Impact vasculaire et métabolique de l'hypoxie intermittente et de l'obésité dans un modèle murin

Abstract : Decades increases the prevalence of many overweigh tassociated diseases including obstructive sleep apnea (OSA). Both OSA and obesity are considered as independent cardio-vascular and metabolic risk factors.The frequent association of OSA and obesity in clinical setting makes difficult to investigate their independent contribution to metabolic and vascular diseases. In the present thesis, we aimed to evaluate the impact of a short term intermittent hypoxia (IH), (animal model of OSA), of a high fat diet (HFD), and of both experimental conditions together (IH and HFD) on the vascular and metabolic outcomes. Short term IH alone had no impact on glucose and lipids levels and mitochondrial and vascular function. Animals fed with HFD presented dyslipidemia, hepatic steatosis, mitochondrial and endothelial dysfunction. Interestingly, when short term IH was applied to HFD fed mice, insulin level was increased, restored endothelial function and mitochondrial activity was restored and limited liver lipid accumulation was limited.Those data underline the polymorphic effects of IH that might target beneficial outcomes when applied for a short term in obesity, which contrast with the deleterious long term outcomes observed in OSA.
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Wojciech Trzepizur. Impact vasculaire et métabolique de l'hypoxie intermittente et de l'obésité dans un modèle murin. Médecine humaine et pathologie. Université d'Angers, 2014. Français. ⟨NNT : 2014ANGE0038⟩. ⟨tel-02171682⟩

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