Annotation des ARN longs non-codants chez la poule et les espèces d’élevage : Focus sur les ARNlnc régulateurs du métabolisme des lipides

Abstract : Genome annotation is a major challenge in connecting genotypes with phenotypes. Identifying long noncoding RNAs (lncRNA) in genomes is part of this challenge; they are relatively low-expressed and have only been highlighted in 2012 thanks to the development of high throughput sequencing technologies. This research work has led to the identification of a large number of lncRNAs in livestock species, particularly in the chicken, in which no lncRNA had yet been described at the beginning of this thesis (2015). First, my aim was to identify these lncRNAs using liver and adipose tissue and to improve this catalogue by integrating other existing lncRNA public databases.Moreover, according to the literature, lncRNAs are involved in the regulation of any biological process, from gene expression to cell structure. One of the goals of our team is to understand the regulation of lipid metabolism in the chicken, I thus established the list of all lncRNAs known within the animal kingdom and involved in this metabolism or in adipogenesis, the process of storage and formation of adipose tissue. The conservation by synteny analyses revealed around twenty conserved lncRNAs in the chicken. From divergent abdominal fat weight chicken lines, I lastly identified new lncRNAs that potentially regulate this lipid metabolism.
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Kévin Muret. Annotation des ARN longs non-codants chez la poule et les espèces d’élevage : Focus sur les ARNlnc régulateurs du métabolisme des lipides. Génétique animale. Agrocampus Ouest, 2018. Français. ⟨NNT : 2018NSARC139⟩. ⟨tel-02178722⟩

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