Characterization of Mouse Lemur Brain by Anatomical, Functional and Glutamate MRI

Clément Garin 1
1 LMN - Laboratoire des Maladies Neurodégénératives - UMR 9199
UP11 - Université Paris-Sud - Paris 11, MIRCEN - Service MIRCEN : DRF/JACOB, CNRS - Centre National de la Recherche Scientifique : UMR 9199
Abstract : The mouse lemur (Microcebus murinus) is a primate that has attracted attention within neuroscience research. Its cerebral anatomy is still poorly described and its cerebral networks have never been investigated. The first objective of this study was to develop new tools to create a 3D digital atlas of the brain of this model and to use this atlas to automatically follow-up brain characteristics in cohorts of animals. We then implemented protocols to analyze connectivity in mouse lemurs so we could evaluate for the first time the cerebral networks in this species. We revealed that the mouse lemur brain is organised in local functional regions integrated within large scale functional networks. These latter networks were classified and compared to large scale networks in humans. This multispecies comparison highlighted common organization rules but also discrepancies. Additionally, Chemical Exchange Saturation Transfer imaging of glutamate (gluCEST) is a method that allows the creation of 3D maps weighted by the glutamate distribution. In a third study, we compared local neuronal activity, functional connectivity and gluCEST contrast in various brain regions. We highlighted various associations between these three biomarkers. Lastly, the impact of aging on local neuronal activity, functional connectivity and gluCEST has been analyzed by comparing two cohorts of lemurs.
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Clément Garin. Characterization of Mouse Lemur Brain by Anatomical, Functional and Glutamate MRI. Neurons and Cognition [q-bio.NC]. Université Paris-Saclay, 2019. English. ⟨NNT : 2019SACLS174⟩. ⟨tel-02268380⟩

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