Caractérisation d'un nouveau modèle animal de polyradiculonévrite chronique et développement de stratégies thérapeutiques

Abstract : Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune pathology of the peripheral nervous system whose pathophysiology is currently poorly understood, for which there are few therapeutic options and no reliable animal model. The first aim of this work was to validate and characterize an animal model of CIDP by immunization of rat Lewis with the palmitoylated peptide P0(180-199). The animals developed a chronic or relapsing pathology that could be characterized clinically, histologically, electrophysiologically and immunologically. The results are in favor of a reliable and reproducible model that mimics the human CIDP. The second aim of this work was to test, on our model, the fingolimod, sphingosine 1-phosphate receptor modulator, as potential treatment of the pathology. In our model, fingolimod has reduced the severity and the chronicity of the disease, improved electrophysiological parameters, reduced infiltration by inflammatory cells and recue immunological abnormalities.
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Laurent Kremer. Caractérisation d'un nouveau modèle animal de polyradiculonévrite chronique et développement de stratégies thérapeutiques. Neurosciences [q-bio.NC]. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAJ058⟩. ⟨tel-02271299⟩

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