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Un grand merci à tous ces collaborateurs qui m'ont beaucoup aidé et appris. Je remercie tout particulièrement Vincenzo et toute l'équipe de Filippo Del Bene pour tout le temps passé ensemble à Curie, et leur accueil si chaleureux, J. Comp. Neurol, vol.524, 2016. ,
, Merci également à Sophie et Claire pour m'avoir formé avec patience et gentillesse sur le modèle du poisson zèbre. Merci à tous ceux qui m'ont aidé dans ma recherche d'embryons de toutes les espèces : Marie Manceau, Bertrand Pain, Nicolas Di-Poï, Peter et Linda Richards. Enfin merci à Sophie, Tahar, Corinne et Emmanuelle pour leur aide et leur encouragement dans mes missions d'enseignement. C'est aussi grâce à vous que je poursuis ma route sur cette voie, Merci à Dietmar et Anteneh pour tout leur travail sur les xénopes et les échanges scientifiques à Louvain et Paris
qui m'ont accompagné pendant ces quatre années. Bien évidemment, merci à tous mes amis ; heureusement que vous étiez là pour me faire sortir du labo et voir le soleil ! Et surtout un grand merci à François qui a été à mes côtés pendant ces quatre belles années, et qui a réussi à me supporter pendant cette période de rédaction ,
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, Volte-face dans la signalisation du récepteur
, Hugues Roest Crollius
, ainsi que Nétrine-1, qui induit l'attraction des axones via son récepteur DCC. Nous avons mis en évidence que le récepteur Robo3 a fondamentalement modifié son mécanisme d'action au cours de l'évolution des mammifères. Contrairement aux autres récepteurs Robo, Robo3 de mammifère n'est pas un récepteur de forte affinité pour les protéines Slits, du fait de quelques mutations spécifiques dans son premier domaine immunoglobuline. En revanche, Nétrine-1 induit spécifiquement la phosphorylation du récepteur Robo3 de mammifère, via les kinases Src. Robo3 ne se lie pas directement à Nétrine-1 mais interagit avec DCC. Nétrine-1 n'est pas capable d'induire l'attraction de neurones du pont déficients en Robo3, Résumé Le développement des neurones commissuraux est régi par des molécules de guidage axonal largement conservées au cours de l'évolution. On y retrouve les protéines Slits, qui sont les ligands répulsifs des récepteurs Roundabout (Robo)
Nous proposons ainsi que l'évolution de Robo3 a joué un rôle clé dans la constitution du cerveau des mammifères, en le faisant passer d'un récepteur répulsif des Slits à, à la fois, un inhibiteur de la répulsion des Slits ,