Etude du métabolisme des pyramides du néocortex dans un modèle murin de la maladie d'Alzheimer - voies de signalisations impliquées dans la modulation de l'excitabilité des pyramides du néocortex par la noradrénaline

Abstract : During my thesis, I focused on the neocortical pyramidal cells in normal and pathological condition. The early alteration of glucose metabolism is an invariant feature of Alzheimer's disease ( AD) which might lead to the late synaptic dysfunctions and neuronal loss related to the pathology. To better understand the AD pathogenesis, I sought to clarify the mechanisms responsible for the early glucose hypometabolism observed in the pathology. This work has highlighted alterations in glucose fluxes at a juvenile presymptomatic stage in a mouse model of AD. The cellular imaging data revealed an increase of the glycolytic pathway associated with a reduction in the PPP in pyramidal neurons of 3xTg-AD mice without any alteration of glucose transport. The noradrenergic system has a significant influence on cognitive processes. A part of my thesis has been devoted to highlight the effect of noradrenaline on pyramidal cells' excitability in the mouse somatosensory cortex. My results show that α1 and β noradrenergic agonists inhibit the currents responsible for sAHP and suggest a cooperative effect of α1 and β noradrenergic receptors. The RA-α1 involvement in the genesis of a slow After Depolarization has yet to be determined. Those two phenomena will lead to an increased depolarization of neuronal membrane, facilitating a novel action potential discharge.
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Juliette Piquet. Etude du métabolisme des pyramides du néocortex dans un modèle murin de la maladie d'Alzheimer - voies de signalisations impliquées dans la modulation de l'excitabilité des pyramides du néocortex par la noradrénaline. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066180⟩. ⟨tel-02176022⟩

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