Wnt11 promotes cardiomyocyte development by caspasemediated suppression of canonical Wnt signals, Mol. Cell. Biol, vol.31, pp.163-178, 2011. ,
Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins, Curr. Biol. CB, vol.14, pp.2046-2051, 2004. ,
Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome, FEBS Lett, vol.588, pp.1322-1330, 2014. ,
,
Canonical Wnt signaling functions in second heart field to promote right ventricular growth, Proc. Natl. Acad. Sci. U. S. A, vol.104, pp.9319-9324, 2007. ,
Proximal events in Wnt signal transduction, 2009. ,
, Nat. Rev. Mol. Cell Biol, vol.10, pp.468-477
,
Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium, Circ. Res, vol.80, pp.88-94, 1997. ,
Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice, Toxicol. Appl. Pharmacol, vol.190, pp.135-145, 2003. ,
,
The need for European Registries in inherited cardiomyopathies, Eur. Heart J, vol.23, pp.1972-1974, 2002. ,
,
Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects, Eur. J. Heart Fail, vol.8, pp.477-483, 2006. ,
,
The MOGE(S) Classification for a Phenotype-Genotype Nomenclature of Cardiomyopathy: Endorsed by the World Heart Federation, Glob. Heart, vol.8, pp.355-382, 2013. ,
The MOGE(S) Classification of Cardiomyopathy for Clinicians, J. Am. Coll. Cardiol, vol.64, pp.304-318, 2014. ,
,
Muscle ring finger protein-1 inhibits PKC? activation and prevents cardiomyocyte hypertrophy, J. Cell Biol, vol.167, pp.1147-1159, 2004. ,
High frequency of APC loss in sporadic colorectal carcinoma due to breaks, pp.5-21, 1989. ,
, Oncogene, vol.4, pp.1169-1174
,
Familial dilated cardiomyopathy: cardiac abnormalities are common in asymptomatic relatives and may represent early disease, J. Am. Coll, 1998. ,
, Cardiol, vol.31, pp.195-201
,
Hypertrophic stimulation increases beta-actin dynamics in adult feline cardiomyocytes, PloS One, vol.5, 2010. ,
,
, Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model, PloS One, vol.10, 140273.
Two classes of tight junctions are revealed by ZO-1 isoforms, Am. J. Physiol, vol.264, pp.918-924, 1993. ,
The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression, EMBO J, vol.19, pp.2024-2033, 2000. ,
,
, Rev, vol.92, pp.1317-1358
Increased association of ZO-1 with connexin43 during remodeling of cardiac gap junctions, Circ. Res, vol.90, pp.317-324, 2002. ,
,
Beta-catenin downregulation is required for adaptive cardiac remodeling, Circ. Res, vol.100, pp.1353-1362, 2007. ,
, , p.2, 2001.
, expression and phosphorylation in neonatal and adult cardiomyocytes, J. Mol. Cell. Cardiol, vol.33, pp.1017-1030
,
PYK2 expression and phosphorylation increases in pressure overload-induced left ventricular hypertrophy, Am. J. Physiol. Heart Circ. Physiol, vol.283, pp.695-706, 2002. ,
Endocytosis is required for E-cadherin redistribution at mature adherens junctions, Proc. Natl, 2009. ,
, Acad. Sci. U. S. A, vol.106, pp.7010-7015
The transitional junction: a new functional subcellular domain at the intercalated disc, 2006. ,
, Mol. Biol. Cell, vol.17, pp.2091-2100
Gap junctions and propagation of the cardiac action potential, Adv. Cardiol, vol.42, pp.71-85, 2006. ,
Connexin43: a protein from rat heart homologous to a gap junction protein from liver, J. Cell Biol, vol.105, pp.2621-2629, 1987. ,
Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1, Cardiovasc. Res, vol.77, pp.757-765, 2008. ,
Building the mammalian heart from two sources of myocardial cells, Nat. Rev. Genet, vol.6, pp.826-835, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00118537
,
Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases, Eur. Heart J, vol.34, 2013. ,
Merits of non-invasive rat models of left ventricular heart failure, Cardiovasc. Toxicol, vol.11, pp.91-112, 2011. ,
,
Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases, Eur. Heart J, vol.31, pp.2715-2726, 2010. ,
,
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy, Mol. Cell. Biol, vol.26, pp.4462-4473, 2006. ,
Remodelling of myocardial intercalated disc protein connexin 43 causes increased susceptibility to malignant arrhythmias in ARVC/D patients, Forensic Sci. Int, vol.275, pp.14-22, 2017. ,
,
, , 2012.
Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization, The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments, vol.9, pp.1133-1140, 2007. ,
, J. Biol. Chem, vol.282, pp.36024-36036
Cardiac hypertrophy and the Wnt/Frizzled pathway, 2007. ,
, , vol.49, pp.427-428, 1979.
, , 2005.
A role of Dishevelled in relocating, 2003. ,
, Axin to the plasma membrane during wingless signaling, Curr. Biol. CB, vol.13, pp.960-966
Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP, Dev. Camb. Engl, vol.131, pp.5103-5115, 2004. ,
,
, , 1997.
, Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study, J. Am. Coll. Cardiol, vol.30, pp.1512-1520
AHNAK: The giant jack of all trades, Cell. Signal, vol.26, pp.2683-2693, 2014. ,
Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential, J. Physiol, vol.591, 1409. ,
, , 2012.
The cell biology of planar cell polarity, J. Cell Biol, vol.207, pp.171-179, 2014. ,
,
, , 2007.
, J. Biol. Chem, vol.282, pp.17259-17271
Alphacatenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actinfilament assembly, Cell, vol.123, pp.903-915, 2005. ,
, , 1995.
, Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos, Mol. Cell. Biol, vol.15, pp.2625-2634
Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells, J. Cell Biol, vol.129, pp.805-817, 1995. ,
,
Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases, Eur. Heart J, vol.29, pp.270-276, 2008. ,
In vitro reestablishment of cellcell contacts in adult rat cardiomyocytes. Functional role of transmembrane components in the formation of new intercalated disk-like cell contacts, FASEB J. Off, 1999. ,
, Publ. Fed. Am. Soc. Exp. Biol, vol.13, pp.83-89
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway, Curr. Opin. Genet. Dev, vol.13, pp.28-33, 2003. ,
,
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development, PLoS Genet, vol.4, 2004. ,
, Cell Sci, vol.117, pp.527-533
Junctional complexes in various epithelia, J. Cell Biol, vol.17, pp.375-412, 1963. ,
,
Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart, J. Cell Sci, vol.115, pp.1623-1634, 2002. ,
Wnt, 2002. ,
, 3A/beta-catenin signaling induces transcription from the LEF-1 promoter, J. Biol
, Chem, vol.277, pp.33398-33410
Wnt signaling and cardiac differentiation, Prog. Mol. Biol. Transl. Sci, vol.111, pp.153-174, 2012. ,
Functional consequences of abnormal Cx43 expression in the heart, Biochim. Biophys. Acta, vol.1818, pp.2020-2029, 2012. ,
Intercalated discs of mammalian heart: a review of structure and function, Tissue Cell, vol.17, pp.605-648, 1985. ,
Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembranedomain receptor signaling pathways, Sci. STKE Signal Transduct. Knowl. Environ, p.41, 2007. ,
The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins, Eur. J. Cell Biol, vol.85, pp.69-82, 2006. ,
Next-generation sequencing: from understanding biology to personalized medicine, Biology, vol.2, pp.378-398, 2013. ,
Hypertrophy of the heart: a new therapeutic target?, Circulation, vol.109, pp.1580-1589, 2004. ,
Dishevelled: The hub of Wnt signaling, Cell. Signal, vol.22, pp.717-727, 2010. ,
,
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2, Dev. Cell, vol.20, pp.163-176, 2011. ,
Suppression of canonical Wnt/ -catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy, J. Clin. Invest, vol.116, pp.2012-2021, 2006. ,
,
Evidence-based diagnosis of familial non-X-linked dilated cardiomyopathy. Prevalence, inheritance and characteristics, Eur. Heart J, vol.22, pp.73-81, 2001. ,
,
Specific AHNAK expression in brain endothelial cells with barrier properties, J. Cell. Physiol, vol.203, pp.362-371, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00380361
The Multiple Phases and Faces of Wnt, 2010. ,
, Signaling During Cardiac Differentiation and Development, Circ. Res, vol.107, pp.186-199
Epithelial cell-cell junctions and plasma membrane domains, Biochim. Biophys. Acta, vol.1788, pp.820-831, 2009. ,
,
Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations, J. Am. Coll. Cardiol, vol.55, pp.1444-1453, 2010. ,
Intercellular junction assembly, dynamics, and homeostasis, Cold Spring Harb. Perspect. Biol, vol.2, p.125, 2010. ,
,
Identification and characterization of the familial adenomatous polyposis coli gene, Cell, vol.66, pp.589-600, 1991. ,
Frizzled6 controls hair patterning in mice, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.9277-9281, 2004. ,
,
Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects, Am. J. Physiol. Heart Circ. Physiol, vol.293, pp.2680-2692, 2007. ,
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1, Cell, vol.107, pp.843-854, 2001. ,
, , 2003.
, Wnt/Frizzled signaling is required for vertebrate gastrulation, Genes Dev, vol.17, pp.295-309
,
, , 2002.
, Cardiol, vol.40, pp.1445-1450
,
Stabilization of beta-catenin by a Wntindependent mechanism regulates cardiomyocyte growth, Proc. Natl. Acad. Sci, 2003. ,
, A, vol.100, pp.4610-4615
,
Identification of c-MYC as a target of the APC pathway, Science, vol.281, pp.1509-1512, 1998. ,
The development and structure of the ventricles in the human heart, Pediatr. Cardiol, vol.30, pp.588-596, 2009. ,
Getting to the heart of planar cell polarity signaling, Birt. Defects Res. A. Clin. Mol. Teratol, vol.91, pp.460-467, 2011. ,
Wnt Signaling in Cardiac Disease, Compr. Physiol, vol.5, pp.1183-1209, 2015. ,
Dilated cardiomyopathy: the complexity of a diverse genetic architecture, Nat. Rev. Cardiol, vol.10, pp.531-547, 2013. ,
,
, N-cadherin in adult rat cardiomyocytes in culture. I. Functional role of Ncadherin and impairment of cell-cell contact by a truncated N-cadherin mutant, J. Cell Sci, vol.109, pp.1-10
,
N-cadherin in adult rat cardiomyocytes in culture, 1996. ,
, Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes, J. Cell Sci, vol.109, pp.11-20
Gap junctional complexes: from partners to functions, Prog. Biophys. Mol. Biol, vol.94, pp.29-65, 2007. ,
, , 2014.
, Influence of the scaffolding protein Zonula Occludens (ZOs) on membrane channels
, Biochim. Biophys. Acta, vol.1838, pp.595-604
Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of betacatenin and down-regulates beta-catenin, J. Biol. Chem, vol.275, pp.34399-34406, 2000. ,
, , 2006.
, Establishment of cardiac cytoarchitecture in the developing mouse heart, Dev. Biol, vol.289, pp.430-441
, , 2006.
, Establishment of cardiac cytoarchitecture in the developing mouse heart, Dev. Biol, vol.289, pp.430-441
,
, , 2010.
, Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death, Basic Res. Cardiol, vol.105, pp.597-608
,
Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis, Proc. Natl. Acad. Sci. U. S. A, vol.109, pp.4044-4051, 2012. ,
,
Regulation of the Wnt signaling pathway by disabled-2 (Dab2), EMBO J, vol.22, pp.3084-3094, 2003. ,
, , 2002.
, The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton
, Biol, vol.16, pp.1205-1216
PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling, Mol. Biol. Cell, vol.21, pp.3269-3277, 2010. ,
, Spontaneous assembly and active disassembly balance adherens junction homeostasis. Proc. Natl, 2010.
, Acad. Sci. U. S. A, vol.107, pp.3528-3533
Budding behaviors: Growth of the limb as a model of morphogenesis, Dev. Dyn. Off. Publ. Am. Assoc. Anat, vol.240, pp.1054-1062, 2011. ,
The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand?, Acta Physiol. Oxf. Engl, vol.204, pp.110-117, 2012. ,
Genetics of inherited cardiomyopathy, 2012. ,
, Eur. Heart J, vol.33, pp.296-304
Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1, N. Engl. J. Med, vol.321, pp.1372-1378, 1989. ,
,
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements, Nat. Cell Biol, vol.4, pp.610-615, 2002. ,
,
, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway, Mol. Cell. Biol, vol.22, pp.1172-1183
,
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling, Nat. Commun, vol.7, p.11267, 2016. ,
Gpr177 regulates pulmonary vasculature development, Dev. Camb. Engl, vol.140, pp.3589-3594, 2013. ,
,
, Proc. Natl. Acad. Sci
, A, vol.107, pp.6906-6911
The prognostic value of late gadolinium enhancement CMR in nonischemic cardiomyopathies, Curr. Cardiol. Rep, vol.15, p.326, 2013. ,
Shaping the vertebrate body plan by polarized embryonic cell movements, Science, vol.298, pp.1950-1954, 2002. ,
,
, Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail, Nat. Genet, vol.28, pp.251-255
Regulation of Wnt signaling by protein-protein interaction and post-translational modifications, 2006. ,
, Mol. Med, vol.38, pp.1-10
Multiplicity of the interactions of Wnt proteins and their receptors, Cell. Signal, vol.19, pp.659-671, 2007. ,
beta-catenin destruction complex: insights and questions from a structural perspective, Oncogene, vol.25, pp.7482-7491, 2006. ,
Wnt signalling and its impact on development and cancer, Nat. Rev. Cancer, vol.8, pp.387-398, 2008. ,
, , 2007.
, Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis
, Proc. Natl. Acad. Sci. U. S. A, vol.104, pp.18531-18536
,
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling, Mol. Biol. Cell, vol.10, pp.3151-3169, 1999. ,
PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into myotubes, J. Cell Sci, vol.119, pp.5106-5113, 2006. ,
Rap1: a key regulator in cellcell junction formation, J. Cell Sci, vol.120, pp.17-22, 2007. ,
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure, Circ. Res, vol.96, pp.346-354, 2005. ,
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure, Circ. Res, vol.96, pp.346-354, 2005. ,
, , 2000.
, Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape, Trends Genet. TIG, vol.16, pp.279-283
The gap junction communication channel, Cell, vol.84, pp.381-388, 1996. ,
Mobility and cytoskeletal interactions of cell adhesion receptors, Curr. Opin. Cell Biol, vol.11, pp.582-590, 1999. ,
Diminished zonula occludens-1 expression in the failing human heart, Cardiovasc. Pathol. Off. J. Soc. Cardiovasc. Pathol, vol.16, pp.159-164, 2007. ,
Cellular mechanisms of normal growth in the mammalian heart. I. Qualitative and quantitative features of ventricular architecture in the dog from birth to five months of age, Circ. Res, vol.44, pp.250-262, 1979. ,
The cardiac connexome: Non-canonical functions of connexin43 and their role in cardiac arrhythmias, Semin. Cell Dev. Biol, vol.50, pp.13-21, 2016. ,
, , 2011.
, Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling, Mol. Cell. Biol, vol.31, pp.1134-1144
, , p.7, 2017.
, prevents cardiac conduction system defect through maintaining intercalated disc integrity, PLoS Genet, vol.13, 1006984.
Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement, J. Cell Biol, vol.190, pp.263-278, 2010. ,
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin, Mol. Biol. Cell, vol.16, pp.1744-1755, 2005. ,
The Wnt signaling pathway in development and disease, Annu. Rev. Cell Dev. Biol, vol.20, pp.781-810, 2004. ,
,
, Circ. Res, vol.104, pp.1076-1084, 2009.
,
Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors, J. Biol. Chem, vol.277, pp.38239-38244, 2002. ,
A systematic review and meta-analysis of genotype-phenotype associations in patients with hypertrophic cardiomyopathy caused by sarcomeric protein mutations, Heart Br. Card. Soc, vol.99, pp.1800-1811, 2013. ,
, , 2015.
, Mechanotransduction in cardiac hypertrophy and failure, Circ. Res, vol.116, pp.1462-1476
Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice, Circ. Res, vol.105, pp.1102-1109, 2009. ,
Wnt/beta-catenin signaling: components, mechanisms, and diseases, Dev. Cell, vol.17, pp.9-26, 2009. ,
Meis1 regulates postnatal cardiomyocyte cell cycle arrest, Nature, vol.497, pp.249-253, 2013. ,
,
Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease, Ann. Intern. Med, vol.143, pp.108-115, 2005. ,
,
Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling, 2010. ,
, , vol.55, pp.939-945, 1979.
Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes, 2009. ,
, Exp. Cell Res, vol.315, pp.2126-2139
,
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas, Proc. Natl. Acad. Sci. U. S. A, vol.96, pp.1603-1608, 1999. ,
Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements, Curr. Biol. CB, vol.12, pp.876-884, 2002. ,
,
, , 2006.
, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention, Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, vol.113, pp.1807-1816
, , 2001.
, Inhibition of Wnt activity induces heart formation from posterior mesoderm, Genes Dev, vol.15, pp.316-327
,
Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts, 2003. ,
, Cardiovasc. Res, vol.60, pp.376-387
,
N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes, Biochem, 2005. ,
, Biophys. Res. Commun, vol.326, pp.228-232
Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development, Genes Dev, vol.19, pp.164-175, 2005. ,
Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy, Circ. Cardiovasc. Genet, vol.10, 2017. ,
, , 1997.
, Experience from clinical genetics in hypertrophic cardiomyopathy: proposal for new diagnostic criteria in adult members of affected families, Heart Br. Card. Soc, vol.77, pp.130-132
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface, Nat. Rev. Drug Discov, vol.6, pp.617-635, 2007. ,
,
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy, Eur. Heart J, vol.35, pp.1069-1077, 2014. ,
Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling, J. Biol. Chem, vol.277, pp.45203-45210, 2002. ,
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals, Nature, vol.423, pp.173-177, 2003. ,
Genetic evaluation of dilated cardiomyopathy, Curr. Cardiol. Rep, vol.15, 2001. ,
, Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification, Hum. Mol. Genet, vol.10, pp.2593-2601
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse, 2003. ,
, , vol.12, pp.87-98
,
Natural history and familial characteristics of isolated left ventricular non-compaction, Eur. Heart J, vol.26, pp.187-192, 2005. ,
Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity?, Trends Genet. TIG, vol.18, pp.447-455, 2002. ,
Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression, Cardiovasc. Res, vol.85, pp.100-109, 2010. ,
Developmental stage-specific biphasic roles of Wnt/betacatenin signaling in cardiomyogenesis and hematopoiesis, Proc. Natl. Acad. Sci, 2006. ,
, A, vol.103, pp.19812-19817
,
Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy, J. Am. Coll. Cardiol, vol.36, pp.2226-2233, 2000. ,
Convergence of Wnt, beta-catenin, and cadherin pathways, Science, vol.303, pp.1483-1487, 2004. ,
Tight junctions/adherens junctions: basic structure and function, J. Invest. Dermatol, vol.127, pp.2525-2532, 2007. ,
,
Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling, J. Mol. Cell. Cardiol, vol.47, pp.23-31, 2009. ,
,
Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy, Circ. Cardiovasc. Genet, vol.6, pp.144-153, 2013. ,
The fine structure of the interrelationship of cells in the human epidermis, J. Biophys. Biochem. Cytol, vol.4, pp.529-538, 1958. ,
ZO-1 determines adherens and gap junction localization at intercalated disks, AJP Heart Circ. Physiol, vol.300, pp.583-594, 2011. ,
The connexin43 carboxyl terminus and cardiac gap junction organization, Biochim. Biophys. Acta, vol.1818, pp.1831-1843, 2012. ,
Increasingly complex: new players enter the Wnt signaling network, BioEssays News Rev. Mol. Cell. Dev. Biol, vol.24, pp.881-884, 2002. ,
, , 2009.
, Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors, Biochim. Biophys. Acta, vol.1788, pp.790-796
, , 2005.
, Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos, Curr. Biol. CB, vol.15, pp.1039-1044
Immediateearly signaling induced by E-cadherin engagement and adhesion, J. Biol. Chem, vol.283, pp.5014-5022, 2008. ,
Dilated cardiomyopathy: a disease of the intercalated disc?, Trends Cardiovasc. Med, vol.13, pp.30-38, 2003. ,
Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium, Circulation, vol.90, pp.713-725, 1994. ,
Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization, Circ. Res, vol.101, pp.137-145, 2007. ,
,
Non-cell-autonomous roles for the planar cell polarity gene Vangl2 in development of the coronary circulation, Circ. Res, vol.102, pp.615-623, 2008. ,
The area composita of adhering junctions connecting heart muscle cells of vertebrates -IV: coalescence and amalgamation of desmosomal and adhaerens junction components -late processes in mammalian heart development, Eur. J. Cell Biol, vol.86, pp.377-391, 2007. ,
Transient regenerative potential of the neonatal mouse heart, Respir. Res, vol.7, pp.1078-1080, 2006. ,
,
Wnt 5a signaling is critical for macrophageinduced invasion of breast cancer cell lines, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.5454-5459, 2006. ,
,
Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction, J. Mol. Cell. Cardiol, vol.43, pp.319-326, 2007. ,
Cardiomyopathies: focus on cardiovascular magnetic resonance, Br. J. Radiol, vol.84, pp.296-305, 2011. ,
An "Omics" Perspective on Cardiomyopathies and Heart Failure, Trends Mol. Med, vol.22, pp.813-827, 2016. ,
,
, , 2017.
, Nat. Commun, vol.8, p.14582
,
Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor, 2016. ,
, Protein Signaling. J. Biol. Chem, vol.291, pp.4128-4143
,
Diagnostic workup in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on Myocardial and Pericardial Diseases, Eur. Heart J, vol.34, pp.1448-1458, 2013. ,
Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment, J. Cell Biol, vol.42, pp.322-326, 1969. ,
Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1, Mol. Biol. Cell, vol.22, pp.1516-1528, 2011. ,
The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless, Cell, vol.50, pp.649-657, 1987. ,
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules, Cell, vol.78, pp.761-771, 1994. ,
Molecular targets and regulators of cardiac hypertrophy, Pharmacol. Res, vol.61, pp.269-280, 2010. ,
, , 2013.
, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC/D): A Systematic Literature Review, Clin. Med. Insights Cardiol, vol.7, pp.97-114
Association of the APC gene product with beta-catenin, Science, vol.262, pp.1731-1734, 1993. ,
Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts, Cardiovasc. Res, vol.72, pp.69-79, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00112269
,
Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43, Circ. Res, vol.106, pp.1592-1602, 2010. ,
,
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion, Circ. Res, vol.120, pp.1305-1317, 2017. ,
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility, Nat. Rev. Genet, vol.8, pp.126-138, 2007. ,
,
The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through, 2014. ,
Wnt/planar cell polarity signalling, Nat. Commun, vol.5 ,
PDZRN3 destabilizes endothelial cell-cell junctions through a PKC?-containing polarity complex to increase vascular permeability, Sci. Signal, vol.10, 2017. ,
,
Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions, Cell, vol.128, pp.547-560, 2007. ,
,
alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture, Circulation, vol.114, pp.1046-1055, 2006. ,
Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development, Dev. Dyn. Off. Publ. Am. Assoc. Anat, vol.225, pp.1-13, 2002. ,
Enhanced functional gap junction neoformation by protein kinase Adependent and Epac-dependent signals downstream of cAMP in cardiac myocytes, 2005. ,
, Circ. Res, vol.97, pp.655-662
Making or breaking the heart: from lineage determination to morphogenesis, Cell, vol.126, pp.1037-1048, 2006. ,
Frizzled signalling and cell polarisation in Drosophila and vertebrates, Dev. Camb. Engl, vol.130, pp.4501-4513, 2003. ,
Genetic testing in the contemporary diagnosis of cardiomyopathy, Curr. Heart Fail. Rep, vol.10, pp.63-72, 2013. ,
,
Lrp6 is required for convergent extension during Xenopus gastrulation, Dev. Camb. Engl, vol.134, pp.4095-4106, 2007. ,
Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent, Cardiovasc. Res, vol.111, pp.410-421, 2016. ,
Cadherins in embryonic and neural morphogenesis, Nat. Rev. Mol. Cell Biol, vol.1, pp.91-100, 2000. ,
Right ventricular cardiomyopathy and sudden death in young people, N. Engl. J. Med, vol.318, pp.129-133, 1988. ,
Planar cell polarity signaling in neural development, Curr. Opin. Neurobiol, vol.20, pp.572-577, 2010. ,
,
Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity, Dev. Cell, vol.4, pp.407-418, 2003. ,
Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion, 2007. ,
, Biol. Cell, vol.18, pp.4343-4352
Wnt signals from the neural tube block ectopic cardiogenesis, Genes Dev, vol.15, pp.255-260, 2001. ,
,
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells, Proc. Natl, 2007. ,
, Acad. Sci. U. S. A, vol.104, pp.9685-9690
Intercalated discs in heart muscle studied with the electron microscope, Anat. Rec, vol.117, pp.49-63, 1953. ,
,
Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart, Cardiovasc. Res, vol.32, pp.886-900, 1996. ,
A second canon, 2003. ,
, Functions and mechanisms of beta-catenin-independent Wnt signaling, Dev. Cell, vol.5, pp.367-377
Refining the molecular organization of the cardiac intercalated disc, Cardiovasc. Res, vol.113, pp.259-275, 2017. ,
,
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy, Eur. Heart J, vol.32, pp.1065-1076, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00616568
The first five years of the Wnt targetome, Cell. Signal, vol.20, pp.795-802, 2008. ,
Assembly of the cardiac intercalated disk during pre-and postnatal development of the human heart, PloS One, vol.9, pp.81-85, 2000. ,
Tissue/planar cell polarity in vertebrates: new insights and new questions, Dev. Camb. Engl, vol.134, pp.647-658, 2007. ,
,
Xin proteins and intercalated disc maturation, signaling and diseases, Front. Biosci. Landmark Ed, vol.17, pp.2566-2593, 2012. ,
Inherited cardiomyopathies, N. Engl. J. Med, vol.364, pp.1643-1656, 2011. ,
, , 2007.
, Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo, Circ. Res, vol.100, pp.456-459
Build it upTear it down: protein quality control in the cardiac sarcomere, Cardiovasc. Res, vol.81, pp.439-448, 2009. ,
,
The role of ubiquitin ligases in cardiac disease, J. Mol. Cell. Cardiol, vol.71, pp.43-53, 2014. ,
Role of p120-catenin in cadherin trafficking, Biochim. Biophys. Acta, vol.1773, pp.8-16, 2007. ,
Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes, J. Mol. Cell. Cardiol, vol.48, pp.899-909, 2010. ,
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion, J. Cell Biol, vol.178, pp.517-527, 2007. ,
, , 2005.
, Deconstructing the cadherin-catenin-actin complex, Cell, vol.123, pp.889-901
, , 2007.
, Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress, Biochem. Biophys. Res. Commun, vol.353, pp.1023-1027
The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains, J. Cell Biol, vol.108, pp.2241-2254, 1989. ,
Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt), Annu. Rev. Cell Dev. Biol, vol.31, pp.623-646, 2015. ,
, , 2006.
, Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy, Circ. Res, vol.99, pp.646-655
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn, J. Cell Biol, vol.141, pp.779-789, 1998. ,
Planar polarity: A new player in both lung development and disease, Organogenesis, vol.7, pp.209-216, 2011. ,
Convergence and extension movements during vertebrate gastrulation, Curr. Top. Dev. Biol, vol.89, pp.163-192, 2009. ,
, Cardiovasc. Res, vol.92, pp.95-105, 2011.
Planar polarity and tissue morphogenesis, Cell, vol.129, p.1051, 2007. ,
,
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes, J. Cell Sci, vol.127, pp.1104-1116, 2014. ,
Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization, Cell Commun. Adhes, vol.21, pp.43-54, 2014. ,
, , 2001.
, Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart, Biochemistry (Mosc.), vol.40, pp.14898-14906
,
Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a, J. Mol. Cell. Cardiol, vol.46, pp.370-377, 2009. ,
Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes, Am. J. Physiol. Heart Circ. Physiol, vol.292, pp.270-276, 2007. ,
PAR3 (Millipore), and F-actin (Molecular Probes). Images were taken with a confocal microscope (Olympus FSV 1000), Visualization was obtained after digitized image multichannel deconvolution by AutoDeblur (Media Cybernetics Inc.), and three-dimensional projections were digitally reconstituted from stacks of confocal optical slices by Imaris software (Bitplane), vol.20, pp.4238-4252, 2000. ,
, Cell culture/DNA transfection and drug treatments HUVECs and HMVECs were cultured in EGM-2 or in EGM-2MV medium, respectively. HeLa cells were cultured in RPMI supplemented with 10% fetal bovine serum and penicillin-streptomycin. Primary endothelial cells from control (iEC WT) and Pdzrn3-deleted (iEC KO) mice were isolated from kidneys after magnetic separation with MACS MS columns (Miltenyi), p.20
, SiRNAs were transfected using interferin (Polyplus) at a final concentration of 30 nM. The oligonucleotides used were designed by Origene for h-Pdzrn3, pp.5-8
,
5?-GGAAUAUUUGUGUAGGUGAtt-3?; 08, 5?-AUUGCCUAAGGACUUGUGCUUtt-3?) as previously reported (47), and for hPKCz Stealth RNAi (#HSS18348) as previously reported (19efficacy of Pdzrn3, MUPP1, and PKCz knockdown was assessed by immunoblotting ,
, V5 (Invitrogen), and MUPP1 (Abcam) were used for immunoprecipitation assays. Proteins were then resolved by SDS-polyacrylamide gel electrophoresis and blotted with antibodies specific for V5 (Invitrogen), claudin 5 (Millipore), ZO1 (Invitrogen), PKCz (Santa Cruz Biotechnology), and phospho-PKCz (Ozyme Cell Signaling). Binding of antibodies to the blots was detected using the Odyssey Infrared Imaging System, p.3
, After a centrifugation at 800g for 5 min, the pellet was reserved for nuclear extract preparation, and the supernatant was collected and spun at 100,000g for 1 hour. The pellet and supernatant were classified as the "cell membrane fraction" and "cytoplasmic fraction," respectively. The pellet obtained after the centrifugation at 800g was washed and placed as a cushion on top of a 1 M sucrose buffer. After a centrifugation at 2700g for 5 min, the pellet was resuspended in a buffer containing tris, Cell fractionation For cell fractionation, cell or tissue lysates were resuspended in a buffer [containing Pipes (pH 6.8), 10 mM KCl, 1.5 mM MgCl 2 , 250 mM sucrose, 1 mM EGTA, and 1 mM EDTA] and potterized 20 times on ice
, Permeability assay HUVECs were seeded on inserts with a pore size of 0.4 mm (BD Biosciences), cultured in medium, and assayed for permeability to FITC dextran
, REFERENCES AND NOTES
Signaling mechanisms regulating endothelial permeability, Physiol. Rev, vol.86, pp.279-367, 2006. ,
Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis, Physiol. Rev, vol.84, pp.869-901, 2004. ,
Claudins and the modulation of tight junction permeability, Physiol. Rev, vol.93, pp.525-569, 2013. ,
Cloning and characterization of MUPP1, a novel PDZ domain protein, FEBS Lett, vol.424, pp.63-68, 1998. ,
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule, J. Biol. Chem, vol.277, pp.455-461, 2002. ,
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells, Cell, vol.125, pp.535-548, 2006. ,
The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex, Exp. Cell Res, vol.319, pp.2514-2525, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00862162
, Sci. Signal, vol.10, p.11, 2017.
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly, Nat. Cell Biol, vol.5, pp.137-142, 2003. ,
Phosphorylationdependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia, Curr. Biol, vol.13, pp.2082-2090, 2003. ,
Apical junctional complexes and cell polarity, Kidney Int, vol.72, pp.1448-1458, 2007. ,
The role of wnt signaling in physiological and pathological angiogenesis, Circ. Res, vol.107, pp.943-952, 2010. ,
Alternative wnt signaling is initiated by distinct receptors, Sci. Signal, vol.1, p.9, 2008. ,
Planar polarity and tissue morphogenesis, Cell, vol.129, pp.1051-1063, 2007. ,
Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity-signaling pathway, Mol. Biol. Cell, vol.27, pp.941-953, 2016. ,
Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis, Dev. Cell, vol.26, pp.31-44, 2013. ,
Principles of planar polarity in animal development, Development, vol.138, pp.1877-1892, 2011. ,
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1, Cell, vol.107, pp.843-854, 2001. ,
Planar cell polarity and the developmental control of cell behavior in vertebrate embryos, Annu. Rev. Cell Dev. Biol, vol.28, pp.627-653, 2012. ,
The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells, J. Cereb. Blood Flow Metab, vol.34, pp.433-440, 2014. ,
The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling, Nat. Commun, vol.5, p.4832, 2014. ,
Efficient, inducible Cre-recombinase activation in vascular endothelium, Genesis, vol.46, pp.74-80, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00282602
Expression of drug transporters at the blood-brain barrier using an optimized isolated rat brain microvessel strategy, Brain Res, vol.1134, pp.1-11, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00176175
Wnt/b-catenin signaling controls development of the blood-brain barrier, J. Cell Biol, vol.183, pp.409-417, 2008. ,
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity, J. Nathans, vol.151, pp.1332-1344, 2012. ,
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5, Nat. Cell Biol, vol.10, pp.923-934, 2008. ,
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells, Genes Cells, vol.7, pp.1161-1171, 2002. ,
CCM1 regulates vascular-lumen organization by inducing endothelial polarity, J. Cell Sci, vol.123, pp.1073-1080, 2010. ,
Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation, J. Cereb. Blood Flow Metab, vol.30, pp.1847-1859, 2010. ,
The PAR-aPKC system: Lessons in polarity, J. Cell Sci, vol.119, pp.979-987, 2006. ,
Rho GEFs in endothelial junctions: Effector selectivity and signaling integration determine junctional response, Tissue Barriers, vol.1, p.27132, 2013. ,
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting, Nat. Cell Biol, vol.12, pp.943-953, 2010. ,
The conditional inactivation of the b-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility, J. Cell Biol, vol.162, pp.1111-1122, 2003. ,
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2, Mol. Biol. Cell, vol.17, pp.5163-5172, 2006. ,
A role for planar cell polarity signaling in angiogenesis, Angiogenesis, vol.11, pp.347-360, 2008. ,
Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling, Circ. Res, vol.110, pp.47-58, 2012. ,
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein, Cell, vol.125, pp.523-533, 2006. ,
Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis, Development, vol.141, pp.1757-1766, 2014. ,
Planar cell polarity signaling: From fly development to human disease, Annu. Rev. Genet, vol.42, pp.517-540, 2008. ,
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature, Science, vol.322, pp.1247-1250, 2008. ,
Wnt/b-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. U.S.A, vol.106, pp.641-646, 2009. ,
Vascular morphogenesis: A Wnt for every vessel?, Curr. Opin. Genet. Dev, vol.19, pp.476-483, 2009. ,
Wnt signaling in the vasculature, Exp. Cell Res, vol.319, pp.1317-1323, 2013. ,
The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/b-catenin signaling, Dev. Cell, vol.32, pp.82-96, 2015. ,
Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun, Nat. Biotechnol, vol.24, pp.856-863, 2006. ,
The blood-brain barrier: An overview: Structure, regulation, and clinical implications, Neurobiol. Dis, vol.16, pp.1-13, 2004. ,
PDZ domain proteins of synapses, Nat. Rev. Neurosci, vol.5, pp.771-781, 2004. ,
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tightjunction proteins, Mol. Cell. Biol, vol.29, pp.2372-2389, 2009. ,
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells, Blood, vol.113, pp.244-253, 2009. ,
Cell polarity proteins: Common targets for tumorigenic human viruses, Oncogene, vol.27, pp.7031-7046, 2008. ,
Syx, a RhoA guanine exchange factor, is essential for angiogenesis in vivo, Circ. Res, vol.103, pp.710-716, 2008. ,
Involvement of FrzA/sFRP-1 and the Wnt/ frizzled pathway in ischemic preconditioning, Circ. Res, vol.96, pp.1299-1306, 2005. ,
Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice, J. Neurosci, vol.28, pp.9451-9462, 2008. ,
Mapping 3-dimensional neovessel organization steps using micro-computed tomography in a murine model of hindlimb ischemia-brief report, Arterioscler. Thromb. Vasc. Biol, vol.29, pp.2090-2092, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00497033
PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling, Mol. Biol. Cell, vol.21, pp.3269-3277, 2010. ,
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis, J. Biol. Chem, vol.286, pp.23511-23520, 2011. ,
Frizzled7 controls vascular permeability through the Wnt-canonical pathway and cross-talk with endothelial cell junction complexes, Cardiovasc. Res, vol.103, pp.291-303, 2014. ,
, Sci. Signal, vol.10, p.11, 2017.
) for providing the FLAG-tagged MUPP1 plasmid. Funding: This work was supported by grants from Fondation pour la Recherche Médicale (DVS20131228623) and from Region Aquitaine (20101301039MP). R.N.S. was supported by a grant from Region Aquitaine (20101301039MP) and from Fondation pour la Recherche Médicale (FDT20130928208). V.J. was supported by a grant from Fondation pour la Recherche Médicale (DEA20130726937), ) for her support with MUPP1 reagents, D. Vivien (GIP Cyceron, Caen, France) for discussions and his help in AVC training, and D. Daret (Inserm U1034 ,
,
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were involved in study design; T.C. and C.D. designed the experiments, analyzed and interpreted the data, and edited the manuscript. All authors discussed the results and commented on the manuscript. Competing interests: The authors declare that they have no competing interests, 2016. ,
, , 2017.
PDZRN3 destabilizes endothelial cell-cell junctions through a PKCz-containing polarity complex to increase vascular permeability, Sci. Signal, vol.10, p.3209, 2017. ,
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