F. F. Aburjaile, M. Madec, S. Parayre, A. Miyoshi, V. Azevedo et al., The long-term survival of Propionibacterium freudenreichii in a context of nutrient shortage, J. Appl, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01251265

. Microbiol, , vol.120, pp.432-440

L. Maréchal, C. Peton, V. Plé, C. Vroland, C. Jardin et al., Surface proteins of Propionibacterium freudenreichii are involved in its anti-inflammatory properties, J. Proteomics, vol.113, pp.447-461, 2015.

V. Loux, M. Mariadassou, S. Almeida, H. Chiapello, A. Hammani et al., , 2015.

, Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii, BMC Genomics, vol.16

G. V. Mukamolova, A. G. Murzin, E. G. Salina, G. R. Demina, D. B. Kell et al.,

, Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation, Mol. Microbiol, vol.59, pp.84-98

J. D. Oliver, Recent findings on the viable but nonculturable state in pathogenic bacteria, FEMS Microbiol. Rev, vol.34, pp.415-425, 2010.

M. M. Palomino, P. M. Waehner, J. Fina-martin, P. Ojeda, L. Malone et al., Influence of osmotic stress on the profile and gene expression of surface layer proteins in Lactobacillus acidophilus ATCC 4356, Appl. Microbiol. Biotechnol, vol.100, pp.8475-8484, 2016.

C. Plé, J. Breton, R. Richoux, M. Nurdin, S. Deutsch et al., Combining selected immunomodulatory Propionibacterium freudenreichii and Lactobacillus delbrueckii strains: reverse engineering development of an anti-inflammatory cheese, Mol. Nutr. Food Res, vol.60, pp.935-948, 2016.

C. Plé, R. Richoux, J. Jardin, M. Nurdin, V. Briard-bion et al., Single-strain starter experimental cheese reveals anti-inflammatory effect of Propionibacterium freudenreichii CIRM BIA 129 in TNBS-colitis model, J. Funct. Foods, vol.18, pp.575-585, 2015.

H. Rabah, F. L. Do-carmo, J. , and G. , Dairy propionibacteria: versatile probiotics. Microorganisms 5, p.24, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01524323

C. Lazzi, M. Povolo, F. Locci, V. Bernini, E. Neviani et al., Can the development and autolysis of lactic acid bacteria influence the cheese volatile fraction? The case of Grana Padano, 2016.

, Int. J. Food Microbiol, vol.233, pp.20-28

J. J. Letterio and A. B. Roberts, Regulation of immune responses by TGF-beta, Annu. Rev, 1998.

. Immunol, , vol.16, pp.137-161

Y. Ohtsuka and I. R. Sanderson, Dextran sulfate sodium-induced inflammation is enhanced by intestinal epithelial cell chemokine expression in mice, Pediatr. Res, vol.53, pp.143-147, 2003.

X. Pang, S. Zhang, J. Lu, L. Liu, C. Ma et al., Identification and Functional Validation of Autolysis-Associated Genes in Lactobacillus bulgaricus ATCC BAA-365, 2017.

. Microbiol, , vol.8, p.1367

M. Per?e and A. Cerar, Dextran sodium sulphate colitis mouse model: traps and tricks, J. Biomed. Biotechnol, p.718617, 2012.

I. Politis and R. Chronopoulou, Milk Peptides and Immune Response in the Neonate, Bioactive Components of Milk Advances in Experimental Medicine and Biology, pp.253-269, 2008.

H. Rabah, F. L. Do-carmo, J. , and G. , Dairy propionibacteria: versatile probiotics. Microorganisms 5, p.24, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01524323

H. Rabah, S. Ferret-bernard, S. Huang, L. Le-normand, F. J. Cousin et al., The Cheese Matrix Modulates the Immunomodulatory Properties of Propionibacterium freudenreichii CIRM-BIA 129 in Healthy Piglets, Front. Microbiol, vol.9, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01910411

G. Roda, M. Marocchi, A. Sartini, R. , and E. , Cytokine Networks in Ulcerative Colitis. Ulcers, 2011.

L. Sang, B. Chang, B. Wang, W. Liu, and M. Jiang, Live and heat-killed probiotic: effects on chronic experimental colitis induced by dextran sulfate sodium (DSS) in rats, Int. J. Clin. Exp, 2015.

. Med, , vol.8, 20072.

R. Santaolalla and M. T. Abreu, Innate immunity in the small intestine, Curr. Opin, 2012.

. Gastroenterol, , vol.28, pp.124-129

S. Rocha, C. Gomes-santos, A. C. Garcias-moreira, T. De-azevedo, M. Diniz-luerce et al., Local and systemic immune mechanisms underlying the anti-colitis effects of the dairy bacterium Lactobacillus delbrueckii, PloS One, vol.9, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01204288

S. Rocha, C. Lakhdari, O. Blottière, H. M. Blugeon, S. Sokol et al., Anti-inflammatory properties of dairy lactobacilli, Inflamm. Bowel Dis, vol.18, pp.657-666, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00632487

W. H. Saris, N. G. Asp, I. Björck, E. Blaak, F. Bornet et al., Functional food science and substrate metabolism, Br. J. Nutr, vol.80, pp.47-75, 1998.

B. K. Thakur, P. Saha, G. Banik, D. R. Saha, S. Grover et al., Live and heatkilled probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response, Int. Immunopharmacol, vol.36, pp.39-50, 2016.

H. A. Thierry, S. M. Falentin, G. Deutsch, and . Jan, Propionibacterium spp, Encyclopedia of dairy sciences F. P. a. M. P. Fuquay JW, pp.403-411, 2011.

R. Abu-qarn, M. Eichler, J. , S. , and N. , Not just for Eukarya anymore: protein glycosylation in Bacteria and Archaea, Carbohydr. Glycoconj. Biophys. Methods, vol.18, pp.544-550, 2008.

F. F. Aburjaile, M. Madec, S. Parayre, A. Miyoshi, V. Azevedo et al., The long-term survival of Propionibacterium freudenreichii in a context of nutrient shortage, J. Appl. Microbiol, vol.120, pp.432-440, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01251265

F. F. Aburjaile, M. Rohmer, H. Parrinello, M. Maillard, E. Beaucher et al., Adaptation of Propionibacterium freudenreichii to long-term survival under gradual nutritional shortage, BMC Genomics, vol.17, p.1007, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01535200

A. Agrawal, L. A. Houghton, J. Morris, B. Reilly, D. Guyonnet et al., Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation, Aliment. Pharmacol. Ther, vol.29, pp.104-114, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00416261

D. Ahl, H. Liu, O. Schreiber, S. Roos, M. Phillipson et al., Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice, Acta Physiol, vol.217, pp.300-310, 2016.

C. Alvarez, J. Badia, M. Bosch, R. Giménez, and L. Baldomà, Outer Membrane Vesicles and Soluble Factors Released by Probiotic Escherichia coli Nissle 1917 and Commensal ECOR63 Enhance Barrier Function by Regulating Expression of Tight Junction Proteins in, Intestinal Epithelial Cells. Front. Microbiol, vol.7, 1981.

V. Anantharaman, A. , and L. , Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes, Genome Biol, vol.4, pp.11-11, 2003.

J. Anzengruber, M. Pabst, L. Neumann, G. Sekot, S. Heinl et al., Protein Oglucosylation in Lactobacillus buchneri, Glycoconj. J, vol.31, pp.117-131, 2014.

F. Araújo, C. Pereira, J. Costa, C. Barrias, P. L. Granja et al., In vitro M-like cells genesis through a tissue-engineered triple-culture intestinal model, J. Biomed. Mater. Res. B Appl. Biomater, vol.104, pp.782-788, 2016.

S. Åvall-jääskeläinen, Characterization and applications of Lactobacillus brevis S-layer proteins and evaluation of Lactococcus lactis as a porcine cytokine producer, 2005.

A. Baer, Influence of casein proteolysis by starter bacteria, rennet and plasmin on the growth of propionibacteria in Swiss-type cheese, Le Lait, vol.75, pp.391-400, 1995.
URL : https://hal.archives-ouvertes.fr/hal-00929445

S. R. Bailey, M. H. Nelson, R. A. Himes, Z. Li, S. Mehrotra et al., Th17 Cells in Cancer: The Ultimate Identity Crisis, Front. Immunol, vol.5, 2014.

S. Balzaretti, V. Taverniti, S. Guglielmetti, W. Fiore, M. Minuzzo et al., A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells, Appl. Environ. Microbiol, vol.83, pp.2702-2718, 2017.

P. A. Bron, P. Van-baarlen, and M. Kleerebezem, Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa, Nat. Rev. Microbiol, vol.10, pp.66-78, 2012.

L. Brown, E. V. Pingitore, F. Mozzi, L. Saavedra, J. M. Villegas et al., Lactic Acid Bacteria as Cell Factories for the Generation of Bioactive Peptides, Protein Pept. Lett, vol.24, pp.146-155, 2017.

J. Burisch, T. Jess, M. Martinato, P. L. Lakatos, and . Ecco--epicom, The burden of inflammatory bowel disease in Europe, J. Crohns Colitis, vol.7, pp.322-337, 2013.

L. M. Cagen and H. C. Friedmann, Enzymatic Phosphorylation of Serine, J. Biol. Chem, vol.247, pp.3382-3392, 1972.

J. A. Cain, N. Solis, and S. J. Cordwell, Beyond gene expression: The impact of protein posttranslational modifications in bacteria, J. Proteomics, vol.97, pp.265-286, 2014.

J. Cao, S. Guo, K. Arai, E. H. Lo, and M. Ning, Studying Extracellular Signaling Utilizing a Glycoproteomic Approach: Lectin Blot Surveys, a First and Important Step, Methods Mol. Biol. Clifton NJ, vol.1013, pp.227-233, 2013.

A. Cardoso, A. Gil-castro, A. C. Martins, G. M. Carriche, V. Murigneux et al., The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis, Front. Immunol, vol.9, 2018.
URL : https://hal.archives-ouvertes.fr/pasteur-01737190

R. D. Carvalho, N. Breyner, Z. Menezes-garcia, N. M. Rodrigues, L. Lemos et al., Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis, Microb. Cell Factories, vol.16, p.27, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01607391

G. J. Cavallero, M. Malamud, A. C. Casabuono, M. Serradell, L. Á. De et al., A glycoproteomic approach reveals that the S-layer glycoprotein of Lactobacillus kefiri CIDCA 83111 is O-and N-glycosylated, J. Proteomics, 2017.

D. Chang, D. J. Smalley, D. L. Tucker, M. P. Leatham, W. E. Norris et al., Carbon nutrition of Escherichia coli in the mouse intestine, Proc. Natl. Acad. Sci. U. S. A, vol.101, pp.7427-7432, 2004.

W. Chanput, J. J. Mes, and H. J. Wichers, THP-1 cell line: an in vitro cell model for immune modulation approach, Int. Immunopharmacol, vol.23, pp.37-45, 2014.

B. Chassaing, J. D. Aitken, M. Malleshappa, and M. Vijay-kumar, Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice, Curr. Protoc. Immunol. Ed. John E Coligan Al, vol.104, 2014.

J. Colangelo and R. Orlando, On-target endoglycosidase digestion matrix-assisted laser desorption/ionization mass spectrometry of glycopeptides, Rapid Commun. Mass Spectrom. RCM, vol.15, pp.2284-2289, 2001.

N. Colliou, Y. Ge, B. Sahay, M. Gong, M. Zadeh et al., Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation, J. Clin. Invest, vol.127, pp.3970-3986, 2017.

H. S. Cooper, S. N. Murthy, R. S. Shah, and D. J. Sedergran, Clinicopathologic study of dextran sulfate sodium experimental murine colitis, Lab. Investig. J. Tech. Methods Pathol, vol.69, pp.238-249, 1993.

A. Cotillard, S. P. Kennedy, L. C. Kong, E. Prifti, N. Pons et al., Dietary intervention impact on gut microbial gene richness, Nature, vol.500, pp.585-588, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01001543

F. J. Cousin, S. Louesdon, M. Maillard, S. Parayre, H. Falentin et al., The first dairy product exclusively fermented by Propionibacterium freudenreichii: A new vector to study probiotic potentialities in vivo, Food Microbiol, vol.32, pp.135-146, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01209321

F. J. Cousin, D. D. Mater, B. Foligné, J. , and G. , Dairy propionibacteria as human probiotics: A review of recent evidence, Dairy Sci. Technol, vol.91, pp.1-26, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00868601

M. Dalmasso, J. Aubert, S. Even, H. Falentin, M. Maillard et al., Accumulation of Intracellular Glycogen and Trehalose by Propionibacterium freudenreichii under Conditions Mimicking Cheese Ripening in the Cold, Appl. Environ. Microbiol, vol.78, pp.6357-6364, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01191223

L. A. David, C. F. Maurice, R. N. Carmody, D. B. Gootenberg, J. E. Button et al., Diet rapidly and reproducibly alters the human gut microbiome, Nature, vol.505, pp.559-563, 2013.

P. De-sa-peixoto, C. Roiland, D. Thomas, V. Briard-bion, R. Le-guellec et al., Recrystallized s-layer protein of a probiotic Propionibacterium: structural and nanomechanical changes upon temperature or ph shifts probed by solid-state nmr and afm, Langmuir, vol.31, pp.199-208, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01116500

Y. Derwa, D. J. Gracie, P. J. Hamlin, and A. C. Ford, Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease, Aliment. Pharmacol. Ther, vol.46, pp.389-400, 2017.

S. M. Deutsch, P. L. Bivic, C. Herve, M. N. Madec, G. Lapointe et al., Correlation of the Capsular Phenotype in Propionibacterium freudenreichii with the Level of Expression of gtf, a Unique Polysaccharide Synthase-Encoding Gene, Appl. Environ. Microbiol, vol.76, pp.2740-2746, 2010.

S. Deutsch, H. Falentin, M. Dols-lafargue, G. Lapointe, R. et al., Capsular exopolysaccharide biosynthesis gene of Propionibacterium freudenreichii subsp. shermanii, Int. J. Food Microbiol, vol.125, pp.252-258, 2008.

S. Deutsch, M. Mariadassou, P. Nicolas, S. Parayre, R. Le-guellec et al., Identification of proteins involved in the anti-inflammatory properties of Propionibacterium freudenreichii by means of a multi-strain study, Sci. Rep, vol.7, p.46409, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01510019

A. T. Diplock, P. Aggett, M. Ashwell, F. R. Bornet, B. Fern et al., Scientific concepts of functional foods in Europe: consensus document, Br. J. Nutr, vol.81, p.27, 1999.

F. L. Do-carmo, H. Rabah, R. D. De-oliveira-carvalho, F. Gaucher, B. F. Cordeiro et al., Extractable Bacterial Surface Proteins in Probiotic-Host Interaction, Front. Microbiol, vol.9, p.645, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01763214

F. L. Do-carmo, W. M. Silva, G. C. Tavares, I. C. Ibraim, B. F. Cordeiro et al., Mutation of the surface layer protein SlpB has pleiotropic effects in the probiotic Propionibacterium freudenreichii 129, Front. Microbiol, vol.9, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01857987

D. Carmo, L. R. Fillipe, H. Rabah, S. Huang, F. Gaucher et al., Propionibacterium freudenreichii surface protein SlpB is involved in adhesion to intestinal ht-29 cells, Front. Microbiol, vol.8, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01824996

H. Dong, I. Rowland, L. V. Thomas, Y. , and P. , Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers, Eur. J. Nutr, vol.52, pp.1853-1863, 2013.

T. M. Dronkers, L. Krist, F. J. Van-overveld, and G. T. Rijkers, The ascent of the blessed: regulatory issues on health effects and health claims for probiotics in Europe and the rest of the world, Benef. Microbes, vol.9, pp.717-723, 2018.

R. Duchmann, I. Kaiser, E. Hermann, W. Mayet, K. Ewe et al., Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD), Clin. Exp. Immunol, vol.102, pp.448-455, 1995.

P. Ducrotté, P. Sawant, J. , and V. , Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome, World J. Gastroenterol, vol.18, pp.4012-4018, 2012.

H. Engelhardt, Mechanism of osmoprotection by archaeal S-layers: A theoretical study, J. Struct. Biol, vol.160, pp.190-199, 2007.

M. A. Engevik and J. Versalovic, Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology, Microbiol. Spectr, vol.5, 2017.

N. P. Evans, S. A. Misyak, E. M. Schmelz, A. J. Guri, R. Hontecillas et al., Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPAR, J. Nutr, vol.140, pp.515-521, 2010.

M. Fábrega, A. Rodríguez-nogales, J. Garrido-mesa, F. Algieri, J. Badía et al., Intestinal Anti-inflammatory Effects of Outer Membrane Vesicles from Escherichia coli Nissle 1917 in DSS-Experimental Colitis in Mice, Front. Microbiol, vol.8, p.1274, 2017.

. Fao and . Who, Probiotics in food: health and nutritional properties and guidelines for evaluation, 2006.

B. Foligné, J. Breton, D. Mater, J. , and G. , Tracking the microbiome functionality: focus on Propionibacterium species, Gut, vol.62, pp.1227-1228, 2013.

B. Foligné, S. Deutsch, J. Breton, F. J. Cousin, J. Dewulf et al., Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo, Appl. Environ. Microbiol, vol.76, pp.8259-8264, 2010.

B. Foligné, S. Nutten, L. Steidler, V. Dennin, D. Goudercourt et al., Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects, Dig. Dis. Sci, vol.51, pp.390-400, 2006.

B. Foligné, S. Parayre, R. Cheddani, M. Famelart, M. Madec et al., Immunomodulation properties of multi-species fermented milks, Food Microbiol, vol.53, pp.60-69, 2016.

A. Forbes, J. Escher, X. Hébuterne, S. K??k, Z. Krznaric et al., ESPEN guideline: Clinical nutrition in inflammatory bowel disease, Clin. Nutr. Edinb. Scotl, vol.36, pp.321-347, 2017.

D. N. Frank, A. L. St-amand, R. A. Feldman, E. C. Boedeker, N. Harpaz et al., Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc. Natl. Acad. Sci. U. S. A, vol.104, pp.13780-13785, 2007.

V. Gagnaire, J. Jardin, H. Rabah, V. Briard-bion, J. et al., Emmental cheese environment enhances Propionibacterium freudenreichii stress tolerance, PLOS ONE, vol.10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01372936

K. Ganguli, M. C. Collado, J. Rautava, L. Lu, R. Satokari et al., Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut, Pediatr. Res, vol.77, pp.528-535, 2015.

T. B. Geijtenbeek and S. I. Gringhuis, C-type lectin receptors in the control of T helper cell differentiation, Nat. Rev. Immunol, vol.16, pp.433-448, 2016.

F. George, C. Daniel, M. Thomas, E. Singer, A. Guilbaud et al., Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective, Front. Microbiol, vol.9, p.2899, 2018.

E. Gerbino, P. Carasi, C. Araujo-andrade, E. E. Tymczyszyn, and A. Gómez-zavaglia, Role of S-layer proteins in the biosorption capacity of lead by Lactobacillus kefir, World J. Microbiol. Biotechnol, vol.31, pp.583-592, 2015.

E. Gerbino, P. Carasi, P. Mobili, M. A. Serradell, and A. Gómez-zavaglia, Role of S-layer proteins in bacteria, World J. Microbiol. Biotechnol, vol.31, pp.1877-1887, 2015.

P. Gionchetti, C. Amadini, F. Rizzello, A. Venturi, V. Palmonari et al., Probiotics--role in inflammatory bowel disease, Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver, vol.34, issue.2, pp.58-62, 2002.

M. Giovannini, C. Agostoni, E. Riva, F. Salvini, A. Ruscitto et al., A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis, Pediatr. Res, vol.62, pp.215-220, 2007.

A. Giulietti, L. Overbergh, D. Valckx, B. Decallonne, R. Bouillon et al., An Overview of Real-Time Quantitative PCR: Applications to Quantify Cytokine Gene Expression, Methods, vol.25, pp.386-401, 2001.

M. Gleeson, N. C. Bishop, M. Oliveira, and P. Tauler, Daily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletes, Int. J. Sport Nutr. Exerc. Metab, vol.21, pp.55-64, 2011.

T. Grabinger, L. Luks, F. Kostadinova, C. Zimberlin, J. P. Medema et al., Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy, Cell Death Dis, vol.5, 2014.

P. A. Grange, J. Raingeaud, W. Morelle, A. Marcelin, V. Calvez et al., Characterization of a Propionibacterium acnes Surface Protein as a Fibrinogen-Binding, Protein. Sci. Rep, vol.7, p.6428, 2017.

F. Groell, O. Jordan, and G. Borchard, In vitro models for immunogenicity prediction of therapeutic proteins, Eur. J. Pharm. Biopharm, vol.130, pp.128-142, 2018.

S. Grosu-tudor, L. Brown, E. M. Hebert, A. Brezeanu, A. Brinzan et al., Slayer production by Lactobacillus acidophilus IBB 801 under environmental stress conditions, Appl. Microbiol. Biotechnol, vol.100, pp.4573-4583, 2016.

F. Guarner, M. E. Sanders, G. Gibson, T. Klaenhammer, M. Cabana et al., Probiotic and prebiotic claims in Europe: seeking a clear roadmap, Br. J. Nutr, vol.106, pp.1765-1767, 2011.

E. Guillemard, J. Tanguy, A. Flavigny, S. De-la-motte, and J. Schrezenmeir, Effects of consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 on common respiratory and gastrointestinal infections in shift workers in a randomized controlled trial, J. Am. Coll. Nutr, vol.29, pp.455-468, 2010.

E. Guillemard, F. Tondu, F. Lacoin, and J. Schrezenmeir, Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial, Br. J. Nutr, vol.103, pp.58-68, 2010.

M. Guslandi, G. Mezzi, M. Sorghi, and P. A. Testoni, Saccharomyces boulardii in maintenance treatment of Crohn's disease, Dig. Dis. Sci, vol.45, pp.1462-1464, 2000.

D. Guyonnet, O. Chassany, P. Ducrotte, C. Picard, M. Mouret et al., Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial, Aliment. Pharmacol. Ther, vol.26, pp.475-486, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00294433

M. G. Hartley, M. J. Hudson, E. T. Swarbrick, M. J. Hill, A. E. Gent et al., The rectal mucosa-associated microflora in patients with ulcerative colitis, J. Med. Microbiol, vol.36, pp.96-103, 1992.

C. L. Hayes, J. M. Natividad, J. Jury, R. Martin, P. Langella et al., Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration, Benef. Microbes, vol.5, pp.79-88, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01204365

S. Heim, M. D. Lleo, B. Bonato, C. A. Guzman, and P. Canepari, The Viable but Nonculturable State and Starvation Are Different Stress Responses of Enterococcus faecalis, as Determined by Proteome Analysis, J. Bacteriol, vol.184, pp.6739-6745, 2002.

J. Henker, S. Müller, M. W. Laass, A. Schreiner, and J. Schulze, Probiotic Escherichia coli Nissle 1917 (EcN) for successful remission maintenance of ulcerative colitis in children and adolescents: an open-label pilot study, Z. Gastroenterol, vol.46, pp.874-875, 2008.

M. Hickson, A. L. Souza, N. Muthu, T. R. Rogers, S. Want et al., Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial, BMJ, vol.335, p.80, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00430232

D. R. Hill and J. R. Spence, Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface, Cell. Mol. Gastroenterol. Hepatol, vol.3, pp.138-149, 2017.

H. Hou, Y. Guo, Q. Chang, T. Luo, X. Wu et al., C-type Lectin Receptor: Old Friend and New Player, Med. Chem. Shariqah United Arab Emir, vol.13, pp.536-543, 2017.

L. Huang, J. Lin, J. Tsai, Y. Chu, Y. Chen et al., Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift, J. Chromatogr. A, vol.1371, pp.136-145, 2014.

S. Huang, H. Rabah, J. Jardin, V. Briard-bion, S. Parayre et al., Hyperconcentrated sweet whey, a new culture medium that enhances Propionibacterium freudenreichii stress tolerance, Appl. Environ. Microbiol, vol.82, pp.4641-4651, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01454632

K. Isawa, K. Hojo, N. Yoda, T. Kamiyama, S. Makino et al., Isolation and identification of a new bifidogenic growth stimulator produced by Propionibacterium freudenreichii ET-3, Biosci. Biotechnol. Biochem, vol.66, pp.679-681, 2002.

K. Ivory, S. J. Chambers, C. Pin, E. Prieto, J. L. Arqués et al., Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis, Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol, vol.38, pp.1282-1289, 2008.

M. Junjua, N. Kechaou, F. Chain, A. A. Awussi, Y. Roussel et al., A large scale in vitro screening of Streptococcus thermophilus strains revealed strains with a high antiinflammatory potential, LWT -Food Sci. Technol, vol.70, pp.78-87, 2016.

B. D. Kana and V. Mizrahi, Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling, FEMS Immunol. Med. Microbiol, vol.58, pp.39-50, 2010.

G. G. Kaplan, The global burden of IBD: from 2015 to 2025, Nat. Rev. Gastroenterol. Hepatol, vol.12, pp.720-727, 2015.

A. Kato-kataoka, K. Nishida, M. Takada, K. Suda, M. Kawai et al., Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress, Benef. Microbes, vol.7, pp.153-156, 2016.

N. H. Keep, J. M. Ward, M. Cohen-gonsaud, H. , and B. , Wake up! Peptidoglycan lysis and bacterial non-growth states, Trends Microbiol, vol.14, pp.271-276, 2006.

S. Kernéis, E. Caliot, H. Stubbe, A. Bogdanova, J. Kraehenbuhl et al., Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells: a technical update, Microbes Infect, vol.2, pp.1119-1124, 2000.

M. Khaleghi and R. Kasra, Effect of Environmental Stresses on S-Layer Production in Lactobacillus acidophilus ATCC 4356, Advances in Applied Biotechnology, ed. M. Petre (InTech). Available at, 2012.

M. Khaleghi, R. K. Kermanshahi, M. M. Yaghoobi, S. H. Zarkesh-esfahani, and A. Baghizadeh, Assessment of bile salt effects on s-layer production, slp gene expression and some physicochemical properties of Lactobacillus acidophilus ATCC 4356, J. Microbiol. Biotechnol, vol.20, pp.749-756, 2010.

H. G. Kim, N. Kim, M. G. Gim, J. M. Lee, S. Y. Lee et al., Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice, J. Immunol. Baltim. Md, vol.180, pp.2553-2561, 1950.

Y. K. Kim, J. S. Shin, and M. H. Nahm, NOD-Like Receptors in Infection, Immunity, and Diseases, Yonsei Med. J, vol.57, pp.5-14, 2016.

J. K. Ko and K. K. Auyeung, Inflammatory bowel disease: etiology, pathogenesis and current therapy, Curr. Pharm. Des, vol.20, pp.1082-1096, 2014.

K. S. Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara et al., Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract, Science, vol.307, pp.731-734, 2005.

C. Koebnick, I. Wagner, P. Leitzmann, U. Stern, and H. J. Zunft, Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation, Can. J. Gastroenterol. J. Can. Gastroenterol, vol.17, pp.655-659, 2003.

V. Koltunov, C. L. Greenblatt, A. V. Goncharenko, G. R. Demina, B. Y. Klein et al., Structural changes and cellular localization of resuscitation-promoting factor in environmental isolates of Micrococcus luteus, Microb. Ecol, vol.59, pp.296-310, 2010.

W. Kruis, P. Fric, J. Pokrotnieks, M. Lukás, B. Fixa et al., Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine, Gut, vol.53, pp.1617-1623, 2004.

W. Kruis, E. Schütz, P. Fric, B. Fixa, G. Judmaier et al., Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis, Aliment. Pharmacol. Ther, vol.11, pp.853-858, 1997.

U. K. Laemmli, Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, Nature, vol.227, pp.680-685, 1970.

J. Laiño, J. Villena, P. Kanmani, and H. Kitazawa, Immunoregulatory Effects Triggered by Lactic Acid Bacteria Exopolysaccharides: New Insights into Molecular Interactions with Host Cells, 2016.

J. Langhorst, S. Elsenbruch, J. Koelzer, A. Rueffer, A. Michalsen et al., Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices, Am. J. Gastroenterol, vol.103, pp.162-169, 2008.

D. Latousakis, J. , and N. , How Sweet Are Our Gut Beneficial Bacteria? A Focus on Protein Glycosylation in Lactobacillus, Int. J. Mol. Sci, vol.19, 2018.

C. Lazzi, M. Povolo, F. Locci, V. Bernini, E. Neviani et al., Can the development and autolysis of lactic acid bacteria influence the cheese volatile fraction? The case of Grana Padano, Int. J. Food Microbiol, vol.233, pp.20-28, 2016.

T. ;. Lea, P. Verhoeckx, I. Cotter, C. López-expósito, T. Kleiveland et al., Caco-2 Cell Line, The Impact of Food Bioactives on Health: in vitro and ex vivo models, 2015.

S. Lebeer, P. A. Bron, M. L. Marco, J. Van-pijkeren, M. Motherway et al., Identification of probiotic effector molecules: present state and future perspectives, Curr. Opin. Biotechnol, vol.49, pp.217-223, 2018.

, Legifrance Décret n°2007-628 du 27 avril 2007 relatif aux fromages et spécialités fromagères | Legifrance, 2019.

J. J. Letterio and A. B. Roberts, Regulation of immune responses by TGF-beta, Annu. Rev. Immunol, vol.16, pp.137-161, 1998.

P. Leverrier, Y. Fremont, A. Rouault, P. Boyaval, J. et al., In vitro tolerance to digestive stresses of propionibacteria: influence of food matrices, Food Microbiol, vol.22, pp.11-18, 2005.
URL : https://hal.archives-ouvertes.fr/hal-01453978

R. Levit, G. S. De-giori, A. De-moreno-de-leblanc, and J. G. Leblanc, Evaluation of the effect of soy milk fermented by a riboflavin-producing Lactobacillus plantarum strain in a murine model of colitis, Benef. Microbes, vol.8, pp.65-72, 2017.

R. Levit, G. Savoy-de-giori, A. De-moreno-de-leblanc, and J. G. Leblanc, Effect of riboflavinproducing bacteria against chemically induced colitis in mice, J. Appl. Microbiol, vol.124, pp.232-240, 2018.

Y. L. Lightfoot, K. Selle, T. Yang, Y. J. Goh, B. Sahay et al., SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis, EMBO J, vol.34, pp.881-895, 2015.

J. Lin, Y. Chiu, N. Lin, C. Chu, K. Huang et al., Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study, Vaccine, vol.27, pp.1073-1079, 2009.

E. Lönnermark, V. Friman, G. Lappas, T. Sandberg, A. Berggren et al., Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics, J. Clin. Gastroenterol, vol.44, pp.106-112, 2010.

V. Loux, M. Mariadassou, S. Almeida, H. Chiapello, A. Hammani et al., Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii, BMC Genomics, vol.16, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01209851

K. Machiels, M. Joossens, J. Sabino, V. De-preter, I. Arijs et al., A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis, Gut, vol.63, pp.1275-1283, 2014.

M. Malamud, P. Carasi, T. Freire, M. Serradell, and L. A. De, S-layer glycoprotein from Lactobacillus kefiri CIDCA 8348 enhances macrophages response to LPS in a Ca+2-dependent manner, Biochem. Biophys. Res. Commun, vol.495, pp.1227-1232, 2018.

A. Marcos, J. Wärnberg, E. Nova, S. Gómez, A. Alvarez et al., The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114001 on the immune response of subjects under academic examination stress, Eur. J. Nutr, vol.43, pp.381-389, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00294403

R. Martín, F. Chain, S. Miquel, J. Motta, N. Vergnolle et al., Using murine colitis models to analyze probiotics-host interactions, FEMS Microbiol. Rev, vol.41, 2017.

D. Martínez-maqueda, B. Miralles, I. ;. Recio, P. Verhoeckx, I. Cotter et al., HT29 Cell Line, The Impact of Food Bioactives on Health, pp.113-124, 2015.

J. Matowicka-karna, Markers of inflammation, activation of blood platelets and coagulation disorders in inflammatory bowel diseases, Postepy Hig. Med. Doswiadczalnej Online, vol.70, pp.305-312, 2016.

O. Ménard, T. Cattenoz, H. Guillemin, I. Souchon, A. Deglaire et al., Validation of a new in vitro dynamic system to simulate infant digestion, Food Chem, vol.145, pp.1039-1045, 2014.

D. Merenstein, M. Murphy, A. Fokar, R. K. Hernandez, H. Park et al., Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial, Eur. J. Clin. Nutr, vol.64, pp.669-677, 2010.

A. L. Meyer, M. Micksche, I. Herbacek, and I. Elmadfa, Daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women, Ann. Nutr. Metab, vol.50, pp.282-289, 2006.

I. Mijakovic and B. Macek, Impact of phosphoproteomics on studies of bacterial physiology, FEMS Microbiol. Rev, vol.36, pp.877-892, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01003426

M. Minekus, M. Alminger, P. Alvito, S. Ballance, T. Bohn et al., A standardised static in vitro digestion method suitable for food ? An international consensus, Food Funct, vol.5, p.1113, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01195466

A. Mizoguchi, Animal Models of Inflammatory Bowel Disease, Progress in Molecular Biology and Translational Science Animal Models of Molecular Pathology, pp.263-320, 2012.

P. Mobili, E. Gerbino, E. Tymczyszyn, and A. Gómez-zavaglia, S-layers in lactobacilli: structural characteristics and putative role in surface and probiotic properties of whole bacteria, Curr Res Technol Educ Top. Appl Microbiol Microb Biotechnol, vol.22, pp.1224-1234, 2010.

M. Mohamadzadeh, E. A. Pfeiler, J. B. Brown, M. Zadeh, M. Gramarossa et al., Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid, Proc. Natl. Acad. Sci, vol.108, 2011.

K. Molly, M. V. Woestyne, I. D. Smet, and W. Verstraete, Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities, Microb. Ecol. Health Dis, vol.7, pp.191-200, 1994.

A. Moradian, A. Kalli, M. J. Sweredoski, and S. Hess, The top-down, middle-down, and bottom-up mass spectrometry approaches for characterization of histone variants and their posttranslational modifications, Proteomics, vol.14, pp.489-497, 2014.

G. V. Mukamolova, A. G. Murzin, E. G. Salina, G. R. Demina, D. B. Kell et al., Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation, Mol. Microbiol, vol.59, pp.84-98, 2006.

Y. Murofushi, J. Villena, K. Morie, P. Kanmani, M. Tohno et al., The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14, Mol. Immunol, vol.64, pp.63-75, 2015.

F. Nagao, M. Nakayama, T. Muto, and K. Okumura, Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects, Biosci. Biotechnol. Biochem, vol.64, pp.2706-2708, 2000.

K. Niedzielin, H. Kordecki, and B. Birkenfeld, A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome, Eur. J. Gastroenterol. Hepatol, vol.13, pp.1143-1147, 2001.

V. D. Nikitushkin, G. R. Demina, M. O. Shleeva, and A. S. Kaprelyants, Peptidoglycan fragments stimulate resuscitation of "non-culturable" mycobacteria, Antonie Van Leeuwenhoek, vol.103, pp.37-46, 2013.

S. Nobaek, M. L. Johansson, G. Molin, S. Ahrné, J. et al., Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome, Am. J. Gastroenterol, vol.95, pp.1231-1238, 2000.

, Observatoire National des MICI Available, 2019.

Y. Ohtsuka and I. R. Sanderson, Dextran sulfate sodium-induced inflammation is enhanced by intestinal epithelial cell chemokine expression in mice, Pediatr. Res, vol.53, pp.143-147, 2003.

Y. Okada, Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing, Gut, vol.55, pp.681-688, 2006.

J. D. Oliver, Recent findings on the viable but nonculturable state in pathogenic bacteria, FEMS Microbiol. Rev, vol.34, pp.415-425, 2010.

A. Ortiz-andrellucchi, A. Sánchez-villegas, C. Rodríguez-gallego, A. Lemes, T. Molero et al., Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114001 in lactating mothers and their children, Br. J. Nutr, vol.100, pp.834-845, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00430211

C. D. Packey and R. B. Sartor, Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases, Curr. Opin. Infect. Dis, vol.22, pp.292-301, 2009.

V. D. Palumbo, M. Romeo, A. Marino-gammazza, F. Carini, P. Damiani et al., The long-term effects of probiotics in the therapy of ulcerative colitis: A clinical study, Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czechoslov, vol.160, pp.372-377, 2016.

X. Pang, S. Zhang, J. Lu, L. Liu, C. Ma et al., Identification and Functional Validation of Autolysis-Associated Genes in Lactobacillus bulgaricus ATCC BAA-365, Front. Microbiol, vol.8, p.1367, 2017.

D. K. Parandhaman, P. Sharma, D. Bisht, and S. Narayanan, Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis, Life Sci, vol.109, pp.116-126, 2014.

C. A. Pedone, C. C. Arnaud, E. R. Postaire, C. F. Bouley, and P. Reinert, Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea, Int. J. Clin. Pract, vol.54, pp.568-571, 2000.
URL : https://hal.archives-ouvertes.fr/hal-00294328

C. A. Pedone, A. O. Bernabeu, E. R. Postaire, C. F. Bouley, and P. Reinert, The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres, Int. J. Clin. Pract, vol.53, pp.179-184, 1999.

M. Per?e and A. Cerar, Dextran sodium sulphate colitis mouse model: traps and tricks, J. Biomed. Biotechnol, p.718617, 2012.

I. Politis and R. Chronopoulou, Milk Peptides and Immune Response in the Neonate, Bioactive Components of Milk Advances in Experimental Medicine and Biology, pp.253-269, 2008.

C. Pothoulakis, Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii, Aliment. Pharmacol. Ther, vol.30, pp.826-833, 2009.

S. Prakash, C. Tomaro-duchesneau, S. Saha, and A. Cantor, The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells, Healthy Piglets. Front. Microbiol, vol.9, 2011.

H. Rabah, O. Ménard, F. Gaucher, F. L. Do-carmo, D. Dupont et al., Cheese matrix protects the immunomodulatory surface protein SlpB of Propionibacterium freudenreichii during in vitro digestion, Food Res. Int, vol.106, pp.712-721, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01707548

T. Ramamurthy, A. Ghosh, G. P. Pazhani, and S. Shinoda, Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria. Front, Public Health, vol.2, 2014.

P. K. Randhawa, K. Singh, N. Singh, and A. S. Jaggi, A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents, Korean J. Physiol. Pharmacol. Off. J. Korean Physiol. Soc. Korean Soc. Pharmacol, vol.18, pp.279-288, 2014.

R. Sengupta, E. Altermann, R. C. Anderson, W. C. Mcnabb, P. J. Moughan et al., The Role of Cell Surface Architecture of Lactobacilli in Host-Microbe Interactions in the Gastrointestinal Tract, 2013.

A. V. Rao, A. C. Bested, T. M. Beaulne, M. A. Katzman, C. Iorio et al., A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome, Gut Pathog, vol.1, p.6, 2009.

C. Reiff, K. , and D. , Inflammatory bowel disease, gut bacteria and probiotic therapy, Int. J. Med. Microbiol. IJMM, vol.300, pp.25-33, 2010.

B. Rioseras, P. V. Shliaha, V. Gorshkov, P. Yagüe, M. T. López-garcía et al., Quantitative Proteome and Phosphoproteome Analyses of Streptomyces coelicolor Reveal Proteins and Phosphoproteins Modulating Differentiation and Secondary Metabolism, Mol. Cell. Proteomics MCP, vol.17, pp.1591-1611, 2018.

G. Roda, M. Marocchi, A. Sartini, R. , and E. , Cytokine Networks in Ulcerative Colitis. Ulcers, 2011.

T. Rodrigues-oliveira, A. Belmok, D. Vasconcellos, B. Schuster, and C. M. Kyaw, Archaeal S-Layers: Overview and Current State of the Art, Front. Microbiol, vol.8, p.2597, 2017.

D. Rubio, A. Paula, J. H. Martínez, M. Casillas, C. et al., Lactobacillus casei BL23 Produces Microvesicles Carrying Proteins That Have Been Associated with, Its Probiotic Effect. Front. Microbiol, vol.8, 2017.

J. A. Salas and C. Méndez, Engineering the glycosylation of natural products in actinomycetes, Trends Microbiol, vol.15, pp.219-232, 2007.

L. Sang, B. Chang, B. Wang, W. Liu, and M. Jiang, Live and heat-killed probiotic: effects on chronic experimental colitis induced by dextran sulfate sodium (DSS) in rats, Int. J. Clin. Exp. Med, vol.8, 2015.

R. Santaolalla and M. T. Abreu, Innate immunity in the small intestine, Curr. Opin. Gastroenterol, vol.28, pp.124-129, 2012.

S. Rocha, C. Gomes-santos, A. C. Garcias-moreira, T. De-azevedo, M. Diniz-luerce et al., Local and systemic immune mechanisms underlying the anticolitis effects of the dairy bacterium Lactobacillus delbrueckii, PloS One, vol.9, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01204288

T. Saraoui, S. Parayre, G. Guernec, V. Loux, J. Montfort et al., A unique in vivo experimental approach reveals metabolic adaptation of the probiotic Propionibacterium freudenreichii to the colon environment, BMC Genomics, vol.14, p.911, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01209705

W. H. Saris, N. G. Asp, I. Björck, E. Blaak, F. Bornet et al., Functional food science and substrate metabolism, Br. J. Nutr, vol.80, pp.47-75, 1998.

A. Sarkar and S. Mandal, Bifidobacteria-Insight into clinical outcomes and mechanisms of its probiotic action, Microbiol. Res, vol.192, pp.159-171, 2016.

C. Schäffer and P. Messner, Surface-layer glycoproteins: an example for the diversity of bacterial glycosylation with promising impacts on nanobiotechnology, Glycobiology, vol.14, pp.31-42, 2004.

C. Schäffer and P. Messner, Emerging facets of prokaryotic glycosylation, FEMS Microbiol. Rev, vol.41, pp.49-91, 2017.

A. Schmidt, D. B. Trentini, S. Spiess, J. Fuhrmann, G. Ammerer et al., Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response, Mol. Cell. Proteomics MCP, vol.13, pp.537-550, 2014.

C. F. Scholz and M. Kilian, The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov, Int. J. Syst. Evol. Microbiol, vol.66, pp.4422-4432, 2016.

V. Schroeckh, M. , and K. , Resuscitation-promoting factors: distribution among actinobacteria, synthesis during life-cycle and biological activity, Antonie Van Leeuwenhoek, vol.89, pp.359-365, 2006.

K. Seki, H. Nakao, H. Umino, H. Isshiki, N. Yoda et al., Effects of Fermented Milk Whey Containing Novel Bifidogenic Growth Stimulator Produced by Propionibacterium on Fecal Bacteria, Putrefactive Metabolite, Defecation Frequency and Fecal Properties in Senile Volunteers Needed Serious Nursing-Care Taking Enteral Nutrition by Tube Feeding, J Intest Microbiol, vol.18, pp.107-115, 2004.

L. Shao, Z. Wu, H. Zhang, W. Chen, L. Ai et al., Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5, Carbohydr. Polym, vol.107, pp.51-56, 2014.

K. Shida, J. Kiyoshima-shibata, R. Kaji, M. Nagaoka, and M. Nanno, Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms, Immunology, vol.128, pp.858-869, 2009.

M. J. Smelt, B. J. De-haan, P. A. Bron, I. Van-swam, M. Meijerink et al., The impact of Lactobacillus plantarum WCFS1 teichoic acid D-alanylation on the generation of effector and regulatory T-cells in healthy mice, PloS One, vol.8, 2013.

M. J. Smeulders, J. Keer, R. A. Speight, and H. D. Williams, Adaptation of Mycobacterium smegmatis to Stationary Phase, J. Bacteriol, vol.181, pp.270-283, 1999.

F. Sommer and F. Bäckhed, The gut microbiota--masters of host development and physiology, Nat. Rev. Microbiol, vol.11, pp.227-238, 2013.

A. Sood, V. Midha, G. K. Makharia, V. Ahuja, D. Singal et al., The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis, Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc, vol.7, pp.1202-1209, 2009.

J. S. Suchodolski and A. E. Jergens, Recent Advances and Understanding of Using ProbioticBased Interventions to Restore Homeostasis of the Microbiome for the Prevention/Therapy of Bacterial Diseases, 2016.

M. Sun, W. Wu, Z. Liu, and Y. Cong, Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases, J. Gastroenterol, vol.52, pp.1-8, 2017.

J. Sýkora, K. Valecková, J. Amlerová, K. Siala, P. Dedek et al., Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study, J. Clin. Gastroenterol, vol.39, pp.692-698, 2005.

M. V. Telkov, G. R. Demina, S. A. Voloshin, E. G. Salina, T. V. Dudik et al., Proteins of the Rpf (resuscitation promoting factor) family are peptidoglycan hydrolases, Biochem. Biokhimiia, vol.71, pp.414-422, 2006.

A. Thierry, S. Deutsch, H. Falentin, M. Dalmasso, F. J. Cousin et al., New insights into physiology and metabolism of Propionibacterium freudenreichii, Int. J. Food Microbiol, vol.149, pp.19-27, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01454487

A. Thierry, H. Falentin, S. M. Deutsch, and G. Jan, Propionibacterium spp, Encyclopedia of dairy sciences F. P. a. M. P. Fuquay JW, pp.403-411, 2011.

C. M. Thomas, D. M. Saulnier, J. K. Spinler, P. Hemarajata, C. Gao et al., FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri, vol.5, pp.802-818, 2016.

S. R. Thomas and T. J. Trust, Tyrosine phosphorylation of the tetragonal paracrystalline array of Aeromonas hydrophila: molecular cloning and high-level expression of the S-layer protein gene, J. Mol. Biol, vol.245, pp.568-581, 1995.

L. Tilley, K. Keppens, A. Kushiro, T. Takada, T. Sakai et al., A probiotic fermented milk drink containing Lactobacillus casei strain Shirota improves stool consistency of subjects with hard stools, Int. J. Probiotics Prebiotics, vol.9, pp.23-30, 2014.

E. Tiollier, M. Chennaoui, D. Gomez-merino, C. Drogou, E. Filaire et al., Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training, Mil. Med, vol.172, pp.1006-1011, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00430241

P. Turchet, M. Laurenzano, S. Auboiron, A. , and J. M. , Effect of fermented milk containing the probiotic Lactobacillus casei DN-114001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study, J. Nutr. Health Aging, vol.7, pp.75-77, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00294395

A. Tursi, G. Brandimarte, G. M. Giorgetti, G. Forti, M. E. Modeo et al., Lowdose balsalazide plus a high-potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild-to-moderate ulcerative colitis, Med. Sci. Monit. Int. Med. J. Exp. Clin. Res, vol.10, pp.126-131, 2004.

A. Tursi, G. Brandimarte, A. Papa, A. Giglio, W. Elisei et al., Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study, Am. J. Gastroenterol, vol.105, pp.2218-2227, 2010.

N. Ueno, M. Fujiya, S. Segawa, T. Nata, K. Moriichi et al., Heat-killed body of Lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function, Inflamm. Bowel Dis, vol.17, pp.2235-2250, 2011.

F. Valence, S. M. Deutsch, R. Richoux, V. Gagnaire, and S. Lortal, Autolysis and related proteolysis in Swiss cheese for two Lactobacillus helveticus strains, J. Dairy Res, vol.67, pp.261-271, 2000.

H. Van-loveren, Y. Sanz, and S. Salminen, Health claims in Europe: probiotics and prebiotics as case examples, Annu. Rev. Food Sci. Technol, vol.3, pp.247-261, 2012.

R. Verma, C. Lee, E. Jeun, J. Yi, K. S. Kim et al., Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells, Sci. Immunol, vol.3, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01901482

S. M. Vindigni, T. L. Zisman, D. L. Suskind, and C. J. Damman, The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions, Ther. Adv. Gastroenterol, vol.9, pp.606-625, 2016.

A. Y. Wang, J. Popov, and N. Pai, Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease, World J. Gastroenterol, vol.22, pp.10304-10315, 2016.

J. Wen, P. Yang, X. Chen, Y. Fang, Q. Chang et al., The role of Th17/Treg balance and Th22 cell in the pathogenesis of DSS-induced colitis in mice, Eur. J. Inflamm, vol.13, pp.101-108, 2015.

M. Wlodarska, B. Willing, K. M. Keeney, A. Menendez, K. S. Bergstrom et al., Antibiotic Treatment Alters the Colonic Mucus Layer and Predisposes the Host to Exacerbated Citrobacter rodentium-Induced Colitis, Infect. Immun, vol.79, pp.1536-1545, 2011.

M. Wu, T. Pan, Y. Wu, S. Chang, M. Chang et al., Exopolysaccharide activities from probiotic Bifidobacterium: Immunomodulatory effects, 2010.

, macrophages) and antimicrobial properties, Int. J. Food Microbiol, vol.144

Y. Yamazaki, R. Tokumasu, H. Kimura, and S. Tsukita, Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens, Mol. Biol. Cell, vol.22, pp.1495-1504, 2011.

Y. Yang, M. He, G. Hu, J. Wei, P. Pages et al., Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women, World J. Gastroenterol. WJG, vol.14, pp.6237-6243, 2008.

X. Yin, D. Heeney, Y. Srisengfa, B. Golomb, S. Griffey et al., Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum, Benef. Microbes, vol.9, pp.333-344, 2018.

A. Yu, J. Zhao, W. Peng, A. Banazadeh, S. D. Williamson et al., Advances in mass spectrometry-based glycoproteomics, Electrophoresis, 2018.

Y. Zhang and Y. Li, Inflammatory bowel disease, Pathogenesis. World J. Gastroenterol. WJG, vol.20, pp.91-99, 2014.

F. Zhao, Y. Wang, H. An, Y. Hao, X. Hu et al., New Insights into the Formation of Viable but Nonculturable Escherichia coli O157:H7 Induced by High-Pressure CO2. mBio, vol.7, pp.961-977, 2016.

Y. Zhao and O. N. Jensen, Modification-specific proteomics: strategies for characterization of post-translational modifications using enrichment techniques, Proteomics, vol.9, pp.4632-4641, 2009.

B. Zheng, J. Van-bergenhenegouwen, H. J. Van-de-kant, G. Folkerts, J. Garssen et al., Specific probiotic dietary supplementation leads to different effects during remission and relapse in murine chronic colitis, Benef. Microbes, vol.7, pp.205-213, 2016.

, Le niveau d'expression des gènes codant pour les récepteurs (A) TLR9 et (B) TLR2. Les cellules HT-29 ont été stimulées par la souche sauvage Pf CIRM-BIA 129 (WT) ou la souche mutante Pf CIRM-BIA 129 KO SlpB (KO)

C. , En plus des effets stériques, l'acétylation modifie également la charge de la protéine, 2014.

C. , L'acylation est le processus par lequel une chaîne hydrocarbonée est ajoutée à la protéine, 2014.

. Beveridge, Cette structure joue un rôle important dans la croissance et la survie de ces microorganismes. Les nombreuses fonctions des Slps comprennent le maintien de l'intégrité de la cellule, la lutte contre des agents pathogènes, l'interaction avec l'hôte et son système immunitaire, Les protéines Slps (« S-Layer Proteins») constituent la couche S, une surface paracristalline structurée qui enveloppe la surface de certaines bactéries à Gram négatif et à Gram positif. Elle était initialement identifiée et bien caractérisée chez les archées, 1997.

, Cependant, il existe une différence en termes du taux de glycosylation observé entre les archées et les bactéries. En effet, les structures des N-glycosylations des Slps des archées présentent une grande diversité en termes de taille des glycanes, 2004.

. Anzengruber, Le nombre de résidus modifiés ainsi que la longueur des chaînes glycanes (50 unités identiques) sont moindres chez les protéines S-layer des bactéries. Les glycosylations des protéines S-layer, décrites essentiellement chez les espèces lactiques, peuvent être ancrées en N ou O sur le squelette peptidique et peuvent se composer d'hexoses, de pentoses, d'heptoses ou de désoxyhexose neutres et d'osamines, 2004.

. Cavallero, , 2010.

, Les modifications covalentes des protéines S-layer de P. freudenreichii Annexes

P. Chez and . Freudenreichii, SlpE et l'internaline like (Inl). L'analyse par spectrométrie de masse a permis de démontrer la présence de modifications covalentes (Figure 1), notamment des sites probables de glycosylation, à la fois des N-glycosylations et d'O-glycosylations, l'analyse des extraits de protéines Slps provenant de différentes souches a révélé la présence d'isoformes de point isoélectrique pour les protéines SlpA, SlpB, 2015.

, Figure 1. Les modifications covalentes ainsi que les sites modifiés identifiés par spectrométrie de masse. Les différentes isoformes des protéines SlpA, SlpB, SlpE et Internaline-like ont été prélevées sur les gels bidimensionnels. Les peptides issus de la protéolyse par trypsine des différentes isoformes ont été analysés par LC-MS/MS. Des sites potentiels de glycosylation ainsi que de phosphorylation ont été identifiés

L. Maréchal, Plusieurs cultures successives sur l'ultrafiltrat de lait ont été réalisées afin de constituer un stock de protéines Slps. Après centrifugation, les culots bactériens sont lavés deux fois par le tampon PBS (Phosphate Buffer saline). Les culots correspondants à une densité optique de 40 sont ensuite repris dans 2, Une extraction des protéines Slps a été réalisée en utilisant l'agent chaotrope, le chlorure de guanidine, tel que décrit précédemment, 2015.

, Les mélanges sont incubés pendant 15 minutes à 50°C. Les surnageants contenant les protéines Slps sont récupérés par centrifugation. Les extraits protéiques successifs obtenus sont dialysés contre de l'eau déminéralisée

, La concentration protéique des différents extraits protéiques obtenus a été déterminée en utilisant le kit 2-D Quant Kit et en suivant les instructions du fabricant

. Cao, La migration a été effectuée à un voltage constant jusqu'à la sortie du front de migration indiqué par le bleu de bromophénol. Les gels ont été ensuite transférés sur des membranes PVDF (Polyvinylidene difluoride) (GE Healthcare) en utilisant le système Trans-Blot® Electrophoretic Transfer Cell (250 mA, 30 V, 1h30). Les membranes ont été incubées à température ambiante dans une, Lectinblot Le lectinblot est une technique d'identification et de caractérisation de motifs glucidiques présents sur des protéines, et qui se repose sur les interactions lectine-glycane. Selon les caractéristiques des lectines, différents types de sucres peuvent être reconnus, 2013.

. Nacl, Les différentes lectines ont été diluées dans une solution de dilution (50 mM de Tris-HCl, 0.25% de gélatine, 0,05% de tween 20, 0,15 M de NaCl, 5 mM EDTA, pH=7,5) à une concentration de 10 µg/ml. Les membranes ont été ensuite rincées, puis incubées avec une solution de R.T.U (Horseradish Peroxidase Streptavidin, Vector Laboratories, Inc). Les membranes ont été révélées en utilisant le système ECL plus ® (GE Healthcare, Vélizy, France) et ensuite scannées en utilisant la GBox Syngene, pH=7,5), les membranes ont été incubées toute la nuit à une température ambiante avec les différentes lectines biotinylées (BIOTINYLATED LECTIN KIT I, Vector Laboratories, Inc)

, Invitrogen) a été utilisé en tant qu'un témoin positif. Les gels obtenus ont été fixés toute la nuit dans une solution contenant 50% méthanol et 10% d'acide acétique, afin de s'assurer que tout le SDS est éliminé du gel. Les gels sont ensuite rincés (3 rinçage de 10 minutes) à l'eau ultra-pure afin d'éliminer toute trace d'acide acétique ou de méthanol. Les gels sont ensuite incubés pendant 2 h dans une solution Pro-Q® Diamond, Les extraits protéiques de Slps, environ 25 µg ont été analysés par SDS-PAGE, tel que décrit précédemment. Un standard de poids moléculaire contenant deux phosphoprotéines

, Les gels ont été visualisés en utilisant la GBox Syngene (Ozyme, Saint-Quentin-en-Yvelines, France), avec une longueur d'excitation de 532 nm

, La quantité protéique en Slps nécessaire à la réalisation d'un gel bidimensionnels a été précipitée avec le kit 2D-Clean Up (GE Healthcare, Vélizy, France) Les protéines sont ensuite réhydratées dans 100 ?L de tampon Destreak, pp.4-7

, Ces bandelettes sont préalablement réhydratées une nuit dans 450 ?L de tampon Destreak additionné d'IPG Buffer (pH 4-7, 2%). Les échantillons sont déposés à l'extrémité acide des bandelettes à l'aide de cupules. La migration s'est effectuée en 24 h selon un programme permettant une augmentation progressive de la tension et une accumulation de 60, Immobiline DryStrip Gels de 13 cm, avec un gradient de pH allant de 4 à 7 (GE Healthcare) sur un système Multiphore II (GE Healthcare

. Kvh, À la fin de la focalisation, les bandelettes sont incubées sous agitation successivement dans les

, Le schéma de fragmentation du HCD est caractérisé par une énergie d'activation plus élevée et un temps d'activation plus court, par comparaison à une fragmentation CID. Les Oglycanes sont habituellement complétement éliminés via un réarrangement en phase gazeuse

, La fragmentation par ETD (Electron-transfer dissociation) permettrait théoriquement d'identifier les modifications post-traductionnelles labiles au CID. Idéalement, elle peut fournir à la fois des informations sur la séquence et sur la localisation des sites de modification

, La fragmentation par ECD (Electron-capture dissociation) est plus préférable lorsqu'il s'agit de peptides ayant des phosphorylations multiples, car elle peut provoquer une fragmentation efficace du squelette peptidique tout en laissant la modification covalente intacte

. Ainsi and . Moradian, identification précise du type de modification et du site de modification peut être très difficile en envisageant un seul type de fragmentation des peptides modifiés, 2014.

, L'analyse de spectrométrie de masse à l'institut Jacques Monod a consisté à combiner les 4 types de fragmentation. Des informations différentes et complémentaires peuvent être ainsi obtenues sur la structure primaire ou les modifications chimiques présentes sur les peptides analysés

, Résultats & Discussion

, Un jeu de sept lectines différentes a été testé, seulement trois d'entre elles ont réagi positivement à la protéine SlpB : la lectin Dolichos biflorus agglutinin (DBA) qui reconnait le motif ?GalNAc, la lectine Ulex europaeus agglutinin 1(UEA 1) qui reconnait le motif ?-fucose, ainsi que la lectine Arachis hypogaea (peanut) agglutinin (PNA) qui reconnait le motif Gal?3GalNAc (Figure 3), Ce volet de travail a consisté à caractériser les modifications covalentes de la protéine SlpB par des outils de protéomique

. Cependant, En effet, la digestion non spécifique par la protéinase K a conduit à la génération de peptides trop courts, ce qui a compliqué l'alignement des séquences peptidiques sur la séquence protéique

. Grange, Il s'agit d'O-glycosylations sur la sérine 283, la sérine 429, la thréonine 415 ; ainsi qu'une N-glycosylation sur l'asparagine 462 (Figure 5). Les types de glycanes mis en évidence sont en cohérence avec les observations faites sur les lectinblot. Cependant, la structure exacte des glycanes reste inconnue, Néanmoins, un niveau d'expression plus bas du gène gtf a été mis en évidence chez les souches présentant le phénotype agglutination (-), ce qui suggère que ces enzymes pourraient être indispensables pour d'autres fonctions bactériennes, 2008.

, En effet, les glycosyltransférases des actinomycètes sont décrites comme étant versatiles, en ce qui concerne le donneur de sucre, mais également dans une moindre mesure, en ce qui concerne l'accepteur des sucres, 2007.

, La coloration au Pro-Q® Diamond des extraits Slps avant ou après le traitement à la phosphatase alkaline montre bien la présence de phosphorylation seulement sur la protéine SlpB

, En ce qui concerne la phosphorylation, seulement des Serine kinases ont été déjà décrites chez les espèces des propionibactéries laitières (Cagen and Friedmann, 1972), mais il n'existe pas d'étude du phosphoprotéome chez P. freudenreichii. Le rôle de la présence d'une telle modification covalente sur la protéine SlpB est inconnu. Néanmoins, l'outil InterPro a prédis la présence d'un domaine dit « Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid » sur la protéine SlpB, L'analyse des données de spectrométrie de masse a également confirmé la présence de phosphorylation sur la thréonine, vol.174

. Parandhaman, En effet, la phosphorylation est décrite comme un mécanisme impliqué dans la dormance, la division cellulaire, l'adaptation aux stress environnementaux, mais également impliquée dans l'interaction avec les cellules hôtes (virulence), chez de nombreuses espèces d'actinobactéries (Mijakovic and Macek, Les auteurs attribuent à cette modification un rôle structural probable ou de transduction de signaux environnementaux, 2012.

, Pour la protéine SlpB, il est probable que la phosphorylation a un rôle dans l'activation ou la désactivation de son activité enzymatique prédite

, Les méthodes d'enrichissement des glycopeptides par chromatographie d'interaction hydrophobe (HILIC) ou des phosphopeptides par chromatographie d'affinité (IMAC) permettra d'augmenter le rapport signal sur bruit, Néanmoins, quand bien même l'ensemble des résultats obtenus semblent cohérents; il faut prendre en compte ces résultats avec quelques précautions, 2001.

, Annexe 3 : publications scientifiques ? Publications publiées dans des journaux à comité de lecture : -Rabah H, Do Carmo FLR, Jan G. Dairy Propionibacteria: Versatile Probiotics. Microorganisms, vol.5, p.24, 2017.

H. -rabah, O. Ménard, F. Gaucher, F. Do-carmo, D. Dupont et al., Cheese matrix protects the immunomodulatory surface protein SlpB of Propionibacterium freudenreichii during in vitro digestion, Food Res Int, vol.106, pp.712-733, 2018.

-. Rabah, H. , D. Oliveira-carvalho, R. D. Gaucher, F. Cordeiro et al., Extractable Bacterial Surface Proteins in Probiotic-Host Interaction. Front Microbiol, vol.9, p.645, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01763214

H. --rabah, S. Ferret-bernard, S. Huang, L. Normand, L. Cousin et al., The Cheese Matrix Modulates the Immunomodulatory Properties of Propionibacterium freudenreichii CIRM-BIA 129 in Healthy Piglets, Front. Microbiol, vol.9, p.2584, 2018.

S. Huang, H. Rabah, S. Ferret-bernard, L. Normand, L. Gaucher et al., Propionic fermentation by the probiotic Propionibacterium freudenreichii to functionalize whey, Journal of Functional Foods
URL : https://hal.archives-ouvertes.fr/hal-02043531

?. Publications-en-préparation-:--rabah, H. Jardin, J. Briard-bion, V. Maillard, M. B. Gaucher et al., The growth medium influence on in vitro Propionibacterium freudenreichii adaptation ability to caecal environment, Target Journal: Applied Microbiology and Biotechnology

H. Rabah, D. Carmo, and F. , Effect of probiotic Emmental cheese on DSS-induced colitis on mice, Target Journal: Applied Microbiology and Biotechnology

H. Rabah, O. Ménard, F. Gaucher, F. Do-carmo, D. Dupont et al., Cheese matrix protects the immunomodulatory surface protein SlpB of Propionibacterium freudenreichii during in vitro digestion, 12th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01707548

L. , young scientist award" à IPC2018 pour la présentation orale, ex aequo avec Stefano Colombo (Italie)

, ? Communications par poster

H. Rabah, F. Do-carmo, and G. Jan, Is cheese a good delivery vehicle for Propionibacterium freudenreichii anti-inflammatory property?, Symposium on Propionibacteria and Bifidobacteria, 2016.

H. Rabah, O. Ménard, F. Gaucher, F. Do-carmo, D. Dupont et al., Cheese matrix as a delivery vehicle for immunomodulatory proteins of Propionibacterium freudenreichii, International Probiotics and Antimicrobial Proteins Conference, 2017.

H. Rabah, S. Ferret-bernard, S. Huang, L. Le-normand, F. J. Cousin et al., The delivery vehicle modulates the immunomodulatory effect of Propionibacterium freudenreichii in healthy piglets. The 10th cheese symposium, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01781893

H. Rabah, F. Gaucher, F. Do-carmo, M. B. Maillard, and G. Jan, In vitro assessment of Propionibacterium freudenreichii adaptation to caecal environment. Congrès national de la société française de microbiologie, 2018.

H. Rabah, S. Ferret-bernard, S. Huang, L. Le-normand, F. J. Cousin et al., The cheese matrix modulates the immunomodulatory effect of Propionibacterium freudenreichii in healthy piglets. les 4èmes rencontres du GIS Nutrition Alimentation Métabolisme et Santé, 2018.

, Annexe 5 : publications et communications scientifiques en collaboration ? Articles scientifiques publiées dans des revues à comité de lecture

D. Carmo, F. Rabah, H. Huang, S. Gaucher, F. Deplanche et al.,

V. and J. G. , Propionibacterium freudenreichii Surface Protein SlpB is involved in adhesion to Intestinal HT-29 Cells, Front Microbiol, vol.8, 2017.

S. Huang, H. Rabah, J. Jardin, V. Briard-bion, S. Parayre et al., Hyperconcentrated Sweet Whey, a New Culture Medium That Enhances Propionibacterium freudenreichii stress tolerance, Appl Environ Microbiol, vol.82, issue.15, pp.4641-51, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01454632

S. Huang, S. Méjean, H. Rabah, A. Dolivet, L. Loir et al., , 2016.

, Double use of concentrated sweet whey for growth and spray drying of probiotics: Towards maximal viability in pilot scale spray dryer, Journal of Food Engineering, vol.196, pp.11-17, 2017.

. ?-chapitre-de-livre,

D. Carmo, F. Rabah, H. , F. Cordeiro, B. et al.,

, Applications of Probiotic Bacteria and Dairy Foods in Health. Current Research in Microbiology, Open Access eBooks 919 North Market Street Suite 425 Wilmington, 2017.