Les fonctions exécutives chez les enfants et adolescents soignés pour une tumeur cérébrale : approche clinique des perturbations en situation d’examen et de vie quotidienne

Abstract : Neuropsychological sequelae associated with pediatric brain tumors represent a major public health issue.Disorders of executive functions have been identified among these children, but the nature of the impaired processes, recommended evaluation modalities and the impact of demographic and medical variables related to the disease remain unclear. The aim of this thesis was to get a broader understanding of the disturbance profile of the different executive processes in this disease context, comparing performance-based measures and daily life indicators (in both the school and home environment). From this perspective, we have 1) analyzed the executive profile of 171 school age children with a brain tumor in the BRIEF (Behavior Rating Inventory of Executive Function) and 2) examined the association of these indicators with performance-based measures adapted in French in 27 patients matched to healthy children. The influence of clinical variables on the executive profiles was discussed. Broad and variable executive difficulties have been identified in patients’ everyday life (all tumor types and locations) at home as well as school, with also increased difficulties reported by parents in the case of radiation therapy at an early age. Disturbances of executive control are confirmed in direct measures, whose convergence with the questionnaires appears however limited. Based on these results, respective contributions of these two types of tools are discussed in order to understand the executive issue in pediatric brain tumor survivors.
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Jeanne Georges Roche. Les fonctions exécutives chez les enfants et adolescents soignés pour une tumeur cérébrale : approche clinique des perturbations en situation d’examen et de vie quotidienne. Psychologie. Université d'Angers, 2017. Français. ⟨NNT : 2017ANGE0023⟩. ⟨tel-02178998v2⟩

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