S. De-la, Stratégie mondiale pour l'alimentation, l'exercice physique et la santé, 2004.

, Rapport sur la Santé dans le Monde 2002 -Réduire les risques et promouvoir une vie saine, 2002.

D. Warburton and S. Bredin, Health benefits of physical activity: a systematic review of current systematic reviews, Curr Opin Cardiol, vol.32, issue.5, pp.541-56, 2017.

D. Warburton and S. Bredin, Reflections on Physical Activity and Health: What Should We Recommend?, Can J Cardiol, vol.32, issue.4, pp.495-504, 2016.

L. Puente-maestu, P. Palange, R. Casaburi, P. Laveneziana, F. Maltais et al., Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement, Eur Respir J, vol.47, issue.2, pp.429-60, 2016.

A. Esteban, A. Anzueto, I. Alía, F. Gordo, C. Apezteguía et al., How Is Mechanical Ventilation Employed in the Intensive Care Unit?: An International Utilization Review, Am J Respir Crit Care Med, vol.161, issue.5, pp.1450-1458, 2000.

D. M. Mannino and A. S. Buist, Global burden of COPD: risk factors, prevalence, and future trends. The Lancet, vol.370, pp.765-73, 2007.

H. Watz, B. Waschki, T. Meyer, and H. Magnussen, Physical activity in patients with COPD, Eur Respir J, vol.33, issue.2, pp.262-72, 2008.

F. Maltais, M. Decramer, R. Casaburi, E. Barreiro, Y. Burelle et al., An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med, vol.189, issue.9, pp.15-62, 2014.

J. P. Kress and J. B. Hall, ICU-Acquired Weakness and Recovery from Critical Illness, N Engl J Med, vol.370, issue.17, pp.1626-1661, 2014.

M. A. Spruit, S. J. Singh, C. Garvey, R. Zuwallack, L. Nici et al., An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation, Am J Respir Crit Care Med, vol.188, issue.8, pp.13-64, 2013.

M. A. Chambers, J. S. Moylan, and M. B. Reid, Physical inactivity and muscle weakness in the critically ill: Crit Care Med, vol.37, pp.337-383, 2009.

P. J. Weijs, W. G. Looijaard, I. M. Dekker, S. N. Stapel, A. R. Girbes et al., Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients, Crit Care, vol.18, issue.1, p.12, 2014.

D. M. Needham, A. D. Truong, and E. Fan, Technology to enhance physical rehabilitation of critically ill patients: Crit Care Med, vol.37, pp.436-477, 2009.

G. D. Rubenfeld, E. Caldwell, E. Peabody, J. Weaver, D. P. Martin et al., Incidence and Outcomes of Acute Lung Injury, N Engl J Med, vol.353, issue.16, pp.1685-93, 2005.

A. Jubran and M. J. Tobin, Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation, Am J Respir Crit Care Med, vol.155, issue.3, pp.906-921, 1997.

M. J. Tobin, Advances in mechanical ventilation, N Engl J Med, vol.344, issue.26, pp.1986-96, 2001.

, Societé de Réanimation de la Langue Française

N. A. Desbiens, A. W. Wu, S. K. Broste, N. S. Wenger, A. F. Connors et al., Pain and satisfaction with pain control in seriously ill hospitalized adults: findings from the SUPPORT research investigations. For the SUPPORT investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatmentm, Crit Care Med, vol.24, issue.12, pp.1953-61, 1996.

G. Chanques, J. P. Kress, A. Pohlman, S. Patel, J. Poston et al., Impact of Ventilator Adjustment and Sedation-Analgesia Practices on Severe Asynchrony in Patients Ventilated in Assist-Control Mode*: Crit Care Med, vol.41, pp.2177-87, 2013.

L. Papazian, J. Forel, A. Gacouin, C. Penot-ragon, G. Perrin et al., Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome, N Engl J Med, vol.363, issue.12, pp.1107-1123, 2010.

J. Batt, C. C. Santos, J. I. Cameron, and M. S. Herridge, Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms, Am J Respir Crit Care Med, vol.187, issue.3, pp.238-284, 2013.

B. De-jonghe, T. Sharshar, J. Lefaucheur, F. Authier, I. Durand-zaleski et al., Paresis acquired in the intensive care unit: a prospective multicenter study, JAMA, vol.288, issue.22, pp.2859-67, 2002.

J. Bednarík, P. Vondracek, L. Dusek, E. Moravcova, and I. Cundrle, Risk factors for critical illness polyneuromyopathy, J Neurol, vol.252, issue.3, pp.343-51, 2005.

N. Latronico and C. F. Bolton, Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis, Lancet Neurol, vol.10, issue.10, pp.931-972, 2011.

N. Latronico, E. Peli, and M. Botteri, Critical illness myopathy and neuropathy, Curr Opin Crit Care, vol.11, issue.2, pp.126-158, 2005.

C. F. Bolton, J. J. Gilbert, A. F. Hahn, and W. J. Sibbald, Polyneuropathy in critically ill patients, J Neurol Neurosurg Psychiatry, vol.47, issue.11, pp.1223-1254, 1984.

Z. A. Puthucheary, J. Rawal, M. Mcphail, B. Connolly, G. Ratnayake et al., Acute skeletal muscle wasting in critical illness, JAMA, vol.310, issue.15, pp.1591-600, 2013.

J. W. Leatherman, W. L. Fluegel, W. S. David, S. F. Davies, and C. Iber, Muscle weakness in mechanically ventilated patients with severe asthma, Am J Respir Crit Care Med, vol.153, issue.5, pp.1686-90, 1996.

S. Levine, T. Nguyen, N. Taylor, M. E. Friscia, M. T. Budak et al., Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans, N Engl J Med, vol.358, issue.13, pp.1327-1362, 2008.

T. J. Iwashyna, E. W. Ely, D. M. Smith, and K. M. Langa, Long-term cognitive impairment and functional disability among survivors of severe sepsis, JAMA, vol.304, issue.16, pp.1787-94, 2010.

G. Van-den-berghe, K. Schoonheydt, P. Becx, F. Bruyninckx, and P. J. Wouters, Insulin therapy protects the central and peripheral nervous system of intensive care patients, Neurology, vol.64, issue.8, pp.1348-53, 2005.

J. Garnacho-montero, J. Madrazo-osuna, J. L. García-garmendia, C. Ortiz-leyba, F. J. Jiménez-jiménez et al., Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients, Intensive Care Med, vol.27, issue.8, pp.1288-96, 2001.

S. Jaber, B. J. Petrof, B. Jung, G. Chanques, J. Berthet et al., Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans, Am J Respir Crit Care Med, vol.183, issue.3, pp.364-71, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01823668

M. S. Herridge, A. M. Cheung, C. M. Tansey, A. Matte-martyn, N. Diaz-granados et al., One-year outcomes in survivors of the acute respiratory distress syndrome, N Engl J Med, vol.348, issue.8, pp.683-93, 2003.

S. K. Powers, A. N. Kavazis, and S. Levine, Prolonged mechanical ventilation alters diaphragmatic structure and function, Crit Care Med, vol.37, pp.347-353, 2009.

X. Capdevila, S. Lopez, N. Bernard, E. Rabischong, M. Ramonatxo et al., Effects of controlled mechanical ventilation on respiratory muscle contractile properties in rabbits, Intensive Care Med, vol.29, issue.1, pp.103-113, 2003.

A. Anzueto, J. I. Peters, M. J. Tobin, R. De-los-santos, J. J. Seidenfeld et al., Effects of prolonged controlled mechanical ventilation on diaphragmatic function in healthy adult baboons, Crit Care Med, vol.25, issue.7, pp.1187-90, 1997.

D. B. Thomason, R. B. Biggs, and F. W. Booth, Protein metabolism and beta-myosin heavychain mRNA in unweighted soleus muscle, Am J Physiol, vol.257, issue.2, pp.300-305, 1989.

C. S. Bruells, I. Bergs, R. Rossaint, J. Du, C. Bleilevens et al., Recovery of diaphragm function following mechanical ventilation in a rodent model, PloS One, vol.9, issue.1, p.87460, 2014.

E. Futier, J. Constantin, L. Combaret, L. Mosoni, L. Roszyk et al., Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm, Crit Care Lond Engl, vol.12, issue.5, p.116, 2008.

D. Matamis, E. Soilemezi, M. Tsagourias, E. Akoumianaki, S. Dimassi et al., Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications, Intensive Care Med, vol.39, issue.5, pp.801-811, 2013.

A. Demoule, B. Jung, H. Prodanovic, N. Molinari, G. Chanques et al., Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study, Am J Respir Crit Care Med, vol.188, issue.2, pp.213-222, 2013.

, ATS/ERS Statement on respiratory muscle testing, Am J Respir Crit Care Med, vol.166, issue.4, pp.518-624, 2002.

B. De-jonghe, S. Bastuji-garin, M. Durand, I. Malissin, P. Rodrigues et al., Respiratory weakness is associated with limb weakness and delayed weaning in critical illness, Crit Care Med, vol.35, issue.9, pp.2007-2022, 2007.

S. N. Nemer, C. Barbas, J. B. Caldeira, B. Guimarães, L. M. Azeredo et al., Evaluation of maximal inspiratory pressure, tracheal airway occlusion pressure, and its ratio in the weaning outcome, J Crit Care, vol.24, issue.3, pp.441-447, 2009.

A. Savi, C. Teixeira, J. M. Silva, L. G. Borges, P. A. Pereira et al., Weaning predictors do not predict extubation failure in simple-to-wean patients, J Crit Care, vol.27, issue.2, pp.221-222, 2012.

P. Caruso, C. Friedrich, S. D. Denari, S. A. Ruiz, and D. Deheinzelin, The unidirectional valve is the best method to determine maximal inspiratory pressure during weaning, Chest, vol.115, issue.4, pp.1096-101, 1999.

V. Lesage, F. E. Gravier, C. Médrinal, and T. Bonnevie, L'entraînement des muscles inspirateurs : une stratégie efficace dans le sevrage de la ventilation mécanique. Réanimation, vol.25, pp.92-101, 2016.

S. Spadaro, E. Marangoni, R. Ragazzi, F. Mojoli, M. Verri et al., A methodological approach for determination of maximal inspiratory pressure in patients undergoing invasive mechanical ventilation, Minerva Anestesiol, vol.81, issue.1, pp.33-41, 2015.

J. Roeseler, T. Sottiaux, V. Lemiale, M. Lesny, G. Beduneau et al., Prise en charge de la mobilisation précoce en réanimation, chez l'adulte et l'enfant (électrostimulation incluse). Réanimation, vol.22, pp.207-225, 2013.

K. Stiller, A. Phillips, and P. Lambert, The safety of mobilisation and its effect on haemodynamic and respiratory status of intensive care patients, Physiother Theory Pract, vol.20, issue.3, pp.175-85, 2004.

P. Bailey, G. E. Thomsen, V. J. Spuhler, R. Blair, J. Jewkes et al., Early activity is feasible and safe in respiratory failure patients, Crit Care Med, vol.35, issue.1, pp.139-184, 2007.

G. Bourdin, J. Barbier, J. Burle, D. G. Passant, S. Vincent et al., The feasibility of early physical activity in intensive care unit patients: a prospective observational one-center study, Respir Care, vol.55, issue.4, pp.400-407, 2010.

M. C. Pohlman, W. D. Schweickert, A. S. Pohlman, C. Nigos, A. J. Pawlik et al., Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation, Crit Care Med, vol.38, issue.11, pp.2089-94, 2010.

L. Denehy, J. Lanphere, and D. M. Needham, Ten reasons why ICU patients should be mobilized early. Intensive Care Med, vol.43, pp.86-90, 2017.

C. Routsi, V. Gerovasili, I. Vasileiadis, E. Karatzanos, T. Pitsolis et al., Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial, Crit Care Lond Engl, vol.14, issue.2, p.74, 2010.

W. D. Schweickert, M. C. Pohlman, A. S. Pohlman, C. Nigos, A. J. Pawlik et al., Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial, Lancet Lond Engl, vol.373, issue.9678, pp.1874-82, 2009.

L. Denehy, E. H. Skinner, L. Edbrooke, K. Haines, S. Warrillow et al., Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up, Crit Care Lond Engl, vol.17, issue.4, p.156, 2013.

M. Moss, A. Nordon-craft, D. Malone, D. Van-pelt, S. K. Frankel et al., A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure, Am J Respir Crit Care Med, vol.193, issue.10, pp.1101-1111, 2016.

B. Connolly, B. O'neill, L. Salisbury, and B. Blackwood, Enhanced Recovery After Critical Illness Programme Group. Physical rehabilitation interventions for adult patients during critical illness: an overview of systematic reviews, Thorax, vol.71, issue.10, pp.881-90, 2016.

S. M. Parry, L. D. Knight, B. Connolly, C. Baldwin, Z. Puthucheary et al., Factors influencing physical activity and rehabilitation in survivors of critical illness: a systematic review of quantitative and qualitative studies, Intensive Care Med, vol.43, issue.4, pp.531-573, 2017.

M. E. Harrold, L. G. Salisbury, S. A. Webb, and G. T. Allison, Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers, Crit Care Lond Engl, vol.19, p.336, 2015.

K. E. Hodgin, A. Nordon-craft, K. K. Mcfann, M. L. Mealer, and M. Moss, Physical therapy utilization in intensive care units: results from a national survey, Crit Care Med, vol.37, issue.2, pp.566-568, 2009.

C. Hodgson, R. Bellomo, S. Berney, M. Bailey, and H. Buhr, Early mobilization and recovery in mechanically ventilated patients in the ICU: a binational, multi-centre, prospective cohort study, TEAM Study Investigators, vol.19, p.81, 2015.

A. C. Castro-avila, P. Serón, F. E. Gaete, M. Mickan, and S. , Effect of Early Rehabilitation during Intensive Care Unit Stay on Functional Status: Systematic Review and MetaAnalysis, PloS One, vol.10, issue.7, p.130722, 2015.

C. J. Tipping, M. Harrold, A. Holland, L. Romero, T. Nisbet et al., The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review, Intensive Care Med, vol.43, issue.2, pp.171-83, 2017.

C. L. Hodgson, M. Bailey, R. Bellomo, S. Berney, H. Buhr et al., A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU*: Crit Care Med, vol.44, pp.1145-52, 2016.

S. E. Wright, K. Thomas, G. Watson, C. Baker, A. Bryant et al., Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial, Thorax, vol.73, issue.3, pp.213-234, 2018.

G. Kovacs, P. Herve, J. A. Barbera, A. Chaouat, D. Chemla et al., An official European Respiratory Society statement: pulmonary haemodynamics during exercise, Eur Respir J, vol.50, issue.5, p.1700578, 2017.

K. Forton, Y. Motoji, G. Deboeck, V. Faoro, and R. Naeije, Effects of body position on exercise capacity and pulmonary vascular pressure-flow relationships, J Appl Physiol, vol.121, issue.5, pp.1145-50, 2016.

J. D. Trinity, J. F. Lee, M. D. Pahnke, K. C. Beck, and E. F. Coyle, Attenuated relationship between cardiac output and oxygen uptake during high-intensity exercise, Acta Physiol Oxf Engl, vol.204, issue.3, pp.362-70, 2012.

B. Lamia, J. Teboul, X. Monnet, C. Richard, and D. Chemla, Relationship between the tricuspid annular plane systolic excursion and right and left ventricular function in critically ill patients. Intensive Care Med, vol.33, pp.2143-2152, 2007.

C. Pires-neto, R. , F. Kawaguchi, Y. M. , S. Hirota et al., Very early passive cycling exercise in mechanically ventilated critically ill patients: physiological and safety aspects--a case series, PloS One, vol.8, issue.9, p.74182, 2013.

L. F. Ferreira, S. Koga, and T. J. Barstow, Dynamics of noninvasively estimated microvascular O2 extraction during ramp exercise, J Appl Physiol Bethesda Md, vol.103, issue.6, pp.1999-2004, 1985.

A. Donati, E. Damiani, R. Domizi, C. Scorcella, A. Carsetti et al., Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study, Crit Care Lond Engl, vol.20, issue.1, p.311, 201601.

J. Mesquida, J. Masip, G. Gili, A. Artigas, and F. Baigorri, Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients, Intensive Care Med, vol.35, issue.6, pp.1106-1115, 2009.

E. Angelopoulos, E. Karatzanos, S. Dimopoulos, G. Mitsiou, C. Stefanou et al., Acute microcirculatory effects of medium frequency versus high frequency neuromuscular electrical stimulation in critically ill patients -a pilot study, Ann Intensive Care, vol.3, issue.1, p.39, 2013.

P. E. Morris, M. J. Berry, D. C. Files, J. C. Thompson, J. Hauser et al., Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial, JAMA, vol.315, issue.24, pp.2694-702, 2016.

R. C. Stockley, J. Hughes, J. Morrison, and J. Rooney, An investigation of the use of passive movements in intensive care by UK physiotherapists, Physiotherapy, vol.96, issue.3, pp.228-261, 2010.

C. Burtin, B. Clerckx, C. Robbeets, F. P. Langer, D. Troosters et al., Early exercise in critically ill patients enhances short-term functional recovery, Crit Care Med, vol.37, issue.9, pp.2499-505, 2009.

V. Gerovasili, K. Stefanidis, K. Vitzilaios, E. Karatzanos, P. Politis et al., Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study, Crit Care Lond Engl, vol.13, issue.5, p.161, 2009.

N. A. Maffiuletti, M. Roig, E. Karatzanos, and S. Nanas, Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review, BMC Med, vol.11, issue.1, 2013.

S. P. Hooker, S. F. Figoni, R. M. Glaser, M. M. Rodgers, B. N. Ezenwa et al., Physiologic responses to prolonged electrically stimulated leg-cycle exercise in the spinal cord injured, Arch Phys Med Rehabil, vol.71, issue.11, pp.863-872, 1990.

C. Fornusek, G. M. Davis, P. J. Sinclair, and B. Milthorpe, Development of an isokinetic functional electrical stimulation cycle ergometer, Neuromodulation J Int Neuromodulation Soc, vol.7, issue.1, pp.56-64, 2004.

S. M. Parry, S. Berney, S. Warrillow, D. El-ansary, A. L. Bryant et al., Functional electrical stimulation with cycling in the critically ill: a pilot case-matched control study, J Crit Care, vol.29, issue.4, pp.695-696, 2014.

C. F. Vogelmeier, G. J. Criner, F. J. Martinez, A. Anzueto, P. J. Barnes et al., Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease, Report. GOLD Executive Summary. Am J Respir Crit Care Med, vol.195, issue.5, pp.557-82, 2017.

T. L. Feenstra, M. L. Van-genugten, R. T. Hoogenveen, E. F. Wouters, and M. P. Rutten-van-mölken, The impact of aging and smoking on the future burden of chronic obstructive pulmonary disease: a model analysis in the Netherlands, Am J Respir Crit Care Med, vol.164, issue.4, pp.590-596, 2001.

N. Roche, B. Aguilaniu, P. Burgel, I. Durand-zaleski, D. Dusser et al.,

, Rev Mal Respir, vol.29, issue.6, pp.756-74, 2012.

P. K. Jeffery, Remodeling in asthma and chronic obstructive lung disease, Am J Respir Crit Care Med, vol.164, issue.10, pp.28-38, 2001.

R. A. Pauwels and K. F. Rabe, Burden and clinical features of chronic obstructive pulmonary disease (COPD), Lancet Lond Engl, vol.364, issue.9434, pp.613-633, 2004.

V. I. Peinado, J. A. Barberá, P. Abate, J. Ramírez, J. Roca et al., Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.159, issue.5, pp.1605-1616, 1999.

H. R. Gosker, M. Engelen, H. Van-mameren, P. J. Van-dijk, G. J. Van-der-vusse et al., Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease, Am J Clin Nutr, vol.76, issue.1, pp.113-122, 2002.

S. Bernard, P. Leblanc, F. Whittom, G. Carrier, J. Jobin et al., Peripheral muscle weakness in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.158, issue.2, pp.629-663, 1998.

A. Couillard and C. Prefaut, From muscle disuse to myopathy in COPD: potential contribution of oxidative stress, Eur Respir J, vol.26, issue.4, pp.703-722, 2005.

A. F. Elbehairy, C. E. Ciavaglia, K. A. Webb, J. A. Guenette, D. Jensen et al., Pulmonary Gas Exchange Abnormalities in Mild Chronic Obstructive Pulmonary Disease. Implications for Dyspnea and Exercise Intolerance, Am J Respir Crit Care Med, vol.191, issue.12, pp.1384-94, 2015.

D. Ofir, P. Laveneziana, K. A. Webb, Y. Lam, and O. De, Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med, vol.177, issue.6, pp.622-631, 2008.

R. C. Chin, J. A. Guenette, S. Cheng, N. Raghavan, N. Amornputtisathaporn et al., Does the Respiratory System Limit Exercise in Mild Chronic Obstructive Pulmonary Disease?, Am J Respir Crit Care Med, vol.187, issue.12, pp.1315-1338, 2013.

J. A. Guenette, R. C. Chin, S. Cheng, P. B. Dominelli, N. Raghavan et al., Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPD, Eur Respir J, vol.44, issue.5, pp.1177-87, 2014.

D. E. O'donnell, A. F. Elbehairy, D. C. Berton, N. J. Domnik, and J. A. Neder, Advances in the Evaluation of Respiratory Pathophysiology during Exercise in Chronic Lung Diseases, Front Physiol, vol.8, 2017.

A. Aliverti and P. T. Macklem, How and Why Exercise Is Impaired in COPD, Respiration, vol.68, issue.3, pp.229-268, 2001.

R. Agrawal, A. Srivastav, M. Ved, and N. Gupta, Echocardiographic evaluation of heart in chronic obstructive pulmonary disease patient and its co-relation with the severity of disease, Lung India, vol.28, issue.2, p.105, 2011.

T. Bonnevie, F. Gravier, M. Leboullenger, C. Médrinal, C. Viacroze et al., Six-minute Stepper Test to Set Pulmonary Rehabilitation Intensity in Patients with COPD -A Retrospective Study, COPD, vol.14, issue.3, pp.293-300, 2017.

M. A. Spruit, S. J. Singh, C. Garvey, R. Zuwallack, L. Nici et al., An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation, Am J Respir Crit Care Med, vol.188, issue.8, pp.13-64, 2013.

F. Pitta, T. Troosters, V. S. Probst, D. Langer, M. Decramer et al., Are patients with COPD more active after pulmonary rehabilitation? Chest, vol.134, pp.273-80, 2008.

T. Troosters, R. Casaburi, R. Gosselink, and M. Decramer, Pulmonary rehabilitation in chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.172, issue.1, pp.19-38, 2005.

G. W. Bisca, M. Proença, A. Salomão, N. A. Hernandes, and F. Pitta, Minimal Detectable Change of the London Chest Activity of Daily Living Scale in Patients With COPD, J Cardiopulm Rehabil Prev, vol.34, issue.3, pp.213-219, 2014.

F. Maltais, P. Leblanc, J. Jobin, C. Bérubé, J. Bruneau et al., Intensity of training and physiologic adaptation in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.155, issue.2, pp.555-61, 1997.

C. A. Camillo, C. R. Osadnik, H. Van-remoortel, C. Burtin, W. Janssens et al., Effect of "add-on" interventions on exercise training in individuals with COPD: a systematic review, ERJ Open Res, vol.2, issue.1, pp.78-2015, 2016.

R. Garrod, E. A. Paul, and J. A. Wedzicha, Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia, Thorax, vol.55, issue.7, pp.539-582, 2000.

F. Gravier, T. Bonnevie, C. Medrinal, D. Debeaumont, J. Dupuis et al., Noninvasive ventilation during pulmonary rehabilitation in COPD patients, Rev Mal Respir, vol.33, issue.6, pp.422-452, 2016.

K. Watanabe, Y. Taniguchi, and T. Moritani, Metabolic and cardiovascular responses during voluntary pedaling exercise with electrical muscle stimulation, Eur J Appl Physiol, vol.114, issue.9, pp.1801-1808, 2014.

P. W. Jones, Health status measurement in chronic obstructive pulmonary disease, Thorax, vol.56, issue.11, pp.880-887, 2001.

D. Ofir, P. Laveneziana, K. A. Webb, Y. Lam, and O. De, Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.177, issue.6, pp.622-631, 2008.

D. Shrikrishna, M. Patel, R. J. Tanner, J. M. Seymour, B. A. Connolly et al., Quadriceps wasting and physical inactivity in patients with COPD, Eur Respir J, vol.40, issue.5, pp.1115-1137, 2012.

E. B. Swallow, D. Reyes, N. S. Hopkinson, W. Man, R. Porcher et al., Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease, Thorax, vol.62, issue.2, pp.115-135, 2007.

B. Mccarthy, D. Casey, D. Devane, K. Murphy, E. Murphy et al., Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev, p.3793, 2015.

N. R. Morris, J. Walsh, L. Adams, and J. Alision, Exercise training in COPD: What is it about intensity? Respirol Carlton Vic, vol.21, pp.1185-92, 2016.

F. Maltais, P. Leblanc, J. Jobin, C. Berube, J. Bruneau et al., Intensity of training and physiologic adaptation in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.155, issue.2, pp.555-61, 1997.

C. Menadue, A. J. Piper, A. J. Van-'t-hul, and K. K. Wong, Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev, p.7714, 2014.

I. Jarosch, R. Gloeckl, E. Damm, A. Schwedhelm, D. Buhrow et al., Short-term Effects of Supplemental Oxygen on 6-Min Walk Test Outcomes in Patients With COPD: A Randomized, Placebo-Controlled, Single-blind, Crossover Trial. Chest, vol.151, issue.4, pp.795-803, 2017.

C. Medrinal, G. Prieur, D. Debeaumont, R. Quesada, A. Combret et al., Comparison of oxygen uptake during cycle ergometry with and without functional electrical stimulation in patients with COPD: protocol for a randomised, single-blind, placebo-controlled, cross-over trial, BMJ Open Respir Res, vol.3, issue.1, p.130, 2016.

, ATS statement: guidelines for the six-minute walk test, Am J Respir Crit Care Med, vol.166, issue.1, pp.111-118, 2002.

I. Vivodtzev, R. Debigare, P. Gagnon, V. Mainguy, D. Saey et al., Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial, Chest, vol.141, issue.3, pp.716-741, 2012.

C. M. Minogue, B. M. Caulfield, and M. M. Lowery, Whole body oxygen uptake and evoked knee torque in response to low frequency electrical stimulation of the quadriceps muscles: V*O2 frequency response to NMES, J Neuroengineering Rehabil, vol.10, issue.1, p.63, 2013.

L. Kern, S. Condrau, F. Baty, J. Wiegand, A. Van-gestel et al., Oxygen kinetics during 6-minute walk tests in patients with cardiovascular and pulmonary disease, BMC Pulm Med, vol.14, p.167, 2014.

F. Baty, C. Ritz, A. Van-gestel, M. Brutsche, and G. D. , Modeling the oxygen uptake kinetics during exercise testing of patients with chronic obstructive pulmonary diseases using nonlinear mixed models, BMC Med Res Methodol, vol.16, p.66, 2016.

G. A. Borg, Psychophysical bases of perceived exertion, Med Sci Sports Exerc, vol.14, issue.5, pp.377-81, 1982.

, R: A language and environment for statistical computing. R Foundation for Statistical Computing, 2016.

J. A. Neder, D. C. Berton, F. F. Arbex, M. C. Alencar, A. Rocha et al., Physiological and clinical relevance of exercise ventilatory efficiency in COPD, Eur Respir J, vol.49, issue.3, 2017.

J. Theurel, R. Lepers, L. Pardon, and N. A. Maffiuletti, Differences in cardiorespiratory and neuromuscular responses between voluntary and stimulated contractions of the quadriceps femoris muscle, Respir Physiol Neurobiol, vol.157, issue.2-3, pp.341-348, 2007.

I. Vivodtzev, B. Rivard, P. Gagnon, V. Mainguy, A. Dube et al., Tolerance and physiological correlates of neuromuscular electrical stimulation in COPD: a pilot study, PloS One, vol.9, issue.5, p.94850, 2014.

M. Sillen, P. P. Janssen, M. A. Akkermans, E. Wouters, and M. A. Spruit, The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study, Respir Med, vol.102, issue.5, pp.786-795, 2008.

M. Sillen, F. Franssen, A. W. Vaes, J. Delbressine, E. Wouters et al., Metabolic load during strength training or NMES in individuals with COPD: results from the DICES trial, BMC Pulm Med, vol.14, p.146, 2014.

M. Maddocks, C. M. Nolan, W. Man, M. I. Polkey, N. Hart et al., Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial, Lancet Respir Med, vol.4, issue.1, pp.27-36, 2016.

D. Saey, B. B. Lemire, P. Gagnon, E. Bombardier, A. R. Tupling et al., Quadriceps metabolism during constant workrate cycling exercise in chronic obstructive pulmonary disease, J Appl Physiol Bethesda Md, vol.110, issue.1, pp.116-140, 1985.

F. Peronnet and B. Aguilaniu, Physiological significance and interpretation of plasma lactate concentration and pH in clinical exercise testing

, Rev Mal Respir, vol.31, issue.6, pp.525-51, 2014.

C. S. Bickel, C. M. Gregory, and J. C. Dean, Motor unit recruitment during neuromuscular electrical stimulation: a critical appraisal, Eur J Appl Physiol, vol.111, issue.10, pp.2399-407, 2011.

P. Gagnon, J. S. Bussieres, F. Ribeiro, S. L. Gagnon, D. Saey et al., Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.186, issue.7, pp.606-621, 2012.

T. Paillard, E. Margnes, J. Maitre, V. Chaubet, Y. Francois et al., Electrical stimulation superimposed onto voluntary muscular contraction reduces deterioration of both postural control and quadriceps femoris muscle strength, Neuroscience, vol.165, issue.4, pp.1471-1476, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01983542

M. J. Belman, L. R. Brooks, D. J. Ross, and Z. Mohsenifar, Variability of breathlessness measurement in patients with chronic obstructive pulmonary disease, Chest, vol.99, issue.3, pp.566-71, 1991.

C. Fornusek and G. M. Davis, Cardiovascular and metabolic responses during functional electric stimulation cycling at different cadences, Arch Phys Med Rehabil, vol.89, issue.4, pp.719-744, 2008.

T. E. Johnston, R. J. Marino, C. V. Oleson, M. Schmidt-read, B. E. Leiby et al., Musculoskeletal Effects of 2 Functional Electrical Stimulation Cycling Paradigms Conducted at Different Cadences for People With Spinal Cord Injury: A Pilot Study, Arch Phys Med Rehabil, vol.97, issue.9, pp.1413-1435, 2016.

R. Maekura, T. Hiraga, K. Miki, S. Kitada, K. Yoshimura et al., Differences in physiological response to exercise in patients with different COPD severity. Respir Care, vol.59, pp.252-62, 2014.

S. Ngai, L. M. Spencer, A. Jones, and J. A. Alison, Acu-TENS Reduces Breathlessness during Exercise in People with Chronic Obstructive Pulmonary Disease. Evid-Based Complement Altern Med ECAM, p.3649257, 2017.

M. A. Puhan, D. Chandra, Z. Mosenifar, A. Ries, B. Make et al., The minimal important difference of exercise tests in severe COPD, Eur Respir J, vol.37, issue.4, pp.784-90, 2011.

. Annexe-a-article,

T. Bonnevie, F. E. Gravier, M. Leboullenger, C. Medrinal, C. Viacroze et al., Six-minute Stepper Test to Set Pulmonary Rehabilation Intensity in Patient with COPD-A Retrospective Study, 2017.

«. Droits and . Copd-».-annexe-b-article,

F. E. Gravier, T. Bonnevie, C. Medrinal, D. Debeaumont, J. Dupuis et al., Ventilation non invasive dans la réhabilitation respiratoire du patient BPCO, Revue des Maladies Respiratoires, 2016.

. N°d'ordre, , p.85267, 2015.

, Diplômé de l'université d'Amiens « Master 2 Santé Ingénierie de la Rééducation du Handicap et de la Performance Motrice

D. Octobre, Doctorat de science à l'Ecole Doctorale Normande en Biologie Intégrative Santé et Environnement, UPRES EA3830 Groupe de Recherche sur le Handicap Respiratoire, 2015.

M. De and . Savantes, Présentation orale au 20 ème congrès de Pneumologie de la Langue Française Janvier, 2017.

, Présentation orale au congrès de l, 2017.

, Présentation d'une affiche discussion au 21 ème congrès de Pneumologie de la Langue Française Septembre, Janvier, 2018.

, Présentation orale au congrès de l, 2018.

C. Medrinal, La réhabilitation précoce en réanimation : Quels résultats ? Kinésithérapie la revue, vol.127, 2012.

C. Medrinal, M. Lebret, M. Bousta, A. Nassaj, and G. Colas, Effets de la station assise au bord de lit du patient intubé et ventilé. Kinésithérapie la revue, vol.138, 2013.

C. Medrinal and M. Gauthier, La thérapie manuelle dans les pathologies chroniques obstructives : une revue systématique des preuves actuelles. Kinésithérapie la revue, p.139, 2013.

C. Medrinal, G. Prieur, and E. Frenoy, Effet de la ventilation en position verticale : à propos d'un cas de patient en réanimation, 2013.

C. Medrinal and G. Prieur, Résumé des Recommandations officielles de l, Les concepts clés et les avancées dans la réhabilitation respiratoire. Kinésithérapie la revue, vol.148, 2014.

C. Medrinal, G. Prieur, B. Hemerick, R. Quesada, A. Combret et al., Effets métaboliques de l'électrothérapie couplée au cycloergomètre de lit : étude préliminaire, Kinésithérapie la Revue, vol.15, issue.168, pp.37-41, 2015.

F. E. Gravier, T. Bonnevie, C. Medrinal, D. Debeaumont, J. Dupuis et al., Ventilation non invasive dans la réhabilitation respiratoire du patient BPCO, Revue des Maladies Respiratoires, vol.33, issue.6, pp.422-452, 2016.

C. Medrinal, G. Prieur, R. Quesada, A. Gravier, F. E. Bonnevie et al., La neuromyopathie de réanimation : Physiopathologie et conséquences, Kinésithérapie la Revue, vol.16, issue.169, pp.28-35, 2016.

V. ?-lesage, F. E. Gravier, C. Medrinal, T. Bonnevie, C. Medrinal et al., NonInvasive Ventilation: Evaluation of CO2 washout by intentional leaking in three recent oronasal masks. A pilot study, Minerva Anestesiologica, vol.25, issue.5, pp.526-532, 2015.

T. Bonnevie, J. C. Villiot-danger, F. E. Gravier, J. Dupuis, G. Prieur et al., Inspiratory muscle training is common in intensive care units but some training methods have uncertain efficacy: a survey of French physiotherapists, Journal of Physiotherapy, vol.4, 2015.

C. Medrinal, G. Prieur, D. Debeaumont, R. Quesada, A. Combret et al., Comparison of oxygen uptake during cycle ergometry with and without functional electrical stimulation in COPD patients: a study protocol for a randomised, single-bind, placebocontrolled, cross-over trial, BMJ Open Respiratory Research, vol.3, issue.1, 2016.

C. Medrinal, G. Prieur, E. Frenoy, R. Quesada, A. Poncet et al., Respiratory weakness after extubation is associated with one year mortality-A prospective study, Critical Care, vol.20, issue.1, p.231, 2016.

C. Medrinal, G. Prieur, E. Frenoy, Y. Combret, F. E. Gravier et al., Is overlap of respiratory and peripheral muscle weakness at weaning from mechanical ventilation associated with poorer outcomes?, Intensive Care Medicine, vol.43, issue.2, pp.282-285, 2017.

Y. Combret, G. Prieur, P. Le-roux, and C. Medrinal, Non-invasive ventilation improves respiratory distress in children with acute viral bronchiolitis: a systematic review. Minerva Anestesiologica, vol.83, pp.624-661, 2017.

C. Medrinal, Y. Combret, G. Prieur, R. Quesada, A. Bonnevie et al., Effects of different early rehabilitation techniques on haemodynamic and metabolic parameters in sedated patients: protocol for a randomised, single-bind, cross-over trial, BMJ Open Respiratory Research, vol.4, issue.1, p.173, 2017.

T. Bonnevie, F. E. Gravier, M. Leboullenger, C. Medrinal, C. Viacroze et al., Six-minute Stepper Test to Set Pulmonary Rehabilation Intensity in Patient with COPD-A Retrospective Study, 2017.

G. Prieur, C. Medrinal, Y. Combret, A. R. Quesada, F. Prieur et al., Effect of high-flow nasal therapy during acute aerobic exercise in patients with chronic obstructive pulmonary disease after exacerbation: protocol for a randomised, controlled, cross-over trial, BMJ Open Respiratory Research, vol.4, issue.1, p.191, 2017.

C. Medrinal, G. Prieur, Y. Combret, A. R. Quesada, T. Bonnevie et al., Reliability of respiratory pressure measurements in ventilated and non-ventilated patients in ICU: an observational study, Annals of Intensive Care, vol.8, issue.1, p.14, 2018.

T. Bonnevie, F. Gravier, D. Debeaumont, C. Viacroze, J. Muir et al., Home-based Neuromuscular Electrical Stimulation as an Add-on to Pulmonary Rehabilitation Does Not Provide Further Benefits in Patients With Chronic Obstructive Pulmonary Disease: A Multicenter Randomized Trial, Archives of Physical Medicine and Rehabilitation, 2018.

C. Medrinal, G. Prieur, Y. Combret, A. R. Quesada, D. Debeaumont et al., Functional Electrical Stimulation-A New Therapeutic Approach to Enhance Exercise Intensity in Chronic Obstructive Pulmonary Disease Patients : A Randomized, Controlled Crossover Trial, Archives of Physical Medicine and Rehabilitation, 2018.

C. Medrinal, Y. Combret, G. Prieur, R. Quesada, A. Bonnevie et al., Comparison of exercise intensity during four early rehabilitation techniques in sedated and ventilated patients in ICU: a randomised cross-over trial, Critical Care, vol.22, issue.1, p.110, 2018.

Y. Combret, C. Medrinal, G. Prieur, R. Quesada, A. et al., Effect of backpack carrying on forced vital capacity in cystic fibrosis: A randomized crossover-controlled trial, PLoS One, vol.13, issue.5, p.196750, 2009.

, Organisation de Journées scientifiques et Formations Mai, 2014.

S. Journée and . Le-muscle-en-réanimation, De la dysfonction à la rééducation

G. Mai-et-novembre2015 and . Splf, Formation Ventilation Non Invasive pour les Kinésithérapeutes Fait à Le Havre