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. Bender, Notre projet adresse la question suivante: Quel est le rôle des crises épileptiques répétées présentées par les enfants SD sur les fonctions cognitives à l'âge adulte? Pour cela nous avons utilisé un modèle murin de la maladie portant une mutation faux-sens du gène Scn1a (R1648H), et qui présente une pathologie très légère. Nous avons induit des crises épileptiques par hyperthermie à l'âge de 21 jours pendant 10 jours et testé les effets à long-terme sur ces animaux à l'âge adulte, GEFS+ et SD sont associés à des crises épileptiques fébriles dès l'âge de 6 mois. Le SD constitue la forme la plus grave où l'on voit apparaitre des retards mentaux mais également des déficits moteurs, visuels, langagiers et mnésiques au cours de l'évolution de la maladie, 2012.

, Même si le rôle possible du canal Na V 1.1 dans le dysfonctionnement neuronal et l'effet des crises répétées ne sont probablement pas mutuellement distinctes, l'induction de la fonction cérébrale et qu'il est donc capital de les prévenir afin de diminuer