al., in prep a. Exposure of adult Crassostrea virginica to Karenia brevis: Toxin accumulation and histopathological and cellular responses in adults and

A. Rolton, J. Vignier, P. Soudant, S. E. Shumway, V. M. Bricelj et al., prep b. Effects of Karenia brevis exposure on adult Mercenaria mercenaria: Histopathological and cellular responses in adults and effects on gamete and larval quality

L. E. Roszell, L. S. Schulman, and D. G. Baden, Toxin profiles are dependent on growth stages in cultures Phytodiscus brevis, Toxic Marine Phytoplankton, pp.403-406, 1990.

G. A. Rounsefell and W. R. Nelson, Red-tide research summarized to 1964 includ-ing an annotated bibliography, United States Department of the interiorFish and Wildlife Service. Contribution number 20. Bureau of CommercialFisheries Special Scientific Report. Fisheries number 535, pp.1-85, 1966.

K. H. Sharp, B. Eam, D. J. Faulkner, and M. G. Haygood, Vertical transmission of diverse microbes in the tropical sponge Corticium sp, Appl. Environ. Microb, vol.73, issue.2, pp.622-629, 2007.

B. .. Shaw and H. I. Battle, The gross and microscopic anatomy of the digestive tract of the oyster Crassostrea virginica (Gmelin), Can. J. Zool, pp.325-347, 1957.

S. E. Shumway and A. D. Cembella, The impact of toxic algae on scallop culture and fisheries, Rev. Fish. Sci, vol.1, pp.121-150, 1993.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aqua-culture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

R. Smolowitz and S. E. Shumway, Possible cytotoxic effects of the dinoflagellate, Gyrodinium aureolum, on juvenile bivalve molluscs, Aquacult. Int, vol.5, issue.4, pp.291-300, 1997.

K. A. Steidinger, Historical perspective on Karenia brevis red tide research in the Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.549-561, 2009.

K. A. Steidinger, J. L. Wolny, and A. J. Haywood, Identification of Kareninaceae (Dinophyceae) in the Gulf of Mexico, Nova Hedwegia, vol.133, pp.269-284, 2008.

K. A. Steidinger, P. Carlson, D. Baden, C. Rodriguez, and J. Seagle, Neurotoxic shellfish poisoning due to toxin retention in the clam Chione cancellata, Harmful Algae. Paris: Xunta de Galicia, IOC, pp.457-458, 1998.

K. A. Steidinger, Some taxonomic and biological aspects of toxic dinoflagellates, pp.1-28, 1993.

K. A. Steidinger, M. Burklew, and R. M. Ingle, Marine Pharmacognosy: Action of Marine Toxins at the Cellular Level, pp.179-202, 1973.

H. Summerson and C. Peterson, Recruitment failure of the bay scallop, Argopecten irradians concentricus, during the first red tide, Ptychodiscus brevis, outbreak recorded in North Carolina, Estuaries, vol.13, issue.3, pp.322-331, 1990.

P. A. Tester and P. K. Fowler, Brevetoxin contamination of Mercenaria mercenaria and Crassostrea virginica: A management issue, pp.499-503, 1990.

R. J. Thompson, R. I. Newell, V. S. Kennedy, and R. Mann, The Eastern Oyster Crassostrea virginica. Maryland Sea Grant College, pp.335-370, 1996.

C. D. Todd and J. N. Havenhand, Reproductive effort: its definition, measurement and interpretation in relation to molluscan life-history strategies, J. Mollus. Stud, vol.49, issue.12, pp.203-208, 1983.

B. S. Washburn, D. G. Baden, N. J. Gassman, and P. J. Walsh, Brevetoxin: tissue distribution and effect on cytochrome P450 enzymes in fish, Toxicon, vol.32, issue.7, pp.799-805, 1994.

F. Wehner, H. Olsen, H. Tinel, E. Kinne-saffran, and R. K. Kinne, Cell volume regulation: osmolytes, osmolyte transport, and signal transduction, Rev. Physiol. Biochem. Pharmacol, vol.148, pp.1-80, 2003.

G. H. Wikfors, A review and new analysis of trophic interactions between Prorocentrum minimum and clams, scallops, and oysters, Harmful Algae, vol.4, issue.3, pp.585-592, 2005.

J. T. Winstead, A. K. Volety, and S. G. Tolley, Parasitic and symbiotic fauna in oysters (Crassostrea virginica) collected from the Caloosahatchee river and estuary in Florida, J. Shellfish Res, vol.23, issue.3, pp.831-840, 2004.

R. Arnold and W. S. , Bivalve enhancement and restoration strategies in Florida, U.S.A. Hydrobiologia, vol.465, pp.7-19, 2001.

D. G. Baden and C. R. Thomas, Variations in major toxin composition for six clones of Ptychodiscus brevis, Red Tides. Biology, Environmental Science and Toxicology, pp.415-418, 1989.

B. S. Baldwin and R. I. Newell, Relative importance of different size food particles in the natural diet of oyster larvae Crassostrea virginica, Mar. Ecol. Prog. Ser, vol.120, issue.1, pp.135-145, 1995.

L. Basti, J. Go, K. Higuchi, K. Nagai, and S. Segawa, Effects of the toxic dinoflagellate Heterocapsa circularisquama on larvae of the pearl oyster Pinctada fucata martensii (Dunker, 1873), J. Shellfish Res, vol.30, issue.1, pp.177-186, 2011.

L. Basti, K. Nagai, Y. Tanaka, and S. Segawa, Sensitivity of gametes, fertilization, and embryo development of the Japanese pearl oyster, Pinctada fucata martensii, to the harmful dinoflagellate, Heterocapsa circularisquama, Mar. Biol, vol.160, issue.1, pp.211-219, 2013.

L. E. Brand and A. Compton, Long-term increase in Karenia brevis abundance along the Southwest Florida Coast, Harmful Algae, vol.6, issue.2, pp.232-252, 2007.

L. E. Brand, L. Campbell, and E. Bresnan, Karenia: the biology and ecology of a toxic genus, Harmful Algae, vol.14, pp.156-178, 2012.

V. M. Bricelj and S. E. Shumway, Paralytic shellfish toxins in bivalve molluscs: occurrence, transfer kinetics and biotransformation, Rev. Fish. Sci, vol.6, issue.4, pp.315-383, 1998.

V. M. Bricelj, S. P. Macquarrie, J. A. Doane, and L. B. Connell, Evidence of selection for resistance to paralytic shellfish toxins during the early life history of soft-shell clam (Mya arenaria) populations, Limnol. Oceanogr, vol.55, issue.6, pp.2463-2475, 2010.

J. M. Burkholder and S. E. Shumway, Bivalve shellfish aquaculture and eutrophication, Shellfish Aquaculture and the Environment, pp.155-215, 2012.

A. Calabrese, R. S. Collier, D. A. Nelson, and J. R. Macinnes, The toxicity of heavy metals to embryos of the American oyster Crassostrea virginica, Mar. Biol, vol.18, issue.3, pp.162-166, 1973.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Dev. Aquac. Fish. Sci, vol.31, pp.77-115, 2001.

F. Conte, Economic impact of paralytic shellfish poison on the oyster industry in the Pacific United States, Aquaculture, vol.39, pp.331-343, 1984.

J. R. Deeds, D. E. Terlizzi, J. E. Adolf, D. K. Stoecker, and A. R. Place, Toxic activity from cultures of Karlodinium micrum (=Gyrodinium galatheanum) (Dinophyceae) a dinoflagellate associated with fish mortalities in an estuarine aquaculture facility, Harmful Algae, vol.1, issue.2, pp.169-189, 2002.

J. H. Finucane, Distribution and seasonal occurrence on Gymnodinium breve on the West Coast of Florida, In: United States Fish and Wildlife Service Special Scientific Report. Fisheries, pp.1954-57, 1964.

P. S. Galtsoff, The American oyster, Crassostrea virginica Gmelin. U.S. Fish. Bull, vol.64, pp.1-480, 1964.

P. M. Glibert, J. Alexander, D. W. Meritt, E. W. North, and D. K. Stoecker, Harmful algae pose additional challenges for oyster restoration: impacts of the harmful algae Karlodinium veneficum and Prorocentrum minimum on early life stages of the oysters Crassostrea virginica and Crassostrea ariakensis, J. Shellfish Res, vol.26, issue.4, pp.919-925, 2007.

D. M. Hesselman, B. J. Barber, and N. J. Blake, The reproductive cycle of adult hard clams, Mercenaria spp. in the Indian River Lagoon, Florida. J. Shellfish Res, vol.8, pp.43-49, 1989.

P. Hoagland and S. Scatasta, The economic effects of harmful algal blooms, Ecology of Harmful Algae, pp.391-401, 2006.

C. Hu, F. E. Muller-karger, and P. W. Swarzenski, Hurricanes, submarine groundwater discharge, and Florida's red tides, Geophys. Res. Lett, vol.33, p.11601, 2006.

A. C. Jensen, The economic halo of a red tide, Proceedings of the First International Conference on Toxic Dinoflagellate Blooms. Wakefield, MA. MIT Science and Technology Foundation, pp.507-516, 1975.

J. N. Kraeuter, M. Castagna, and R. Van-dessel, Egg size and larval survival of Mercenaria mercenaria and Argopecten irradians (Lamarck), J. Exp. Mar. Biol. Ecol, vol.56, issue.1, pp.3-8, 1981.

J. Kubanek, M. K. Hicks, J. Naar, and T. A. Villareal, Does the red tide dinoflagellate Karenia brevis use allelopathy to outcompete other phytoplankton?, Limnol. Oceanogr, vol.50, issue.3, pp.883-895, 2005.

J. Kubanek, T. W. Snell, and C. Pirkle, Chemical defense of the red tide dinoflagellate Karenia brevis against rotifer grazing, Limnol. Oceanogr, vol.52, issue.3, pp.1026-1035, 2007.

J. H. Landsberg, The effects of harmful algal blooms on aquatic organisms, Rev. Fish. Sci, vol.10, issue.2, pp.113-390, 2002.

J. R. Leverone, N. J. Blake, R. H. Pierce, and S. E. Shumway, Effects of the dinoflagellate Karenia brevis on larval development in three species of bivalve mollusc from Florida, Toxicon, vol.48, pp.75-84, 2006.

J. R. Leverone, S. P. Geiger, S. P. Stephenson, and W. S. Arnold, Increase in Bay scallop (Argopecten irradians) populations following releases of competent larvae in two west Florida estuaries, J. Shellfish Res, vol.29, issue.2, pp.395-406, 2010.

J. Marshall, T. Ross, S. Pyecroft, and G. Hallegraeff, Action Plan for Harmful Algal Blooms and the Gulf of Mexico Coastal Ocean Observing System: Results from a Regional Workshop, National Oceanic and Atmospheric Administration (NOAA), vol.147, pp.541-549, 2004.

T. Neely and L. Campbell, A modified assay to determine hemolytic toxin variability among Karenia clones isolated from the Gulf of Mexico, Harmful Algae, vol.5, pp.592-598, 2006.

R. I. Newell, Ecosystem influences of natural and cultivated populations of suspension-feeding bivalve molluscs: a review, J. Shellfish Res, vol.23, issue.1, pp.51-62, 2004.

R. I. Newell and C. J. Langdon, Mechanisms and physiology of adult and larval feeding, pp.185-229, 1996.

J. A. Pechenik, Environmental influences on larval survival and development, Reproduction of Marine Invertebrates, pp.551-608, 1987.

R. H. Pierce and M. Henry, Harmful algal toxins of the Florida red tide (Karenia brevis): natural chemical stressors in South Florida coastal ecosystems, Ecotoxicology, vol.17, issue.7, pp.623-631, 2008.

R. H. Pierce, M. S. Henry, P. C. Blum, S. L. Hamel, B. Kirkpatrick et al., Brevetoxin composition in water and marine aerosol along a Florida beach: assessing potential human exposure to marine biotoxins, Harmful Algae, vol.4, pp.965-972, 2005.

R. Pierce, M. Henry, P. Blum, and S. Payne, Gymnodinium breve toxins without cells: intra-cellular and extra-cellular toxins, Harmful Algal Blooms. Intergovernmental Oceanographic Commission of UNESCO, pp.421-424, 2001.

M. A. Poli, T. J. Mende, and D. G. Baden, Brevetoxins, unique activators of voltagesensitive sodium channels, bind to specific sites in rat brain synaptosomes, Mol. Pharmacol, vol.30, issue.2, pp.129-135, 1986.

G. A. Rounsefell and W. R. Nelson, Red-tide research summarized to 1964 including an annotated bibliography. In: United States Department of the interior Fish and Wildlife Service. Contribution number 20, Bureau of Commercial Fisheries Special Scientific Report. Fisheries number, vol.535, pp.1-85, 1966.

P. B. Roth, M. J. Twiner, Z. Wang, M. B. Dechraoui, and G. J. Doucette, Fate and distribution of brevetoxin (PbTx) following lysis of Karenia brevis by algicidal bacteria, including analysis of open A-ring derivatives, Toxicon, vol.50, pp.1175-1191, 2007.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aquaculture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

T. J. Smayda, Novel and nuisance phytoplankton blooms in the sea: evidence for a global epidemic, Toxic Marine Phytoplankton, pp.29-40, 1990.

K. A. Steidinger, Historical perspective on Karenia brevis red tide research in the Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.549-561, 2009.

D. K. Stoecker, J. E. Adolf, A. R. Place, P. M. Glibert, and D. W. Meritt, Effects of the dinoflagellates Karlodinium veneficum and Prorocentrum minimum on early life history stages of the eastern oyster (Crassostrea virginica), Mar. Biol, vol.154, issue.1, pp.81-90, 2008.

R. R. Strathmann, Feeding and non-feeding larval development and life-history evolution in marine invertebrates, Annu. Rev. Ecol. Syst, vol.16, pp.339-361, 1985.

P. A. Tester and K. A. Steidinger, Gymnodiniumbreve red tide blooms: Initiation, transport, and consequences of surface circulation, Limnol. Oceanogr, vol.42, issue.5, pp.1039-1051, 1997.

R. J. Thompson, E. I. Newell, V. S. Kennedy, and R. Mann, Reproductive processes and early development, pp.335-370, 1996.

, Census of Agriculture: United States Summary and State Data, Part 51 AC-07-A-51, vol.1, pp.438-439, 2007.

F. M. Van-dolah, Marine algal toxins: origins, health effects, and their increased occurrence, Environ. Health Perspect, vol.108, issue.1, pp.133-141, 2000.

F. M. Van-dolah, K. B. Lidie, E. A. Monroe, D. Bhattacharya, L. Campbell et al., The Florida red tide dinoflagellate Karenia brevis: new insights into cellular and molecular processes underlying bloom dynamics, Harmful Algae, vol.8, issue.4, pp.562-572, 2009.

G. A. Vargo, C. A. Heil, D. N. Ault, M. B. Neely, S. Murasko et al., Four Karenia brevis blooms: a comparative analysis, Proceedings of the Xth International Conference on Harmful Algae, Florida Fish and Wildlife Conservation Commission, Florida Institute of Oceanography, and the Intergovernmental Oceanographic Commission of UNESCO, pp.14-16, 2002.

A. K. Volety, Effects of salinity, heavy metals and pesticides on health and physiology of oysters in the Caloosahatchee Estuary, Florida. Ecotoxicology, vol.17, pp.579-590, 2008.

L. Wang, T. Yan, and M. Zhou, Impacts of HAB species Heterosigma akashiwo on early development of the scallop Argopecten irradians Lamarck, Aquaculture, vol.255, issue.1-4, pp.374-383, 2006.

H. W. Wells, The fauna of oyster beds, with special reference to the salinity factor, Ecol. Monogr, vol.31, issue.3, pp.239-266, 1961.

G. H. Wikfors and R. M. Smolowitz, Experimental and histological studies of four life-history stages of the eastern oyster, Crassostrea virginica, exposed to a cultured strain of the dinoflagellate Prorocentrum minimum, Biol. Bull, vol.188, pp.313-328, 1995.

T. Yan, M. Zhou, M. Fu, Y. Wang, R. Yu et al., Inhibition of egg hatching success and larvae survival of the scallop, Chlamysfarreri, associated with exposure to cells and cell fragments of the dinoflagellate Alexandrium tamarense, Toxicon, vol.39, issue.8, pp.1239-1244, 2001.

A. Abraham, S. M. Plakas, L. J. Flewelling, K. R. El-said, E. L. Jester et al., Biomarkers of neurotoxic shellfish poisoning, Toxicon, vol.52, issue.2, pp.237-245, 2008.

D. M. Anderson, P. M. Glibert, and J. M. Burkholder, Harmful algal blooms and eutrophication nutrient sources, composition, and consequences, Estuaries, vol.25, issue.4b, pp.704-726, 2002.

D. G. Baden, Brevetoxins: unique polyether dinoflagellate toxins, FASEB J, vol.3, pp.1807-1817, 1989.

D. G. Baden and C. R. Thomas, Variations in major toxin composition for six clones of Ptychodiscus brevis, Red Tides, pp.415-418, 1989.

L. Basti, S. Nagai, J. Go, S. Okano, K. Nagai et al., Differential inimical effects of Alexandrium spp. and Karenia spp. on cleavage, hatching, and two larval stages of the Japanese pearl oyster, Pinctada fucata martensii, Harmful Algae, vol.43, pp.1-12, 2015.

L. Basti, J. Go, K. Higuchi, K. Nagai, S. Segawa et al., Effects of the toxic dinoflagellate Heterocapsa circularisquama on larvae of the pearl oyster Pinctada fucata martensii (Dunker, 1873), J. Shellfish Res, vol.30, issue.1, pp.232-252, 2007.

V. M. Bricelj and S. P. Macquarrie, Effects of brown tide (Aureococcus anophagefferens) on hard clam Mercenaria mercenaria larvae and implications for benthic recruitment, Mar. Ecol. Prog. Ser, vol.331, pp.147-159, 2007.

J. M. Burkholder and S. E. Shumway, Bivalve shellfish aquaculture and eutrophication, Shellfish Aquaculture and the Environment, pp.155-215, 2012.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Dev. Aquac. Fish. Sci, vol.31, pp.77-115, 2001.

E. Costas and V. L. Rodas, Identification of marine dinoflagellates using fluorescent lectins 1, J. Phycol, vol.30, issue.6, pp.987-990, 1994.

Q. Dong, B. Eudeline, C. Huang, and T. R. Tiersch, Standardization of photometric measurement of sperm concentration from diploid and tetraploid Pacific oysters, Crassostrea gigas (Thunberg), Aquac. Res, vol.36, pp.86-93, 2005.

J. L. Fitzpatrick, S. Nadella, C. Bucking, S. Balshine, and C. M. Wood, The relative sensitivity of sperm, eggs and embryos to copper in the blue mussel (Mytilus trossulus), Comp. Biochem. Physiol. Part C, vol.147, pp.441-449, 2008.

C. Franchet, M. Goudeau, and H. Goudeau, Mercuric ions impair the fertilization potential, the resumption of meiosis, the formation of male pronucleus, and increase polyspermy, in the egg of the ascidian Phallusia mammillata, J. Exp. Zool, vol.278, issue.4, pp.255-272, 1997.

L. F. Gainey and S. E. Shumway, The physiological effect of Aureococcus anophagefferens ("brown tide") on the lateral cilia of bivalve mollusks, Biol. Bull, vol.181, issue.2, pp.298-306, 1991.

P. S. Galtsoff, The American oyster, Crassostrea virginica Gmelin. U. S. Fish. Bull, vol.64, pp.1-480, 1964.

M. Geesey and P. A. Tester, Gymnodinium breve: Ubiquitous in Gulf of Mexico waters?, pp.251-255, 1993.

P. Gentien, M. Lunven, P. Lazure, A. Youenou, and M. P. Crassous, Motility and autotoxicity in Karenia mikimotoi (Dinophyceae), Phil. Trans. R. Soc. B, vol.362, 2007.

L. A. Gosselin and P. Qian, Juvenile mortality in benthic marine invertebrates, Mar. Ecol. Prog. Ser, vol.146, issue.1, pp.265-282, 1997.

A. Granmo, J. Havenhand, K. Magnusson, and I. Svane, Effects of the planktonic flagellate Chrysochromulina polylepis (Manton et Park) on fertilization and early development of the ascidian Ciona intestinalis (L.) and the blue mussel Mytilus edulis L, J. Exp. Mar. Biol. Ecol, vol.124, pp.65-71, 1988.

C. A. Heil, D. A. Bronk, L. K. Dixon, G. L. Hitchcock, G. J. Kirkpatrick et al., The Gulf of Mexico ECOHAB: Karenia Program, Harmful Algae, vol.38, pp.3-7, 2014.

J. M. Huang, C. H. Wu, and D. G. Baden, Depolarizing action of red tide dinoflagellate brevetoxin on axonal membranes, J. Pharmacol. Exp. Ther, vol.299, pp.615-621, 1984.

J. N. Kraeuter, M. Castagna, and R. Van-dessel, Egg size and larval survival of Mercenaria mercenaria and Argopecten irradians (Lamarck), J. Exp. Mar. Biol. Ecol, vol.56, issue.1, pp.3-8, 1981.

J. Kubanek, T. W. Snell, and C. Pirkle, Chemical defense of the red tide dinoflagellate Karenia brevis against rotifer grazing, Limnol. Oceanogr, vol.52, issue.3, pp.1026-1035, 2007.

J. H. Landsberg, The effects of harmful algal blooms on Aquatic organisms, Rev. Fish. Sci, vol.10, issue.2, pp.113-390, 2002.

L. Goïc, N. Egaret, H. Fabioux, C. Miner, P. Suquet et al., Impact of the toxic dinoflagellate Alexandrium catenella on Pacific oyster reproductive output: application of flow cytometry assays on spermatozoa, Aquat. Living Resour, vol.26, issue.3, pp.221-228, 2013.

L. Goïc, N. Egaret, H. Lambert, L. Fabioux, C. Soudant et al., Cellular changes of Crassostrea gigas spermatozoa upon exposure to the toxic dinoflagellate Alexandrium catenella, Aquaculture 2013, 2013.

L. Goïc, N. Egaret, H. Boulais, M. , J. Lambert et al., Flow cytometric assessment of morphology, viability, and production of reactive oxygen species of Crassostrea gigas oocytes. Application to toxic dinoflagellate (Alexandrium minutum) exposure, Cytom. Part A, vol.85, issue.12, 2014.

J. D. Leblond, T. J. Evans, and P. J. Chapman, The biochemistry of dinoflagellate lipids, with particular reference to the fatty acid and sterol composition of a Karenia brevis bloom, Phycologia, vol.42, issue.4, pp.324-331, 2003.

D. K. Lekan and C. R. Tomas, The brevetoxin and brevenal composition of three Karenia brevis clones at different salinities and nutrient conditions, Harmful Algae, vol.9, issue.1, pp.39-47, 2010.

H. Liu and E. J. Buskey, The exopolymer secretions (EPS) layer surrounding Aureoumbra lagunensis cells affects growth, grazing, and behavior of protozoa, Limnol. Oceanogr, vol.45, issue.5, pp.1187-1191, 2000.

J. Marshall, T. Ross, S. Pyecroft, and G. Hallegraeff, Superoxide production by marine microalgae 2: towards understanding ecological consequences and possible functions, Mar. Biol, vol.147, pp.541-549, 2005.

Y. Matsuyama, T. Uchida, and T. Honjo, Toxic effects of the dinoflagellate Heterocapsa circularisquama on clearance rate of the blue mussel Mytilus galloprovincialis, Mar. Ecol. Prog. Ser, vol.146, pp.73-80, 1997.

A. Rolton, Toxicon, vol.99, pp.6-15, 2015.

Y. Matsuyama, T. Uchida, T. Honjo, and S. E. Shumway, Impacts of the harmful dinoflagellate Heterocapsa circlarisquama on shellfish aquaculture in Japan, J. Shellfish Res, vol.20, issue.3, pp.1269-1272, 2001.

R. T. Moon and J. B. Morrill, The effects of Gymnodinium breve lysate on the larval development of the sea urchin Lytechinus variegatus, J. Environ. Sci. Health A, vol.11, pp.673-683, 1976.

B. D. Mooney, P. D. Nichols, M. F. De-salas, G. M. Hallegraeff, T. Neely et al., Lipid, fatty acid, and sterol composition of eight species of Kareniaceae (dinophyta): Chemotaxonomy and putative lipid phycotoxins, Harmful Algae, vol.43, pp.592-598, 2006.

R. I. Newell, Ecosystem influences of natural and cultivated populations of suspension-feeding bivalve molluscs: a review, Mar. Pollut. Bull, vol.23, issue.1, 2004.

D. K. Padilla, M. H. Doall, C. J. Gobler, A. Hartson, and K. O'boyle, Brown tide alga, Aureococcus anophagefferens, can affect growth but not survivorship of Mercenaria mercenaria larvae, Harmful Algae, vol.5, pp.736-748, 2006.

C. C. Parrish, G. Bodennec, and P. Gentien, Haemolytic glycoglycerolipids from Gymnodinium species, Phytochemistry, vol.47, issue.5, 1998.

J. A. Pechenik, Environmental influences on larval survival and development, pp.551-608, 1987.

R. H. Pierce, M. Henry, and P. Blum, Brevetoxin abundance and composition during ECOHAB-Florida field monitoring cruises in the Gulf of Mexico, Cont. Shelf Res, vol.28, issue.1, pp.45-58, 2008.

R. Pierce, M. Henry, P. Blum, and S. Payne, Gymnodinium breve toxins without cells: intra-cellular and extra-cellular toxins, Harmful Algal Blooms, Intergovernmental Oceanographic Commission of UNESCO, pp.421-424, 2001.

S. M. Plakas, E. L. Jester, K. R. Elsaid, H. R. Granade, A. Abraham et al., Monitoring of brevetoxins in the Karenia brevis bloom-exposed Eastern oyster (Crassostrea virginica), Toxicon, vol.52, pp.32-38, 2008.

A. Rolton, J. Vignier, P. Soudant, S. E. Shumway, V. M. Bricelj et al., Effects of the red tide dinoflagellate, Karenia brevis, on early development of the eastern oyster Crassostrea virginica and northern quahog Mercenaria mercenaria, Aquat. Toxicol, vol.155, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01056612

L. E. Roszell, L. S. Schulman, and D. G. Baden, Toxin profiles are dependent on growth stages in cultures Phytodiscus brevis, pp.403-406, 1990.

K. R. Schneider, R. H. Pierce, and G. E. Rodrick, The degradation of Karenia brevis toxins utilizing ozonated seawater, Harmful Algae, vol.2, pp.101-107, 2003.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aquaculture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

R. E. Sipler, L. R. Mcguinness, G. J. Kirkpatrick, L. J. Kerkhof, and O. M. Schofield, Bacteriocidal effects of brevetoxin on natural microbial communities, Harmful Algae, vol.38, pp.101-109, 2014.

K. A. Steidinger, Historical perspective on Karenia brevis red tide research in the Gulf of Mexico, Harmful Algae, vol.8, issue.4, pp.549-561, 2009.

R. P. Stumpf, M. E. Culver, P. A. Tester, M. Tomlinson, G. J. Kirkpatrick et al., Monitoring Karenia brevis blooms in the Gulf of Mexico using satellite ocean color imagery and other data, Harmful Algae, vol.2, pp.147-160, 2003.

A. O. Tatters, H. I. Muhlstein, and C. R. Tomas, The hemolytic activity of Karenia selliformis and two clones of Karenia brevis throughout a growth cycle, J. Appl. Phycol, vol.22, pp.435-442, 2010.

P. A. Tester, D. Shea, S. R. Kibler, S. M. Varnam, M. D. Black et al., Relationships among water column toxins, cell abundance and chlorophyll concentrations during Karenia brevis blooms, Limnol. Oceanogr, vol.28, issue.1, pp.1039-1051, 1997.

R. J. Thompson, R. I. Newell, V. S. Kennedy, and R. Mann, Reproductive processes and early development, pp.335-370, 1996.

G. Thorson, Reproductive and larval ecology of marine bottom invertebrates, Biol. Rev, vol.25, issue.1, pp.1-45, 1950.

A. K. Volety, Effects of salinity, heavy metals and pesticides on health and physiology of oysters in the Caloosahatchee Estuary, Florida. Ecotoxicol, vol.17, pp.579-590, 2008.

A. M. Waite, R. J. Olson, H. G. Dam, and U. Passow, Sugar-containing compounds on the cell surfaces of marine diatoms measured using concanavalin a and flow cytometry, J. Phycol, vol.31, issue.6, pp.925-933, 1995.

L. Wang, T. Yan, and M. Zhou, Impacts of HAB species Heterosigma akashiwo on early development of the scallop Argopecten irradians Lamarck, Aquaculture, vol.255, pp.374-383, 2006.

H. W. Wells, The fauna of oyster beds, with special reference to the salinity factor, Ecol. Monogr, vol.31, issue.3, pp.239-266, 1961.

M. Yokote and T. Honjo, Morphological and histochemical demonstration of a glycocalyx on the cell surface of Chattonella antiqua,a'naked flagellate, Experientia, vol.41, issue.9, pp.1143-1145, 1985.

A. Rolton, Toxicon, vol.99, pp.6-15, 2015.

R. Abraham, A. Wang, Y. El-said, K. R. Plakas, and S. M. , Characterization of brevetoxin metabolism in Karenia brevis bloom-exposed clams (Mercenaria sp, Toxicon, vol.60, issue.6, pp.1030-1040, 2012.

A. Abraham, S. M. Plakas, Z. Wang, E. L. Jester, K. R. El-said et al., Characterization of polar brevetoxin derivatives isolated from Karenia brevis cultures and natural blooms, Toxicon, vol.48, issue.1, pp.104-115, 2006.

P. A. Anderson, J. Roberts-misterly, and R. M. Greenberg, The evolution of voltage-gated sodium channels: were algal toxins involved, Harmful Algae, vol.4, pp.95-107, 2005.

L. E. Brand and A. Compton, Long-term increase in Karenia brevis abundance along the Southwest Florida Coast, Harmful Algae, vol.6, issue.2, pp.232-252, 2007.

V. M. Bricelj and S. E. Shumway, Paralytic Shellfish Toxins in Bivalve Molluscs: Occurrence, Transfer Kinetics, and Biotransformation, vol.6, pp.315-383, 1998.

V. M. Bricelj and D. J. Lonsdale, Aureococcus anophagefferens: causes and ecological consequences of brown tides in US mid-Atlantic coastal waters, Limnol. Oceanogr, vol.42, issue.5, pp.1023-1038, 1997.

V. M. Bricelj, A. Cembella, D. Laby, S. E. Shumway, and T. L. Cucci, Comparative physiological and behavioral responses to PSP toxins in two bivalve molluscs, the softshell clam, Mya arenaria, and surfclam, Spisula solidissima, Harmful and Toxic Algal Blooms, pp.405-408, 1996.

V. M. Bricelj, J. H. Lee, and A. Cembella, Influence of dinoflagellate cell toxicity on uptake and loss of paralytic shellfish toxins in the northern quahog Mercenaria mercenaria, Mar. Ecol. Prog. Ser, vol.74, pp.33-46, 1991.

N. T. Brun, W. Neil, A. D. Ross, and . Boghen, Changes in the electrophoretic profiles of gill mucus proteases of the eastern oyster Crassostrea virginica in response to infection by the Turbellarian Urastoma cyprinae, J. Invert. Pathol, vol.75, issue.2, pp.163-170, 2000.

M. R. Carriker, Embryogenesis and organogenesis of veligers and early juveniles, Biology of the hard clam, vol.31, pp.77-115, 2001.

M. A. Carroll and E. J. Catapane, The nervous system control of lateral ciliary activity of the gill of the bivalve mollusc, Crassostrea virginica, Comp. Biochem. Phys. A, vol.148, issue.2, pp.445-450, 2007.

E. J. Catapane, Comparative study of the lateral ciliary activity in marine bivalves, Comp. Biochem. Physiol. C, vol.75, pp.403-405, 1983.

N. W. Davis and R. E. Hillman, Effect of artificial shell damage on sex determination in oysters, Proc. Natl. Shellfish Assoc, vol.61, issue.2, 1971.

R. E. Dickey, R. G. Jester, D. Mowdy, C. Moncreiff, D. Rebarchik et al., Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts, Natural Toxins, vol.7, issue.4, pp.157-165, 1999.

L. Donaghy, C. Lambert, K. S. Choi, and P. Soudant, Hemocytes of the carpet shell clam (Ruditapes decussatus) and the Manila clam (Ruditapes philippinarum): Current knowledge and future prospects, Aquaculture, vol.297, issue.1, pp.10-24, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00460793

M. Echevarria, J. P. Naar, C. Tomas, and J. R. Pawlik, Effects of Karenia brevis on clearance rates and bioaccumulation of brevetoxins in benthic suspension feeding invertebrates, Aquat. Toxicol, vol.106, pp.85-94, 2012.

W. S. Fisher, Occurrence of agglutinins in the pallial cavity mucus of oysters, J. Exp. Mar. Biol. Ecol, vol.162, issue.1, pp.1-13, 1992.

L. E. Fleming, B. Kirkpatrick, L. C. Backer, C. J. Walsh, K. Nierenberg et al., Review of Florida Red Tide and Human Health Effects, Harmful Algae, vol.10, issue.2, pp.224-233, 2011.

A. Franchini, A. Milandri, R. Poletti, and E. Ottaviani, Immunolocalization of yessotoxins in the mussel Mytilus galloprovincialis, Toxicon, vol.41, pp.967-970, 2003.

L. F. Gainey and S. E. Shumway, A compendium of the responses of bivalve molluscs to toxic dinoflagellates, J. Shellfish Res, vol.7, issue.4, pp.623-628, 1988.

S. M. Gallager, R. Mann, and G. C. Sasaki, Lipid as an index of growth and viability in three species of bivalve larvae, Aquaculture, vol.56, issue.2, pp.81-103, 1986.

D. Grzebyk, A. Denardou, B. Berland, and Y. F. Pouchus, Evidence of a new toxin in the red-tide dinoflagellate Prorocentrum minimum, J. Plankton Res, vol.19, issue.8, pp.1111-1124, 1997.

H. Haberkorn, C. Lambert, N. Le-goïc, C. Quéré, A. Bruneau et al., Cellular and biochemical responses of the oyster Crassostrea gigas to controlled exposures to metals and Alexandrium minutum, Aquatic Toxicology, vol.147, pp.158-167, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00948644

G. M. Hallegraeff, A review of harmful algal blooms and their apparent global increase, Phycologia, vol.32, issue.2, pp.79-99, 1993.

H. Hégaret, P. M. Da-silva, I. Sunila, S. E. Shumway, M. S. Dixon et al., Perkinsosis in the Manila clam Ruditapes philippinarum affects responses to the harmfulalga, Prorocentrum minimum, J. Exp. Mar. Biol. Ecol, vol.371, issue.2, pp.112-120, 2009.

H. Hégaret, Impacts of harmful algal blooms on physiological and cellular processes of bivalve molluscs, 2008.

H. Hégaret, G. H. Wikfors, and S. E. Shumway, Diverse feeding responses of five species of bivalve mollusc when exposed to three species of harmful algae, J. Shellfish Res, vol.26, issue.2, pp.549-559, 2007.

H. Hégaret, P. M. Da-silva, G. H. Wikfors, C. Lambert, T. De-bettignies et al., Hemocyte responses of Manila clams, Ruditapes philippinarum, with varying parasite, Perkinsus olseni, severity to toxic-algal exposures, Aquat. Toxicol, vol.84, issue.4, pp.469-479, 2007.

H. Hégaret, G. H. Wikfors, P. Soudant, C. Lambert, S. E. Shumway et al., Toxic dinoflagellates (Alexandrium fundyense and A. catenella) have minimal apparent effects on oyster hemocytes, Mar. Biol, vol.152, issue.2, pp.441-447, 2007.

J. B. Jones, M. Crockford, J. Creeper, and F. Stephens, Histopathology of oedema in pearl oysters Pinctada maxima, Dis. Aquat. Organ, vol.91, issue.1, pp.67-73, 2010.

K. L. Kimm-brinson and J. S. Ramsdell, The red tide toxin, brevetoxin, induces embryo toxicity and developmental abnormalities, Environ. Health Persp, vol.109, issue.4, pp.377-381, 2001.

B. Kirkpatrick, L. E. Fleming, D. Squicciarini, L. C. Backer, R. Clark et al., Literature review of Florida red tide: implications for human health effects, Harmful algae, vol.3, issue.2, pp.99-115, 2004.

J. Kubanek, T. W. Snell, and C. Pirkle, Chemical defense of the red tide dinoflagellate Karenia brevis against rotifer grazing, Limnol. Oceanogr, vol.52, issue.3, pp.1026-1035, 2007.

J. H. Landsberg, L. J. Flewelling, and J. Naar, Karenia brevis red tides, brevetoxins in the food web, and impacts on natural resources: Decadal advancements, Harmful Algae, vol.8, issue.4, pp.598-607, 2009.

J. H. Landsberg, The Effects of Harmful Algal Blooms on Aquatic Organisms, Rev. Fish. Sci, vol.10, issue.2, pp.113-390, 2002.

C. Lauritano, Y. Carotenuto, G. Procaccini, J. T. Turner, and A. Ianora, Changes in expression of stress genes in copepods feeding upon a non-brevetoxin-producing strain of the dinoflagellate Karenia brevis, Harmful Algae, vol.28, pp.23-30, 2013.

D. K. Lekan and C. R. Tomas, The brevetoxin and brevenal composition of three Karenia brevis clones at different salinities and nutrient conditions, Harmful Algae, vol.9, issue.1, pp.39-47, 2010.

J. R. Leverone, Comparative effects of the toxic dinoflagellate, Karenia brevis, on bivalve molluscs from Florida (Doctoral dissertation, 2007.

J. R. Leverone, S. E. Shumway, and N. J. Blake, Comparative effects of the toxic dinoflagellate Karenia brevis on clearance rates in juveniles of four bivalve molluscs from Florida, Toxicon, vol.49, issue.5, pp.634-645, 2007.

P. Loret, T. Tengs, T. A. Villareal, H. Singler, B. Richardson et al., No difference found in ribosomal DNA sequences from physiologically diverse clones of Karenia brevis (Dinophyceae) from the Gulf of Mexico, J. Plankton Res, vol.24, issue.7, pp.735-739, 2002.

D. F. Mello, E. S. De-oliveira, R. C. Vieira, E. Simoes, R. Trevisan et al., Cellular and transcriptional responses of Crassostrea gigas hemocytes exposed in vitro to brevetoxin (PbTx-2), Mar. Drugs, vol.10, issue.3, pp.583-597, 2012.

R. T. Moon and J. B. Morrill, The effects of Gymnodinium breve lysate on the larval development of the sea urchin Lytechinus variegatus, J. Environ. Sci. Health A, vol.11, pp.673-683, 1976.

T. Neely and L. Campbell, A modified assay to determine hemolytic toxin variability among Karenia clones isolated from the Gulf of Mexico, Harmful Algae, vol.5, issue.5, pp.592-598, 2006.

A. Paparo, Neuroregulatory activities and potassium enhancement of lateral ctenidial beating in Crassostrea virginica, Comp. Biochem. Physiol. A, vol.84, pp.585-588, 1986.

A. Paparo, DOPA decarboxylase activities and potassium stimulation of lateral cilia on the ctenidium of Crassostrea virginica (Gmelin), J. Exp. Mar. Biol. Ecol, vol.95, pp.225-231, 1986.

C. C. Parrish, G. Bodennec, and P. Gentien, Haemolytic glycoglycerolipids from Gymnodinium species, Phytochemistry, vol.47, issue.5, pp.783-787, 1998.

R. H. Pierce,

M. S. Henry, L. S. Proffitt, and A. J. De-rosset, Evaluation of Solid Sorbents for the Recovery of Polyether Toxins (Brevetoxins) in Seawater Bull, Environ. Contain. Toxicol, vol.49, pp.479-484, 1992.

M. A. Poli, S. M. Musser, R. W. Dickey, P. P. Eilers, and S. Hall, Neurotoxic shellfish poisoning and brevetoxin metabolites: A case study from Florida, Toxicon, vol.38, issue.7, pp.981-993, 2000.

S. M. Ray and D. V. Aldrich, Ecological interactions of toxic dinoflagellates and molluscs in the Gulf of Mexico, Animal Toxins, pp.75-83, 1967.

S. E. Shumway, A review of the effects of algal blooms on shellfish and aquaculture, J. World Aquac. Soc, vol.21, issue.2, pp.65-104, 1990.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquat. Toxicol, vol.10, issue.1, pp.9-27, 1987.

A. M. Sievers, Comparative toxicity of Gonyaulax monilata and Gymnodinium breve to annelids, crustaceans, molluscs and a fish, J. Protozool, vol.16, issue.3, pp.401-404, 1969.

R. E. Sipler, L. R. Mcguinness, G. J. Kirkpatrick, L. J. Kerkhof, and O. M. Schofield, Bacteriocidal effects of brevetoxin on natural microbial communities, Harmful Algae, vol.38, pp.101-109, 2014.

R. Smolowitz and S. E. Shumway, Possible cytotoxic effects of the dinoflagellate, Gyrodinium aureolum, on juvenile bivalve molluscs, Aquacult. Int, vol.5, issue.4, pp.291-300, 1997.

P. Soudant, F. L. Chu, and A. Volety, Host-parasite interactions: Marine bivalve molluscs and protozoan parasites, Perkinsus species, J.Invert. Pathol, vol.114, issue.2, pp.196-216, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00946055

A. O. Tatters, H. I. Muhlstein, and C. R. Tomas, The hemolytic activity of Karenia selliformis and two clones of Karenia brevis throughout a growth cycle, J. Appl. Phycol, vol.22, pp.435-442, 2010.

R. J. Thompson, R. I. Newell, V. S. Kennedy, and R. Mann, Reproductive processes and early development, pp.335-370, 1996.

G. Thorson, Reproductive and larval ecology of marine bottom invertebrates, Biol. Rev, vol.25, issue.1, pp.1-45, 1950.

J. T. Turner, V. Roncalli, P. Camarillo, C. Dell'aversano, E. Fattorusso et al., Biogeographic effects of the Gulf of Mexico red tide dinoflagellate Karenia brevis on Mediterranean copepods, Harmful Algae, vol.16, pp.63-73, 2012.

B. M. Twarog, T. Hidaka, and H. Yamaguchi, Resistance to tetrodotoxin and saxitoxin in nerves of bivalve molluscs: a possible correlation with paralytic shellfish poisoning, Toxicon, vol.10, issue.3, pp.273-278, 1972.

Z. Wang, S. M. Plakas, K. R. El-said, E. L. Jester, H. R. Granade et al., LC/MS analysis of brevetoxin metabolites in the Eastern oyster (Crassostrea virginica), Toxicon, vol.43, issue.4, pp.455-65, 2004.

J. E. Ward, J. S. Levinton, S. E. Shumway, and T. Cucci, Site of particle selection in a bivalve mollusc, Nature, vol.390, issue.6656, pp.131-132, 1997.

J. E. Ward and S. E. Shumway, Separating the grain from the chaff: particle selection in suspension-and deposit-feeding bivalves, Journal of Experimental Marine Biology and Ecology, vol.300, issue.1, pp.83-130, 2004.

G. H. Wikfors and R. M. Smolowitz, Detrimental effects of a Prorocentrum isolate upon hard clams and bay scallops in laboratory feeding studies, Dev. Mar. Biol, 1993.

J. Volety, K. Vignier, J. P. Mceachern, E. Roberts, A. Nickols et al., Impacts of Deepwater Horizon oil and dispersants on the metamorphosis and settlement success of Eastern oysters Crassostrea virginica, 2014.

J. Vignier, A. Rolton, A. Volety, R. Robert, P. Soudant et al., Sub-lethal effects of Deepwater Horizon oil on Crassostrea virginica larvae using dietary pathways, EAS, pp.14-17, 2014.

J. Vignier, R. Ketover, J. Divine, A. Rolton, A. Volety et al., Sub-lethal effects of DWH oil on Crassostrea virginica using dietary pathways, Symposium on Environmental Toxicity and Chemistry, SETAC 2013, 2013.

, Winner of the Thurlow C. Nelson Award, given for the outstanding oral presentation of research that represents a distinctive and valuable contribution to shellfisheries science at NSA/WAS, 2013.