, Transcriptomique comparative et conservation des profils d'expression chien / homme

. Le, Sur le site ENCODE 14 , j'ai utilisé les filtres suivants : (i) Organism -Homo sapiens ; (ii) Biosample type -tissue ; (iii) Assay -total RNA-seq ; (iv) Genome assembly (visualization) -hg19 and (v) Project -ENCODE. Ensuite j'ai comparé les tissus humains disponibles avec ceux utilisés chez le chien dans notre étude afin qu'ils soient communs aux deux espèces. Onze tissus communs ont ainsi été sélectionnés : la glande surrénale, l'intestin-côlon, Pour réaliser cette analyse, j'ai extrait les données d'expression des gènes humain à partir des données produites par le projet ENCODE (ENCODE Project Consortium, 2012.

. Krzywinski, Représentation circulaire des données de transcriptomique comparative avec Circos L'outil Circos, 2009.

, matrix/?type=Experiment niveaux d'expression, puis à gauche, se trouve la représentation des 23 chromosomes humains. Les différentes couches d'informations Circos sont composées, de l'extérieur vers l'intérieur, de la manière suivante, Circos est réalisé avec, à droite, les relations d'orthologies chien-homme des lncRNAs, vol.19

, Couche 2 : le niveau d'expression des lncRNAs canins indiqué par l'histogramme bleu

. Le, Onze tissus comprenant la glande surrénale, l'intestin-côlon, Couche, vol.3

, Couche 5 : l'arc de cercle vert représente le chromosome canin et le rouge représente les chromosomes humains. Couche 6 : les lignes colorées relient les relations orthologues chien-homme des lncRNAs et les lignes grises représentent les relations orthologues des mRNAs

, Analyse de la co-expression des paires lncRNA:mRNAs canins Pour étudier les co-expressions entre les lncRNAs et les mRNAs canins, j'ai utilisé le module de classification de FEELnc : FEELnc classifier (Wucher et al., 2017suivante : FEELnc_classifier.pl -i lncRNA_exons.gtf -a mRNA_exons

, Données initiales issues de 60 RNA-seq

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