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. De-la-même-manière, CICLOSAAR qui est actuellement en cours a pour but d'étudier, grâce à la TEP-IRM, le bénéfice de la CsA perfusée, en continu, une heure avant la reperfusion, sur les paramètres fonctionnels rénaux, de manière non invasive, chez l'homme. L'étude concomitante de la perfusion, du métabolisme et du contenu tissulaire en oxygène sur rein séparé devrait nous permettre d'améliorer notre compréhension des mécanismes physiopathologiques à l'oeuvre après dilatation d'une sténose de l'artère rénale afin d, la prévention des lésions d'ischémie-reperfusion cardiaques et de reperfusion. L'étude

, Nos travaux devraient permettre de renforcer l'applicabilité clinique des techniques TEP en permettant d'obtenir deux informations à l'issue d'une seule injection de traceur : perfusion (K1) et métabolisme oxydatif (k2) pour réduire la durée, le coût et l'irradiation d'un examen. La corrélation entre les mesures obtenues après l'injection d'eau marquée par rapport à celles obtenues en acétate marqué nous a permis d'isoler le coefficient d'extraction rénal de l'acétate, qui n'était jusque-là pas connu. La connaissance de ce coefficient permet d'obtenir une évaluation quantitative de la perfusion rénale à l'issue de l, Dans un second temps, nous avons démontré que l'acétate pouvait être utilisé comme un marqueur de perfusion au-delà d'être un marqueur de métabolisme oxydatif